GO:0009755

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Name hormone-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0009755
Unique Molecular Interactions 514
Total Molecular Interactions 756
Total Single Events 7525
Pain Genes Associated 38

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hormone-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for hormone-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20133 Trh Positive_regulation of Localization of Prl 23 0.78 2.04 5.44
2 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
3 INT1390 Trh Positive_regulation of Prl 14 0.67 4.42 4.39
4 INT1392 Trh Regulation of Prl 15 0.29 2.47 4.29
5 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
6 INT26677 Penk Regulation of Localization of Trh 5 0.50 0 3.05
7 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
8 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
9 INT26676 Pomc Regulation of Localization of Trh 3 0.14 0 1.73
10 INT32839 Binding of Trh and Penk 2 0.42 0 1.63
11 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
12 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
13 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
14 INT19013 Ghsr Negative_regulation of Localization of Sst 1 0.15 0 1.44
15 INT19012 Ghsr Negative_regulation of Localization of Sstr1 1 0.10 0 1.44
16 INT33988 TRH Regulation of Localization of IGKV1D-39 1 0.12 0.47 1.35
17 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
18 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
19 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
20 INT209088 Binding of Ceacam3 and Crhr1 1 0.34 1.26 1.11
21 INT25036 TRH Regulation of Prl 4 0.27 1.75 1.09
22 INT81788 Binding of AGRP and MC4R 4 0.51 0 1.09
23 INT7927 Penk Regulation of Trh 2 0.26 0.66 1.09
24 INT34900 Trh Positive_regulation of Localization of Prl 1 0.05 0 1.09
25 INT17414 TRH Positive_regulation of Prl 4 0.47 0 1.07
26 INT69871 ASIP Negative_regulation of TYRP1 1 0.36 0 1.07
27 INT57509 Trh Negative_regulation of Adarb1 1 0.02 0.22 1.05
28 INT25155 TRH Positive_regulation of PRL 2 0.50 0.4 1
29 INT30135 S100A9 Positive_regulation of REN 1 0.32 0.32 1
30 INT140068 Binding of GH1 and Ghsr 1 0.00 0.47 0.97
31 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
32 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91
33 INT32840 Regulation of Binding of Trh and Penk 1 0.26 0 0.91
34 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
35 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88
36 INT17416 TRH Positive_regulation of Localization of Prl 1 0.47 0 0.85
37 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84
38 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
39 INT7926 Regulation of Penk Regulation of Trh 1 0.26 0.66 0.8
40 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77
41 INT52561 Trh Positive_regulation of Localization of Lhb 1 0.01 0.14 0.77
42 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
43 INT99335 Binding of Agrp and Mc1r 1 0.30 0 0.77
44 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
45 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
46 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
47 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
48 INT353718 Binding of Rbm39 and Ghsr 1 0.01 0 0.76
49 INT3570 Trh Regulation of Localization of Gnrhr 2 0.26 0.3 0.75
50 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
51 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
52 INT196799 Prkaca Positive_regulation of Phosphorylation of Trh 1 0.02 0 0.74
53 INT41919 Binding of Tacr1 and Trh 1 0.06 0 0.74
54 INT288371 Binding of Atrn and a 1 0.39 0 0.74
55 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
56 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
57 INT290548 Positive_regulation of Crhr1 Positive_regulation of Etf1 1 0.01 0.38 0.72
58 INT43717 Positive_regulation of Binding of Trh and Penk 1 0.56 0 0.72
59 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69
60 INT122190 Binding of Crhr1 and Ucn 4 0.49 0.65 0.67
61 INT40763 Trh Negative_regulation of Penk 1 0.19 0 0.65
62 INT107330 Binding of Adarb1 and Trh 1 0.01 0 0.65
63 INT40762 Trh Negative_regulation of Prss12 1 0.06 0 0.65
64 INT356329 Crhr1 Regulation of Cea 1 0.09 0.31 0.64
65 INT6465 Trh Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
66 INT356314 Binding of Crhr1 and ORF61 1 0.00 0 0.63
67 INT3617 Trh Regulation of Localization of Gh1 3 0.65 0.55 0.62
68 INT2687 Negative_regulation of Binding of Thra and SGSM3 1 0.43 0.1 0.62
69 INT19011 Binding of Ghrh and Ghsr 1 0.40 0 0.62
70 INT2686 Binding of Thra and SGSM3 1 0.36 0.1 0.61
71 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
72 INT40153 Gnrh1 Regulation of Trh 1 0.47 0 0.59
73 INT2685 S100A6 Positive_regulation of Regulation of Thra 1 0.47 0.09 0.58
74 INT2684 S100A6 Regulation of Regulation of Thra 1 0.45 0.09 0.58
75 INT98815 Binding of Crhr2 and Ucn 3 0.32 0.5 0.56
76 INT25156 TRH Regulation of PRL 2 0.27 0.81 0.56
77 INT356321 Positive_regulation of Crhr1 Positive_regulation of Cea 1 0.19 0.37 0.56
78 INT81792 AGRP Negative_regulation of INSRR 3 0.01 0 0.55
79 INT356322 Positive_regulation of Crhr1 Positive_regulation of ORF61 1 0.00 0 0.54
80 INT10079 Cp Regulation of Trh 1 0.01 0.59 0.53
81 INT34368 TRH Positive_regulation of GHRH 1 0.23 0.4 0.53
82 INT49696 Trh Regulation of GH1 2 0.02 0.22 0.52
83 INT130161 IgG-2a Positive_regulation of Gene_expression of Crhr1 1 0.01 0 0.52
84 INT130158 Pomc Regulation of Gene_expression of Crhr1 1 0.20 0 0.52
85 INT130163 Pomc Positive_regulation of Gene_expression of Crhr1 1 0.15 0 0.52
86 INT130159 IgG-2a Regulation of Gene_expression of Crhr1 1 0.01 0 0.52
87 INT205030 Crh Positive_regulation of Crhr1 2 0.54 1.33 0.51
88 INT89187 Agrp Negative_regulation of Mc3r 1 0.33 0 0.51
89 INT89186 Agrp Negative_regulation of Mc4r 1 0.40 0 0.51
90 INT222524 Abat Negative_regulation of Localization of Trh 1 0.02 0.16 0.51
91 INT34980 Regulation of Trh Positive_regulation of Localization of Prl 1 0.50 0 0.49
92 INT140067 GH1 Positive_regulation of Ghsr 1 0.00 0.23 0.49
93 INT17610 Binding of Ctse and Trh 1 0.27 0.89 0.49
94 INT30801 Penk Negative_regulation of Trh 1 0.09 0 0.49
95 INT61510 Binding of Trh and Gm14673 1 0.01 0 0.48
96 INT140066 Ghsr Positive_regulation of GH1 1 0.00 0.23 0.48
97 INT30802 Pomc Negative_regulation of Trh 1 0.11 0 0.48
98 INT17463 Trh Regulation of Localization of Prl 2 0.30 0.22 0.47
99 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
100 INT136141 Hsd11b1 Positive_regulation of Gene_expression of Agrp 1 0.64 0.2 0.47
101 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
102 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
103 INT34982 Trh Regulation of Dbi 1 0.12 0 0.47
104 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
105 INT34984 Negative_regulation of Trh Regulation of Dbi 1 0.19 0 0.47
106 INT93508 Binding of ASIP and Mc1r 1 0.02 0 0.47
107 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
108 INT39142 ras Positive_regulation of REN 1 0.01 1.34 0.45
109 INT35167 Adrb2 Positive_regulation of Trh 1 0.05 0 0.45
110 INT69873 ASIP Negative_regulation of Binding of POMC 1 0.35 0 0.45
111 INT39143 ras Positive_regulation of Gene_expression of REN 1 0.01 1.35 0.45
112 INT288370 a Positive_regulation of Mc1r 1 0.39 0 0.44
113 INT325391 Binding of Ghrl and Ghsr 2 0.17 0.14 0.43
114 INT19906 Positive_regulation of Trh Regulation of Prl 2 0.04 0.47 0.43
115 INT323484 Ghsr Positive_regulation of Localization of Ins1 1 0.27 0.87 0.43
116 INT32161 Negative_regulation of Trh Positive_regulation of Prl 1 0.48 0 0.42
117 INT34985 Gene_expression of Pomc Positive_regulation of Localization of Trh 1 0.09 0 0.42
118 INT17415 Negative_regulation of TRH Positive_regulation of Prl 1 0.44 0 0.42
119 INT34983 Gene_expression of Dbi Positive_regulation of Localization of Trh 1 0.22 0 0.42
120 INT44312 Binding of Trh and Pag1 1 0.05 0.36 0.41
121 INT196797 Trh Negative_regulation of Prkaca 1 0.01 0 0.41
122 INT214151 Gabrg1 Negative_regulation of Gene_expression of Agrp 1 0.04 0.52 0.4
123 INT35201 Trh Regulation of Tshb 1 0.01 0.28 0.39
124 INT33713 Binding of ITPR3 and Trh 1 0.00 0.86 0.39
125 INT196800 Trh Negative_regulation of Ppp1cc 1 0.01 0 0.39
126 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
127 INT196796 Ppp1r1b Negative_regulation of Phosphorylation of Trh 1 0.01 0 0.39
128 INT3634 Trh Regulation of Gh1 3 0.20 0.23 0.38
129 INT105770 SST Negative_regulation of Localization of TRH 1 0.17 0.54 0.38
130 INT45798 TRH Regulation of Lhb 1 0.36 0.09 0.38
131 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
132 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
133 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
134 INT175016 Binding of REN and S100A6 2 0.11 1.13 0.37
135 INT214140 Agrp Positive_regulation of Mc3r 1 0.34 0.23 0.37
136 INT39093 Negative_regulation of Prss12 Positive_regulation of Localization of Ren 1 0.10 0 0.37
137 INT39094 Negative_regulation of Nts Positive_regulation of Localization of Ren 1 0.16 0 0.37
138 INT39096 Prss12 Negative_regulation of Ren 1 0.12 0 0.37
139 INT214158 Binding of Agrp and Mc3r 1 0.35 0.18 0.37
140 INT214142 Agrp Positive_regulation of Mc4r 1 0.39 0.23 0.37
141 INT214145 Binding of Agrp and Mc4r 1 0.40 0.18 0.37
142 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
143 INT3616 Trh Positive_regulation of Localization of Gh1 4 0.73 0.49 0.36
144 INT122189 Binding of Crhr1 and Ucn2 2 0.08 0.27 0.36
145 INT16896 GHSR Regulation of GH1 2 0.23 0.24 0.36
146 INT77494 PREP Positive_regulation of TRH 1 0.16 0 0.36
147 INT16893 GHSR Positive_regulation of GH1 2 0.26 0.24 0.35
148 INT107726 BIRC2 Regulation of ASIP 1 0.03 0.24 0.35
149 INT27848 Calca Positive_regulation of Localization of Ren 1 0.39 0.06 0.34
150 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
151 INT59602 Crhr1 Positive_regulation of Localization of LH 1 0.25 0 0.33
152 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
153 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
154 INT356323 Binding of ac and Crhr1 1 0.01 0 0.32
155 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
156 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
157 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
158 INT29118 Trh Regulation of Oprd1 1 0.24 0.79 0.31
159 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
160 INT196798 Trh Positive_regulation of Phosphorylation of Ppp1r1b 1 0.01 0 0.3
161 INT73053 Prl Positive_regulation of Trh 1 0.22 0 0.3
162 INT136143 Positive_regulation of Binding of Agrp and Hsd11b1 1 0.43 0.56 0.3
163 INT136142 Binding of Agrp and Hsd11b1 1 0.33 0.56 0.3
164 INT104353 Agrp Negative_regulation of Positive_regulation of Oxt 1 0.02 0.45 0.3
165 INT39033 Hrh1 Positive_regulation of Localization of Ren 1 0.00 0.29 0.3
166 INT126696 Binding of Crhr1 and Crh 3 0.50 0.44 0.29
167 INT175017 Negative_regulation of Binding of REN and S100A6 1 0.13 0.45 0.29
168 INT222529 Binding of Trh and Vip 1 0.07 0.09 0.29
169 INT83750 Gh1 Regulation of Gene_expression of Ghsr 1 0.36 0 0.29
170 INT295549 Ghrl Positive_regulation of Gene_expression of Ghsr 1 0.29 0 0.29
171 INT3638 Trh Regulation of Localization of Gnrh1 1 0.17 0 0.29
172 INT40151 Nts Regulation of Trh 1 0.21 0 0.29
173 INT40152 Sst Regulation of Trh 1 0.22 0 0.29
174 INT41192 Trh Positive_regulation of Localization of POMC 1 0.04 0 0.29
175 INT175018 Positive_regulation of Binding of REN and S100A6 1 0.15 0.45 0.29
176 INT104352 Agrp Regulation of Positive_regulation of Etohcta1 1 0.01 0.42 0.29
177 INT81791 AGRP Negative_regulation of MC1R 2 0.47 0 0.28
178 INT25375 Trh Regulation of Gh 1 0.04 1.01 0.28
179 INT98816 Crhr2 Positive_regulation of Negative_regulation of Ucn 1 0.33 0.09 0.28
180 INT17351 Npy Regulation of Trh 1 0.46 0 0.28
181 INT3569 Trh Negative_regulation of Positive_regulation of Gh1 1 0.20 0 0.27
182 INT3574 Trh Negative_regulation of Localization of Gh1 1 0.15 0 0.27
183 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27
184 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
185 INT44443 GNRH1 Positive_regulation of Localization of TRH 1 0.08 0.19 0.26
186 INT16895 Regulation of GHSR Regulation of GH1 1 0.23 0 0.26
187 INT54263 Ghsr Regulation of Localization of Gh1 1 0.23 0 0.26
188 INT280811 Binding of Crhr1 and Ucn3 1 0.08 0.05 0.25
189 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
190 INT122232 Trh Positive_regulation of Positive_regulation of LH 1 0.18 0 0.24
191 INT122225 Trh Positive_regulation of Gh1 1 0.06 0 0.24
192 INT122222 Trh Positive_regulation of LH 1 0.18 0 0.24
193 INT25247 TRH Regulation of CGA 1 0.26 0 0.24
194 INT89469 Fk Positive_regulation of Gene_expression of Lhcgr 1 0.01 0 0.24
195 INT14642 PENK Positive_regulation of REN 1 0.72 0.19 0.23
196 INT14643 PENK Positive_regulation of Positive_regulation of REN 1 0.48 0.19 0.23
197 INT49682 Positive_regulation of Trh Positive_regulation of Prl 1 0.05 0.26 0.23
198 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
199 INT89470 CGA Regulation of Gene_expression of Lhcgr 1 0.00 0 0.23
200 INT63703 Regulation of TRH Positive_regulation of Prl 1 0.07 0 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported for hormone-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in hormone-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT339 Regulation of Trh 156 0.62 39.27 83.55
2 INT403 Localization of Trh 241 0.81 28.55 81.45
3 INT1376 Binding of Trh 121 0.48 20 69.86
4 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83
5 INT46 Localization of Ren 233 0.81 46.15 62.44
6 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
7 INT2323 Gene_expression of Trh 146 0.78 29.92 49.5
8 INT654 Localization of REN 250 0.81 75.12 47.86
9 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
10 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63
11 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
12 INT1116 Regulation of Ren 103 0.62 27.66 33.26
13 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
14 INT660 Negative_regulation of REN 194 0.59 82.06 29.46
15 INT2140 Regulation of REN 104 0.62 28.24 24.49
16 INT61665 Phosphorylation of Trh 53 0.79 2.26 23.9
17 INT55251 Gene_expression of a 142 0.67 81.21 23.03
18 INT1327 Regulation of Localization of Trh 45 0.62 6.05 22.09
19 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
20 INT14419 Negative_regulation of Localization of Trh 40 0.59 2.04 17.42
21 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7
22 INT13209 Regulation of Binding of Trh 19 0.62 2.84 16.26
23 INT9751 Localization of Crhr1 26 0.78 10.47 15.69
24 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56
25 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
26 INT661 Gene_expression of REN 100 0.78 48.21 11.36
27 INT23825 Negative_regulation of Binding of Trh 17 0.59 1.62 11.24
28 INT987 Localization of TRH 37 0.78 10.53 11.1
29 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03
30 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
31 INT8963 Gene_expression of Trh 25 0.68 7.5 10.97
32 INT8966 Regulation of Trh 12 0.62 2.73 10.79
33 INT3637 Positive_regulation of Localization of Trh 33 0.70 2.13 10.55
34 INT143964 Positive_regulation of Phosphorylation of Trh 10 0.20 0.1 10.54
35 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
36 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81
37 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93
38 INT89180 Gene_expression of Agrp 54 0.78 14.29 8.84
39 INT892 Regulation of TRH 23 0.60 8.46 8.54
40 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17
41 INT9932 Positive_regulation of Positive_regulation of Trh 13 0.50 1.8 7.63
42 INT7570 Transcription of Crhr1 7 0.66 6.6 7.6
43 INT93507 Gene_expression of ASIP 14 0.60 3.98 7.55
44 INT74326 Gene_expression of Crhr1 25 0.66 9.7 7.48
45 INT80161 Positive_regulation of Crhr1 13 0.67 9.66 7.33
46 INT9753 Positive_regulation of Localization of Crhr1 8 0.49 1.72 6.55
47 INT7923 Transcription of Trh 14 0.72 4.44 6.32
48 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31
49 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27
50 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19
51 INT34440 Negative_regulation of Positive_regulation of Trh 12 0.59 0 5.7
52 INT9895 Binding of GHR 18 0.36 4.8 5.65
53 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62
54 INT31648 Binding of Trh 11 0.48 2.09 5.48
55 INT94652 Binding of a 15 0.48 4.18 5.4
56 INT81796 Binding of AGRP 62 0.36 37.19 5.3
57 INT18661 Localization of Ghsr 32 0.78 3.19 5.2
58 INT10078 Positive_regulation of Gene_expression of Trh 17 0.50 4.23 5.19
59 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04
60 INT18245 Negative_regulation of Localization of Crhr1 4 0.17 0.28 4.81
61 INT7568 Negative_regulation of Crhr1 8 0.43 4.63 4.77
62 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
63 INT4577 Negative_regulation of Thra 24 0.56 3.75 4.73
64 INT149091 Gene_expression of Ghsr 42 0.76 5.11 4.6
65 INT8965 Positive_regulation of Trh 11 0.57 5.28 4.46
66 INT3097 Binding of Ren 12 0.48 3.15 4.4
67 INT8964 Regulation of Gene_expression of Trh 1 0.22 1.78 4.4
68 INT5015 Regulation of Gene_expression of Trh 9 0.62 6.47 4.25
69 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24
70 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
71 INT178261 Positive_regulation of Gene_expression of a 23 0.55 14.67 4.07
72 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
73 INT128415 Positive_regulation of Agrp 36 0.64 11.87 3.91
74 INT85537 Regulation of Crhr1 4 0.45 1.64 3.53
75 INT949 Negative_regulation of TRH 12 0.43 3.06 3.4
76 INT12388 Negative_regulation of Crhr1 17 0.59 9.47 3.33
77 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27
78 INT127336 Positive_regulation of Transcription of Crhr1 3 0.48 3.37 3.19
79 INT211708 Regulation of a 4 0.42 1.92 3.15
80 INT2897 Positive_regulation of Thra 20 0.45 5.17 3.01
81 INT1177 Positive_regulation of Positive_regulation of Ren 16 0.70 6.11 3
82 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
83 INT9752 Regulation of Localization of Crhr1 3 0.44 0.36 2.82
84 INT34814 Negative_regulation of Trh 5 0.43 0.36 2.8
85 INT19009 Positive_regulation of Ghsr 17 0.64 5.71 2.78
86 INT2324 Positive_regulation of Regulation of Trh 7 0.50 2.22 2.65
87 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
88 INT122187 Positive_regulation of Crhr2 3 0.58 2.46 2.56
89 INT1815 Positive_regulation of Negative_regulation of Ren 6 0.47 1.32 2.54
90 INT188756 Positive_regulation of AGRP 43 0.60 23.67 2.51
91 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47
92 INT27267 Localization of Trh 11 0.80 1.76 2.47
93 INT59531 Positive_regulation of Transcription of Trh 6 0.69 1.31 2.42
94 INT1178 Positive_regulation of Gene_expression of Ren 16 0.60 7.71 2.41
95 INT39394 Regulation of Ren1 13 0.45 4.83 2.4
96 INT22019 Regulation of GHR 9 0.62 2.56 2.39
97 INT988 Positive_regulation of Negative_regulation of Trh 3 0.50 0 2.39
98 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38
99 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
100 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
101 INT101955 Gene_expression of Crhr2 6 0.64 3.62 2.31
102 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
103 INT99331 Binding of Agrp 6 0.40 1.08 2.3
104 INT25159 Regulation of Positive_regulation of TRH 4 0.44 0.35 2.28
105 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26
106 INT35210 Gene_expression of Ghsr 39 0.75 6 2.24
107 INT30202 Positive_regulation of GHRL 5 0.44 3.04 2.22
108 INT16285 Regulation of Negative_regulation of Trh 3 0.62 0.9 2.22
109 INT178246 Negative_regulation of Gene_expression of a 8 0.43 4.27 2.19
110 INT3533 Binding of REN 24 0.37 10.84 2.16
111 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11
112 INT178260 Positive_regulation of a 6 0.50 3.09 2.08
113 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
114 INT323480 Negative_regulation of Ghsr 4 0.36 0.9 2.06
115 INT91608 Negative_regulation of ASIP 3 0.40 0.51 2.04
116 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
117 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
118 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9
119 INT14536 Positive_regulation of Gene_expression of Trh 4 0.50 0.54 1.9
120 INT133703 Negative_regulation of Phosphorylation of Trh 4 0.19 0.85 1.88
121 INT25332 Positive_regulation of Binding of Trh 3 0.50 0.08 1.84
122 INT88269 Binding of ASIP 4 0.19 0.41 1.82
123 INT4786 Gene_expression of GHRL 7 0.78 7.94 1.76
124 INT16284 Negative_regulation of Negative_regulation of Trh 5 0.43 0.39 1.75
125 INT142929 Regulation of Crhr2 1 0.44 1.28 1.73
126 INT1500 Negative_regulation of Gene_expression of Ren 10 0.43 4.44 1.68
127 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
128 INT3084 Negative_regulation of Negative_regulation of REN 6 0.42 2.2 1.68
129 INT89467 Gene_expression of Lhcgr 9 0.36 1.59 1.62
130 INT19007 Binding of Ghsr 5 0.46 0.46 1.6
131 INT30683 Binding of TRH 4 0.36 0.96 1.55
132 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
133 INT205025 Positive_regulation of Positive_regulation of Crhr1 2 0.70 1.22 1.51
134 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
135 INT44164 Localization of Ren1 18 0.49 10.53 1.49
136 INT93792 Binding of Crhr1 4 0.48 1.32 1.49
137 INT129198 Negative_regulation of Agrp 16 0.59 3.88 1.43
138 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43
139 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
140 INT23764 Regulation of Localization of TRH 4 0.45 0.75 1.4
141 INT112934 Binding of Crhr1 7 0.46 2.69 1.39
142 INT178249 Regulation of Gene_expression of a 4 0.35 2.3 1.39
143 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
144 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
145 INT101954 Binding of Crhr2 4 0.31 1.23 1.34
146 INT948 Negative_regulation of Regulation of TRH 3 0.42 0.74 1.28
147 INT2681 Binding of Thra 11 0.32 5.98 1.27
148 INT19999 Regulation of Positive_regulation of Trh 5 0.44 0.15 1.26
149 INT47 Negative_regulation of Negative_regulation of Ren 2 0.59 0.34 1.25
150 INT11242 Transcription of TRH 1 0.14 0 1.24
151 INT28888 Positive_regulation of Crhr2 6 0.68 3.8 1.23
152 INT31647 Negative_regulation of Gene_expression of Trh 5 0.43 1.07 1.22
153 INT111655 Localization of Agrp 4 0.75 0.88 1.21
154 INT2682 Regulation of Thra 4 0.55 0.49 1.21
155 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
156 INT17918 Regulation of Regulation of Trh 4 0.45 1.37 1.11
157 INT57852 Regulation of Ghsr 15 0.59 1.02 1.1
158 INT178255 Localization of a 4 0.65 0.72 1.1
159 INT19277 Gene_expression of Thra 4 0.58 0.68 1.1
160 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
161 INT149090 Positive_regulation of Ghsr 10 0.70 2.33 1.06
162 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05
163 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
164 INT13808 Negative_regulation of Regulation of Trh 3 0.43 0.18 1
165 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
166 INT253957 Gene_expression of THRA 14 0.58 7.07 0.97
167 INT219980 Positive_regulation of THRA 4 0.49 1.17 0.96
168 INT169336 Binding of Jak2 2 0.42 1.31 0.93
169 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
170 INT16898 Localization of GHSR 8 0.74 1.76 0.91
171 INT2482 Regulation of Positive_regulation of REN 4 0.59 2.62 0.91
172 INT174281 Positive_regulation of Positive_regulation of Agrp 4 0.41 1.71 0.91
173 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
174 INT81794 Regulation of AGRP 12 0.39 4.94 0.9
175 INT178252 Transcription of a 3 0.67 0.73 0.9
176 INT75050 Binding of GHSR 3 0.47 0.64 0.89
177 INT353715 Negative_regulation of Gene_expression of Ghsr 1 0.35 0 0.89
178 INT81795 Negative_regulation of AGRP 23 0.41 10.93 0.87
179 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
180 INT23756 Regulation of Negative_regulation of REN 5 0.44 0.77 0.87
181 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
182 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
183 INT44300 Negative_regulation of Regulation of Ren 1 0.42 0.1 0.84
184 INT145073 Regulation of Gene_expression of ASIP 1 0.27 0 0.83
185 INT43998 Regulation of Gene_expression of TRH 1 0.44 0.32 0.83
186 INT99723 Binding of Ren1 7 0.27 3.98 0.82
187 INT219983 Binding of THRA 1 0.08 1.08 0.82
188 INT104350 Regulation of Agrp 9 0.52 3.53 0.81
189 INT40053 Positive_regulation of Positive_regulation of Ren1 4 0.54 4.41 0.81
190 INT104040 Regulation of Crhr2 2 0.36 1.29 0.81
191 INT118986 Positive_regulation of Gene_expression of ASIP 1 0.39 0.97 0.8
192 INT74324 Positive_regulation of Gene_expression of Crhr1 6 0.49 2.91 0.79
193 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
194 INT77256 Negative_regulation of Gene_expression of Crhr1 5 0.40 2.52 0.77
195 INT101952 Negative_regulation of Crhr2 1 0.17 0.97 0.77
196 INT5312 Regulation of Gene_expression of REN 4 0.41 0.73 0.76
197 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
198 INT89109 Regulation of Transcription of Trh 2 0.45 1.98 0.74
199 INT290527 Positive_regulation of Localization of Crhr1 1 0.37 1.4 0.74
200 INT290534 Localization of Crhr1 1 0.56 1.4 0.74
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