GO:0009798

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Name axis specification
Categary Process
Go Slim No
Go Link GO:0009798
Unique Molecular Interactions 77
Total Molecular Interactions 94
Total Single Events 743
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for axis specification. They are ordered first by their pain relevance and then by number of times they were reported for axis specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
2 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
3 INT129270 Binding of Wnt4 and Efs 1 0.00 0 0.55
4 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
5 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
6 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42
7 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
8 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
9 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
10 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
11 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
12 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
13 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
14 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
15 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
16 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
17 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
18 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
19 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
20 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
21 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
22 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
23 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
24 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
25 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
26 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
27 INT340608 Binding of Creb1 and Wnt3a 1 0.30 0.24 0.14
28 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
29 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
30 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
31 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
32 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
33 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
34 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
35 INT262255 Binding of APC and F2R 1 0.05 3 0.1
36 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
37 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
38 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
39 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
40 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05
41 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05
42 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
43 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
44 INT343744 mn Negative_regulation of Regulation of Wnt7a 1 0.01 0.1 0
45 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
46 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
47 INT251072 Wnt3a Positive_regulation of Axin2 1 0.23 0.29 0
48 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
49 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
50 INT326893 Binding of Tcf4 and Wnt3a 1 0.13 0 0
51 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
52 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
53 INT268521 Binding of WNT1 and MIR221 1 0.02 1.36 0
54 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
55 INT301674 Binding of APC and CD80 1 0.01 0.53 0
56 INT326896 Wnt3a Positive_regulation of Transcription of PLD2 1 0.24 0.06 0
57 INT195661 Binding of APC and PROC 1 0.23 0.89 0
58 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
59 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
60 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0
61 INT251070 Wnt3a Positive_regulation of Cldn3 1 0.30 0.29 0
62 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
63 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
64 INT326894 Wnt3a Positive_regulation of Transcription of Pld1 1 0.24 0.06 0
65 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
66 INT268395 Binding of APC and Kras 1 0.04 1.21 0
67 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0
68 INT80660 INS Positive_regulation of APC 1 0.32 0.65 0
69 INT283362 AXIN2 Negative_regulation of APC 1 0.10 1.67 0
70 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
71 INT195659 APC Positive_regulation of Gene_expression of PROC 1 0.26 0.31 0
72 INT213025 Vtn Positive_regulation of Apc 1 0.01 1.19 0
73 INT213054 Hdl1 Regulation of Apc 1 0.05 1.24 0
74 INT80659 Positive_regulation of INS Positive_regulation of APC 1 0.32 0.65 0
75 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0
76 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0
77 INT341501 Binding of Apc and Pdcd1 1 0.00 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for axis specification. They are ordered first by their pain relevance and then by number of times they were reported in axis specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
2 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
3 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
4 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
5 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
6 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
7 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
8 INT63121 Binding of APC 29 0.41 23.02 3.8
9 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
10 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
11 INT55090 Positive_regulation of Wnt7a 13 0.37 2.25 2.2
12 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1
13 INT3818 Regulation of Apc 13 0.39 12.52 1.68
14 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
15 INT220177 Binding of Apc 21 0.37 15.34 1.37
16 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
17 INT141834 Negative_regulation of Gene_expression of WNT1 3 0.57 1.31 1.2
18 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
19 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
20 INT127647 Regulation of Wnt7a 3 0.07 1.28 1.01
21 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
22 INT242134 Localization of Apc 8 0.74 4.83 0.88
23 INT141835 Negative_regulation of WNT1 2 0.41 1.02 0.83
24 INT57062 Regulation of APC 24 0.58 14.3 0.7
25 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
26 INT28958 Negative_regulation of Wnt7a 3 0.45 0.49 0.65
27 INT127648 Gene_expression of Wnt7a 2 0.13 1.11 0.56
28 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
29 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
30 INT340598 Binding of Wnt3a 1 0.33 0.15 0.46
31 INT228057 Positive_regulation of WNT1 1 0.49 1.8 0.44
32 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
33 INT340606 Positive_regulation of Wnt3a 1 0.61 0.49 0.4
34 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38
35 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
36 INT216379 Positive_regulation of Gene_expression of WNT1 5 0.30 3.1 0.34
37 INT118243 Transcription of APC 4 0.45 3.33 0.33
38 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
39 INT225667 Transcription of Apc 3 0.52 3.73 0.32
40 INT195672 Localization of APC 7 0.74 3.76 0.3
41 INT51514 Positive_regulation of Wnt3a 3 0.04 3.32 0.28
42 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
43 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
44 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
45 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
46 INT55089 Positive_regulation of Positive_regulation of Wnt7a 2 0.27 0.06 0.16
47 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
48 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
49 INT51512 Negative_regulation of Positive_regulation of Wnt3a 1 0.04 1.3 0.13
50 INT51513 Positive_regulation of Positive_regulation of Wnt3a 1 0.04 1.31 0.13
51 INT242140 Regulation of Localization of Apc 1 0.12 0.12 0.11
52 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1
53 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09
54 INT214463 Binding of Wnt3a 2 0.26 0.23 0.08
55 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05
56 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05
57 INT159426 Positive_regulation of Gene_expression of Wnt7a 1 0.10 0.51 0.05
58 INT287956 Regulation of WNT1 2 0.26 2.38 0.04
59 INT287936 Regulation of Gene_expression of WNT1 1 0.20 1.06 0.04
60 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03
61 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0
62 INT214465 Localization of Wnt3a 2 0.52 0.29 0
63 INT251053 Gene_expression of Wnt3a 2 0.47 0.5 0
64 INT326853 Positive_regulation of Gene_expression of Wnt3a 1 0.36 0.2 0
65 INT266460 Positive_regulation of Binding of Wnt7a 1 0.04 0.06 0
66 INT337657 Negative_regulation of Negative_regulation of APC 1 0.37 0.99 0
67 INT104591 Negative_regulation of Negative_regulation of Apc 1 0.04 0.16 0
68 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0
69 INT251054 Regulation of Localization of Wnt3a 1 0.27 0.07 0
70 INT191087 Regulation of Regulation of Apc 1 0.06 1.02 0
71 INT266459 Binding of Wnt7a 1 0.03 0.06 0
72 INT283365 Positive_regulation of Binding of APC 1 0.50 1.43 0
73 INT205585 Regulation of Wnt4 1 0.45 0.7 0
74 INT337667 Regulation of Transcription of APC 1 0.23 1 0
75 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0
76 INT251066 Regulation of Gene_expression of Wnt3a 1 0.31 0.07 0
77 INT205578 Negative_regulation of Wnt4 1 0.43 1.69 0
78 INT343743 Negative_regulation of Regulation of Wnt7a 1 0.04 0.1 0
79 INT205581 Regulation of Negative_regulation of Wnt4 1 0.27 0.7 0
80 INT326843 Negative_regulation of Gene_expression of Wnt3a 1 0.22 0.29 0
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