GO:0009804

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Name coumarin metabolic process
Categary Process
Go Slim No
Go Link GO:0009804
Unique Molecular Interactions 50
Total Molecular Interactions 57
Total Single Events 855
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for coumarin metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for coumarin metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
2 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
3 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
4 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
5 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
6 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
7 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
8 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
9 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
10 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
11 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
12 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
13 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
14 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
15 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
16 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
17 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
18 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
19 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
20 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
21 INT261631 Binding of CYP2A6 and CYP2B6 1 0.18 0.32 0.18
22 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
23 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
24 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
25 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
26 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
27 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
28 INT57170 Binding of Cyp1a1 and Cyp2b1 1 0.39 0 0.13
29 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
30 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
31 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
32 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
33 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09
34 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
35 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
36 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
37 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
38 INT180344 CYP2A6 Regulation of AMELX 1 0.01 2.01 0.05
39 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05
40 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
41 INT180348 CYP2A6 Regulation of AIRE 1 0.01 2.01 0.05
42 INT199717 2610029G23Rik Regulation of CYP2D6 1 0.02 0.44 0
43 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
44 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
45 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0
46 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
47 INT199721 2610029G23Rik Regulation of CYP2A6 1 0.02 0.42 0
48 INT169147 Binding of CYP2D6 and CYP3A 1 0.17 0 0
49 INT210416 ITGA4 Negative_regulation of CYP2D6 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for coumarin metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in coumarin metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
2 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
3 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
4 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
5 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
6 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
7 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
8 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
9 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
10 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
11 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
12 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
13 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
14 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
15 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
16 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
17 INT101342 Negative_regulation of CYP2A6 11 0.53 3.68 2.39
18 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
19 INT89701 Binding of CYP2A6 4 0.36 0.92 2.23
20 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
21 INT70878 Gene_expression of CYP2A6 17 0.75 4.25 2.02
22 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01
23 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
24 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
25 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
26 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
27 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34
28 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25
29 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19
30 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
31 INT68220 Binding of CYP1A1 8 0.48 0.8 0.99
32 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
33 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6
34 INT115826 Transcription of Cyp1a1 4 0.52 1.15 0.53
35 INT2438 Regulation of Regulation of Cyp1a1 1 0.27 0 0.52
36 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51
37 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47
38 INT27414 Positive_regulation of Negative_regulation of Cyp1a1 1 0.49 0.44 0.41
39 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4
40 INT115835 Negative_regulation of Positive_regulation of Cyp1a1 2 0.32 1.35 0.36
41 INT13676 Negative_regulation of Gene_expression of Cyp1a1 1 0.33 0.1 0.29
42 INT96886 Positive_regulation of Gene_expression of CYP1A1 8 0.64 3.15 0.27
43 INT99628 Positive_regulation of Gene_expression of Cyp1a1 4 0.25 1.3 0.27
44 INT115926 Negative_regulation of Positive_regulation of CYP1A1 1 0.30 0.16 0.27
45 INT52176 Positive_regulation of Binding of Cyp1a1 1 0.44 0 0.26
46 INT347186 Regulation of Negative_regulation of Cyp2d4 1 0.45 0.21 0.25
47 INT115834 Positive_regulation of Transcription of Cyp1a1 2 0.38 0.64 0.23
48 INT65885 Negative_regulation of CYP1A1 2 0.18 0.64 0.2
49 INT96884 Regulation of Gene_expression of CYP1A1 2 0.60 0.54 0.2
50 INT96889 Negative_regulation of Gene_expression of CYP1A1 2 0.42 0.9 0.2
51 INT85595 Positive_regulation of CYP2A6 5 0.67 1.02 0.17
52 INT137622 Protein_catabolism of CYP2D6 2 0.38 0 0.17
53 INT222905 Regulation of CYP2A6 2 0.32 0.8 0.17
54 INT344065 Negative_regulation of Binding of CYP2D6 1 0.15 0.05 0.17
55 INT344067 Negative_regulation of Binding of CYP2A6 1 0.19 0.05 0.17
56 INT134195 Regulation of Transcription of Cyp1a1 1 0.13 0.14 0.16
57 INT261231 Negative_regulation of Gene_expression of Cyp2d4 2 0.42 0.36 0.14
58 INT17866 Positive_regulation of Localization of Cyp1a1 1 0.49 0 0.12
59 INT349935 Transcription of CYP1A1 1 0.47 1.22 0.12
60 INT113802 Transcription of Cyp2d4 1 0.69 0 0.11
61 INT137624 Protein_catabolism of CYP2A6 1 0.32 0 0.11
62 INT68218 Regulation of Positive_regulation of CYP1A1 3 0.45 2.35 0.1
63 INT17863 Regulation of Positive_regulation of Cyp1a1 1 0.27 0 0.09
64 INT274054 Localization of CYP1A1 1 0.12 0 0.07
65 INT274056 Protein_catabolism of CYP1A1 1 0.15 0 0.06
66 INT199792 Negative_regulation of Gene_expression of CYP2A6 2 0.41 0.55 0.05
67 INT68219 Positive_regulation of Binding of CYP1A1 1 0.50 0 0.05
68 INT180329 Positive_regulation of Binding of Cyp2d4 1 0.33 1.97 0.05
69 INT264053 Positive_regulation of Negative_regulation of Cyp2d4 1 0.25 0.18 0.03
70 INT167112 Regulation of CYP1A1 3 0.26 0.37 0
71 INT294588 Positive_regulation of Positive_regulation of CYP1A1 1 0.07 0.25 0
72 INT199800 Transcription of CYP2A6 1 0.52 0.77 0
73 INT330999 Negative_regulation of Positive_regulation of CYP2D6 1 0.40 0 0
74 INT85223 Regulation of Localization of Cyp1a1 1 0.03 0.1 0
75 INT167111 Regulation of Binding of CYP1A1 1 0.43 0 0
76 INT169150 Regulation of Binding of CYP2D6 1 0.41 0 0
77 INT180326 Regulation of Gene_expression of Cyp2d4 1 0.18 0.77 0
78 INT197269 Regulation of Gene_expression of Cyp1a1 1 0.16 0 0
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