GO:0009820

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Name alkaloid metabolic process
Categary Process
Go Slim No
Go Link GO:0009820
Unique Molecular Interactions 60
Total Molecular Interactions 65
Total Single Events 1032
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for alkaloid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for alkaloid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
2 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
3 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
4 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
5 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
6 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
7 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
8 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
9 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
10 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
11 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
12 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
13 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
14 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
15 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
16 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
17 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
18 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
19 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
20 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
21 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
22 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
23 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
24 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
25 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
26 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
27 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
28 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
29 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
30 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
31 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
32 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
33 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
34 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
35 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
36 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
37 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
38 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
39 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
40 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
41 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
42 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05
43 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
44 INT285385 Ass1 Positive_regulation of Transcription of Cyp1a2 1 0.00 0.09 0.03
45 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
46 INT199717 2610029G23Rik Regulation of CYP2D6 1 0.02 0.44 0
47 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
48 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
49 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
50 INT53286 Binding of CYP1A2 and OPN1LW 1 0.03 0 0
51 INT157283 CYP1A2 Positive_regulation of Gm7100 1 0.00 0 0
52 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
53 INT95055 Binding of CYP1A2 and TXNRD1 1 0.04 0 0
54 INT169147 Binding of CYP2D6 and CYP3A 1 0.17 0 0
55 INT210416 ITGA4 Negative_regulation of CYP2D6 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for alkaloid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in alkaloid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
2 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
3 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
4 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
5 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
6 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
7 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
8 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
9 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
10 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
11 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
12 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
13 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
14 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
15 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
16 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
17 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
18 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
19 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
20 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
21 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
22 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
23 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
24 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
25 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
26 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
27 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
28 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
29 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
30 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
31 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
32 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
33 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
34 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
35 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
36 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
37 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
38 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19
39 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
40 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
41 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
42 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
43 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
44 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
45 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
46 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
47 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
48 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
49 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
50 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
51 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
52 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68
53 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6
54 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51
55 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47
56 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4
57 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34
58 INT273509 Positive_regulation of Gene_expression of Cyp1a2 2 0.14 1.2 0.33
59 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28
60 INT347186 Regulation of Negative_regulation of Cyp2d4 1 0.45 0.21 0.25
61 INT17861 Positive_regulation of Localization of Cyp1a2 2 0.50 0.05 0.21
62 INT137622 Protein_catabolism of CYP2D6 2 0.38 0 0.17
63 INT344065 Negative_regulation of Binding of CYP2D6 1 0.15 0.05 0.17
64 INT344068 Negative_regulation of Binding of CYP1A2 1 0.15 0.05 0.17
65 INT261231 Negative_regulation of Gene_expression of Cyp2d4 2 0.42 0.36 0.14
66 INT314338 Positive_regulation of Transcription of Cyp1a2 1 0.13 0.38 0.14
67 INT231567 Negative_regulation of Gene_expression of CYP1A2 2 0.36 0.06 0.13
68 INT162937 Regulation of Regulation of CYP1A2 1 0.45 0 0.12
69 INT162936 Regulation of Gene_expression of CYP1A2 1 0.45 0 0.12
70 INT113802 Transcription of Cyp2d4 1 0.69 0 0.11
71 INT137619 Protein_catabolism of Cyp1a2 1 0.33 0 0.11
72 INT135458 Negative_regulation of Negative_regulation of Cyp1a2 1 0.35 0.36 0.09
73 INT274055 Protein_catabolism of CYP1A2 1 0.47 0 0.06
74 INT73220 Regulation of Gene_expression of Cyp1a2 1 0.62 1.01 0.06
75 INT180329 Positive_regulation of Binding of Cyp2d4 1 0.33 1.97 0.05
76 INT306772 Positive_regulation of Negative_regulation of Cyp1a2 1 0.08 0.06 0.04
77 INT264053 Positive_regulation of Negative_regulation of Cyp2d4 1 0.25 0.18 0.03
78 INT303488 Negative_regulation of Positive_regulation of Cyp1a2 1 0.18 0.96 0
79 INT83244 Regulation of Positive_regulation of CYP1A2 1 0.43 1.18 0
80 INT158582 Negative_regulation of Positive_regulation of CYP1A2 1 0.41 0 0
81 INT330999 Negative_regulation of Positive_regulation of CYP2D6 1 0.40 0 0
82 INT169150 Regulation of Binding of CYP2D6 1 0.41 0 0
83 INT180326 Regulation of Gene_expression of Cyp2d4 1 0.18 0.77 0
84 INT167110 Regulation of Binding of CYP1A2 1 0.45 0 0
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