GO:0009822

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Name alkaloid catabolic process
Categary Process
Go Slim No
Go Link GO:0009822
Unique Molecular Interactions 79
Total Molecular Interactions 96
Total Single Events 1276
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for alkaloid catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for alkaloid catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
2 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
3 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
4 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
5 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
6 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
7 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
8 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
9 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
10 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
11 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
12 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
13 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
14 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
15 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
16 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
17 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
18 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
19 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
20 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
21 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
22 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
23 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
24 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
25 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
26 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
27 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
28 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
29 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
30 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
31 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
32 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
33 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
34 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
35 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
36 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
37 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
38 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
39 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
40 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
41 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
42 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
43 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
44 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
45 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
46 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
47 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
48 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
49 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
50 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
51 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
52 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
53 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05
54 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05
55 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05
56 INT177274 Binding of CYP3A4 and TNFRSF25 1 0.19 0 0.04
57 INT177273 Binding of CYP3A4 and FAUP1 1 0.02 0 0.04
58 INT339707 TRO Positive_regulation of CYP3A4 1 0.12 0.97 0.04
59 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04
60 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 0.08 0.13 0
61 INT96893 Binding of CYP3A4 and Orm2 1 0.07 0 0
62 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0
63 INT96894 Binding of CYP3A4 and Orm1 1 0.00 0 0
64 INT135130 Binding of CYP3A4 and NR1I2 1 0.34 0.31 0
65 INT199717 2610029G23Rik Regulation of CYP2D6 1 0.02 0.44 0
66 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
67 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 0.09 0.13 0
68 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
69 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
70 INT339700 CYP2B6 Positive_regulation of CYP3A4 1 0.13 0.3 0
71 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 0.08 0 0
72 INT199719 2610029G23Rik Regulation of CYP3A4 1 0.01 0.45 0
73 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
74 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0
75 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 0.00 0 0
76 INT135129 NR1I2 Regulation of Transcription of CYP3A4 1 0.58 0.6 0
77 INT169147 Binding of CYP2D6 and CYP3A 1 0.17 0 0
78 INT210416 ITGA4 Negative_regulation of CYP2D6 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for alkaloid catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in alkaloid catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
2 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
3 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
4 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
5 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
6 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
7 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
8 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
9 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
10 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
11 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
12 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
13 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
14 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
15 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
16 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
17 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
18 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
19 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
20 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
21 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
22 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
23 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
24 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
25 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
26 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
27 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
28 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
29 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
30 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
31 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19
32 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
33 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
34 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
35 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6
36 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51
37 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5
38 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47
39 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44
40 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41
41 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4
42 INT155222 Positive_regulation of Transcription of CYP3A4 2 0.50 0.13 0.34
43 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29
44 INT347186 Regulation of Negative_regulation of Cyp2d4 1 0.45 0.21 0.25
45 INT137622 Protein_catabolism of CYP2D6 2 0.38 0 0.17
46 INT344065 Negative_regulation of Binding of CYP2D6 1 0.15 0.05 0.17
47 INT345946 Negative_regulation of Localization of CYP3A4 1 0.09 0.56 0.16
48 INT261231 Negative_regulation of Gene_expression of Cyp2d4 2 0.42 0.36 0.14
49 INT113802 Transcription of Cyp2d4 1 0.69 0 0.11
50 INT100094 Regulation of Positive_regulation of CYP3A4 3 0.45 0.31 0.1
51 INT262138 Positive_regulation of Regulation of CYP3A4 1 0.15 0.06 0.07
52 INT180329 Positive_regulation of Binding of Cyp2d4 1 0.33 1.97 0.05
53 INT264053 Positive_regulation of Negative_regulation of Cyp2d4 1 0.25 0.18 0.03
54 INT123100 Positive_regulation of Positive_regulation of CYP3A4 2 0.54 0 0
55 INT277007 Negative_regulation of Transcription of CYP3A4 1 0.39 0.34 0
56 INT330999 Negative_regulation of Positive_regulation of CYP2D6 1 0.40 0 0
57 INT169150 Regulation of Binding of CYP2D6 1 0.41 0 0
58 INT277008 Regulation of Transcription of CYP3A4 1 0.41 0.67 0
59 INT180326 Regulation of Gene_expression of Cyp2d4 1 0.18 0.77 0
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