GO:0009880

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Name embryonic pattern specification
Categary Process
Go Slim No
Go Link GO:0009880
Unique Molecular Interactions 164
Total Molecular Interactions 211
Total Single Events 1163
Pain Genes Associated 33

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for embryonic pattern specification. They are ordered first by their pain relevance and then by number of times they were reported for embryonic pattern specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13
2 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
3 INT249494 Binding of Ephb1 and Efnb1 1 0.01 1.34 1.4
4 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
5 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
6 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
7 INT344388 Efnb1 Positive_regulation of Phosphorylation of Grin2b 1 0.40 1.45 0.92
8 INT156989 LPA Positive_regulation of Gene_expression of EFNB1 1 0.00 0.91 0.92
9 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
10 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
11 INT344383 Olfr360 Regulation of Gene_expression of Efnb1 1 0.01 1.27 0.74
12 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
13 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
14 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
15 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
16 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
17 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
18 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
19 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
20 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
21 INT256296 Efnb1 Positive_regulation of Ephb1 1 0.03 0.66 0.54
22 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
23 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
24 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
25 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
26 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
27 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
28 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
29 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
30 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42
31 INT326473 Positive_regulation of PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.41
32 INT326470 PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.4
33 INT326472 AGXT Negative_regulation of PGAP1 1 0.00 0.05 0.39
34 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
35 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
36 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
37 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
38 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
39 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
40 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
41 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
42 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29
43 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
44 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
45 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
46 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
47 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
48 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
49 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
50 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
51 INT340608 Binding of Creb1 and Wnt3a 1 0.30 0.24 0.14
52 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
53 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
54 INT280484 Bdnf Positive_regulation of Gene_expression of Lhx1 1 0.48 1.49 0.11
55 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
56 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
57 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
58 INT165161 Ihh Positive_regulation of Sostdc1 1 0.58 0.07 0.09
59 INT341008 Nrg1 Regulation of Binding of Erbb4 1 0.04 0 0.09
60 INT165160 Regulation of Ihh Positive_regulation of Sostdc1 1 0.23 0.07 0.09
61 INT165158 Positive_regulation of Ihh Positive_regulation of Sostdc1 1 0.42 0.07 0.09
62 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
63 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
64 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
65 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
66 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
67 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
68 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
69 INT129627 Bmp7 Positive_regulation of Id2 1 0.24 0.25 0.07
70 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
71 INT129626 Bmp7 Positive_regulation of Id3 1 0.25 0.25 0.07
72 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
73 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
74 INT251776 Negative_regulation of TXK Negative_regulation of ERBB4 1 0.04 1.07 0.06
75 INT201973 Bmp7 Positive_regulation of ap 1 0.00 0.18 0.06
76 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
77 INT118462 BMP7 Regulation of Bmp7 1 0.19 0 0.06
78 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
79 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05
80 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05
81 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
82 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
83 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
84 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
85 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
86 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
87 INT231276 Erbb4 Positive_regulation of Nrg1 2 0.35 0.06 0.03
88 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03
89 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
90 INT316060 Binding of Erbb4 and Ncor2 1 0.12 0.41 0.03
91 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
92 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03
93 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
94 INT287234 PDLIM7 Positive_regulation of Gene_expression of BMP7 1 0.14 0.12 0.03
95 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
96 INT231275 Erbb4 Positive_regulation of Gene_expression of Nrg1 1 0.35 0 0.03
97 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03
98 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
99 INT316055 Binding of Erbb4 and Tab2 1 0.23 0.4 0.03
100 INT294088 Binding of ERBB2 and ERBB4 2 0.13 0.88 0
101 INT294089 Negative_regulation of Binding of ERBB2 and ERBB4 1 0.08 0.6 0
102 INT80013 BTC Positive_regulation of ERBB4 1 0.31 0.26 0
103 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
104 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
105 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
106 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
107 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
108 INT218669 Olr811 Negative_regulation of Phosphorylation of Smad2 1 0.01 0.18 0
109 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
110 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
111 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
112 INT251072 Wnt3a Positive_regulation of Axin2 1 0.23 0.29 0
113 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
114 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
115 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
116 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
117 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
118 INT326893 Binding of Tcf4 and Wnt3a 1 0.13 0 0
119 INT244853 Lbx1 Positive_regulation of Satb2 1 0.41 0 0
120 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
121 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
122 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
123 INT327845 Binding of Aqp9 and Ooep 1 0.00 0 0
124 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
125 INT196038 Gene_expression of Bmp7 Positive_regulation of ALPP 1 0.03 0.1 0
126 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
127 INT268521 Binding of WNT1 and MIR221 1 0.02 1.36 0
128 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
129 INT185453 Binding of PRKCB and Lhx1 1 0.35 1.99 0
130 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
131 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
132 INT244857 Lbx1 Positive_regulation of Lhx1 1 0.37 0 0
133 INT326896 Wnt3a Positive_regulation of Transcription of PLD2 1 0.24 0.06 0
134 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
135 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0
136 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
137 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
138 INT251070 Wnt3a Positive_regulation of Cldn3 1 0.30 0.29 0
139 INT245828 Binding of VEGFA and Tfap2a 1 0.01 0.64 0
140 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
141 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
142 INT326894 Wnt3a Positive_regulation of Transcription of Pld1 1 0.24 0.06 0
143 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
144 INT88409 BMP7 Positive_regulation of Gene_expression of ACTA1 1 0.09 0 0
145 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
146 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
147 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
148 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
149 INT337918 sb Positive_regulation of Negative_regulation of Smad2 1 0.00 0.15 0
150 INT218670 Olr811 Regulation of Phosphorylation of Smad2 1 0.00 0.33 0
151 INT269938 Smad2 Positive_regulation of Tpt1 1 0.14 0.07 0
152 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
153 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
154 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
155 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0
156 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for embryonic pattern specification. They are ordered first by their pain relevance and then by number of times they were reported in embryonic pattern specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT256285 Gene_expression of Efnb1 32 0.70 36.25 24.73
2 INT344368 Positive_regulation of Gene_expression of Efnb1 13 0.63 18.39 13.31
3 INT150285 Positive_regulation of Efnb1 6 0.29 10.22 11.44
4 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
5 INT142694 Positive_regulation of PGAP1 3 0.08 2.78 8.68
6 INT145188 Gene_expression of Efnb1 4 0.32 6.07 5.74
7 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
8 INT322474 Regulation of PGAP1 1 0.38 4.82 5.06
9 INT322475 Negative_regulation of PGAP1 9 0.36 4.78 4.69
10 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
11 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
12 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
13 INT344366 Negative_regulation of Gene_expression of Efnb1 1 0.53 5.02 3.29
14 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
15 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
16 INT344371 Phosphorylation of Efnb1 1 0.57 3.35 2.81
17 INT150288 Positive_regulation of Gene_expression of Efnb1 2 0.21 2.73 2.53
18 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
19 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
20 INT344367 Regulation of Gene_expression of Efnb1 1 0.41 4.64 2.24
21 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1
22 INT150284 Negative_regulation of Positive_regulation of Efnb1 1 0.18 1.53 1.86
23 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
24 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
25 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
26 INT237409 Localization of Erbb4 3 0.57 1.31 1.41
27 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
28 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
29 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
30 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
31 INT141834 Negative_regulation of Gene_expression of WNT1 3 0.57 1.31 1.2
32 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
33 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
34 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
35 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
36 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
37 INT156991 Positive_regulation of EFNB1 1 0.01 0.91 1
38 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
39 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
40 INT107609 Regulation of EFNB1 1 0.00 0 0.93
41 INT148861 Gene_expression of EFNB1 3 0.55 1.23 0.92
42 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
43 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
44 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
45 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
46 INT141835 Negative_regulation of WNT1 2 0.41 1.02 0.83
47 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
48 INT326487 Positive_regulation of Positive_regulation of PGAP1 1 0.01 0.07 0.8
49 INT141150 Localization of BMP7 4 0.56 2.84 0.76
50 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
51 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
52 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
53 INT249511 Binding of Efnb1 1 0.01 0.67 0.7
54 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
55 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
56 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
57 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
58 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
59 INT237411 Negative_regulation of Localization of Erbb4 1 0.25 0.08 0.64
60 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
61 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
62 INT113042 Localization of IHH 1 0.70 0.77 0.61
63 INT86624 Binding of Efnb1 4 0.27 1.09 0.6
64 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
65 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
66 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
67 INT140984 Regulation of Ihh 5 0.54 2.81 0.56
68 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
69 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
70 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
71 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
72 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
73 INT277464 Positive_regulation of Efnb1 3 0.36 0.2 0.49
74 INT326485 Negative_regulation of Positive_regulation of PGAP1 1 0.01 0.08 0.49
75 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
76 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
77 INT340598 Binding of Wnt3a 1 0.33 0.15 0.46
78 INT228057 Positive_regulation of WNT1 1 0.49 1.8 0.44
79 INT155507 Binding of EFNB1 2 0.35 0.74 0.43
80 INT283838 Gene_expression of Erbb4 5 0.59 2.37 0.42
81 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
82 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
83 INT86627 Negative_regulation of Binding of Efnb1 1 0.00 0.07 0.4
84 INT86626 Negative_regulation of Efnb1 1 0.00 0.07 0.4
85 INT340606 Positive_regulation of Wnt3a 1 0.61 0.49 0.4
86 INT92197 Gene_expression of PGAP1 1 0.00 0.3 0.4
87 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
88 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
89 INT216379 Positive_regulation of Gene_expression of WNT1 5 0.30 3.1 0.34
90 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33
91 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
92 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
93 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
94 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
95 INT260038 Localization of Efnb1 3 0.57 1.14 0.3
96 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
97 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
98 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
99 INT185428 Gene_expression of Lhx1 4 0.75 2.6 0.28
100 INT51514 Positive_regulation of Wnt3a 3 0.04 3.32 0.28
101 INT322476 Positive_regulation of Negative_regulation of PGAP1 1 0.29 0.46 0.28
102 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
103 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
104 INT80017 Gene_expression of ERBB4 10 0.77 6.94 0.26
105 INT149893 Positive_regulation of Gene_expression of Ihh 1 0.69 0.62 0.26
106 INT149892 Gene_expression of Ihh 1 0.77 0.61 0.26
107 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
108 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
109 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
110 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
111 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
112 INT265311 Localization of Smad2 5 0.50 1.57 0.21
113 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2
114 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
115 INT149888 Localization of Ihh 1 0.75 0.77 0.2
116 INT185427 Negative_regulation of Lhx1 4 0.42 3.48 0.17
117 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
118 INT268365 Binding of SMAD2 2 0.47 0.56 0.17
119 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
120 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
121 INT339267 Negative_regulation of BMP7 1 0.43 0.55 0.17
122 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
123 INT162941 Negative_regulation of Binding of Tfap2a 1 0.32 0.34 0.17
124 INT118459 Regulation of Bmp7 3 0.43 0.25 0.15
125 INT272026 Binding of Ooep 1 0.21 1.08 0.15
126 INT201968 Positive_regulation of Bmp7 2 0.43 1.11 0.14
127 INT278241 Regulation of IHH 2 0.31 1.16 0.14
128 INT135490 Localization of Smad2 1 0.51 0.08 0.14
129 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
130 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
131 INT158893 Negative_regulation of Gene_expression of Smad2 1 0.30 0.13 0.13
132 INT51512 Negative_regulation of Positive_regulation of Wnt3a 1 0.04 1.3 0.13
133 INT51513 Positive_regulation of Positive_regulation of Wnt3a 1 0.04 1.31 0.13
134 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12
135 INT129616 Negative_regulation of Phosphorylation of Smad2 4 0.38 0.78 0.12
136 INT311892 Regulation of Positive_regulation of Smad2 1 0.23 0.24 0.12
137 INT80018 Binding of ERBB4 5 0.35 2.84 0.09
138 INT80019 Regulation of ERBB4 2 0.27 1.52 0.09
139 INT325505 Transcription of Smad2 1 0.67 0.16 0.09
140 INT231258 Binding of Erbb4 3 0.23 0.16 0.08
141 INT214463 Binding of Wnt3a 2 0.26 0.23 0.08
142 INT210805 Negative_regulation of IHH 2 0.42 0.74 0.08
143 INT355332 Localization of Bmp7 1 0.09 1.92 0.08
144 INT316570 Binding of BMP7 3 0.37 0.95 0.07
145 INT205973 Binding of SHH 3 0.35 1.03 0.07
146 INT287244 Transcription of BMP7 1 0.66 0.15 0.07
147 INT168919 Regulation of Regulation of Ihh 1 0.40 0.43 0.07
148 INT287242 Positive_regulation of Transcription of BMP7 1 0.64 0.15 0.07
149 INT251797 Positive_regulation of ERBB4 3 0.33 3.14 0.06
150 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
151 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
152 INT153022 Negative_regulation of Bmp7 1 0.01 0.27 0.06
153 INT80014 Negative_regulation of Gene_expression of ERBB4 1 0.42 0.47 0.05
154 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
155 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
156 INT80016 Negative_regulation of Transcription of ERBB4 1 0.43 0.47 0.05
157 INT80015 Transcription of ERBB4 1 0.53 0.76 0.05
158 INT251811 Positive_regulation of IHH 1 0.29 0.09 0.05
159 INT254814 Positive_regulation of Phosphorylation of Smad2 7 0.33 3.74 0.04
160 INT262799 Localization of Smad3 6 0.56 2.09 0.04
161 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
162 INT337908 Binding of Smad2 3 0.24 1.06 0.04
163 INT287956 Regulation of WNT1 2 0.26 2.38 0.04
164 INT185429 Regulation of Lhx1 1 0.12 1.33 0.04
165 INT353261 Negative_regulation of Localization of Smad2 1 0.33 0 0.04
166 INT277256 Negative_regulation of Localization of Satb2 1 0.43 0.59 0.04
167 INT277254 Negative_regulation of Satb2 1 0.43 3.26 0.04
168 INT165149 Positive_regulation of Ihh 1 0.42 0.09 0.04
169 INT353263 Positive_regulation of Localization of Smad2 1 0.33 0.15 0.04
170 INT277258 Localization of Satb2 1 0.81 3.59 0.04
171 INT287936 Regulation of Gene_expression of WNT1 1 0.20 1.06 0.04
172 INT244771 Gene_expression of Satb2 4 0.68 1.27 0.03
173 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
174 INT260760 Positive_regulation of Fgf10 2 0.53 0.43 0.03
175 INT201965 Transcription of Bmp7 2 0.49 0.93 0.03
176 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
177 INT316038 Positive_regulation of Erbb4 2 0.45 0.22 0.03
178 INT254799 Transcription of Smad2 1 0.19 0.52 0.03
179 INT277259 Regulation of Satb2 1 0.45 0.72 0.03
180 INT353266 Negative_regulation of Negative_regulation of Smad2 1 0.28 0 0.03
181 INT303535 Positive_regulation of Gene_expression of Fgf10 1 0.53 0.34 0.03
182 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
183 INT283837 Phosphorylation of Erbb4 1 0.63 0.95 0.03
184 INT296618 Negative_regulation of Smad2 1 0.37 1.42 0.03
185 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
186 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
187 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
188 INT294470 Transcription of IHH 1 0.16 0.28 0.03
189 INT207729 Regulation of FGFR2 4 0.22 2.35 0
190 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0
191 INT268378 Positive_regulation of Phosphorylation of SMAD2 3 0.67 1.22 0
192 INT271411 Positive_regulation of Positive_regulation of Smad2 2 0.45 0.9 0
193 INT99716 Transcription of FGFR2 2 0.34 0.22 0
194 INT305351 Positive_regulation of Regulation of FGFR2 2 0.37 0.97 0
195 INT99715 Regulation of Gene_expression of FGFR2 2 0.22 0.19 0
196 INT307588 Positive_regulation of Gene_expression of ERBB4 2 0.38 1.84 0
197 INT214465 Localization of Wnt3a 2 0.52 0.29 0
198 INT265337 Binding of Smad3 2 0.35 1 0
199 INT251053 Gene_expression of Wnt3a 2 0.47 0.5 0
200 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0
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