GO:0009913

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Name epidermal cell differentiation
Categary Process
Go Slim No
Go Link GO:0009913
Unique Molecular Interactions 77
Total Molecular Interactions 90
Total Single Events 436
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for epidermal cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for epidermal cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
2 INT346225 Binding of PRTN3 and Flg 1 0.01 1.74 0.69
3 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
4 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
5 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
6 INT297427 Flg Positive_regulation of Gene_expression of Il13 1 0.11 1.2 0.3
7 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
8 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
9 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
10 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
11 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
12 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
13 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
14 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
15 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
16 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
17 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
18 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
19 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
20 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
21 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
22 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
23 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
24 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
25 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
26 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
27 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
28 INT24321 Pomc Positive_regulation of Localization of Gli1 1 0.07 0 0.1
29 INT165159 Gli1 Regulation of Penk 1 0.24 0.07 0.09
30 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
31 INT165157 Gli1 Regulation of Igfbp5 1 0.24 0.07 0.09
32 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
33 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
34 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07
35 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
36 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07
37 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07
38 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
39 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
40 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
41 INT268676 Binding of HDAC1 and BCOR 1 0.01 1.31 0.04
42 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
43 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
44 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
45 INT348592 Binding of HDAC1 and PPARG 1 0.23 0 0.03
46 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
47 INT319171 Binding of Cgn and Hdac1 1 0.00 0 0
48 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
49 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
50 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
51 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0
52 INT333294 Binding of Zic2 and Gli1 1 0.03 0 0
53 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
54 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
55 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0
56 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0
57 INT337408 Binding of TCF4 and KLF4 1 0.09 0 0
58 INT289372 Negative_regulation of Gli1 Positive_regulation of cac 1 0.48 0.68 0
59 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
60 INT205964 SMOX Positive_regulation of GLI1 1 0.20 0.66 0
61 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
62 INT196946 Binding of E2f1 and Hdac1 1 0.26 0.65 0
63 INT337401 Binding of E2F1 and HDAC1 1 0.07 0 0
64 INT333293 Binding of Zic1 and Gli1 1 0.01 0 0
65 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
66 INT289373 Gli1 Positive_regulation of cac 1 0.52 0.68 0
67 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
68 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
69 INT196941 Hdac1 Negative_regulation of Rb1 1 0.27 0.44 0
70 INT196944 Binding of Rb1 and Hdac1 1 0.24 0.4 0
71 INT301470 Binding of Smyd2 and Hdac1 1 0.35 0.31 0
72 INT319170 Casp3 Regulation of Hdac1 1 0.01 0.27 0
73 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0
74 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
75 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
76 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0
77 INT333684 Binding of Hr and Hdac1 1 0.19 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for epidermal cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in epidermal cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
2 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
3 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12
4 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
5 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
6 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
7 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
8 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
9 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
10 INT219879 Positive_regulation of SPINK5 4 0.30 7.64 1.16
11 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
12 INT68339 Gene_expression of HDAC2 3 0.51 1.71 1.1
13 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
14 INT119674 Localization of GLI2 6 0.52 2.84 0.99
15 INT317791 Localization of HDAC2 2 0.50 2.31 0.99
16 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
17 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
18 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
19 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
20 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
21 INT104840 Binding of GLI2 6 0.08 1.89 0.72
22 INT126376 Gene_expression of Gli1 8 0.68 4.52 0.7
23 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
24 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
25 INT152437 Localization of SPINK5 4 0.54 3.97 0.69
26 INT303669 Regulation of SPINK5 1 0.24 0.65 0.53
27 INT297421 Positive_regulation of Flg 1 0.40 1.6 0.53
28 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5
29 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49
30 INT24317 Gene_expression of Gli1 4 0.54 1.46 0.47
31 INT149890 Positive_regulation of Gene_expression of Gli1 1 0.48 1.56 0.41
32 INT158764 Binding of SPINK5 7 0.35 8.84 0.37
33 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
34 INT333916 Negative_regulation of HDAC2 2 0.18 1.38 0.36
35 INT116727 Gene_expression of Flg 3 0.53 3.13 0.34
36 INT40753 Gene_expression of GLI1 9 0.75 5.98 0.33
37 INT163253 Binding of Flg 3 0.31 3.6 0.32
38 INT272882 Positive_regulation of Binding of Hdac2 2 0.20 1.12 0.32
39 INT177856 Negative_regulation of Gene_expression of HDAC2 1 0.19 0.12 0.3
40 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
41 INT24320 Localization of Gli1 6 0.77 0.63 0.29
42 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
43 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
44 INT165153 Positive_regulation of Gli1 4 0.59 1.17 0.25
45 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
46 INT24316 Regulation of Localization of Gli1 1 0.51 0 0.19
47 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
48 INT266991 Regulation of Hdac2 2 0.07 0.74 0.15
49 INT149891 Negative_regulation of Gene_expression of Gli1 1 0.41 0.68 0.14
50 INT316526 Localization of Flg 1 0.35 0.85 0.12
51 INT316527 Positive_regulation of Localization of Flg 1 0.22 0.86 0.12
52 INT196934 Negative_regulation of Hdac1 4 0.39 1.41 0.11
53 INT331783 Regulation of Negative_regulation of Hdac1 1 0.04 0.98 0.11
54 INT282593 Gene_expression of KLF4 8 0.61 1.09 0.09
55 INT158767 Negative_regulation of SPINK5 1 0.31 0.45 0.09
56 INT24318 Regulation of Gene_expression of Gli1 1 0.23 0 0.09
57 INT331786 Negative_regulation of Binding of Hdac2 1 0.11 1.2 0.08
58 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08
59 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08
60 INT352606 Localization of Gli1 1 0.38 1.19 0.08
61 INT165151 Negative_regulation of Positive_regulation of Gli1 1 0.50 0.09 0.07
62 INT246361 Positive_regulation of Gene_expression of SPINK5 1 0.07 2.55 0.06
63 INT290112 Positive_regulation of Gene_expression of Gli1 1 0.50 1.09 0.05
64 INT290114 Negative_regulation of Gene_expression of Gli1 1 0.31 1.09 0.05
65 INT331784 Negative_regulation of Positive_regulation of Hdac2 1 0.11 0.52 0.05
66 INT205969 Regulation of GLI1 4 0.41 3.09 0.04
67 INT282606 Positive_regulation of Gene_expression of KLF4 2 0.54 0.8 0.04
68 INT352603 Negative_regulation of Localization of Gli1 1 0.18 0.6 0.04
69 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04
70 INT270456 Positive_regulation of Gli1 1 0.02 0.62 0.04
71 INT352604 Regulation of Gli1 1 0.21 0.6 0.04
72 INT328554 Regulation of HDAC1 1 0.26 1.12 0.03
73 INT331778 Regulation of Phosphorylation of Hdac2 1 0.11 0.49 0.03
74 INT331787 Phosphorylation of Hdac2 1 0.20 0.49 0.03
75 INT282592 Regulation of KLF4 1 0.26 0.14 0.03
76 INT277595 Localization of Hdac1 4 0.73 0.81 0
77 INT294852 Negative_regulation of KLF4 2 0.20 0.49 0
78 INT261751 Regulation of Hdac1 2 0.41 0 0
79 INT246011 Transcription of Gli1 2 0.29 0 0
80 INT205972 Regulation of Gene_expression of GLI1 1 0.41 1.17 0
81 INT268585 Negative_regulation of Gene_expression of GLI1 1 0.24 1.01 0
82 INT294855 Negative_regulation of Gene_expression of KLF4 1 0.13 0.49 0
83 INT350509 Phosphorylation of HDAC1 1 0.25 0.62 0
84 INT337478 Binding of HDAC2 1 0.14 0.07 0
85 INT319154 Transcription of Hdac1 1 0.66 0 0
86 INT207371 Positive_regulation of Transcription of GLI2 1 0.03 0.08 0
87 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0
88 INT337469 Binding of KLF4 1 0.17 0 0
89 INT277596 Phosphorylation of Hdac1 1 0.61 0.59 0
90 INT116726 Negative_regulation of Gene_expression of Flg 1 0.01 0.45 0
91 INT319169 Negative_regulation of Transcription of Hdac1 1 0.54 0 0
92 INT294846 Positive_regulation of Negative_regulation of KLF4 1 0.15 0.49 0
93 INT339596 Localization of KLF4 1 0.26 0 0
94 INT355198 Positive_regulation of Localization of Hdac1 1 0.19 0.48 0
95 INT24319 Positive_regulation of Localization of Gli1 1 0.66 0 0
96 INT307407 Regulation of Localization of GLI2 1 0.01 0.67 0
97 INT207369 Transcription of GLI2 1 0.05 0.08 0
98 INT205967 Localization of GLI1 1 0.50 0.57 0
99 INT319162 Regulation of Gene_expression of Hdac1 1 0.56 0 0
100 INT268570 Positive_regulation of Gene_expression of GLI1 1 0.19 0.97 0
101 INT319152 Positive_regulation of Gene_expression of Hdac1 1 0.46 0 0
102 INT268563 Transcription of GLI1 1 0.29 0.91 0
103 INT311329 Positive_regulation of Hdac1 1 0.19 0.14 0
104 INT289370 Binding of Gli1 1 0.37 2.78 0
105 INT294861 Positive_regulation of KLF4 1 0.15 0.49 0
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