GO:0009953

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Name dorsal/ventral pattern formation
Categary Process
Go Slim No
Go Link GO:0009953
Unique Molecular Interactions 446
Total Molecular Interactions 642
Total Single Events 3782
Pain Genes Associated 35

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for dorsal/ventral pattern formation. They are ordered first by their pain relevance and then by number of times they were reported for dorsal/ventral pattern formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
2 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
3 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
4 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
5 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
6 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
7 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
8 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
9 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
10 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
11 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
12 INT269443 Positive_regulation of Binding of RAB5A and HHIP 1 0.04 0 1.06
13 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
14 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
15 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
16 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
17 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
18 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
19 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
20 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
21 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
22 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
23 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
24 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
25 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
26 INT269454 Positive_regulation of Binding of GOPC and HHIP 1 0.01 0 0.73
27 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
28 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
29 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
30 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
31 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
32 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
33 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
34 INT274871 Positive_regulation of Cbr2 Positive_regulation of Positive_regulation of Dusp6 1 0.02 0.72 0.67
35 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
36 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
37 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
38 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
39 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
40 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
41 INT52478 Binding of Adarb1 and Ift172 1 0.00 0 0.62
42 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
43 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
44 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
45 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
46 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
47 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
48 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
49 INT269442 Binding of GOPC and HHIP 1 0.01 0 0.52
50 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
51 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
52 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
53 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
54 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
55 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
56 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
57 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
58 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
59 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
60 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
61 INT269448 HHIP Positive_regulation of Binding of RAB5A 1 0.04 0 0.42
62 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
63 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
64 INT269456 RAB5A Regulation of Binding of HHIP 1 0.04 0 0.38
65 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
66 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
67 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
68 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
69 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
70 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
71 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
72 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
73 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
74 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
75 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
76 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
77 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
78 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
79 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
80 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
81 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
82 INT274872 Positive_regulation of Cbr2 Positive_regulation of Dusp6 1 0.02 0.63 0.32
83 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
84 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
85 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
86 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
87 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
88 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
89 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
90 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
91 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
92 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
93 INT269459 Binding of ISYNA1 and HHIP 1 0.00 0 0.27
94 INT269490 Binding of Racgap1 and HHIP 1 0.00 0 0.27
95 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
96 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
97 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
98 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
99 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
100 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
101 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
102 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
103 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
104 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
105 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
106 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
107 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
108 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
109 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
110 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
111 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
112 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
113 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
114 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
115 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
116 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
117 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
118 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
119 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
120 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
121 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
122 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
123 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
124 INT269446 Binding of EPHA3 and HHIP 1 0.01 0 0.2
125 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
126 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
127 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
128 INT274832 Dusp6 Positive_regulation of Localization of Tlr4 1 0.00 0 0.19
129 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
130 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
131 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
132 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
133 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
134 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
135 INT230455 FOXG1 Negative_regulation of HBS1L 1 0.02 1.73 0.18
136 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
137 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
138 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
139 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
140 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
141 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
142 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
143 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
144 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
145 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
146 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
147 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
148 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
149 INT269451 Negative_regulation of Binding of RAB5A and HHIP 1 0.03 0 0.15
150 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
151 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
152 INT269452 RAB5A Regulation of Localization of HHIP 1 0.04 0 0.15
153 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
154 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
155 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
156 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
157 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
158 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
159 INT269445 Localization of HHIP Regulation of Gene_expression of RAB5A 1 0.03 0 0.13
160 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
161 INT223535 Binding of HAND1 and Pax6 1 0.33 0.92 0.13
162 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
163 INT269457 RAB5A Regulation of Regulation of HHIP 1 0.02 0 0.13
164 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
165 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
166 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
167 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
168 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
169 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
170 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
171 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
172 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
173 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
174 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
175 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
176 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
177 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
178 INT280484 Bdnf Positive_regulation of Gene_expression of Lhx1 1 0.48 1.49 0.11
179 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
180 INT269458 HHIP Regulation of Gene_expression of RAB5A 1 0.04 0 0.1
181 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
182 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
183 INT181570 Binding of Edn1 and Mapk1 1 0.13 2.72 0.1
184 INT24321 Pomc Positive_regulation of Localization of Gli1 1 0.07 0 0.1
185 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
186 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
187 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
188 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
189 INT262255 Binding of APC and F2R 1 0.05 3 0.1
190 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
191 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09
192 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09
193 INT165159 Gli1 Regulation of Penk 1 0.24 0.07 0.09
194 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
195 INT165157 Gli1 Regulation of Igfbp5 1 0.24 0.07 0.09
196 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
197 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
198 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
199 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
200 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported for dorsal/ventral pattern formation. They are ordered first by their pain relevance and then by number of times they were reported in dorsal/ventral pattern formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
6 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
7 INT5048 Binding of Edn1 55 0.47 18.86 19.16
8 INT9191 Localization of EDN1 94 0.81 57.01 14.78
9 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
10 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
11 INT6365 Localization of Edn1 56 0.81 18.84 13.83
12 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57
13 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
14 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
15 INT6361 Localization of Edn1 30 0.81 19.09 9.7
16 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
17 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
18 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
19 INT10237 Binding of EDN1 40 0.48 16 8.48
20 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
21 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
22 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
23 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
24 INT178763 Binding of HHIP 37 0.08 6.3 5.29
25 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
26 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
27 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
28 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
29 INT125478 Localization of HHIP 32 0.80 3.43 4.68
30 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
31 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
32 INT63121 Binding of APC 29 0.41 23.02 3.8
33 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75
34 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49
35 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
36 INT53374 Binding of Edn1 17 0.43 11.66 2.98
37 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
38 INT9242 Negative_regulation of FOXG1 13 0.40 1.43 2.86
39 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
40 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
41 INT23219 Regulation of FOXG1 8 0.22 1.32 2.34
42 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
43 INT55090 Positive_regulation of Wnt7a 13 0.37 2.25 2.2
44 INT125480 Regulation of HHIP 17 0.38 6.16 2.16
45 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
46 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
47 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
48 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
49 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
50 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
51 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
52 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
53 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
54 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
55 INT3818 Regulation of Apc 13 0.39 12.52 1.68
56 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
57 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
58 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
59 INT274884 Positive_regulation of Dusp6 1 0.07 2.08 1.52
60 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
61 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
62 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
63 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
64 INT140245 Binding of Gli3 3 0.36 2.65 1.46
65 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
66 INT274892 Gene_expression of Dusp6 1 0.08 1.81 1.4
67 INT220177 Binding of Apc 21 0.37 15.34 1.37
68 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
69 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
70 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
71 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
72 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
73 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
74 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
75 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
76 INT125476 Regulation of Gene_expression of HHIP 2 0.39 1.1 1.1
77 INT269487 Positive_regulation of Binding of HHIP 1 0.06 0 1.08
78 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
79 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
80 INT9243 Gene_expression of FOXG1 14 0.53 7.52 1.02
81 INT127647 Regulation of Wnt7a 3 0.07 1.28 1.01
82 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
83 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
84 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
85 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
86 INT274888 Negative_regulation of Dusp6 1 0.06 1.82 0.93
87 INT269485 Positive_regulation of Gene_expression of HHIP 9 0.41 1.08 0.92
88 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
89 INT242134 Localization of Apc 8 0.74 4.83 0.88
90 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
91 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
92 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
93 INT17330 Binding of FOXG1 3 0.33 0.23 0.83
94 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
95 INT270447 Binding of Smo 2 0.07 2.61 0.78
96 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
97 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
98 INT217098 Gene_expression of Hoxa2 1 0.77 2.23 0.72
99 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
100 INT57062 Regulation of APC 24 0.58 14.3 0.7
101 INT126376 Gene_expression of Gli1 8 0.68 4.52 0.7
102 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
103 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
104 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
105 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
106 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
107 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
108 INT28958 Negative_regulation of Wnt7a 3 0.45 0.49 0.65
109 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
110 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
111 INT274881 Regulation of Dusp6 1 0.04 0.9 0.63
112 INT269461 Positive_regulation of Localization of HHIP 1 0.05 0 0.63
113 INT269465 Positive_regulation of Positive_regulation of HHIP 4 0.11 0.5 0.62
114 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
115 INT274885 Negative_regulation of Gene_expression of Dusp6 1 0.04 0.89 0.6
116 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
117 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
118 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
119 INT127648 Gene_expression of Wnt7a 2 0.13 1.11 0.56
120 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
121 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
122 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
123 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
124 INT274880 Negative_regulation of Positive_regulation of Dusp6 1 0.04 0.89 0.52
125 INT135062 Transcription of Gli3 1 0.05 0 0.52
126 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
127 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
128 INT24317 Gene_expression of Gli1 4 0.54 1.46 0.47
129 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
130 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
131 INT206484 Localization of Shh 2 0.75 1.14 0.46
132 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
133 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
134 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
135 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43
136 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
137 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
138 INT149890 Positive_regulation of Gene_expression of Gli1 1 0.48 1.56 0.41
139 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
140 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
141 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
142 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
143 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
144 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
145 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
146 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
147 INT118243 Transcription of APC 4 0.45 3.33 0.33
148 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
149 INT225667 Transcription of Apc 3 0.52 3.73 0.32
150 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
151 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
152 INT195672 Localization of APC 7 0.74 3.76 0.3
153 INT356400 Transcription of Smo 1 0.02 0.05 0.3
154 INT24320 Localization of Gli1 6 0.77 0.63 0.29
155 INT185428 Gene_expression of Lhx1 4 0.75 2.6 0.28
156 INT274883 Positive_regulation of Gene_expression of Dusp6 1 0.07 0.39 0.27
157 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
158 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
159 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
160 INT165153 Positive_regulation of Gli1 4 0.59 1.17 0.25
161 INT274876 Positive_regulation of Positive_regulation of Dusp6 1 0.04 0.49 0.25
162 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
163 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
164 INT335874 Regulation of Lrp4 1 0.18 0 0.23
165 INT269484 Negative_regulation of Localization of HHIP 1 0.04 0 0.22
166 INT269463 Phosphorylation of HHIP 1 0.05 0 0.22
167 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
168 INT269489 Positive_regulation of Phosphorylation of HHIP 1 0.04 0 0.22
169 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
170 INT312604 Gene_expression of Lrp4 2 0.71 1.48 0.21
171 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
172 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
173 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
174 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
175 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
176 INT104539 Regulation of Positive_regulation of FOXG1 1 0.38 0.2 0.19
177 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
178 INT24316 Regulation of Localization of Gli1 1 0.51 0 0.19
179 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
180 INT185427 Negative_regulation of Lhx1 4 0.42 3.48 0.17
181 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
182 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
183 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
184 INT161283 Positive_regulation of Positive_regulation of FOXG1 1 0.02 0 0.17
185 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
186 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
187 INT210123 Localization of Axin1 1 0.04 0.84 0.17
188 INT185254 Gene_expression of Pax6 14 0.72 1.77 0.16
189 INT269464 Negative_regulation of Gene_expression of HHIP 4 0.10 0.74 0.16
190 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
191 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
192 INT55089 Positive_regulation of Positive_regulation of Wnt7a 2 0.27 0.06 0.16
193 INT269486 Regulation of Localization of HHIP 1 0.04 0 0.15
194 INT149891 Negative_regulation of Gene_expression of Gli1 1 0.41 0.68 0.14
195 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
196 INT253190 Localization of Shh 2 0.77 1.06 0.13
197 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
198 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
199 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
200 INT353269 Negative_regulation of Positive_regulation of Tgif1 1 0.11 0.5 0.13
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