GO:0009966

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Name regulation of signal transduction
Categary Process
Go Slim No
Go Link GO:0009966
Unique Molecular Interactions 89
Total Molecular Interactions 118
Total Single Events 811
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for regulation of signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 0.50 1.4 1.48
2 INT310069 Negative_regulation of Pain1 Positive_regulation of Mgll 1 0.02 1.32 1.23
3 INT310067 Pain1 Positive_regulation of Mgll 1 0.02 1.29 1.21
4 INT285659 Binding of Faah and Mgll 1 0.15 0.99 1.11
5 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 0.52 0.88 1.09
6 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
7 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
8 INT326455 Runx1 Positive_regulation of Gene_expression of Trpv1 1 0.45 0 0.88
9 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
10 INT298295 Runx1 Negative_regulation of Gene_expression of Ntrk1 2 0.38 0.45 0.86
11 INT326457 Runx1 Regulation of Mrgpra3 1 0.37 0.1 0.71
12 INT326456 Runx1 Regulation of Pip4k2b 1 0.09 0.11 0.71
13 INT253137 Ptpn1 Negative_regulation of Ins1 1 0.19 4.11 0.63
14 INT280895 Runx1 Positive_regulation of Gene_expression of Ret 2 0.33 0.2 0.58
15 INT298278 Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.8 0.56
16 INT192160 Cxcl9 Negative_regulation of Furin 1 0.02 0.8 0.54
17 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
18 INT245553 Runx1 Positive_regulation of Gene_expression of Ntrk1 2 0.45 1.41 0.52
19 INT285661 Binding of Mgll and FAAH2 1 0.05 0.23 0.45
20 INT246024 IL23A Positive_regulation of SOCS2 1 0.01 0.99 0.43
21 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43
22 INT326458 Runx1 Negative_regulation of Gene_expression of Calca 1 0.18 0.05 0.43
23 INT298287 Runx1 Negative_regulation of Gene_expression of Ntrk3 1 0.32 0.4 0.43
24 INT298286 Runx3 Regulation of Gene_expression of Runx1 1 0.47 0.36 0.41
25 INT298270 Gene_expression of Runx1 Positive_regulation of Ntrk3 1 0.35 0.34 0.4
26 INT298261 Pou4f1 Negative_regulation of Gene_expression of Runx1 1 0.45 0.58 0.4
27 INT298296 Gene_expression of Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.33 0.39
28 INT298266 Gene_expression of Runx1 Positive_regulation of Ntrk1 1 0.28 0.34 0.39
29 INT253147 Positive_regulation of Nr1h2 Negative_regulation of Positive_regulation of Ptpn1 1 0.17 0.61 0.33
30 INT80304 Nrd1 Negative_regulation of Furin 1 0.01 0 0.3
31 INT298282 Pou4f1 Regulation of Gene_expression of Runx1 1 0.48 0.36 0.29
32 INT245563 Negative_regulation of Runx1 Regulation of Ret 1 0.39 0.76 0.29
33 INT245556 Runx1 Regulation of Ret 1 0.56 0.76 0.29
34 INT245557 Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.75 0.25
35 INT245561 Gene_expression of Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.8 0.25
36 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
37 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
38 INT305533 Runx1 Positive_regulation of Il3 1 0.03 0.28 0.19
39 INT237924 PTPN1 Regulation of Gene_expression of CFLAR 1 0.01 0.7 0.19
40 INT253127 Il6 Regulation of Gene_expression of Ptpn1 1 0.24 1.31 0.17
41 INT298293 Runx1 Positive_regulation of Negative_regulation of Ntrk2 1 0.52 0.54 0.16
42 INT245568 Runx1 Regulation of Gtf3a 1 0.00 0.65 0.16
43 INT298256 Runx1 Positive_regulation of Negative_regulation of Ntrk1 1 0.30 0.55 0.16
44 INT245559 Runx3 Regulation of Runx1 1 0.31 0.63 0.16
45 INT245566 Runx1 Negative_regulation of Ntrk1 1 0.39 0.65 0.15
46 INT245552 Runx1 Negative_regulation of Calca 1 0.33 0.65 0.15
47 INT253154 TNF Positive_regulation of Ptpn1 1 0.73 0.91 0.15
48 INT175196 Binding of NCOR1 and NUP62 1 0.02 0.84 0.12
49 INT280893 Gene_expression of Runx1 Positive_regulation of Gene_expression of Ntrk1 1 0.33 0.44 0.1
50 INT298267 Tcf3 Positive_regulation of Gene_expression of Runx1 1 0.21 0.6 0.1
51 INT245570 Runx1 Regulation of Regulation of BDNF 1 0.26 0.28 0.1
52 INT305535 Binding of HPRT1 and Runx1 1 0.41 0.7 0.1
53 INT125089 Binding of HLA-B and TDGF1 1 0.24 0.18 0.09
54 INT351011 Binding of HDAC9 and TSPYL2 1 0.04 0.63 0.08
55 INT175195 Binding of SH2B2 and NUP62 1 0.01 0 0.07
56 INT280894 Runx1 Positive_regulation of Transcription of Ntrk1 1 0.38 0.36 0.07
57 INT236147 Binding of Ins1 and Ptpn1 2 0.03 1.29 0.05
58 INT253132 Il6 Positive_regulation of Gene_expression of Ptpn1 1 0.42 0.54 0.03
59 INT336752 Sparc Regulation of Regulation of Ilk 1 0.30 0.71 0.03
60 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0
61 INT324058 Fn1 Positive_regulation of Furin 1 0.08 0.27 0
62 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0
63 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
64 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
65 INT324056 Binding of Itk and Furin 1 0.03 0.48 0
66 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0
67 INT222539 Negative_regulation of Binding of Inhba and Acvr2a 1 0.01 0 0
68 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
69 INT225873 Ilk Positive_regulation of AKT1 1 0.00 0.07 0
70 INT301245 Binding of FUT1 and Runx1 1 0.00 0.66 0
71 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0
72 INT225876 PIK3CG Positive_regulation of Ilk 1 0.00 0 0
73 INT320400 Binding of Vcp and Khdrbs1 1 0.01 0.07 0
74 INT222504 Binding of Inhba and Acvr2a 1 0.01 0 0
75 INT175192 Binding of NUP62 and GOPC 1 0.03 0 0
76 INT301241 Mir29a Positive_regulation of Runx1 1 0.00 2.85 0
77 INT253144 Il6 Positive_regulation of Ptpn1 1 0.62 0.42 0
78 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0
79 INT188436 Negative_regulation of NUP62 Positive_regulation of TNFRSF11A 1 0.39 1.6 0
80 INT350722 Binding of Runx1 and Negative_regulation of Gene_expression of MIR17 1 0.01 0.22 0
81 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0
82 INT301238 Gene_expression of Mir29a Positive_regulation of Runx1 1 0.00 1.39 0
83 INT184461 Binding of Adamts1 and Furin 1 0.09 0 0
84 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
85 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
86 INT301235 Binding of Runx1 and Mir29a 1 0.00 0.48 0
87 INT311657 Binding of Cbl and Spry2 1 0.10 0.18 0
88 INT347297 ILK Regulation of Gene_expression of AKT1 1 0.21 0.62 0
89 INT175191 Binding of TRAF6 and NUP62 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in regulation of signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16
2 INT245517 Positive_regulation of Gene_expression of Runx1 49 0.69 17.7 12.38
3 INT133212 Negative_regulation of Runx1 21 0.58 11.16 11.89
4 INT133210 Positive_regulation of Runx1 33 0.69 18.25 10.12
5 INT245538 Negative_regulation of Gene_expression of Runx1 20 0.58 11.68 9.97
6 INT169596 Transcription of Runx1 12 0.71 5.55 6.27
7 INT245515 Regulation of Runx1 14 0.61 5.07 6.22
8 INT169653 Negative_regulation of Mgll 6 0.42 3.75 6.16
9 INT245536 Regulation of Gene_expression of Runx1 11 0.58 6.22 4.88
10 INT57157 Gene_expression of TDGF1 5 0.75 3.97 4.02
11 INT153616 Gene_expression of Mgll 5 0.50 2.72 3.03
12 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
13 INT153611 Protein_catabolism of Mgll 3 0.86 1 2.09
14 INT169597 Negative_regulation of Transcription of Runx1 3 0.58 1.92 2.07
15 INT245529 Binding of Runx1 9 0.48 4.42 1.9
16 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
17 INT207100 Gene_expression of Ptpn1 13 0.73 8.13 1.68
18 INT305526 Negative_regulation of Positive_regulation of Runx1 1 0.42 2.7 1.65
19 INT53673 Gene_expression of Furin 6 0.40 1.99 1.54
20 INT53666 Regulation of Furin 4 0.37 0.3 1.24
21 INT333924 Positive_regulation of TDGF1 1 0.02 1.03 1.24
22 INT245530 Localization of Runx1 2 0.80 1.55 1.17
23 INT98595 Regulation of ILK 6 0.62 3.84 1.16
24 INT333920 Negative_regulation of Gene_expression of TDGF1 1 0.02 0.89 1.16
25 INT326445 Negative_regulation of Negative_regulation of Runx1 1 0.43 0.77 1.06
26 INT236138 Negative_regulation of Ptpn1 10 0.55 5.83 1.04
27 INT253114 Positive_regulation of Ptpn1 9 0.44 5.48 0.96
28 INT333922 Negative_regulation of TDGF1 1 0.02 0.91 0.96
29 INT298252 Regulation of Localization of Runx1 1 0.43 0.85 0.88
30 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86
31 INT53669 Regulation of Transcription of Furin 1 0.16 0.15 0.82
32 INT53670 Transcription of Furin 3 0.50 0.39 0.81
33 INT253103 Negative_regulation of Gene_expression of Ptpn1 1 0.55 2.56 0.79
34 INT305528 Regulation of Binding of Runx1 1 0.27 1.06 0.77
35 INT27546 Positive_regulation of Furin 4 0.40 0.49 0.75
36 INT27545 Gene_expression of Furin 6 0.63 0.75 0.74
37 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
38 INT169651 Positive_regulation of Protein_catabolism of Mgll 1 0.49 0.07 0.72
39 INT169654 Positive_regulation of Mgll 2 0.49 0.26 0.66
40 INT27742 Negative_regulation of Furin 2 0.17 0.22 0.64
41 INT98590 Negative_regulation of Positive_regulation of ILK 1 0.43 1.17 0.55
42 INT175219 Binding of NUP62 31 0.27 4.51 0.53
43 INT98592 Gene_expression of ILK 6 0.78 5.23 0.53
44 INT192154 Negative_regulation of Furin 2 0.22 0.94 0.53
45 INT98594 Positive_regulation of ILK 3 0.70 1.74 0.49
46 INT253098 Positive_regulation of Gene_expression of Ptpn1 3 0.65 2.05 0.48
47 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
48 INT90764 Positive_regulation of Furin 4 0.32 1.7 0.44
49 INT305525 Positive_regulation of Positive_regulation of Runx1 1 0.46 0.76 0.39
50 INT207088 Localization of Ptpn1 2 0.35 1.48 0.36
51 INT245547 Positive_regulation of Localization of Runx1 1 0.50 0.73 0.31
52 INT98593 Positive_regulation of Positive_regulation of ILK 1 0.50 0.58 0.28
53 INT98597 Positive_regulation of Gene_expression of ILK 4 0.70 3.08 0.23
54 INT245526 Regulation of Transcription of Runx1 1 0.27 0.92 0.21
55 INT80306 Localization of Furin 1 0.08 0 0.21
56 INT59961 Localization of Furin 3 0.76 2.21 0.2
57 INT286108 Negative_regulation of Afap1 1 0.08 3.35 0.18
58 INT98591 Positive_regulation of Regulation of ILK 1 0.47 0.7 0.18
59 INT164729 Binding of Mgll 3 0.48 0.2 0.14
60 INT306281 Gene_expression of SOCS2 1 0.01 0.52 0.14
61 INT102402 Binding of TSPYL2 1 0.04 0.5 0.14
62 INT311644 Positive_regulation of Gene_expression of Spry1 1 0.46 2.54 0.13
63 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
64 INT253100 Positive_regulation of Positive_regulation of Ptpn1 1 0.44 0.81 0.11
65 INT184448 Binding of Furin 2 0.36 0.81 0.09
66 INT253928 Negative_regulation of Binding of Furin 1 0.41 0.82 0.09
67 INT234419 Phosphorylation of TSPYL2 1 0.16 2.05 0.06
68 INT175226 Gene_expression of NUP62 4 0.52 1.26 0.05
69 INT311643 Negative_regulation of Spry1 1 0.40 0.95 0.05
70 INT188456 Negative_regulation of Gene_expression of NUP62 1 0.33 0.99 0.05
71 INT272847 Binding of Furin 1 0.04 0.52 0.05
72 INT350904 Localization of TSPYL2 1 0.03 1.04 0.04
73 INT236144 Regulation of Gene_expression of Ptpn1 1 0.21 0.84 0.04
74 INT311641 Regulation of Gene_expression of Spry1 1 0.57 0.5 0.04
75 INT311647 Negative_regulation of Gene_expression of Spry1 1 0.39 0.18 0.04
76 INT222608 Negative_regulation of Gene_expression of Acvr2a 3 0.10 0.29 0.03
77 INT234409 Gene_expression of TSPYL2 2 0.21 5.16 0.03
78 INT336745 Regulation of Ilk 1 0.33 0.7 0.03
79 INT286095 Gene_expression of Afap1 1 0.09 2.42 0.03
80 INT108539 Gene_expression of Khdrbs1 3 0.12 0.9 0
81 INT110369 Localization of TDGF1 2 0.60 0.15 0
82 INT222633 Negative_regulation of Acvr2a 1 0.10 0 0
83 INT323511 Positive_regulation of Gene_expression of Mgll 1 0.15 0.52 0
84 INT286084 Regulation of Acvr2a 1 0.02 0.32 0
85 INT188443 Negative_regulation of NUP62 1 0.33 1.53 0
86 INT311653 Binding of Spry1 1 0.34 0.98 0
87 INT292404 Negative_regulation of PTPN1 1 0.25 1.19 0
88 INT171687 Positive_regulation of Gene_expression of Furin 1 0.28 0.42 0
89 INT286097 Binding of Afap1 1 0.05 1.72 0
90 INT347313 Binding of ILK 1 0.22 0.12 0
91 INT286081 Regulation of Gene_expression of Acvr2a 1 0.05 0.32 0
92 INT218291 Positive_regulation of Gene_expression of Acvr2b 1 0.49 0.55 0
93 INT311645 Gene_expression of Spry2 1 0.70 1.81 0
94 INT311639 Positive_regulation of Spry1 1 0.64 0.19 0
95 INT323522 Regulation of Mgll 1 0.03 0.09 0
96 INT175215 Negative_regulation of Binding of NUP62 1 0.19 0.13 0
97 INT311640 Regulation of Binding of Spry1 1 0.42 0.77 0
98 INT347317 Localization of ILK 1 0.45 0 0
99 INT323518 Regulation of Gene_expression of Mgll 1 0.11 0.1 0
100 INT260764 Negative_regulation of Spry2 1 0.28 0.1 0
101 INT347314 Regulation of Gene_expression of ILK 1 0.27 1.15 0
102 INT311634 Positive_regulation of Spry2 1 0.45 0.4 0
103 INT188454 Positive_regulation of NUP62 1 0.36 0.92 0
104 INT311633 Localization of Spry2 1 0.68 0.26 0
105 INT311628 Negative_regulation of Gene_expression of Spry2 1 0.39 0.43 0
106 INT218282 Regulation of Acvr2a 1 0.23 0.33 0
107 INT323515 Positive_regulation of Positive_regulation of Mgll 1 0.11 0.1 0
108 INT218296 Regulation of Acvr2b 1 0.12 0.33 0
109 INT347307 Regulation of Binding of ILK 1 0.27 0.12 0
110 INT218286 Regulation of Gene_expression of Acvr2b 1 0.60 0.5 0
111 INT323524 Negative_regulation of Binding of Mgll 1 0.09 0.2 0
112 INT323510 Negative_regulation of Gene_expression of Mgll 1 0.11 0.06 0
113 INT218289 Gene_expression of Acvr2a 1 0.65 1.44 0
114 INT286092 Positive_regulation of Afap1 1 0.06 2.48 0
115 INT320424 Binding of Khdrbs1 1 0.04 0.19 0
116 INT311654 Regulation of Spry2 1 0.21 0.75 0
117 INT336102 Phosphorylation of Ptpn1 1 0.59 0.34 0
118 INT222620 Binding of Acvr2a 1 0.08 0 0
119 INT320414 Negative_regulation of Khdrbs1 1 0.04 0.44 0
120 INT230978 Positive_regulation of SOCS2 1 0.23 0.08 0
121 INT286082 Positive_regulation of Gene_expression of Acvr2a 1 0.06 1.25 0
122 INT305522 Positive_regulation of Negative_regulation of Runx1 1 0.50 0.15 0
123 INT218281 Binding of Acvr2b 1 0.36 0.07 0
124 INT323516 Localization of Mgll 1 0.19 0.19 0
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