GO:0009968

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Name negative regulation of signal transduction
Categary Process
Go Slim No
Go Link GO:0009968
Unique Molecular Interactions 366
Total Molecular Interactions 514
Total Single Events 3547
Pain Genes Associated 55

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
2 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
3 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
4 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
5 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
6 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
7 INT93782 Racgap1 Positive_regulation of Rgs9 1 0.55 0.07 1.49
8 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
9 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
10 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
11 INT236835 Binding of CISH and CSF2 1 0.06 1.43 1.25
12 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
13 INT146352 Binding of Rgs14 and Mors1 1 0.23 0.27 1.17
14 INT144153 Socs6 Positive_regulation of Gene_expression of Gabrg1 1 0.07 0 1.16
15 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
16 INT123987 RGS17 Positive_regulation of Rgs20 1 0.13 0 1.09
17 INT269443 Positive_regulation of Binding of RAB5A and HHIP 1 0.04 0 1.06
18 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
19 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
20 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
21 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
22 INT317550 Binding of Hint1 and Rgs20 1 0.32 0.07 0.98
23 INT354306 Binding of Rgs4 and Rgs1 1 0.40 0.36 0.98
24 INT317529 Binding of Hint1 and Rgs17 1 0.32 0.07 0.98
25 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
26 INT146096 Positive_regulation of Binding of Oprm1 and Rgs9 1 0.44 0 0.94
27 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
28 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
29 INT124160 Binding of Rgs9 and Mors1 1 0.23 0.28 0.9
30 INT325807 CXCL13 Positive_regulation of CISH 1 0.16 3.65 0.89
31 INT151630 Il1rn Negative_regulation of Dock9 1 0.03 1.33 0.88
32 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
33 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
34 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82
35 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
36 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
37 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
38 INT21543 Binding of Oprd1 and Cish 2 0.09 0.15 0.78
39 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
40 INT269454 Positive_regulation of Binding of GOPC and HHIP 1 0.01 0 0.73
41 INT126305 Binding of Rgs10 and Pag1 1 0.16 0.41 0.72
42 INT126303 Binding of Rgs7 and Pag1 1 0.15 0.41 0.72
43 INT126304 Binding of Rgs2 and Pag1 1 0.16 0.41 0.72
44 INT150148 Binding of CISH and Myoz1 1 0.01 0.7 0.68
45 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
46 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
47 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
48 INT254199 Il10 Positive_regulation of Gene_expression of Socs3 2 0.06 0.75 0.63
49 INT124158 Binding of Oprm1 and Rgs7 1 0.30 0.18 0.62
50 INT124161 Binding of Rgs7 and Rgs11 1 0.29 0.18 0.62
51 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
52 INT143938 Il1rn Negative_regulation of Il1b 1 0.04 0.52 0.57
53 INT143940 Il1rn Negative_regulation of Il1f5 1 0.00 0.51 0.57
54 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56
55 INT176370 IL18BP Negative_regulation of IL18 1 0.15 0.76 0.56
56 INT117199 Rgs1 Regulation of Rgs19 1 0.02 0.16 0.56
57 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
58 INT164973 Binding of RASA1 and Rgs7 1 0.00 0 0.54
59 INT164971 Binding of Rgs7 and Gnai2 1 0.01 0 0.54
60 INT164972 Binding of RASA1 and Rgs8 1 0.00 0 0.53
61 INT164970 Binding of Rgs8 and Gnai2 1 0.01 0 0.53
62 INT269442 Binding of GOPC and HHIP 1 0.01 0 0.52
63 INT184105 Il6 Positive_regulation of Socs3 2 0.42 1.34 0.48
64 INT184094 Gene_expression of Socs3 Negative_regulation of Positive_regulation of Il6 1 0.12 1.49 0.48
65 INT130726 Negative_regulation of Binding of IL1B and Il1rn 1 0.01 0.6 0.48
66 INT130723 Binding of IL1A and Il1rn 1 0.01 0.59 0.47
67 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
68 INT130724 Negative_regulation of Binding of IL1A and Il1rn 1 0.01 0.59 0.47
69 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
70 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
71 INT264136 IFNA1 Positive_regulation of Socs3 1 0.01 0.38 0.46
72 INT264137 IFNA1 Positive_regulation of Socs1 1 0.01 0.38 0.46
73 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45
74 INT246024 IL23A Positive_regulation of SOCS2 1 0.01 0.99 0.43
75 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43
76 INT184124 Socs3 Regulation of Il6 1 0.13 1.4 0.43
77 INT269448 HHIP Positive_regulation of Binding of RAB5A 1 0.04 0 0.42
78 INT264135 Socs1 Positive_regulation of Protein_catabolism of TOLLIP 1 0.00 0.33 0.41
79 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
80 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41
81 INT319313 Socs4 Positive_regulation of Mapk14 1 0.02 0.68 0.41
82 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
83 INT234608 Socs3 Negative_regulation of SOAT1 1 0.01 0.54 0.39
84 INT234607 Socs3 Negative_regulation of JAK1 1 0.01 0.54 0.39
85 INT269456 RAB5A Regulation of Binding of HHIP 1 0.04 0 0.38
86 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
87 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
88 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
89 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
90 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
91 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
92 INT184128 Socs3 Negative_regulation of Il6 1 0.12 1.14 0.36
93 INT261044 CHR Positive_regulation of CISH 1 0.01 0.05 0.35
94 INT242363 Binding of Il1a and Il1rn 1 0.05 0.19 0.35
95 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
96 INT184095 Il10 Positive_regulation of Socs3 1 0.21 0.49 0.34
97 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
98 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
99 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
100 INT184082 Binding of Socs3 and Il6 1 0.11 0.49 0.33
101 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
102 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
103 INT184107 Cish Negative_regulation of Ik 1 0.01 0.1 0.32
104 INT176362 Binding of IL18 and IL18BP 1 0.12 0.49 0.32
105 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
106 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
107 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
108 INT261053 Negative_regulation of VIP Positive_regulation of CISH 1 0.00 0 0.3
109 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
110 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
111 INT220388 Gh1 Regulation of Cish 1 0.03 0.29 0.28
112 INT265652 Binding of CISH and MYCN 1 0.00 0.28 0.28
113 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
114 INT141870 Binding of Slc2a4 and Cav1 1 0.36 0.38 0.28
115 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
116 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
117 INT269459 Binding of ISYNA1 and HHIP 1 0.00 0 0.27
118 INT269490 Binding of Racgap1 and HHIP 1 0.00 0 0.27
119 INT315200 Negative_regulation of Binding of Socs3 and Stat3 1 0.26 1.18 0.27
120 INT12629 Binding of Dbp and Cish 1 0.03 0 0.25
121 INT148574 Rgs7bp Regulation of Gene_expression of Rgs9 1 0.26 0 0.24
122 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
123 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
124 INT87750 IGFBP3 Negative_regulation of INS 1 0.11 0.86 0.23
125 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
126 INT25907 Binding of PRLR and Cish 1 0.00 0 0.23
127 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22
128 INT316491 Socs3 Positive_regulation of Il11ra1 1 0.45 0.92 0.22
129 INT220528 Ugt1a6b Positive_regulation of Cav1 1 0.01 1.31 0.22
130 INT45008 Cish Negative_regulation of pcp 1 0.13 0 0.22
131 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
132 INT269446 Binding of EPHA3 and HHIP 1 0.01 0 0.2
133 INT165750 Regulation of Binding of Rgs9 and Naip7 1 0.02 0.07 0.19
134 INT339510 Tlr4 Positive_regulation of Socs1 1 0.06 0.1 0.18
135 INT289241 Cish Regulation of Il6 1 0.03 0.85 0.18
136 INT165752 Binding of Rgs9 and Naip7 1 0.03 0.07 0.18
137 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
138 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
139 INT220520 Ugt1a6b Positive_regulation of Gene_expression of Cav1 1 0.01 0.81 0.17
140 INT108663 Lrpap1 Negative_regulation of Positive_regulation of Ephb1 1 0.11 0.28 0.17
141 INT261046 VIP Positive_regulation of CISH 1 0.00 0 0.17
142 INT184103 Binding of Socs3 and Il11ra1 1 0.12 0 0.17
143 INT165751 Hspa8 Positive_regulation of Protein_catabolism of Rgs9 1 0.50 0.17 0.17
144 INT108664 Lrpap1 Negative_regulation of Positive_regulation of Trpv1 1 0.26 0.28 0.17
145 INT184086 Socs5 Negative_regulation of Binding of Jak1 1 0.20 0 0.16
146 INT224136 ARRB2 Positive_regulation of Adora2b 1 0.19 0 0.16
147 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
148 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
149 INT269451 Negative_regulation of Binding of RAB5A and HHIP 1 0.03 0 0.15
150 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
151 INT226366 Binding of CISH and JAK1 1 0.00 0.46 0.15
152 INT184098 Binding of Il4 and Socs5 1 0.09 2.05 0.15
153 INT224132 ARRB2 Negative_regulation of Positive_regulation of Adora2b 1 0.14 0.28 0.15
154 INT339513 Binding of Socs1 and Eif2ak2 1 0.04 0.07 0.15
155 INT269452 RAB5A Regulation of Localization of HHIP 1 0.04 0 0.15
156 INT250778 Binding of Socs3 and Atl1 1 0.01 0.6 0.14
157 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14
158 INT184104 Binding of Socs3 and Gopc 1 0.10 0 0.14
159 INT184122 Binding of Socs1 and Sh2 1 0.14 0 0.14
160 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
161 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
162 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13
163 INT184129 Socs2 Negative_regulation of Stat5a 1 0.22 0.05 0.13
164 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
165 INT269445 Localization of HHIP Regulation of Gene_expression of RAB5A 1 0.03 0 0.13
166 INT184091 Socs2 Negative_regulation of Gh 1 0.11 0.05 0.13
167 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
168 INT269457 RAB5A Regulation of Regulation of HHIP 1 0.02 0 0.13
169 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
170 INT327703 Cish Regulation of Transcription of Comt 1 0.13 0.77 0.12
171 INT182481 Binding of Cav1 and Ighg2b 1 0.10 0 0.12
172 INT279799 ATP6V0A2 Regulation of ERBB3 1 0.00 1.77 0.12
173 INT148572 Binding of Rgs7bp and Regulation of Gene_expression of Rgs9 1 0.11 0 0.12
174 INT182482 Binding of Cav1 and Cxcl16 1 0.07 0 0.12
175 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11
176 INT312218 INPP5K Positive_regulation of Protein_catabolism of IGFBP3 1 0.17 0.39 0.11
177 INT148573 Binding of Rgs7bp and Positive_regulation of Rgs9 1 0.21 0 0.11
178 INT258147 IGFBP3 Negative_regulation of Hcrt 1 0.28 1.87 0.11
179 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11
180 INT289765 Akt1 Regulation of Phosphorylation of Gsk3a 1 0.05 0.45 0.11
181 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
182 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
183 INT268626 Mpz Positive_regulation of Positive_regulation of Gsk3b 1 0.29 1.08 0.11
184 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
185 INT269458 HHIP Regulation of Gene_expression of RAB5A 1 0.04 0 0.1
186 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 0.05 0 0.1
187 INT32547 Gsk3b Negative_regulation of Localization of LH 1 0.04 0 0.1
188 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1
189 INT234626 IGFBP3 Regulation of IGF2 1 0.15 1.31 0.1
190 INT220517 Negative_regulation of Ugt1a6b Positive_regulation of Cav1 1 0.01 0.35 0.1
191 INT188357 Csf2 Positive_regulation of Socs3 1 0.36 0.15 0.1
192 INT347647 Inpp5d Negative_regulation of Pik3r1 1 0.31 0.37 0.1
193 INT78446 Binding of GH1 and IGFBP3 1 0.11 0.48 0.1
194 INT228809 Gtf3a Regulation of Rgs1 1 0.00 0.25 0.09
195 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09
196 INT339500 Negative_regulation of Socs1 Positive_regulation of Eif2ak2 1 0.05 0.31 0.09
197 INT165161 Ihh Positive_regulation of Sostdc1 1 0.58 0.07 0.09
198 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09
199 INT165160 Regulation of Ihh Positive_regulation of Sostdc1 1 0.23 0.07 0.09
200 INT165158 Positive_regulation of Ihh Positive_regulation of Sostdc1 1 0.42 0.07 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
2 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34
3 INT49606 Gene_expression of Il1rn 30 0.66 15.78 14.82
4 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
5 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57
6 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
7 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
8 INT111264 Gene_expression of Rgs9 16 0.76 1.96 10.94
9 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
10 INT111258 Regulation of Rgs9 11 0.54 1.81 8.9
11 INT12861 Gene_expression of Cish 40 0.57 23.01 8.48
12 INT126258 Gene_expression of Rgs17 9 0.71 0.73 8.38
13 INT142462 Positive_regulation of Gene_expression of Socs3 23 0.68 23.27 8.27
14 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19
15 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
16 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17
17 INT119439 Positive_regulation of Rgs7 1 0.67 2.07 7
18 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
19 INT69980 Negative_regulation of Il1rn 11 0.33 7.75 6.7
20 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
21 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
22 INT80447 Negative_regulation of ARRB2 5 0.39 3.12 6.3
23 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
24 INT53871 Gene_expression of Socs1 32 0.71 22.83 6.21
25 INT107441 Positive_regulation of Gene_expression of Il1rn 7 0.46 3.24 5.95
26 INT42378 Positive_regulation of Socs3 21 0.67 15.81 5.71
27 INT93776 Negative_regulation of Rgs9 5 0.44 0.35 5.67
28 INT126289 Regulation of Rgs17 3 0.41 0.89 5.47
29 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
30 INT178763 Binding of HHIP 37 0.08 6.3 5.29
31 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
32 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03
33 INT49130 Positive_regulation of IGFBP3 49 0.63 27.55 4.78
34 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
35 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
36 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69
37 INT125478 Localization of HHIP 32 0.80 3.43 4.68
38 INT126257 Positive_regulation of Gene_expression of Rgs17 4 0.41 0.17 4.62
39 INT116986 Gene_expression of Rgs20 4 0.77 0.69 4.45
40 INT76683 Positive_regulation of Il1rn 9 0.51 9.3 4.41
41 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
42 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
43 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
44 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
45 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
46 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
47 INT124141 Positive_regulation of Gene_expression of Rgs9 5 0.68 0.82 3.91
48 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
49 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
50 INT70529 Positive_regulation of Cish 16 0.59 14.43 3.8
51 INT146350 Phosphorylation of Rgs14 1 0.80 0.79 3.77
52 INT130842 Gene_expression of Rgs4 5 0.78 0.59 3.76
53 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75
54 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
55 INT83646 Binding of Il1rn 12 0.37 4.41 3.51
56 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
57 INT32517 Positive_regulation of LRPAP1 13 0.49 7.4 3.44
58 INT40232 Transcription of Il1rn 8 0.53 9.6 3.37
59 INT126291 Positive_regulation of Rgs4 3 0.67 1.3 3.19
60 INT25906 Negative_regulation of Cish 6 0.29 5.41 3.17
61 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
62 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
63 INT119443 Gene_expression of Rgs7 4 0.65 0.41 3.04
64 INT116985 Negative_regulation of Rgs20 1 0.43 0 3
65 INT126247 Negative_regulation of Rgs17 2 0.36 0.26 2.97
66 INT111259 Negative_regulation of Gene_expression of Rgs9 3 0.41 0.15 2.96
67 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
68 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
69 INT93777 Negative_regulation of Rgs2 3 0.43 2.5 2.81
70 INT184005 Negative_regulation of Gene_expression of Socs3 6 0.48 8.76 2.74
71 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
72 INT80880 Gene_expression of ARRB2 4 0.65 3.51 2.71
73 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
74 INT126250 Binding of Rgs17 1 0.36 0.36 2.7
75 INT142465 Negative_regulation of Socs3 8 0.48 8.31 2.62
76 INT112252 Regulation of Rgs7 3 0.38 0 2.62
77 INT76679 Positive_regulation of Transcription of Il1rn 1 0.37 9.13 2.55
78 INT62064 Negative_regulation of Gene_expression of Il1rn 6 0.32 4.81 2.53
79 INT112253 Positive_regulation of Regulation of Rgs9 2 0.41 0.29 2.51
80 INT119435 Negative_regulation of Positive_regulation of Rgs7 1 0.42 0.77 2.51
81 INT126299 Regulation of Rgs20 3 0.41 0.89 2.5
82 INT69981 Positive_regulation of Negative_regulation of Il1rn 2 0.09 3.28 2.48
83 INT51279 Regulation of IGFBP3 17 0.49 15.89 2.45
84 INT126277 Regulation of Gene_expression of Rgs9 3 0.61 0.53 2.45
85 INT159604 Gene_expression of IL18BP 3 0.49 4.56 2.42
86 INT142788 Transcription of Rgs19 1 0.32 0.28 2.42
87 INT126249 Negative_regulation of Gene_expression of Rgs17 2 0.48 0.05 2.4
88 INT108796 Binding of ESR2 5 0.46 6.84 2.36
89 INT126285 Regulation of Rgs4 4 0.62 1.05 2.36
90 INT119437 Binding of Rgs9 2 0.33 0.45 2.32
91 INT126256 Positive_regulation of Rgs17 1 0.35 0 2.31
92 INT126252 Positive_regulation of Transcription of Rgs17 1 0.35 0 2.31
93 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
94 INT102234 Gene_expression of ESR2 17 0.65 9.29 2.3
95 INT112255 Positive_regulation of Rgs9 2 0.54 0.35 2.26
96 INT126254 Transcription of Rgs17 1 0.40 0 2.25
97 INT131928 Localization of Il1rn 3 0.74 2.22 2.24
98 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
99 INT184054 Negative_regulation of Gene_expression of Socs1 7 0.53 9.18 2.22
100 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
101 INT125480 Regulation of HHIP 17 0.38 6.16 2.16
102 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
103 INT119450 Transcription of Rgs9 3 0.51 0.58 2.05
104 INT124145 Phosphorylation of Rgs9 2 0.72 0.29 2.05
105 INT119449 Positive_regulation of Transcription of Rgs9 1 0.37 0.54 2.02
106 INT220360 Transcription of Cish 1 0.32 2.57 2.01
107 INT140053 Positive_regulation of Cish 9 0.41 2.4 2
108 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
109 INT119448 Transcription of Rgs7 1 0.69 0.46 1.98
110 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
111 INT49371 Positive_regulation of Gene_expression of IGFBP3 27 0.70 23.13 1.9
112 INT184042 Negative_regulation of Socs1 9 0.46 8.1 1.88
113 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
114 INT184031 Gene_expression of Cish 14 0.49 9.82 1.86
115 INT80885 Positive_regulation of Gene_expression of ARRB2 3 0.49 1.36 1.82
116 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73
117 INT184068 Positive_regulation of Socs1 7 0.51 4.03 1.73
118 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
119 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
120 INT142790 Gene_expression of Rgs19 1 0.30 0.18 1.67
121 INT254250 Regulation of Socs1 5 0.06 3.04 1.66
122 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
123 INT319253 Regulation of Socs4 1 0.05 2.9 1.66
124 INT126276 Regulation of Rgs14 1 0.39 0.71 1.63
125 INT150215 Localization of LRPAP1 1 0.73 1.52 1.62
126 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
127 INT142784 Regulation of Transcription of Rgs19 1 0.20 0.19 1.61
128 INT140058 Regulation of Cish 17 0.37 8.69 1.58
129 INT176382 Negative_regulation of IL18BP 1 0.19 3.16 1.56
130 INT184052 Localization of Socs1 3 0.59 4.07 1.54
131 INT112247 Positive_regulation of Regulation of Rgs7 1 0.42 0 1.52
132 INT159605 Binding of IL18BP 2 0.24 2.56 1.5
133 INT184032 Regulation of Socs3 6 0.37 4.08 1.48
134 INT158184 Localization of ARRB2 2 0.52 1.3 1.47
135 INT220376 Positive_regulation of Gene_expression of Cish 8 0.31 5.41 1.46
136 INT109419 Regulation of Rgs7 1 0.23 0.07 1.44
137 INT109423 Regulation of Gene_expression of Rgs7 1 0.23 0.07 1.44
138 INT126298 Localization of Rgs4 2 0.78 0.67 1.4
139 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
140 INT109421 Gene_expression of Rgs7 1 0.51 0.07 1.39
141 INT126253 Positive_regulation of Binding of Rgs17 1 0.52 0.19 1.37
142 INT126251 Binding of Rgs20 1 0.07 0.19 1.37
143 INT126248 Positive_regulation of Binding of Rgs20 1 0.08 0.19 1.37
144 INT158183 Positive_regulation of Negative_regulation of ARRB2 1 0.35 1.13 1.33
145 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
146 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
147 INT163592 Localization of CISH 5 0.54 5.9 1.26
148 INT141862 Binding of Cav1 11 0.36 1.32 1.25
149 INT146351 Positive_regulation of Phosphorylation of Rgs14 1 0.45 0.27 1.23
150 INT184056 Regulation of Gene_expression of Socs3 4 0.45 4.24 1.22
151 INT48728 Negative_regulation of IGFBP3 28 0.59 14.84 1.21
152 INT101022 Regulation of Il1rn 5 0.44 2.15 1.21
153 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
154 INT116537 Binding of ARRB2 1 0.34 0.3 1.19
155 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
156 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
157 INT144152 Gene_expression of Socs6 2 0.39 0.19 1.16
158 INT176387 Negative_regulation of Binding of IL18BP 1 0.14 2.37 1.16
159 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
160 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
161 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
162 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
163 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
164 INT140052 Binding of Cish 12 0.39 1.63 1.1
165 INT125476 Regulation of Gene_expression of HHIP 2 0.39 1.1 1.1
166 INT92106 Localization of Socs6 2 0.16 1.54 1.1
167 INT269487 Positive_regulation of Binding of HHIP 1 0.06 0 1.08
168 INT184020 Localization of Socs3 3 0.75 4.05 1.06
169 INT149380 Localization of Cish 3 0.64 3.44 1.06
170 INT124149 Positive_regulation of Phosphorylation of Rgs9 1 0.44 0.29 1.05
171 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
172 INT126295 Negative_regulation of Localization of Rgs4 1 0.38 0.36 1.01
173 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
174 INT126287 Regulation of Gene_expression of Rgs17 1 0.25 0.34 0.99
175 INT354302 Regulation of Transcription of Rgs4 1 0.44 0.58 0.98
176 INT126279 Gene_expression of Rgs14 1 0.67 0.34 0.98
177 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
178 INT292529 Phosphorylation of Il1rn 1 0.09 1 0.97
179 INT136613 Negative_regulation of Cav1 2 0.57 2.28 0.96
180 INT354298 Transcription of Rgs4 1 0.67 0.58 0.95
181 INT145851 Negative_regulation of Positive_regulation of Il1rn 1 0.08 0.7 0.95
182 INT119436 Positive_regulation of Transcription of Rgs7 1 0.67 0.19 0.94
183 INT17574 Binding of CISH 23 0.31 4.3 0.93
184 INT145852 Negative_regulation of Negative_regulation of Il1rn 1 0.08 0.69 0.93
185 INT269485 Positive_regulation of Gene_expression of HHIP 9 0.41 1.08 0.92
186 INT253940 Gene_expression of Gsk3a 1 0.08 2.82 0.92
187 INT182513 Regulation of AGTR2 4 0.14 4.31 0.91
188 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
189 INT253938 Positive_regulation of Gsk3a 3 0.06 3.4 0.9
190 INT220375 Positive_regulation of Transcription of Cish 1 0.22 1.01 0.9
191 INT84571 Gene_expression of Rgs2 6 0.67 3.18 0.89
192 INT141442 Negative_regulation of Phosphorylation of Cav1 1 0.59 0.94 0.87
193 INT211737 Localization of Rgs7 1 0.02 0 0.86
194 INT142791 Positive_regulation of Rgs19 1 0.21 0.1 0.86
195 INT142782 Positive_regulation of Transcription of Rgs19 1 0.21 0.1 0.86
196 INT142792 Positive_regulation of Gene_expression of Rgs19 1 0.22 0.1 0.86
197 INT142789 Regulation of Gene_expression of Rgs19 1 0.20 0.1 0.86
198 INT211730 Localization of Rgs20 1 0.55 0 0.85
199 INT211729 Localization of Rgs17 1 0.60 0 0.85
200 INT184014 Binding of Socs1 2 0.34 0.97 0.84
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