GO:0010033

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Name response to organic substance
Categary Process
Go Slim No
Go Link GO:0010033
Unique Molecular Interactions 2266
Total Molecular Interactions 3055
Total Single Events 34744
Pain Genes Associated 128

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to organic substance. They are ordered first by their pain relevance and then by number of times they were reported for response to organic substance. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
2 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
3 INT69229 Ngf Positive_regulation of Gene_expression of Bdnf 6 0.76 8.19 6.66
4 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
5 INT170447 Binding of Pax3 and Spr 1 0.01 0.1 5.37
6 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
7 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42
8 INT240653 Ngf Positive_regulation of Positive_regulation of Bdnf 1 0.55 2.97 4.23
9 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
10 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
11 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
12 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
13 INT180813 Ngf Positive_regulation of Sorbs1 1 0.04 2.09 3.79
14 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
15 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
16 INT132862 Ngf Positive_regulation of Bdnf 4 0.46 4.05 3.65
17 INT17317 Binding of Jun and Fos 7 0.42 1.03 3.5
18 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
19 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
20 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
21 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
22 INT309150 Edc4 Positive_regulation of Creb1 1 0.03 3.46 3.09
23 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
24 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
25 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
26 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
27 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
28 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
29 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
30 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
31 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
32 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
33 INT170037 Ngf Regulation of Gene_expression of DRGX 1 0.01 1.37 2.46
34 INT103330 Ngf Positive_regulation of Gdnf 2 0.28 1.27 2.45
35 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
36 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
37 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
38 INT108987 Ngf Regulation of Gene_expression of Sit1 1 0.00 1.46 2.32
39 INT54489 Binding of Jun and Rabep2 4 0.16 1.48 2.3
40 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27
41 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
42 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
43 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
44 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
45 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
46 INT113451 Ngf Regulation of Gene_expression of ASIC3 1 0.07 1.35 2.18
47 INT12140 Ngf Regulation of Chat 1 0.44 1.67 2.18
48 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
49 INT66157 Binding of ALB and BDP1 1 0.11 0 2.13
50 INT120319 Ghrh Regulation of Ngf 1 0.25 1.89 2.11
51 INT113452 Ngf Positive_regulation of Gene_expression of ASIC3 1 0.19 1.34 2.08
52 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07
53 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
54 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
55 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
56 INT54488 Npepo Regulation of Gene_expression of Jun 1 0.30 0 1.98
57 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
58 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
59 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
60 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
61 INT276668 Ngf Regulation of Nav1 1 0.09 0.98 1.85
62 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
63 INT139640 Jun Regulation of Gene_expression of Npy 1 0.21 1.98 1.75
64 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
65 INT80199 Ngf Regulation of Transcription of Rab38 1 0.01 1.48 1.68
66 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
67 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
68 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
69 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
70 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
71 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
72 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55
73 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55
74 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
75 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
76 INT170654 Binding of Ntf3 and Ngf 1 0.38 1.66 1.54
77 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
78 INT256360 Car2 Positive_regulation of Localization of Rela 1 0.14 0 1.51
79 INT79021 Regulation of Binding of Jun and Fos 2 0.50 0.66 1.5
80 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
81 INT149743 Ean5 Positive_regulation of Gene_expression of P2rx2 1 0.10 1.54 1.5
82 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
83 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49
84 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
85 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
86 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
87 INT73650 Binding of Pim3 and Creb1 1 0.03 2.48 1.47
88 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
89 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
90 INT180789 Ngf Regulation of Localization of Trpv1 1 0.28 1.22 1.44
91 INT180809 Ngf Positive_regulation of Positive_regulation of Sorbs1 1 0.03 0.84 1.4
92 INT180808 Ngf Positive_regulation of Gene_expression of Sorbs1 1 0.03 0.84 1.4
93 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
94 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
95 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 0.47 0.64 1.37
96 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
97 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
98 INT60992 Ngf Regulation of CRTAC1 1 0.00 0 1.35
99 INT151770 Binding of P2RX3 and Ngf 1 0.18 0.9 1.35
100 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
101 INT140531 Ngf Positive_regulation of DYT10 1 0.72 1.83 1.34
102 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
103 INT2641 Binding of Pomc and Lct 2 0.31 0.57 1.32
104 INT180786 Calca Regulation of Positive_regulation of Ngf 1 0.40 0 1.32
105 INT39950 Binding of ALB and PDYN 1 0.31 0 1.32
106 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
107 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
108 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
109 INT124925 Negative_regulation of Slc6a1 Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
110 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
111 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
112 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
113 INT19819 Penk Regulation of Gene_expression of Ins1 1 0.05 0 1.27
114 INT195541 Lct Positive_regulation of Gene_expression of Grm2 1 0.02 0.4 1.27
115 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
116 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
117 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 0.02 0.18 1.24
118 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
119 INT136256 Creb1 Regulation of SGCG 1 0.26 0.18 1.23
120 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23
121 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
122 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
123 INT121729 Negative_regulation of Ngf Positive_regulation of Ephb1 1 0.24 0.69 1.22
124 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
125 INT285185 Binding of Ca2 and Cd2 1 0.25 0.24 1.21
126 INT121724 Ngf Positive_regulation of Ephb1 1 0.40 0.68 1.21
127 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 0.38 0 1.21
128 INT108065 Negative_regulation of Binding of Ngf and IgG-2a 1 0.01 2.38 1.2
129 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
130 INT108064 Binding of Ngf and IgG-2a 1 0.01 2.36 1.19
131 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
132 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19
133 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
134 INT122370 Positive_regulation of Tacr1 Positive_regulation of Ngf 1 0.30 0.17 1.18
135 INT170655 Binding of Csf2 and Ngf 1 0.36 1.25 1.18
136 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
137 INT148437 Binding of Bdnf and Ngf 2 0.32 1.9 1.17
138 INT124435 Gene_expression of Chrna9 Positive_regulation of Phosphorylation of Creb1 1 0.11 0.6 1.17
139 INT93290 Ngf Regulation of Transcription of Trpv1 1 0.02 0.34 1.16
140 INT335435 Ngf Positive_regulation of Ltb4r 1 0.52 1.06 1.16
141 INT93289 Ngf Regulation of Trpv1 1 0.05 0.34 1.16
142 INT19535 Binding of ADRA1D and ALB 3 0.42 0.8 1.15
143 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
144 INT160653 Binding of P2rx1 and Ptgfr 1 0.28 0.66 1.14
145 INT122369 Tacr1 Positive_regulation of Ngf 1 0.30 0.16 1.14
146 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
147 INT121362 Trpv1 Regulation of Localization of Ins1 1 0.51 0.17 1.12
148 INT121728 Ngf Positive_regulation of Phosphorylation of Pik3cb 1 0.45 0.69 1.11
149 INT105423 Jun Positive_regulation of Gene_expression of Penk 1 0.43 0 1.09
150 INT69889 Ngf Regulation of Localization of Calca 1 0.49 0.1 1.08
151 INT105690 Ngf Positive_regulation of TRPV1 1 0.05 1.43 1.08
152 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
153 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
154 INT120315 Gnrhr Negative_regulation of Positive_regulation of Ngf 1 0.11 0.85 1.07
155 INT120318 Gnrhr Negative_regulation of Ngf 1 0.11 0.85 1.07
156 INT69340 Binding of Igh-6 and Ngf 2 0.06 1.04 1.06
157 INT87320 Ngf Regulation of Gene_expression of Bdnf 2 0.38 0.97 1.06
158 INT139227 Icam1 Negative_regulation of Timp1 1 0.37 1.13 1.06
159 INT120317 Ghrh Regulation of Positive_regulation of Ngf 1 0.25 0.95 1.06
160 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
161 INT120311 Ghrh Regulation of Gene_expression of Ngf 1 0.25 0.95 1.06
162 INT93614 Ngf Positive_regulation of Ntrk1 2 0.52 0.85 1.05
163 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
164 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
165 INT119888 Binding of Creb1 and Usf1 1 0.18 0.15 1.05
166 INT170653 Ngf Regulation of Csf2 1 0.34 1.11 1.05
167 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
168 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04
169 INT180806 Ngf Positive_regulation of Regulation of Sorbs1 1 0.03 0.28 1.04
170 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
171 INT335401 Hgf Positive_regulation of Ngf 1 0.30 1.13 1.04
172 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
173 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03
174 INT95378 Binding of Jun and Jund 5 0.20 2.06 1.02
175 INT74027 Creb1 Regulation of Jun 4 0.27 1.04 1.02
176 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
177 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
178 INT151768 Ngf Positive_regulation of P2rx6 1 0.00 0.81 1.01
179 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01
180 INT139636 Jun Negative_regulation of Phosphorylation of Npy 1 0.33 1.07 1.01
181 INT137441 Ngf Negative_regulation of Sema3a 1 0.46 2.07 1.01
182 INT12138 Ins1 Negative_regulation of Chat 1 0.27 0.71 1.01
183 INT151765 Ngf Positive_regulation of Positive_regulation of P2rx6 1 0.00 0.81 1.01
184 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
185 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
186 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
187 INT139639 Jun Negative_regulation of Positive_regulation of Vip 1 0.53 1.07 1
188 INT139643 Jun Negative_regulation of Positive_regulation of Npy 1 0.33 1.07 1
189 INT83987 Ngf Regulation of Atf2 1 0.52 0.49 1
190 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
191 INT170449 Pax3 Positive_regulation of Spr 1 0.01 0.26 0.99
192 INT86662 Ngf Regulation of SCN10A 1 0.27 1.24 0.99
193 INT139641 Positive_regulation of Jun Positive_regulation of Positive_regulation of Vip 1 0.37 0.95 0.99
194 INT65631 Ufm1 Positive_regulation of Kcna5 1 0.02 0 0.99
195 INT73681 Regulation of KNG1 Positive_regulation of ALB 1 0.30 0.38 0.99
196 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
197 INT73680 KNG1 Positive_regulation of ALB 1 0.51 0.38 0.98
198 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
199 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
200 INT139642 Positive_regulation of Jun Regulation of Gene_expression of Npy 1 0.21 1.07 0.97

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to organic substance. They are ordered first by their pain relevance and then by number of times they were reported in response to organic substance. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56
2 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238
3 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97
4 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
5 INT1114 Localization of Ins1 748 0.80 192.95 165.48
6 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64
7 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52
8 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132
9 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
10 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01
11 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96
12 INT4822 Localization of Ca2 417 0.80 99.57 96.45
13 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36
14 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71
15 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08
16 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19
17 INT12001 Regulation of Ngf 97 0.62 54.64 76.25
18 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76
19 INT3034 Localization of Ngf 126 0.81 50.81 72.84
20 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
21 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26
22 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54
23 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37
24 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
25 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01
26 INT46 Localization of Ren 233 0.81 46.15 62.44
27 INT546 Binding of ALB 311 0.48 85.98 60.14
28 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77
29 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
30 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39
31 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72
32 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14
33 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
34 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
35 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
36 INT2276 Regulation of Ins1 234 0.61 103.78 54.05
37 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64
38 INT1032 Regulation of Ca2 202 0.52 54.91 53.03
39 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
40 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64
41 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24
42 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97
43 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94
44 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
45 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
46 INT19078 Binding of Ngf 78 0.48 31.03 44.33
47 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29
48 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07
49 INT613 Gene_expression of Alb 268 0.78 149.84 42.78
50 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75
51 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
52 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45
53 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
54 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
55 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5
56 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
57 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66
58 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
59 INT5489 Localization of CA2 172 0.80 39.46 33.56
60 INT16714 Regulation of Creb1 64 0.62 22.23 33.56
61 INT1116 Regulation of Ren 103 0.62 27.66 33.26
62 INT234 Binding of Alb 151 0.48 52.34 32.97
63 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
64 INT47764 Binding of Jun 106 0.48 22.62 31.39
65 INT8027 Regulation of Gene_expression of Ngf 34 0.62 26.32 31.16
66 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75
67 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25
68 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
69 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
70 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
71 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65
72 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04
73 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
74 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
75 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7
76 INT5966 Localization of Il1a 50 0.78 22.91 26.54
77 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
78 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6
79 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9
80 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
81 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
82 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31
83 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28
84 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17
85 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
86 INT7678 Localization of Alb 142 0.81 80.93 22.49
87 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46
88 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
89 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
90 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
91 INT61159 Regulation of Gene_expression of Creb1 46 0.62 24.07 20.52
92 INT65907 Negative_regulation of Gene_expression of Ngf 36 0.59 19.5 20.03
93 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79
94 INT64261 Negative_regulation of Positive_regulation of Ngf 21 0.59 16.28 19.78
95 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
96 INT74286 Regulation of Il10 42 0.44 28.06 19.44
97 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4
98 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15
99 INT91916 Gene_expression of P2rx3 51 0.78 21.2 19.05
100 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78
101 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72
102 INT9482 Positive_regulation of Gene_expression of Jun 60 0.69 9.95 18.61
103 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
104 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35
105 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
106 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
107 INT187513 Positive_regulation of Pla2g4a 5 0.62 34.09 18.22
108 INT62577 Negative_regulation of Creb1 55 0.59 19.68 18.1
109 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09
110 INT61158 Negative_regulation of Creb1 33 0.59 11.54 18.06
111 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
112 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69
113 INT49922 Positive_regulation of Positive_regulation of Ngf 21 0.67 14.46 17.68
114 INT72564 Localization of Il10 41 0.78 28.62 17.6
115 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
116 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36
117 INT78233 Positive_regulation of P2rx3 36 0.56 21.49 17.25
118 INT195831 Phosphorylation of Pla2g4a 15 0.74 34.43 17.14
119 INT15358 Transcription of Ngf 29 0.72 10.43 16.94
120 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
121 INT48892 Transcription of Il10 31 0.71 27.26 16.77
122 INT102023 Regulation of Creb1 51 0.62 16.29 16.71
123 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07
124 INT48540 Gene_expression of Kcna5 37 0.77 14.04 16.07
125 INT91285 Negative_regulation of P2rx2 29 0.57 12.74 15.48
126 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42
127 INT69652 Regulation of P2rx3 26 0.61 17.17 15.4
128 INT92839 Regulation of P2rx2 36 0.45 13.19 15.38
129 INT615 Regulation of Alb 66 0.62 33.43 15.33
130 INT93482 Localization of Rela 56 0.78 24.52 14.82
131 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
132 INT17593 Regulation of Jun 37 0.60 5.5 14.35
133 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07
134 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85
135 INT18773 Localization of ALB 117 0.80 69.18 13.8
136 INT2336 Negative_regulation of Lct 51 0.58 33.79 13.73
137 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69
138 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
139 INT107248 Negative_regulation of Gene_expression of Creb1 26 0.58 9.24 13.41
140 INT6794 Negative_regulation of Jun 37 0.53 8.04 13.37
141 INT67611 Positive_regulation of Pparg 39 0.69 18.33 13.23
142 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2
143 INT16713 Binding of Creb1 53 0.48 20.24 13.06
144 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
145 INT2578 Binding of Ins1 74 0.48 33.57 12.92
146 INT19799 Binding of Ca2 71 0.48 13.69 12.92
147 INT78234 Positive_regulation of Gene_expression of P2rx2 18 0.69 12.86 12.75
148 INT86950 Negative_regulation of Gene_expression of Il10 26 0.42 18.92 12.73
149 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66
150 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
151 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
152 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35
153 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
154 INT47743 Negative_regulation of Slc6a4 22 0.59 6.23 12.23
155 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
156 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
157 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35
158 INT270238 Localization of Pla2g4a 1 0.72 17.99 11.35
159 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
160 INT52233 Transcription of Jun 37 0.66 6.39 11.15
161 INT15597 Negative_regulation of Gene_expression of Jun 20 0.48 6.04 11.08
162 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
163 INT3535 Regulation of CA2 61 0.32 16.48 10.8
164 INT65627 Negative_regulation of Kcna5 19 0.59 7.82 10.79
165 INT78579 Negative_regulation of P2rx3 23 0.59 10.13 10.78
166 INT62576 Transcription of Creb1 34 0.69 16.97 10.6
167 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6
168 INT66303 Regulation of Slc6a4 10 0.45 4.82 10.55
169 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
170 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
171 INT109280 Negative_regulation of Phosphorylation of Creb1 29 0.59 11.81 10.37
172 INT85015 Gene_expression of ADM 29 0.73 30.75 10.21
173 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07
174 INT85535 Negative_regulation of Gene_expression of Ptgs2 27 0.51 16.04 10.01
175 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96
176 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
177 INT105304 Negative_regulation of Gene_expression of P2rx2 11 0.28 11.07 9.53
178 INT116705 Positive_regulation of Positive_regulation of P2rx2 13 0.49 9.44 9.47
179 INT47744 Binding of Slc6a4 21 0.48 5.52 9.45
180 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43
181 INT75997 Positive_regulation of Localization of Ngf 14 0.69 7.78 9.41
182 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
183 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35
184 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19
185 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
186 INT109279 Regulation of Phosphorylation of Creb1 14 0.62 4.06 8.96
187 INT860 Regulation of ALB 48 0.60 25.11 8.95
188 INT78578 Localization of P2rx3 21 0.78 9.55 8.86
189 INT66213 Localization of RELA 63 0.78 14.71 8.77
190 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57
191 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52
192 INT70775 Positive_regulation of Positive_regulation of P2rx1 15 0.49 8.65 8.49
193 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
194 INT4159 Gene_expression of Hp 33 0.72 12.49 8.39
195 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
196 INT12762 Negative_regulation of Positive_regulation of Ins1 24 0.59 8.51 8.28
197 INT93673 Transcription of Creb1 19 0.66 9.27 8.26
198 INT53975 Positive_regulation of Binding of Jun 28 0.70 4.67 8.16
199 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
200 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
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