GO:0010042

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Name response to manganese ion
Categary Process
Go Slim No
Go Link GO:0010042
Unique Molecular Interactions 235
Total Molecular Interactions 293
Total Single Events 5099
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to manganese ion. They are ordered first by their pain relevance and then by number of times they were reported for response to manganese ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
8 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
9 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
10 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
11 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
12 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 0.24 0.4 1.39
13 INT69279 Regulation of Binding of TSPO and Gabrg1 1 0.00 2.05 1.26
14 INT122267 Prkcg Positive_regulation of Grin2b 1 0.26 0.61 1.14
15 INT59606 Binding of Tspo and Penk 1 0.04 0 1.12
16 INT132683 Bdnf Positive_regulation of Phosphorylation of Grin2a 1 0.00 0.93 1.11
17 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
18 INT269189 Binding of Grin2a and Grin3a 2 0.25 1.05 1.09
19 INT269193 Prkcg Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
20 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
21 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
22 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
23 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
24 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
25 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
26 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
27 INT310348 Binding of Tspo and Gabrd 1 0.00 0.43 0.88
28 INT116559 Olr1627 Negative_regulation of Regulation of Ptgs2 1 0.01 1.52 0.86
29 INT212290 Binding of Grin2a and Grin2b 2 0.20 1.36 0.82
30 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
31 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78
32 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
33 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
34 INT186160 Negative_regulation of Grin2b Negative_regulation of Grin1 1 0.37 0.5 0.72
35 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
36 INT249485 Trib3 Negative_regulation of Phosphorylation of Grin2b 1 0.02 0.64 0.68
37 INT250084 Negative_regulation of Grin2b Negative_regulation of Positive_regulation of Ltp 1 0.18 0.07 0.66
38 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
39 INT250078 Negative_regulation of Grin2b Negative_regulation of Ltp 1 0.18 0.07 0.66
40 INT302441 Binding of GRIN1 and Grin2b 1 0.10 1.27 0.63
41 INT69280 Negative_regulation of Binding of TSPO and Gabrg1 1 0.00 1.03 0.63
42 INT186159 Grin2d Negative_regulation of Grin2b 1 0.21 0.82 0.62
43 INT69278 Binding of TSPO and Gabrg1 1 0.00 1.01 0.62
44 INT71942 Negative_regulation of PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.62
45 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 0.03 0.2 0.62
46 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
47 INT249484 Trib3 Positive_regulation of Phosphorylation of Grin2b 1 0.01 0.57 0.61
48 INT71944 PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.61
49 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
50 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
51 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
52 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 0.19 1.38 0.58
53 INT137248 Slc6a14 Negative_regulation of Gene_expression of Ptgs2 1 0.19 1.32 0.58
54 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
55 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
56 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
57 INT71943 Regulation of ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.54
58 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 0.00 0.87 0.54
59 INT249497 Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.02 0.51 0.54
60 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
61 INT249479 Binding of Ephb1 and Grin2b 1 0.29 0.37 0.54
62 INT71945 ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.53
63 INT69882 Ptger2 Positive_regulation of Gene_expression of Ptgs2 1 0.19 0.6 0.52
64 INT250080 Grin2b Positive_regulation of Ltp 1 0.22 0.19 0.49
65 INT150205 Tnrc6a Negative_regulation of PTGS2 1 0.00 0.42 0.49
66 INT135584 CSF2 Regulation of PTGS2 1 0.06 1.28 0.49
67 INT150788 ZNF398 Regulation of PTGS2 1 0.02 0.5 0.48
68 INT250081 Grin2a Positive_regulation of Ltp 1 0.20 0.14 0.48
69 INT348402 LPA Positive_regulation of Gene_expression of Ptgs2 1 0.01 0.62 0.48
70 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47
71 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47
72 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
73 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47
74 INT127662 Negative_regulation of PDE4A Negative_regulation of Gene_expression of PTGS2 1 0.15 0.75 0.47
75 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46
76 INT249486 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Grin2b 1 0.33 0.4 0.46
77 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
78 INT127394 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin2a 1 0.01 0.71 0.45
79 INT127396 Negative_regulation of Mdk Negative_regulation of Gene_expression of Grin2a 1 0.00 0.71 0.45
80 INT105733 Grin2b Negative_regulation of Gene_expression of Grin2a 1 0.22 0.09 0.41
81 INT279620 Negative_regulation of Binding of Grin2a and Grin2b 1 0.18 0.99 0.4
82 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
83 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37
84 INT52632 Binding of TSPO and CCK 1 0.15 0.53 0.37
85 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
86 INT250076 Grin2a Regulation of Positive_regulation of Ltp 1 0.10 0.06 0.35
87 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35
88 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
89 INT278749 NUP98 Positive_regulation of Gene_expression of PTGS2 1 0.46 1.28 0.35
90 INT249492 Trib3 Regulation of Phosphorylation of Grin2b 1 0.01 0.23 0.35
91 INT89501 Il6 Positive_regulation of Ptgs2 1 0.01 1.07 0.35
92 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
93 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34
94 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
95 INT236006 HTR1A Regulation of Grin2b 1 0.00 0 0.33
96 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
97 INT284689 Binding of Tspo and Map3k12 1 0.00 0.59 0.32
98 INT52700 Prkcg Positive_regulation of Ptgs2 1 0.12 0.3 0.32
99 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
100 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
101 INT64859 Negative_regulation of PTGS1 Negative_regulation of PTGS2 1 0.07 0.05 0.31
102 INT116594 Negative_regulation of PTGS2 Negative_regulation of Gene_expression of IL6 1 0.22 0.45 0.31
103 INT139044 AKR1B1 Regulation of Gene_expression of PTGS2 1 0.09 0.37 0.3
104 INT84426 Binding of TSPO and INSRR 1 0.01 0.22 0.3
105 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
106 INT62207 Binding of PTGS1 and PTGS2 3 0.06 0.07 0.29
107 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29
108 INT250079 Grin2b Regulation of Ltp 1 0.18 0.31 0.29
109 INT158922 Positive_regulation of Binding of TSPO and Tspo 1 0.54 0.83 0.28
110 INT212289 Vsnl1 Negative_regulation of Grin2a 1 0.04 0.38 0.28
111 INT158923 Binding of TSPO and Tspo 1 0.40 0.82 0.28
112 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
113 INT142447 PTGS2 Regulation of Gene_expression of PTGIS 1 0.30 0.24 0.27
114 INT107392 PTGS2 Positive_regulation of PTGS1 2 0.31 1.01 0.26
115 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
116 INT69120 MOCS1 Regulation of PTGS2 1 0.00 0.39 0.26
117 INT96402 Binding of PTGS2 and TBXAS1 1 0.02 0.32 0.26
118 INT64860 PTGS1 Negative_regulation of PTGS2 1 0.07 0 0.26
119 INT96401 Binding of PTGER1 and PTGS2 1 0.00 0.32 0.26
120 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
121 INT102625 IL6 Regulation of Gene_expression of PTGS2 1 0.11 0.29 0.24
122 INT136798 Spp1 Regulation of Gene_expression of PTGS2 1 0.08 0.65 0.24
123 INT126552 Agt Positive_regulation of Gene_expression of Ptgs2 1 0.32 0.92 0.24
124 INT250075 Binding of Hpcal4 and Negative_regulation of Gene_expression of Grin2a 1 0.03 0 0.24
125 INT102617 PTAFR Regulation of Gene_expression of PTGS2 1 0.12 0.29 0.24
126 INT132382 Nos2 Positive_regulation of PTGS2 1 0.02 0.1 0.23
127 INT272143 PTAFR Positive_regulation of Gene_expression of PTGS2 1 0.12 1.59 0.23
128 INT126549 Agt Positive_regulation of Ptgs2 1 0.32 0.9 0.23
129 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
130 INT145014 Positive_regulation of GAST Positive_regulation of PTGS2 1 0.31 0.51 0.22
131 INT133164 Ptgs2 Regulation of Tnf 1 0.14 0.98 0.22
132 INT145012 GAST Positive_regulation of PTGS2 1 0.42 0.51 0.22
133 INT69318 ST3GAL4 Positive_regulation of Gene_expression of PTGS2 1 0.35 0.09 0.21
134 INT151424 Tfrc Negative_regulation of Positive_regulation of Tnni3 1 0.21 0.98 0.2
135 INT250074 Grin2b Positive_regulation of Gene_expression of Hpcal4 1 0.04 0.3 0.2
136 INT231639 Binding of PTGER2 and PTGS2 1 0.00 0.44 0.19
137 INT117517 PROC Positive_regulation of PTGS2 1 0.01 0.61 0.19
138 INT326737 IL8 Positive_regulation of Gene_expression of ARG1 1 0.38 2.41 0.19
139 INT79651 PTGS2 Positive_regulation of Phosphorylation of NR3C1 1 0.07 0.1 0.19
140 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19
141 INT139015 STAT1 Negative_regulation of Gene_expression of PTGS2 1 0.01 0.36 0.19
142 INT73332 IL1B Positive_regulation of Transcription of PTGS2 1 0.44 0.54 0.18
143 INT73331 PTAFR Positive_regulation of Transcription of PTGS2 1 0.13 0.54 0.18
144 INT319173 TXN Positive_regulation of Gene_expression of SOD2 1 0.23 0.1 0.18
145 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16
146 INT191336 Binding of TSPO and GOPC 1 0.01 0.65 0.16
147 INT69317 PTGS2 Positive_regulation of Gene_expression of PTGS1 1 0.42 0.09 0.16
148 INT141753 Nfkb1 Regulation of Ptgs2 1 0.16 1.18 0.16
149 INT146745 UGCG Positive_regulation of Gene_expression of PTGS2 1 0.23 0.1 0.16
150 INT141754 Nfkb1 Regulation of Positive_regulation of Ptgs2 1 0.16 1.21 0.16
151 INT191338 Binding of TSPO and IDO1 1 0.02 0.65 0.16
152 INT176621 PTGS2 Regulation of Gene_expression of PTGER2 1 0.00 0.09 0.15
153 INT87710 MYB Regulation of PTGS2 1 0.28 0.64 0.15
154 INT92342 Zfp697 Negative_regulation of Ptgs2 1 0.02 0.63 0.15
155 INT138321 PPA1 Positive_regulation of Gene_expression of PTGS2 1 0.02 0.09 0.14
156 INT141111 Sftpa1 Positive_regulation of Ptgs2 1 0.64 0.3 0.14
157 INT328851 Binding of PTGS2 and ZNF434 1 0.00 0.7 0.14
158 INT141112 Negative_regulation of Sftpa1 Positive_regulation of Ptgs2 1 0.39 0.31 0.14
159 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14
160 INT326735 Negative_regulation of IL8 Negative_regulation of Gene_expression of ARG1 1 0.32 0.33 0.14
161 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13
162 INT81983 IL1A Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.27 0.13
163 INT306270 CCL4 Positive_regulation of Transcription of PTGS2 1 0.34 0.31 0.12
164 INT173129 PTGS2 Regulation of IER3 1 0.01 0.36 0.12
165 INT306262 NFKB1 Positive_regulation of Transcription of PTGS2 1 0.42 0.31 0.12
166 INT63521 Negative_regulation of Ptgs2 Negative_regulation of Gene_expression of Fos 1 0.66 0.1 0.12
167 INT249495 Binding of Grin2b and Efnb2 1 0.02 0.05 0.11
168 INT147073 NFKB1 Regulation of PTGS2 1 0.37 0 0.11
169 INT133361 FABP6 Negative_regulation of PTGS2 1 0.01 0.07 0.11
170 INT52701 Slc3a1 Positive_regulation of Ptgs2 1 0.06 0.27 0.11
171 INT52702 Capza2 Positive_regulation of Ptgs2 1 0.00 0.27 0.11
172 INT294454 KLK4 Negative_regulation of PTGS2 1 0.01 0 0.1
173 INT151423 Tfrc Positive_regulation of Gene_expression of Nos2 1 0.24 0.49 0.1
174 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
175 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
176 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
177 INT302131 Negative_regulation of SOD2 Regulation of BAK1 1 0.09 1.22 0.07
178 INT302128 SOD2 Regulation of BAK1 1 0.09 1.22 0.07
179 INT140895 PTGS2 Positive_regulation of Gene_expression of VEGFA 1 0.27 0.07 0.07
180 INT98715 HGF Positive_regulation of Gene_expression of PTGS2 1 0.02 1.03 0.07
181 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
182 INT250073 Grin2a Regulation of Grin2b 1 0.39 0.9 0.05
183 INT345245 Adam9 Regulation of Adam10 1 0.09 0.18 0.05
184 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
185 INT341882 Positive_regulation of Oxtr Positive_regulation of Positive_regulation of Ptgs2 1 0.02 0.11 0.05
186 INT17850 Binding of PTGS2 and Ptgs2 1 0.00 0.08 0.04
187 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04
188 INT17851 Negative_regulation of Binding of PTGS2 and Ptgs2 1 0.00 0.08 0.04
189 INT331157 Ptgis Positive_regulation of Ptgs2 1 0.04 0.77 0.03
190 INT326742 AR Regulation of Gene_expression of ARG1 1 0.24 0.43 0.03
191 INT144761 Binding of INSR and Insr 1 0.05 0 0
192 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0
193 INT235623 Binding of INS and INSR 1 0.14 0.47 0
194 INT346838 ZNF434 Regulation of PTGS2 1 0.01 0.34 0
195 INT121545 Mif Negative_regulation of Regulation of Ptgs2 1 0.13 0.15 0
196 INT346836 MECP2 Regulation of PTGS2 1 0.00 0.34 0
197 INT352066 Binding of PTGS2 and PTGES2 1 0.04 0 0
198 INT197677 Binding of ESR1 and Arg1 1 0.04 0 0
199 INT326744 ARG1 Regulation of ARG2 1 0.50 1.04 0
200 INT144754 Negative_regulation of Binding of Insr and Slc2a2 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to manganese ion. They are ordered first by their pain relevance and then by number of times they were reported in response to manganese ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
2 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
3 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
4 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
5 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
6 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
7 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
8 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
9 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
10 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
11 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
12 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
13 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
14 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
15 INT8691 Localization of Insr 85 0.80 9.27 30.32
16 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
17 INT5300 Regulation of Insr 54 0.60 11.33 29.26
18 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54
19 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
20 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
21 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84
22 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
23 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84
24 INT93037 Regulation of Grin2b 26 0.57 11.9 16.92
25 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
26 INT103996 Negative_regulation of Phosphorylation of Grin2b 11 0.58 7.81 12.85
27 INT103997 Phosphorylation of Grin2a 17 0.64 10.75 12.67
28 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55
29 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
30 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6
31 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6
32 INT51626 Transcription of Grin2a 16 0.68 1.65 10.5
33 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32
34 INT18088 Binding of Tspo 26 0.48 9.12 10.2
35 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02
36 INT85535 Negative_regulation of Gene_expression of Ptgs2 27 0.51 16.04 10.01
37 INT80006 Regulation of Gene_expression of Grin2b 8 0.57 3.75 9.62
38 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
39 INT78769 Regulation of Grin2a 16 0.58 5.22 9.28
40 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52
41 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05
42 INT6335 Binding of TSPO 39 0.44 10.88 7.66
43 INT52688 Transcription of Ptgs2 16 0.69 8.31 7.52
44 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
45 INT103824 Positive_regulation of SOD2 26 0.70 17.42 7.17
46 INT39282 Negative_regulation of SOD2 27 0.59 16.89 7.03
47 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
48 INT90097 Localization of PTGS2 15 0.69 6.14 6.63
49 INT59079 Transcription of PTGS2 30 0.72 14.21 6.52
50 INT100926 Positive_regulation of Gene_expression of Grin2a 11 0.63 3.24 6.41
51 INT14258 Regulation of TSPO 32 0.60 10.16 6.24
52 INT67656 Positive_regulation of Positive_regulation of PTGS2 12 0.46 4.83 6.17
53 INT100658 Negative_regulation of Positive_regulation of Grin2b 7 0.41 1.39 6.17
54 INT78955 Regulation of Gene_expression of Ptgs2 12 0.62 7.22 6.02
55 INT74593 Transcription of Grin2b 10 0.66 1.21 5.98
56 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
57 INT67693 Binding of Grin2a 9 0.38 1.74 5.68
58 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
59 INT127353 Regulation of Phosphorylation of Grin2b 5 0.45 1.6 5.29
60 INT92541 Localization of Grin2b 11 0.75 2.85 5.14
61 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
62 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
63 INT79505 Binding of Grin2b 9 0.36 1.43 4.61
64 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5
65 INT7841 Gene_expression of Tspo 10 0.75 7.63 4.45
66 INT51084 Binding of Insr 13 0.30 4.25 4.23
67 INT52616 Negative_regulation of Positive_regulation of PTGS2 13 0.43 4.95 4.13
68 INT83035 Binding of INSR 16 0.47 9.29 4.11
69 INT103999 Positive_regulation of Phosphorylation of Grin2a 5 0.38 3.12 3.94
70 INT99453 Gene_expression of SOD2 25 0.77 13.28 3.6
71 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58
72 INT10116 Localization of INSR 11 0.57 5.43 3.48
73 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
74 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3
75 INT52694 Negative_regulation of Positive_regulation of Ptgs2 9 0.43 4.72 3.11
76 INT25745 Regulation of Tspo 6 0.45 0.25 3.1
77 INT90611 Positive_regulation of Positive_regulation of Grin2a 4 0.63 1.89 3
78 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76
79 INT51753 Negative_regulation of Tfrc 7 0.41 3.47 2.62
80 INT105730 Localization of Grin2a 7 0.67 0.64 2.56
81 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
82 INT17846 Binding of Ptgs2 8 0.32 4.66 2.48
83 INT136850 Positive_regulation of Arg1 10 0.50 6.96 2.47
84 INT21726 Gene_expression of Tfrc 10 0.74 7.38 2.36
85 INT78958 Regulation of Negative_regulation of Ptgs2 6 0.42 2.61 2.3
86 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
87 INT109334 Regulation of SOD2 13 0.60 7.48 2.14
88 INT74131 Positive_regulation of Tspo 7 0.50 0.92 2.11
89 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
90 INT82543 Negative_regulation of Gene_expression of TFRC 4 0.57 1.27 2.03
91 INT83332 Regulation of Gene_expression of TFRC 5 0.22 3.03 1.99
92 INT97579 Negative_regulation of Localization of PTGS2 2 0.08 2.37 1.99
93 INT151942 Regulation of Negative_regulation of Grin2b 2 0.41 0.41 1.92
94 INT74595 Regulation of Transcription of Grin2a 2 0.42 0.66 1.92
95 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9
96 INT103624 Negative_regulation of Gene_expression of Grin2a 5 0.56 1.58 1.9
97 INT52691 Positive_regulation of Transcription of Ptgs2 5 0.44 3 1.9
98 INT14257 Localization of TSPO 9 0.73 1.48 1.87
99 INT151174 Negative_regulation of Transcription of Grin2a 3 0.40 0 1.8
100 INT74594 Regulation of Transcription of Grin2b 1 0.42 0.17 1.8
101 INT19576 Negative_regulation of Tspo 3 0.42 1.02 1.75
102 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
103 INT232645 Transcription of INSR 2 0.09 1.19 1.71
104 INT178615 Binding of SOD2 12 0.48 6.93 1.51
105 INT59795 Regulation of Tfrc 5 0.43 4.43 1.48
106 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42
107 INT190768 Regulation of Positive_regulation of Ptgs2 1 0.04 1.2 1.41
108 INT86823 Regulation of Transcription of PTGS2 3 0.19 1.48 1.4
109 INT135658 Phosphorylation of Ptgs2 2 0.23 1.39 1.34
110 INT105729 Negative_regulation of Localization of Grin2a 3 0.38 0.08 1.29
111 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
112 INT249527 Positive_regulation of Positive_regulation of Grin2b 2 0.37 1.12 1.22
113 INT179372 Positive_regulation of Localization of PTGS2 2 0.38 0.35 1.21
114 INT6996 Positive_regulation of Tfrc 6 0.70 2.22 1.2
115 INT59078 Positive_regulation of Transcription of PTGS2 5 0.69 2.36 1.17
116 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
117 INT62981 Protein_catabolism of PTGS2 5 0.78 1.09 1.11
118 INT64862 Negative_regulation of Negative_regulation of PTGS2 3 0.36 0.76 1.09
119 INT70505 Positive_regulation of Positive_regulation of Ptgs2 4 0.49 2.22 1.08
120 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
121 INT82540 Negative_regulation of TFRC 3 0.41 0.77 1.07
122 INT83647 Negative_regulation of Negative_regulation of Ptgs2 1 0.28 1.97 1.05
123 INT64177 Negative_regulation of Transcription of PTGS2 4 0.41 1.99 1.03
124 INT156727 Gene_expression of Arg1 4 0.44 2.1 0.97
125 INT68265 Positive_regulation of Negative_regulation of Ptgs2 3 0.46 0.08 0.92
126 INT284686 Positive_regulation of Gene_expression of Tspo 1 0.66 2.55 0.9
127 INT132883 Gene_expression of Slc11a2 5 0.75 2.96 0.89
128 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
129 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
130 INT186168 Negative_regulation of Negative_regulation of Grin2b 2 0.35 0.54 0.85
131 INT6806 Localization of Tspo 3 0.70 0 0.82
132 INT21727 Positive_regulation of Gene_expression of Tfrc 3 0.19 1.68 0.82
133 INT103823 Positive_regulation of Gene_expression of SOD2 10 0.68 4.69 0.79
134 INT120057 Regulation of Localization of PTGS2 1 0.28 0.14 0.78
135 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
136 INT165578 Regulation of Positive_regulation of Grin2b 3 0.41 1.07 0.74
137 INT71950 Positive_regulation of Binding of PTGS2 2 0.31 0.31 0.74
138 INT197722 Regulation of TFRC 4 0.14 1.2 0.72
139 INT78957 Regulation of Transcription of Ptgs2 1 0.17 0.49 0.72
140 INT82544 Regulation of Positive_regulation of PTGS2 4 0.39 1.41 0.71
141 INT69003 Negative_regulation of Binding of TSPO 4 0.03 2.78 0.69
142 INT112173 Regulation of Transcription of SOD2 3 0.60 2.25 0.67
143 INT108857 Transcription of SOD2 5 0.70 3.51 0.66
144 INT92341 Localization of Ptgs2 5 0.75 2.04 0.64
145 INT191341 Negative_regulation of Gene_expression of TSPO 3 0.34 1.66 0.64
146 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
147 INT18446 Transcription of Insr 2 0.18 0.84 0.62
148 INT122116 Negative_regulation of Transcription of Grin2b 1 0.43 0.34 0.62
149 INT73850 Transcription of TSPO 6 0.59 0.83 0.61
150 INT204138 Regulation of Gene_expression of TSPO 2 0.36 0.99 0.6
151 INT120054 Regulation of Gene_expression of Tspo 2 0.44 0.97 0.59
152 INT108856 Regulation of Gene_expression of SOD2 3 0.44 0.79 0.58
153 INT271625 Protein_catabolism of Grin2b 1 0.38 0.26 0.57
154 INT178718 Phosphorylation of TSPO 1 0.79 0.91 0.56
155 INT178717 Negative_regulation of Localization of TSPO 1 0.41 0.92 0.56
156 INT73849 Negative_regulation of TSPO 8 0.59 2.4 0.53
157 INT156379 Regulation of Binding of Grin2a 1 0.36 0.17 0.52
158 INT156378 Regulation of Binding of Grin2b 1 0.28 0.17 0.52
159 INT228248 Gene_expression of Adam9 4 0.45 1.63 0.51
160 INT205265 Regulation of Transcription of TSPO 1 0.21 0.13 0.49
161 INT110165 Negative_regulation of Arg1 8 0.38 3.21 0.48
162 INT271628 Negative_regulation of Regulation of Grin2a 2 0.28 1.05 0.47
163 INT271632 Negative_regulation of Regulation of Grin2b 2 0.28 1.06 0.47
164 INT250065 Positive_regulation of Localization of Grin2b 1 0.45 0 0.47
165 INT250060 Positive_regulation of Localization of Grin2a 1 0.42 0 0.47
166 INT197674 Positive_regulation of Gene_expression of Arg1 2 0.33 0.63 0.44
167 INT61831 Regulation of Regulation of TSPO 1 0.03 0.16 0.43
168 INT94036 Negative_regulation of Transcription of Ptgs2 1 0.30 0.52 0.43
169 INT326766 Positive_regulation of Gene_expression of ARG1 12 0.67 8.32 0.42
170 INT271627 Regulation of Positive_regulation of Grin2a 1 0.30 0.23 0.4
171 INT296112 Positive_regulation of Positive_regulation of Arg1 1 0.05 0.55 0.4
172 INT136851 Regulation of Arg1 7 0.38 3.05 0.37
173 INT135139 Regulation of Positive_regulation of Tspo 1 0.05 0.17 0.37
174 INT271630 Negative_regulation of Localization of Grin2b 1 0.25 0 0.37
175 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
176 INT159542 Localization of SOD2 5 0.80 1.91 0.36
177 INT82545 Positive_regulation of Regulation of PTGS2 1 0.19 0.15 0.35
178 INT250062 Positive_regulation of Transcription of Grin2b 1 0.39 0.47 0.34
179 INT249529 Regulation of Phosphorylation of Grin2a 1 0.21 0.16 0.34
180 INT146646 Protein_catabolism of TSPO 3 0.86 0.58 0.32
181 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
182 INT27399 Protein_catabolism of Arg1 1 0.64 0 0.31
183 INT271629 Positive_regulation of Protein_catabolism of Grin2b 1 0.27 0.13 0.28
184 INT319179 Positive_regulation of Positive_regulation of SOD2 1 0.68 0.51 0.27
185 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
186 INT109333 Negative_regulation of Gene_expression of SOD2 2 0.42 0.71 0.24
187 INT212295 Regulation of Negative_regulation of Grin2a 1 0.39 0.28 0.24
188 INT108279 Positive_regulation of Binding of Grin2a 1 0.41 0 0.23
189 INT314003 Negative_regulation of Positive_regulation of Arg1 1 0.13 0.63 0.23
190 INT238311 Negative_regulation of Gene_expression of Tfrc 2 0.16 0.48 0.21
191 INT17849 Negative_regulation of Binding of PTGS2 2 0.38 0.16 0.2
192 INT258055 Positive_regulation of ARG1 7 0.49 3.45 0.19
193 INT148274 Negative_regulation of Regulation of PTGS2 1 0.01 0.47 0.19
194 INT118595 Binding of Tfrc 3 0.25 1.24 0.18
195 INT319182 Positive_regulation of Negative_regulation of SOD2 1 0.46 0.95 0.17
196 INT232580 Protein_catabolism of SOD2 2 0.97 1.22 0.16
197 INT326763 Negative_regulation of ARG1 1 0.57 1.49 0.16
198 INT280717 Positive_regulation of Regulation of Arg1 1 0.12 0 0.16
199 INT204148 Regulation of Gene_expression of Slc11a2 1 0.15 1.1 0.15
200 INT129433 Regulation of Binding of PTGS2 1 0.25 1.01 0.14
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