GO:0010044

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Name response to aluminum ion
Categary Process
Go Slim No
Go Link GO:0010044
Unique Molecular Interactions 105
Total Molecular Interactions 130
Total Single Events 1946
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to aluminum ion. They are ordered first by their pain relevance and then by number of times they were reported for response to aluminum ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
2 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
3 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
4 INT34837 Maob Regulation of Negative_regulation of Mme 1 0.48 0.15 0.92
5 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
6 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
7 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
8 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
9 INT340110 MAOB Positive_regulation of Ltp 1 0.02 0.59 0.49
10 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
11 INT309143 Dlat Positive_regulation of Bcl2 1 0.06 1.04 0.42
12 INT309152 Dlat Positive_regulation of Gene_expression of Bcl2 1 0.04 1.05 0.42
13 INT155062 Csf2 Positive_regulation of Transcription of Bcl2 1 0.31 2.91 0.36
14 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
15 INT155060 Stat3 Negative_regulation of Bcl2 1 0.21 3.7 0.33
16 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28
17 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
18 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26
19 INT272157 Gh1 Negative_regulation of Bcl2 1 0.23 1.2 0.26
20 INT272158 Gh1 Regulation of Bcl2 1 0.15 1.2 0.26
21 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
22 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23
23 INT180600 MAOB Positive_regulation of TAC1 1 0.00 0.13 0.22
24 INT316370 Ang Positive_regulation of Xdh 1 0.07 0.62 0.2
25 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
26 INT285026 Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
27 INT285022 Regulation of Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
28 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
29 INT155233 TXNIP Regulation of BCL2 1 0.23 0.15 0.17
30 INT285024 Bcl2 Regulation of Bak1 1 0.09 0.71 0.17
31 INT229203 Binding of Bcl2 and Cyp2c11 1 0.36 1.2 0.17
32 INT155068 Csf2 Negative_regulation of Bcl2 1 0.12 1.88 0.17
33 INT347445 CD99 Positive_regulation of BCL2 1 0.17 0.95 0.16
34 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15
35 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
36 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
37 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
38 INT309139 Edc4 Positive_regulation of Bcl2 1 0.03 0.12 0.13
39 INT148594 Binding of BCL2 and CD34 1 0.39 1.17 0.13
40 INT309142 Edc4 Regulation of Bcl2 1 0.02 0.12 0.13
41 INT246016 Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
42 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
43 INT348542 BCL2 Negative_regulation of NLRP1 1 0.07 2.02 0.13
44 INT246017 Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
45 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
46 INT305194 Bcl2 Positive_regulation of Epo 1 0.06 0.29 0.12
47 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 0.01 0.72 0.11
48 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1
49 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1
50 INT239643 Binding of BCL2 and BCL2L11 3 0.16 2.26 0.09
51 INT282094 Apoa2 Negative_regulation of BCL2 1 0.06 1.15 0.09
52 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
53 INT204300 Bcl2 Negative_regulation of Positive_regulation of Bak1 1 0.02 1.13 0.09
54 INT204299 Bcl2 Negative_regulation of Localization of Aifm1 1 0.06 1.22 0.07
55 INT302177 PTGER2 Positive_regulation of BCL2 1 0.04 2.08 0.06
56 INT352299 Regulation of Binding of BCL2 and VIM 1 0.10 1.07 0.06
57 INT352298 Binding of BCL2 and VIM 1 0.09 1.06 0.06
58 INT218734 Negative_regulation of Maob Positive_regulation of Positive_regulation of Ap3d1 1 0.00 0 0.05
59 INT341375 Sod2 Regulation of Bcl2 1 0.08 1.96 0.05
60 INT190824 Binding of Cl and Bcl2 1 0.02 1.4 0.05
61 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
62 INT192164 Binding of BAK1 and BCL2 3 0.04 2.8 0.03
63 INT192167 Negative_regulation of Binding of BAK1 and BCL2 2 0.05 1.89 0.03
64 INT217148 MIR21 Regulation of BCL2 1 0.32 0.98 0.03
65 INT101159 Gene_expression of Bcl2 Positive_regulation of Gene_expression of CHAT 1 0.31 0.96 0.03
66 INT229204 Olr1254 Negative_regulation of Gene_expression of Bcl2 1 0.02 0.18 0.03
67 INT178861 Binding of BAX and BCL2 3 0.27 3.07 0
68 INT292454 Binding of BAD and BCL2 2 0.03 1.73 0
69 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0
70 INT217150 MIR16-2 Regulation of BCL2 2 0.09 1.89 0
71 INT217137 MIR15B Regulation of BCL2 2 0.15 1.88 0
72 INT285031 Binding of Bcl2 and Bcl2l1 1 0.27 0.1 0
73 INT321406 VEGFA Regulation of BCL2 1 0.01 0.75 0
74 INT240867 Binding of Ros1 and Xdh 1 0.02 0.07 0
75 INT292503 Mlph Regulation of Gene_expression of BCL2 1 0.00 0.4 0
76 INT348531 Binding of BCL2 and BECN1 1 0.06 0.43 0
77 INT280566 Binding of ARAF and BCL2 1 0.02 0.69 0
78 INT100424 Bcl2 Regulation of Pcbd1 1 0.14 0.06 0
79 INT315060 PAR4 Regulation of BCL2 1 0.53 0.48 0
80 INT327972 Negative_regulation of BCL2 Positive_regulation of BAX 1 0.22 0.82 0
81 INT285028 Binding of Bcl2 and Bax 1 0.32 0.1 0
82 INT268516 Gene_expression of MIR16-2 Positive_regulation of Gene_expression of BCL2 1 0.00 1.15 0
83 INT335953 Binding of BCL2 and Bad 1 0.14 0.37 0
84 INT198021 Binding of BCL2 and MCL1 1 0.17 2.88 0
85 INT296670 Binding of Bcl2 and Vim 1 0.00 1.31 0
86 INT292458 Negative_regulation of Binding of BAD and BCL2 1 0.01 0.81 0
87 INT327977 TNFRSF11A Regulation of BCL2 1 0.05 0.67 0
88 INT337707 Naf1 Regulation of Gene_expression of Bcl2 1 0.11 0.57 0
89 INT286030 Creb1 Regulation of Transcription of Bcl2 1 0.07 0.34 0
90 INT189673 BCL2 Positive_regulation of Transcription of TERT 1 0.09 0 0
91 INT330056 Bcl2 Regulation of Localization of Cyct 1 0.27 0.97 0
92 INT262515 Positive_regulation of Kcnj6 Positive_regulation of Binding of Bcl2 1 0.00 0.48 0
93 INT201774 Binding of BCL2 and BCL2L1 1 0.00 0.37 0
94 INT292461 PTK2 Regulation of BCL2 1 0.02 0.76 0
95 INT217141 Binding of BCL2 and MIR15B 1 0.21 1.26 0
96 INT193965 Binding of BCL2 and Ps 1 0.05 0.59 0
97 INT296684 Binding of CD99 and Bcl2 1 0.01 1.68 0
98 INT104536 Binding of Bcl2 and MIB1 1 0.00 1.61 0
99 INT229816 Fos Regulation of Bcl2 1 0.13 0.31 0
100 INT327976 PNLIP Negative_regulation of Gene_expression of BCL2 1 0.29 0.53 0
101 INT217146 Binding of BCL2 and MIR16-2 1 0.12 1.25 0
102 INT327974 GOPC Regulation of Gene_expression of BCL2 1 0.13 0.6 0
103 INT201538 Binding of BCL2 and NPC1 1 0.17 1.41 0
104 INT260393 Hmox1 Regulation of Positive_regulation of Bcl2 1 0.22 0.86 0
105 INT185853 Binding of BCL2 and BIK 1 0.36 0.59 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to aluminum ion. They are ordered first by their pain relevance and then by number of times they were reported in response to aluminum ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
2 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
3 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
4 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
5 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66
6 INT1218 Negative_regulation of Maob 24 0.59 9.76 9.39
7 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
8 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
9 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
10 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
11 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
12 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67
13 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
14 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
15 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
16 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
17 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
18 INT35744 Binding of MAOB 13 0.46 7.52 4.26
19 INT22223 Positive_regulation of Xdh 18 0.67 5.87 3.84
20 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
21 INT9295 Regulation of MAOB 12 0.56 3.32 3.6
22 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
23 INT105884 Binding of Bcl2 19 0.35 15.67 3
24 INT22194 Gene_expression of Xdh 20 0.75 10.03 2.83
25 INT1219 Regulation of Maob 5 0.47 0.78 2.16
26 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03
27 INT53998 Positive_regulation of MAOB 8 0.61 1.22 2
28 INT101108 Localization of Bcl2 16 0.72 11.68 1.86
29 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86
30 INT72535 Binding of Maob 3 0.42 1.98 1.73
31 INT19626 Regulation of Xdh 4 0.22 2.69 1.7
32 INT101958 Positive_regulation of Transcription of Bcl2 4 0.50 2.22 1.65
33 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
34 INT18521 Localization of MAOB 6 0.71 1.46 1.56
35 INT101107 Positive_regulation of Localization of Bcl2 3 0.48 3.13 1.28
36 INT70021 Localization of BCL2 23 0.74 21.6 1.09
37 INT242372 Positive_regulation of Negative_regulation of MAOB 2 0.35 1.85 1.05
38 INT22224 Positive_regulation of Positive_regulation of Xdh 3 0.42 0.87 0.92
39 INT84964 Gene_expression of MAOB 14 0.61 2.8 0.89
40 INT151115 Regulation of Regulation of Bcl2 4 0.21 4.12 0.88
41 INT92117 Phosphorylation of BCL2 26 0.80 9.93 0.86
42 INT70019 Binding of BCL2 25 0.47 17.55 0.79
43 INT109404 Transcription of BCL2 6 0.69 4.49 0.77
44 INT124844 Regulation of Positive_regulation of Bcl2 3 0.43 2.55 0.75
45 INT155392 Negative_regulation of Negative_regulation of Bcl2 3 0.21 1.64 0.74
46 INT134444 Positive_regulation of Binding of Bcl2 3 0.47 2.67 0.72
47 INT104632 Negative_regulation of Positive_regulation of Xdh 2 0.14 0.9 0.61
48 INT219026 Positive_regulation of Localization of MAOB 1 0.01 0.39 0.61
49 INT151668 Positive_regulation of Maob 1 0.61 3.26 0.6
50 INT70025 Positive_regulation of Positive_regulation of BCL2 3 0.27 0.96 0.58
51 INT178128 Negative_regulation of Phosphorylation of BCL2 7 0.27 3.94 0.56
52 INT155090 Regulation of Positive_regulation of BCL2 3 0.26 1.78 0.54
53 INT120699 Negative_regulation of Negative_regulation of MAOB 1 0.43 0.26 0.54
54 INT144696 Regulation of Transcription of Bcl2 5 0.44 2.96 0.51
55 INT227331 Binding of Xdh 5 0.29 1.83 0.49
56 INT134445 Positive_regulation of Positive_regulation of Bcl2 3 0.47 2.43 0.49
57 INT140295 Protein_catabolism of BCL2 4 0.64 5.7 0.44
58 INT53997 Transcription of MAOB 3 0.61 1.51 0.44
59 INT111388 Negative_regulation of Gene_expression of Xdh 1 0.13 0.51 0.38
60 INT155724 Negative_regulation of Transcription of Bcl2 6 0.53 2.35 0.37
61 INT347843 Protein_catabolism of MAOB 2 0.09 0.39 0.33
62 INT350393 Negative_regulation of Protein_catabolism of MAOB 1 0.04 0.4 0.33
63 INT58744 Regulation of Negative_regulation of MAOB 1 0.43 0.26 0.29
64 INT178114 Positive_regulation of Phosphorylation of BCL2 11 0.49 4.44 0.28
65 INT292743 Negative_regulation of Binding of Bcl2 1 0.05 1.97 0.24
66 INT285003 Positive_regulation of Regulation of Bcl2 1 0.46 0.68 0.23
67 INT180601 Regulation of Binding of MAOB 1 0.03 0.12 0.18
68 INT151667 Negative_regulation of Binding of Maob 1 0.38 0.88 0.17
69 INT238507 Regulation of Regulation of BCL2 3 0.44 5.14 0.16
70 INT101109 Negative_regulation of Localization of Bcl2 1 0.03 0.62 0.16
71 INT113024 Regulation of Gene_expression of Xdh 1 0.03 0.1 0.16
72 INT255793 Positive_regulation of Gene_expression of Xdh 1 0.12 0.27 0.16
73 INT229235 Regulation of Localization of BCL2 2 0.29 3.7 0.15
74 INT324856 Localization of Xdh 1 0.04 0.61 0.15
75 INT102109 Protein_catabolism of Bcl2 1 0.65 0.55 0.15
76 INT121075 Positive_regulation of Negative_regulation of Xdh 1 0.11 0 0.07
77 INT273064 Positive_regulation of Positive_regulation of MAOB 1 0.46 0.12 0.05
78 INT302229 Negative_regulation of Negative_regulation of BCL2 3 0.21 2.69 0.04
79 INT269499 Regulation of Negative_regulation of Xdh 1 0.32 0.38 0.04
80 INT258045 Positive_regulation of Regulation of BCL2 2 0.36 1.78 0.03
81 INT310419 Negative_regulation of Localization of BCL2 3 0.41 2.51 0
82 INT185909 Regulation of Phosphorylation of BCL2 3 0.24 1.63 0
83 INT155391 Positive_regulation of Negative_regulation of Bcl2 2 0.22 0.92 0
84 INT185887 Regulation of Binding of BCL2 2 0.24 2.22 0
85 INT183619 Negative_regulation of Regulation of BCL2 2 0.33 1.01 0
86 INT153083 Positive_regulation of Negative_regulation of BCL2 2 0.32 2.9 0
87 INT330962 Negative_regulation of Transcription of BCL2 1 0.10 1.21 0
88 INT208960 Positive_regulation of Gene_expression of MAOB 1 0.04 0.15 0
89 INT356124 Positive_regulation of Transcription of BCL2 1 0.45 0.3 0
90 INT184508 Positive_regulation of Localization of BCL2 1 0.07 0.87 0
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