GO:0010310

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Name regulation of hydrogen peroxide metabolic process
Categary Process
Go Slim No
Go Link GO:0010310
Unique Molecular Interactions 99
Total Molecular Interactions 126
Total Single Events 1190
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of hydrogen peroxide metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for regulation of hydrogen peroxide metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
8 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
9 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
10 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
11 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
12 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
13 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
14 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
15 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
16 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
17 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
18 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
19 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
20 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
21 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
22 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
23 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
24 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
25 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
26 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
27 INT295722 PTGER2 Positive_regulation of RAC1 1 0.02 2.14 0.32
28 INT295725 PTGER2 Positive_regulation of RAC2 1 0.05 1.92 0.32
29 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
30 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
31 INT292561 MAP3K5 Positive_regulation of Positive_regulation of RAC1 1 0.03 0 0.23
32 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
33 INT353285 Prdx2 Regulation of Gene_expression of Col1a2 1 0.02 0.73 0.21
34 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
35 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
36 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
37 INT206054 RAC1 Positive_regulation of STAT3 1 0.07 0.11 0.09
38 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
39 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
40 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
41 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
42 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
43 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
44 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
45 INT339979 Binding of PRDX2 and HDAC9 1 0.02 0.16 0.05
46 INT206087 RAC1 Positive_regulation of Gene_expression of STAT3 1 0.08 0.05 0.05
47 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
48 INT143993 Prdx2 Positive_regulation of Atp13a4 1 0.00 0 0.05
49 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
50 INT206073 Negative_regulation of RAC1 Positive_regulation of IL6 1 0.14 0.06 0.04
51 INT206067 Gene_expression of RAC1 Positive_regulation of Positive_regulation of IL6 1 0.16 0.07 0.04
52 INT206068 RAC1 Positive_regulation of IL6 1 0.16 0.06 0.04
53 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04
54 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
55 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
56 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
57 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03
58 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03
59 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
60 INT206061 RAC1 Positive_regulation of Positive_regulation of STAT3 1 0.07 0.43 0.03
61 INT194707 RAC1 Positive_regulation of PAK1 1 0.01 0 0.03
62 INT194738 Binding of PAK1 and RAC1 1 0.01 0 0.03
63 INT254511 RAC1 Positive_regulation of Positive_regulation of CYBB 1 0.14 0.39 0.03
64 INT353283 Prdx2 Positive_regulation of Phosphorylation of Tgif1 1 0.10 0.06 0.03
65 INT353292 Prdx2 Positive_regulation of Tgif1 1 0.10 0.06 0.03
66 INT144761 Binding of INSR and Insr 1 0.05 0 0
67 INT225898 Positive_regulation of RAC1 Positive_regulation of PAK1 1 0.01 0.08 0
68 INT295710 PTGER2 Regulation of Positive_regulation of RAC1 1 0.01 1.62 0
69 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0
70 INT295701 Positive_regulation of Binding of RAC1 and Racgap1 1 0.28 0.16 0
71 INT235623 Binding of INS and INSR 1 0.14 0.47 0
72 INT306257 Binding of MAPK8 and RAC2 1 0.24 0 0
73 INT287892 PRDX2 Positive_regulation of HNF4A 1 0.00 0.52 0
74 INT235011 Ctnnd1 Positive_regulation of RAC1 1 0.00 0.07 0
75 INT144754 Negative_regulation of Binding of Insr and Slc2a2 1 0.01 0 0
76 INT277315 Binding of Insr and Mbnl1 1 0.18 1.1 0
77 INT306269 Binding of MAPK8 and RAC1 1 0.25 0 0
78 INT101591 Binding of RAC1 and RAC3 1 0.13 0.52 0
79 INT225908 Binding of RAC1 and IQGAP1 1 0.00 0.09 0
80 INT225890 Binding of RAC1 and STAT3 1 0.01 0 0
81 INT235624 INS Regulation of Phosphorylation of INSR 1 0.08 0.26 0
82 INT271281 Gene_expression of Stat1 Positive_regulation of Insr 1 0.19 0.51 0
83 INT295700 Binding of RAC1 and Racgap1 1 0.21 0.16 0
84 INT271287 Gene_expression of IFNA1 Positive_regulation of Insr 1 0.03 0.51 0
85 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0
86 INT144760 Binding of ABCA1 and Insr 1 0.00 0 0
87 INT206077 RAC1 Positive_regulation of Phosphorylation of STAT3 1 0.07 0.35 0
88 INT194695 RAC1 Positive_regulation of PAK4 1 0.00 0 0
89 INT348534 ELMO1 Positive_regulation of RAC1 1 0.02 0.7 0
90 INT218307 Grb10 Positive_regulation of Protein_catabolism of INSR 1 0.03 0 0
91 INT225891 DOCK1 Positive_regulation of RAC1 1 0.01 0 0
92 INT144753 Binding of Insr and Slc2a2 1 0.01 0 0
93 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0
94 INT144762 Negative_regulation of Binding of INSR and Insr 1 0.06 0 0
95 INT212083 Binding of SSRP1 and NOXO1 1 0.02 0.67 0
96 INT311386 Celf1 Regulation of Insr 1 0.00 0.24 0
97 INT225899 Binding of DOCK1 and RAC1 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of hydrogen peroxide metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in regulation of hydrogen peroxide metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
2 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
3 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
4 INT8691 Localization of Insr 85 0.80 9.27 30.32
5 INT5300 Regulation of Insr 54 0.60 11.33 29.26
6 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
7 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
8 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
9 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
10 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
11 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
12 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
13 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54
14 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
15 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
16 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
17 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
18 INT51084 Binding of Insr 13 0.30 4.25 4.23
19 INT83035 Binding of INSR 16 0.47 9.29 4.11
20 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75
21 INT10116 Localization of INSR 11 0.57 5.43 3.48
22 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
23 INT121967 Regulation of RAC1 9 0.45 6.14 3.41
24 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
25 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
26 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
27 INT70987 Binding of RAC1 14 0.37 12.14 2.13
28 INT108250 Regulation of Prdx2 5 0.25 2.02 2.08
29 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
30 INT114059 Localization of Insr 10 0.46 3.49 1.87
31 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
32 INT232645 Transcription of INSR 2 0.09 1.19 1.71
33 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
34 INT19342 Regulation of Insr 12 0.24 6.11 1.54
35 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4
36 INT108249 Negative_regulation of Prdx2 3 0.32 1.85 1.36
37 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
38 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
39 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
40 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
41 INT108243 Positive_regulation of Prdx2 3 0.34 0.85 0.95
42 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
43 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
44 INT175904 Localization of RAC1 7 0.41 5.05 0.86
45 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
46 INT111943 Negative_regulation of Positive_regulation of RAC1 2 0.46 1.33 0.86
47 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
48 INT111945 Protein_catabolism of RAC1 1 0.31 0.67 0.79
49 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
50 INT117392 Binding of Insr 8 0.23 4.88 0.68
51 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
52 INT193672 Gene_expression of Prdx2 3 0.50 2.75 0.64
53 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
54 INT18446 Transcription of Insr 2 0.18 0.84 0.62
55 INT147734 Phosphorylation of RAC1 3 0.64 1.33 0.58
56 INT127736 Regulation of Gene_expression of RAC1 2 0.27 2 0.53
57 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
58 INT164267 Negative_regulation of Phosphorylation of RAC1 1 0.33 0.96 0.46
59 INT164266 Positive_regulation of Phosphorylation of RAC1 1 0.39 0.95 0.45
60 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
61 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
62 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
63 INT295683 Positive_regulation of RAC2 1 0.49 1.72 0.3
64 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
65 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
66 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
67 INT143991 Gene_expression of Prdx2 5 0.61 1.54 0.22
68 INT212089 Gene_expression of NOXO1 4 0.10 2.05 0.21
69 INT161959 Gene_expression of PRDX2 2 0.65 1.38 0.2
70 INT353278 Binding of Prdx2 1 0.21 0.05 0.18
71 INT353270 Regulation of Binding of Prdx2 1 0.25 0.05 0.18
72 INT353274 Transcription of Prdx2 1 0.39 0.51 0.16
73 INT353264 Negative_regulation of Negative_regulation of Prdx2 1 0.24 0.45 0.15
74 INT119145 Binding of RAC2 2 0.13 0.47 0.14
75 INT282160 Regulation of Binding of RAC1 1 0.18 0.45 0.13
76 INT92634 Negative_regulation of Binding of Insr 1 0.25 0.08 0.12
77 INT308981 Positive_regulation of Negative_regulation of Insr 1 0.27 0.95 0.11
78 INT323945 Positive_regulation of Binding of Insr 1 0.08 0.94 0.11
79 INT193676 Positive_regulation of Gene_expression of Prdx2 2 0.06 1.31 0.09
80 INT176593 Positive_regulation of Gene_expression of RAC1 2 0.17 0.97 0.08
81 INT159858 Negative_regulation of Negative_regulation of RAC1 1 0.40 0.17 0.07
82 INT184013 Protein_catabolism of Insr 1 0.05 0.4 0.04
83 INT254550 Negative_regulation of Gene_expression of RAC1 1 0.13 0.63 0.04
84 INT340756 Positive_regulation of PRDX2 1 0.02 1.23 0.04
85 INT254537 Negative_regulation of Binding of RAC1 1 0.13 0.64 0.04
86 INT117362 Positive_regulation of Positive_regulation of INSR 1 0.22 0.1 0.03
87 INT143990 Regulation of Prdx2 1 0.22 0 0.03
88 INT206165 Positive_regulation of Localization of RAC1 1 0.16 0.07 0.03
89 INT235634 Phosphorylation of INSR 24 0.70 3.64 0
90 INT206742 Negative_regulation of PRDX2 5 0.04 5.04 0
91 INT215912 Gene_expression of RAC2 2 0.50 0 0
92 INT215947 Positive_regulation of Gene_expression of INSR 2 0.14 0.25 0
93 INT212098 Positive_regulation of NOXO1 1 0.06 0.88 0
94 INT212099 Negative_regulation of Gene_expression of NOXO1 1 0.05 0.76 0
95 INT257362 Negative_regulation of Localization of RAC1 1 0.24 0.58 0
96 INT144758 Negative_regulation of Negative_regulation of INSR 1 0.41 0 0
97 INT235628 Negative_regulation of Phosphorylation of INSR 1 0.16 0.25 0
98 INT230481 Positive_regulation of Regulation of Insr 1 0.01 0.24 0
99 INT212087 Negative_regulation of NOXO1 1 0.05 0.47 0
100 INT144756 Positive_regulation of Negative_regulation of INSR 1 0.49 0 0
101 INT144757 Negative_regulation of Gene_expression of INSR 1 0.41 0 0
102 INT339996 Positive_regulation of Negative_regulation of PRDX2 1 0.05 1.27 0
103 INT295687 Positive_regulation of Binding of RAC1 1 0.25 0 0
104 INT295678 Regulation of Positive_regulation of RAC1 1 0.23 1.55 0
105 INT212097 Regulation of Gene_expression of NOXO1 1 0.06 0.71 0
106 INT256230 Positive_regulation of Gene_expression of NOXO1 1 0.09 0.75 0
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