GO:0010459

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Name negative regulation of heart rate
Categary Process
Go Slim No
Go Link GO:0010459
Unique Molecular Interactions 211
Total Molecular Interactions 282
Total Single Events 2435
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of heart rate. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of heart rate. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
2 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
3 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
4 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
5 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
6 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
7 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
8 INT169441 TAC1 Positive_regulation of Tac1 1 0.01 1.7 1.64
9 INT147258 Binding of Tac1 and Penk 1 0.35 0 1.64
10 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
11 INT73016 PDYN Regulation of TAC1 1 0.29 0.34 1.54
12 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
13 INT71543 IFNA1 Negative_regulation of Positive_regulation of TAC1 1 0.20 0.19 1.4
14 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4
15 INT51160 Binding of TAC1 and Tacr1 2 0.28 0.55 1.38
16 INT15277 Binding of Tac1 and Gal 1 0.39 0.19 1.35
17 INT185330 Binding of Hrh1 and Tac1 1 0.00 0.1 1.34
18 INT91305 Binding of Npff and Npffr2 2 0.31 0.64 1.32
19 INT49231 TAC1 Negative_regulation of Penk 1 0.00 0 1.3
20 INT138213 Mzb1 Regulation of Localization of Tac1 1 0.01 0.41 1.29
21 INT138214 Mzb1 Regulation of Tac1 1 0.01 0.41 1.28
22 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26
23 INT48809 Pax3 Negative_regulation of Binding of Tac1 1 0.22 0 1.16
24 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
25 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
26 INT314136 Binding of TAC1 and SFTPA1 2 0.03 0.78 1.06
27 INT8416 LIF Regulation of TAC1 1 0.13 0.36 1.04
28 INT84959 Negative_regulation of Tacr1 Negative_regulation of Positive_regulation of Tac1 1 0.48 0.59 1.02
29 INT83903 Penk Positive_regulation of Npff 1 0.49 0 1.02
30 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
31 INT107951 Pax3 Positive_regulation of Tac1 1 0.11 1.21 0.95
32 INT314142 Binding of TAC1 and Tacr3 1 0.06 0.73 0.94
33 INT24938 TAC1 Regulation of Calca 1 0.22 0.35 0.94
34 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
35 INT24940 TAC1 Regulation of Nka1 1 0.10 0.34 0.87
36 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
37 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84
38 INT41860 Agtr2 Regulation of Vip 1 0.02 0 0.84
39 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
40 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8
41 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
42 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
43 INT142454 Npff Positive_regulation of Gtpbp4 1 0.56 0 0.78
44 INT213978 Binding of TAC1 and Tac1 1 0.02 0.36 0.78
45 INT142455 Binding of Npff and Gtpbp4 1 0.40 0 0.78
46 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
47 INT73822 TAC1 Positive_regulation of Localization of IL1B 1 0.04 0.56 0.71
48 INT79937 TAC1 Positive_regulation of Gene_expression of VCAM1 1 0.20 0.15 0.68
49 INT109718 Tac1 Negative_regulation of Mpo 1 0.25 0.81 0.67
50 INT147257 Tac1 Regulation of Penk 1 0.19 0 0.67
51 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
52 INT63655 Binding of NPY and TAC1 1 0.39 0.17 0.64
53 INT9824 Binding of Agtr2 and Bcl2a1a 1 0.16 0.24 0.64
54 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
55 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
56 INT133707 Npff Positive_regulation of Npffr1 1 0.73 0.73 0.61
57 INT167859 Tac1 Regulation of Gene_expression of Tacr1 1 0.09 0 0.6
58 INT91306 Binding of Npff and Npffr1 1 0.23 0.17 0.6
59 INT121288 Binding of TAC1 and Cd79a 1 0.12 0.32 0.58
60 INT76248 Tac1 Positive_regulation of Gene_expression of Fos 1 0.34 0.34 0.56
61 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56
62 INT14387 GAL Regulation of TAC1 1 0.10 0 0.56
63 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
64 INT49225 Mdk Regulation of Tac1 1 0.00 0 0.53
65 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
66 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
67 INT8438 Cntf Regulation of TAC1 1 0.20 0.18 0.52
68 INT90067 Binding of Oprd1 and Npff 1 0.20 0.09 0.52
69 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
70 INT126341 Tac1 Regulation of Gene_expression of Tnfrsf10b 1 0.06 0.71 0.52
71 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
72 INT14410 Tac1 Negative_regulation of Calca 1 0.26 0.33 0.52
73 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
74 INT126336 Negative_regulation of Binding of Pax3 and Tac1 1 0.01 0.66 0.49
75 INT97487 ADCYAP1 Positive_regulation of Tac1 1 0.02 0 0.48
76 INT88696 Tac1 Regulation of Regulation of Mme 1 0.00 0.39 0.48
77 INT61848 Npff Regulation of Localization of Avp 1 0.26 0.3 0.48
78 INT66438 Tac2 Regulation of Binding of TAC1 1 0.01 0.12 0.47
79 INT67733 Binding of Tac1 and SLAMF6 1 0.00 0.17 0.45
80 INT101981 D2Ertd127e Positive_regulation of TAC1 1 0.00 0 0.44
81 INT51025 Klra3 Positive_regulation of Gene_expression of Tac1 1 0.11 0 0.42
82 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
83 INT133708 Npff Negative_regulation of Phosphorylation of Ppp1r1b 1 0.30 0.41 0.4
84 INT41612 Tac1 Regulation of Localization of Sst 1 0.02 0 0.39
85 INT166157 Ccr9 Positive_regulation of Pik3r1 1 0.55 2.14 0.39
86 INT63707 TACR1 Negative_regulation of TAC1 1 0.03 0.12 0.37
87 INT337114 Tg(CAG-EGFP)D4Nagy Positive_regulation of Gene_expression of TAC1 1 0.04 0.07 0.36
88 INT46147 Dpa Negative_regulation of TAC1 1 0.01 0.09 0.34
89 INT90543 Npff Negative_regulation of Regulation of Pnoc 1 0.26 0 0.34
90 INT46145 HLA-DQA1 Negative_regulation of TAC1 1 0.04 0.09 0.34
91 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
92 INT101968 TAC1 Regulation of PENK 1 0.00 0 0.33
93 INT353128 Negative_regulation of Binding of TAC1 and B3GAT1 1 0.29 1.95 0.33
94 INT168779 Binding of Pik3r1 and Tnf 1 0.01 0.73 0.33
95 INT101978 Regulation of Tac1 Regulation of PENK 1 0.01 0 0.33
96 INT101979 TAC1 Regulation of Tac1 1 0.01 0 0.33
97 INT101980 Tac1 Regulation of PENK 1 0.01 0 0.33
98 INT222441 Tlr4 Positive_regulation of Gene_expression of Tac1 1 0.00 0.39 0.32
99 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
100 INT230752 Gene_expression of Agtr2 Positive_regulation of Gene_expression of Mcpt1 1 0.01 1.34 0.3
101 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
102 INT118545 Binding of Agtr2 and Msr1 1 0.00 0.09 0.29
103 INT185141 Pik3r1 Positive_regulation of Snrpd1 1 0.00 0.16 0.29
104 INT106893 Ptpn2 Positive_regulation of Tac1 1 0.02 2.02 0.29
105 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
106 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27
107 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
108 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26
109 INT14412 Positive_regulation of Tac1 Negative_regulation of Calca 1 0.28 0.16 0.26
110 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
111 INT208936 Tac1 Positive_regulation of Tacr1 1 0.13 0.39 0.25
112 INT297258 Binding of Agt and Agtr2 1 0.23 0.7 0.25
113 INT278582 Atp6v1e1 Positive_regulation of Positive_regulation of Tac1 1 0.15 0.13 0.24
114 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23
115 INT66437 Tac2 Regulation of TAC1 1 0.01 0.06 0.23
116 INT230751 Agtr2 Positive_regulation of Gene_expression of Serpine1 1 0.03 1.3 0.23
117 INT155158 Agtr2 Regulation of Rtn4 1 0.00 0.1 0.22
118 INT180600 MAOB Positive_regulation of TAC1 1 0.00 0.13 0.22
119 INT48509 GRP Positive_regulation of Localization of Tac1 1 0.00 0 0.22
120 INT297257 Agtr1a Positive_regulation of Agtr2 1 0.27 0.59 0.22
121 INT281351 Tenc1 Regulation of Agtr2 1 0.06 0.8 0.21
122 INT55827 Bdnf Negative_regulation of Negative_regulation of Tac1 1 0.45 0 0.21
123 INT304882 Agtr2 Positive_regulation of Mapk1 1 0.07 0.95 0.2
124 INT148995 Uts2 Positive_regulation of CDNF 1 0.00 0.41 0.2
125 INT139358 Tac1 Regulation of Avp 1 0.41 0.08 0.19
126 INT339329 Binding of TAC1 and TAC4 1 0.40 0.08 0.18
127 INT126074 Binding of Npff and Npvf 1 0.35 0 0.18
128 INT314038 THL Negative_regulation of Pik3r1 1 0.14 0.78 0.18
129 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
130 INT320883 Agtr2 Positive_regulation of Localization of VEGFA 1 0.08 2.8 0.17
131 INT138305 Binding of PNN and Agtr2 1 0.01 0.73 0.15
132 INT350081 Pik3r1 Positive_regulation of Hmox1 1 0.07 0.2 0.15
133 INT330486 MSR1 Negative_regulation of TAC1 1 0.01 0.23 0.13
134 INT256020 Ace Negative_regulation of Gene_expression of Agtr2 1 0.03 0.37 0.13
135 INT339348 Binding of TAC1 and Nka1 1 0.03 0.07 0.13
136 INT304188 Agtr2 Negative_regulation of Gene_expression of VEGFA 1 0.06 0.6 0.12
137 INT129094 Binding of GRP and Pik3r1 1 0.00 0.49 0.12
138 INT129075 Binding of Pik3r1 and Lyn 1 0.00 0.47 0.12
139 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
140 INT166153 Pik3r1 Regulation of Gene_expression of Ccr9 1 0.36 0.78 0.12
141 INT119158 Binding of NOS1 and Agtr2 1 0.01 0 0.11
142 INT119157 Agt Positive_regulation of Positive_regulation of Agtr2 1 0.06 0 0.11
143 INT317888 Binding of Eef1a1 and Pik3r1 1 0.01 1.04 0.11
144 INT317887 Binding of Mtf1 and Pik3r1 1 0.25 1.04 0.11
145 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
146 INT106894 Ptpn2 Negative_regulation of Tac1 1 0.02 1.17 0.1
147 INT102587 Npff Positive_regulation of Gene_expression of Nts 1 0.37 0.07 0.1
148 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1
149 INT347647 Inpp5d Negative_regulation of Pik3r1 1 0.31 0.37 0.1
150 INT65411 Tac1 Positive_regulation of Binding of Sst 1 0.13 0.38 0.1
151 INT304887 Agtr2 Positive_regulation of Positive_regulation of Mapk1 1 0.10 0.45 0.09
152 INT304886 Agtr2 Positive_regulation of Ros1 1 0.03 0.45 0.09
153 INT213051 Hdl1 Positive_regulation of Pik3r1 1 0.13 1.93 0.09
154 INT304883 Agtr2 Positive_regulation of Agtrap 1 0.10 0.46 0.09
155 INT233907 Positive_regulation of Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
156 INT325489 Agtr2 Positive_regulation of Ephx2 1 0.04 0.51 0.08
157 INT233906 Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
158 INT207310 Pik3r1 Positive_regulation of Prnp 1 0.36 0.65 0.08
159 INT331796 Akt1 Negative_regulation of Negative_regulation of Pik3r1 1 0.04 0.88 0.08
160 INT320880 Chi3l1 Positive_regulation of Agtr2 1 0.01 1.22 0.08
161 INT340553 Pik3r1 Regulation of Gene_expression of Fbxo32 1 0.04 0.52 0.07
162 INT340320 Binding of Shc1 and Positive_regulation of Pik3r1 1 0.23 0 0.07
163 INT120569 Binding of Egfr and Pik3r1 1 0.40 1.22 0.06
164 INT200634 Binding of Agtr2 and Ace2 1 0.00 0.91 0.06
165 INT120570 Positive_regulation of Binding of Egfr and Pik3r1 1 0.55 1.22 0.06
166 INT200638 Binding of ACE and Agtr2 1 0.10 0.93 0.06
167 INT65412 Tac1 Positive_regulation of Sst 1 0.13 0.19 0.05
168 INT289769 Positive_regulation of Agtr2 Negative_regulation of Gene_expression of Col7a1 1 0.00 0.1 0.05
169 INT213016 Regulation of Hdl1 Positive_regulation of Pik3r1 1 0.09 0.97 0.05
170 INT65413 Tac1 Positive_regulation of Uchl1 1 0.02 0.19 0.05
171 INT199106 Negative_regulation of Pik3r1 Negative_regulation of Gene_expression of Ros1 1 0.03 0.08 0.04
172 INT133987 Pou2f1 Regulation of Gene_expression of Npff 1 0.20 0 0.04
173 INT133997 Meis1 Regulation of Gene_expression of Npff 1 0.16 0 0.04
174 INT133994 Pou1f1 Regulation of Gene_expression of Npff 1 0.15 0 0.04
175 INT213031 Positive_regulation of Pik3r1 Positive_regulation of Gene_expression of Nos3 1 0.10 0.8 0.04
176 INT320882 Agtr2 Positive_regulation of Gene_expression of VEGFA 1 0.08 0.9 0.04
177 INT134000 Pdx1 Regulation of Gene_expression of Npff 1 0.46 0 0.04
178 INT133980 Kcnip3 Regulation of Gene_expression of Npff 1 0.23 0 0.04
179 INT234991 Binding of Dsg3 and Positive_regulation of Pik3r1 1 0.05 0.32 0.03
180 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
181 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
182 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
183 INT302908 Agtr2 Positive_regulation of Gene_expression of Agt 1 0.00 0.22 0.03
184 INT306646 Mapk1 Regulation of Pik3r1 1 0.03 0.39 0
185 INT241030 Agtr2 Positive_regulation of Phosphorylation of Mapk1 1 0.06 0.19 0
186 INT287676 Negative_regulation of Sphk1 Negative_regulation of Pik3r1 1 0.14 0.42 0
187 INT176551 Binding of Pik3r1 and Spp1 1 0.03 0.65 0
188 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0
189 INT344401 Agtr2 Positive_regulation of Gene_expression of Spp1 1 0.01 3.21 0
190 INT253565 Akt1 Positive_regulation of Positive_regulation of Pik3r1 1 0.10 0 0
191 INT320877 Agtr2 Positive_regulation of Pla2g2a 1 0.10 0.67 0
192 INT211572 Binding of Kit and Pik3r1 1 0.21 0.06 0
193 INT149883 Agtr2 Positive_regulation of Gene_expression of Ptgs2 1 0.06 0.31 0
194 INT176553 Pik3r1 Positive_regulation of Positive_regulation of Mapk14 1 0.02 0.41 0
195 INT176542 Pik3r1 Positive_regulation of Positive_regulation of Mapk1 1 0.01 0.41 0
196 INT176536 Binding of Pik3r1 and Mtv7 1 0.02 0.46 0
197 INT320878 Positive_regulation of Agtr2 Positive_regulation of Pla2g2a 1 0.10 0.67 0
198 INT211574 Regulation of Binding of Kit and Pik3r1 1 0.16 0.06 0
199 INT278575 Atp6v1e1 Negative_regulation of Gene_expression of Tac1 1 0.14 0 0
200 INT306618 Myoz1 Regulation of Pik3r1 1 0.00 0.39 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of heart rate. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of heart rate. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66
2 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26
3 INT8690 Localization of Tac1 71 0.80 22.98 50.75
4 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67
5 INT8713 Regulation of Tac1 56 0.60 25.29 45.94
6 INT4776 Localization of TAC1 82 0.78 16.89 45.21
7 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06
8 INT4850 Binding of Tac1 57 0.47 14.25 42.17
9 INT4843 Gene_expression of Npff 50 0.78 12.92 36.37
10 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97
11 INT4727 Regulation of TAC1 60 0.47 6.74 32.83
12 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41
13 INT11773 Gene_expression of Tac1 56 0.77 10 25.72
14 INT8779 Binding of TAC1 50 0.47 11.19 25.57
15 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
16 INT4841 Localization of Npff 26 0.80 4.36 19.91
17 INT12360 Regulation of Tac1 31 0.61 5.9 18
18 INT16155 Positive_regulation of Npff 25 0.70 6.21 17.58
19 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
20 INT11980 Positive_regulation of Tac1 27 0.69 6.17 14.5
21 INT46582 Binding of Npff 20 0.48 1.49 13.99
22 INT4842 Regulation of Npff 13 0.54 4.59 13.62
23 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
24 INT4723 Transcription of Tac1 26 0.71 8.33 11.18
25 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
26 INT48806 Negative_regulation of Binding of Tac1 11 0.56 0.83 10.52
27 INT12358 Regulation of Gene_expression of Tac1 17 0.60 3.34 8.84
28 INT23331 Positive_regulation of Localization of Tac1 10 0.54 4.63 8.76
29 INT4984 Positive_regulation of Positive_regulation of Tac1 11 0.50 5.34 8.73
30 INT81597 Transcription of Npff 10 0.69 5.52 8.53
31 INT22700 Positive_regulation of Gene_expression of Tac1 13 0.69 6.89 8.2
32 INT51206 Regulation of Gene_expression of Tac1 13 0.45 5.92 7.74
33 INT14548 Localization of Tac1 13 0.78 1.43 7.48
34 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
35 INT12359 Negative_regulation of Tac1 26 0.58 8.16 6.89
36 INT11975 Transcription of Tac1 24 0.71 4.06 6.72
37 INT4840 Positive_regulation of Localization of Npff 7 0.69 0.79 6.69
38 INT15674 Positive_regulation of Gene_expression of Tac1 17 0.68 4.97 6.56
39 INT81596 Positive_regulation of Gene_expression of Npff 6 0.69 3.41 6.1
40 INT129645 Negative_regulation of Gene_expression of TAC1 5 0.42 3.33 5.55
41 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
42 INT53959 Negative_regulation of Npff 6 0.57 0.55 4.86
43 INT14771 Regulation of Localization of Tac1 4 0.48 1.77 4.83
44 INT53442 Gene_expression of Npff 12 0.76 0.57 4.75
45 INT8838 Positive_regulation of Localization of TAC1 7 0.49 0.86 4.7
46 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69
47 INT41816 Negative_regulation of Localization of Tac1 5 0.35 1.2 4.66
48 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
49 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56
50 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41
51 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
52 INT68099 Positive_regulation of Agtr2 21 0.48 16.63 4.07
53 INT9822 Binding of Agtr2 9 0.36 3 3.93
54 INT17819 Regulation of Agtr2 10 0.51 9.33 3.9
55 INT117561 Positive_regulation of Transcription of Tac1 6 0.69 3.19 3.78
56 INT53142 Negative_regulation of Gene_expression of Tac1 7 0.56 1.59 3.61
57 INT39986 Regulation of Agtr2 13 0.45 10.39 3.55
58 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
59 INT15276 Binding of Tac1 6 0.36 0.56 3.16
60 INT10869 Regulation of Npff 3 0.45 0.37 3.15
61 INT73017 Regulation of Gene_expression of TAC1 5 0.54 0.44 3.08
62 INT74674 Transcription of TAC1 7 0.67 1 3.01
63 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94
64 INT51307 Negative_regulation of Positive_regulation of TAC1 4 0.42 2 2.82
65 INT73837 Positive_regulation of Gene_expression of TAC1 6 0.67 3.49 2.68
66 INT118374 Negative_regulation of Npff 2 0.42 0.59 2.56
67 INT124746 Positive_regulation of Npff 2 0.50 1.13 2.44
68 INT53960 Negative_regulation of Localization of Npff 3 0.38 0.31 2.34
69 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
70 INT36927 Regulation of Transcription of Tac1 3 0.26 0.33 2.27
71 INT49139 Positive_regulation of Positive_regulation of Tac1 4 0.68 1.74 2.24
72 INT49183 Positive_regulation of Positive_regulation of TAC1 4 0.49 0.66 2.15
73 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
74 INT49731 Transcription of Agtr2 4 0.44 0.95 2.06
75 INT100498 Negative_regulation of Positive_regulation of Tac1 3 0.41 2.81 2.06
76 INT53036 Binding of Agtr2 9 0.33 3.74 1.99
77 INT61650 Protein_catabolism of Tac1 3 0.52 0.88 1.98
78 INT81598 Regulation of Transcription of Npff 1 0.44 0.78 1.68
79 INT112668 Positive_regulation of Gene_expression of Agtr2 7 0.50 3.8 1.58
80 INT68100 Positive_regulation of Positive_regulation of Agtr2 2 0.08 0.83 1.51
81 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
82 INT80770 Positive_regulation of Binding of Tac1 2 0.12 0.45 1.37
83 INT44147 Positive_regulation of Gene_expression of Agtr2 11 0.50 9.02 1.28
84 INT85613 Positive_regulation of Transcription of Npff 2 0.50 0.67 1.28
85 INT151325 Binding of Npff 2 0.32 0.39 1.24
86 INT82003 Negative_regulation of Localization of Tac1 2 0.20 0.1 1.23
87 INT109663 Regulation of Gene_expression of Npff 1 0.62 0.65 1.21
88 INT61100 Localization of Agtr2 7 0.51 2.53 1.13
89 INT50174 Negative_regulation of Gene_expression of Tac1 3 0.40 0.32 1.11
90 INT82483 Negative_regulation of Positive_regulation of Tac1 3 0.47 0 1.06
91 INT4839 Regulation of Localization of Npff 1 0.24 0.06 0.97
92 INT141332 Positive_regulation of Binding of Npff 1 0.21 0 0.94
93 INT24851 Negative_regulation of Regulation of TAC1 1 0.02 0 0.93
94 INT182513 Regulation of AGTR2 4 0.14 4.31 0.91
95 INT60985 Regulation of Transcription of Tac1 4 0.27 1.75 0.88
96 INT51744 Regulation of Uts2 8 0.56 0.23 0.86
97 INT23842 Protein_catabolism of TAC1 2 0.96 0.57 0.84
98 INT288191 Positive_regulation of Localization of Pik3r1 4 0.15 1.27 0.81
99 INT49181 Regulation of Positive_regulation of Tac1 1 0.12 0 0.81
100 INT113536 Positive_regulation of Phosphorylation of Tac1 1 0.07 0.08 0.79
101 INT84761 Positive_regulation of Binding of TAC1 1 0.32 0 0.78
102 INT113535 Phosphorylation of Tac1 1 0.12 0.08 0.78
103 INT31046 Negative_regulation of Uts2 6 0.42 0.44 0.76
104 INT137080 Positive_regulation of Positive_regulation of Agtr2 3 0.26 2.34 0.74
105 INT137081 Positive_regulation of Regulation of Agtr2 1 0.24 0.54 0.72
106 INT103886 Negative_regulation of Negative_regulation of Agtr2 5 0.31 2.16 0.71
107 INT85023 Negative_regulation of Gene_expression of Agtr2 4 0.57 2.97 0.71
108 INT141062 Negative_regulation of Gene_expression of Agtr2 2 0.18 1.61 0.7
109 INT113538 Regulation of Binding of TAC1 2 0.44 0.15 0.66
110 INT112666 Positive_regulation of Transcription of Agtr2 1 0.32 0.74 0.65
111 INT166456 Negative_regulation of Gene_expression of Pik3r1 4 0.41 1.72 0.64
112 INT14433 Regulation of Binding of Tac1 1 0.13 0.27 0.64
113 INT122470 Negative_regulation of Negative_regulation of TAC1 1 0.41 0 0.62
114 INT41634 Positive_regulation of Negative_regulation of Tac1 1 0.45 0 0.61
115 INT135666 Negative_regulation of Negative_regulation of Pik3r1 2 0.29 0.3 0.6
116 INT31890 Positive_regulation of Protein_catabolism of Tac1 1 0.06 0 0.56
117 INT65954 Positive_regulation of Transcription of Tac1 2 0.43 0.78 0.55
118 INT233916 Positive_regulation of AGTR2 5 0.37 3.67 0.51
119 INT113826 Positive_regulation of Negative_regulation of TAC1 1 0.01 0 0.51
120 INT14409 Positive_regulation of Negative_regulation of Tac1 1 0.27 0.31 0.49
121 INT31891 Protein_catabolism of Tac1 1 0.12 0 0.49
122 INT182508 Positive_regulation of Gene_expression of AGTR2 1 0.26 3.13 0.46
123 INT50176 Negative_regulation of Transcription of Tac1 3 0.22 0.07 0.42
124 INT133702 Phosphorylation of Npff 1 0.52 0.41 0.4
125 INT79808 Negative_regulation of Transcription of Tac1 1 0.12 1.21 0.38
126 INT182510 Negative_regulation of Gene_expression of AGTR2 1 0.23 0.78 0.37
127 INT305070 Negative_regulation of Binding of TAC1 2 0.41 1.94 0.36
128 INT53068 Negative_regulation of Binding of Tac1 1 0.42 0.47 0.36
129 INT168766 Positive_regulation of Binding of Pik3r1 3 0.21 1.54 0.35
130 INT126578 Regulation of Gene_expression of Agtr2 2 0.49 1.08 0.34
131 INT51743 Gene_expression of Uts2 5 0.76 0.3 0.33
132 INT133970 Transcription of Npff 1 0.52 0.1 0.32
133 INT356392 Negative_regulation of Positive_regulation of Agtr2 1 0.07 1.01 0.32
134 INT133976 Regulation of Gene_expression of Npff 1 0.60 0.09 0.32
135 INT133977 Regulation of Transcription of Npff 1 0.26 0.1 0.32
136 INT36926 Regulation of Negative_regulation of Tac1 1 0.24 0 0.31
137 INT57883 Regulation of Binding of Npff 1 0.45 0 0.31
138 INT212985 Negative_regulation of Positive_regulation of Pik3r1 3 0.19 3.28 0.3
139 INT185119 Regulation of Positive_regulation of Pik3r1 3 0.13 0.45 0.3
140 INT53854 Regulation of Negative_regulation of Uts2 3 0.44 0 0.29
141 INT182515 Binding of AGTR2 3 0.32 2.4 0.29
142 INT182509 Regulation of Gene_expression of AGTR2 1 0.24 1.72 0.29
143 INT82624 Positive_regulation of Regulation of Tac1 1 0.07 0.25 0.28
144 INT136741 Protein_catabolism of Agtr2 1 0.07 0 0.26
145 INT133967 Positive_regulation of Gene_expression of Npff 1 0.45 0.07 0.25
146 INT14408 Negative_regulation of Regulation of Tac1 1 0.23 0.15 0.25
147 INT70497 Regulation of Localization of TAC1 1 0.26 0 0.21
148 INT209345 Negative_regulation of AGTR2 5 0.17 4.83 0.2
149 INT65953 Regulation of Regulation of Tac1 1 0.25 0 0.2
150 INT31926 Negative_regulation of Negative_regulation of Agtr2 1 0.00 0.19 0.2
151 INT305069 Phosphorylation of TAC1 1 0.19 0 0.19
152 INT236698 Transcription of Pik3r1 1 0.15 1.3 0.18
153 INT17822 Regulation of Gene_expression of Agtr2 1 0.05 0.1 0.18
154 INT134496 Negative_regulation of Localization of TAC1 1 0.57 0.26 0.18
155 INT268208 Transcription of Agtr2 1 0.05 3.15 0.17
156 INT69750 Regulation of Positive_regulation of TAC1 1 0.16 0.28 0.16
157 INT60984 Negative_regulation of Negative_regulation of Tac1 1 0.19 0.35 0.16
158 INT326469 Positive_regulation of Negative_regulation of AGTR2 1 0.09 2.96 0.16
159 INT236359 Negative_regulation of Positive_regulation of Agtr2 2 0.07 1.61 0.15
160 INT309653 Negative_regulation of Localization of Pik3r1 1 0.14 0.55 0.15
161 INT241008 Phosphorylation of Agtr2 1 0.09 0.13 0.14
162 INT356371 Localization of Agtr2 1 0.04 0.74 0.11
163 INT53855 Positive_regulation of Gene_expression of Uts2 1 0.49 0 0.11
164 INT129082 Positive_regulation of Pik3r1 1 0.00 0.47 0.11
165 INT288190 Regulation of Localization of Pik3r1 1 0.04 0.07 0.1
166 INT143360 Regulation of Negative_regulation of Agtr2 1 0.27 0.56 0.1
167 INT51742 Binding of Uts2 1 0.34 0 0.08
168 INT288913 Regulation of Positive_regulation of AGTR2 1 0.28 0.43 0.06
169 INT308619 Regulation of Phosphorylation of Pik3r1 1 0.09 1.06 0.06
170 INT239161 Positive_regulation of Negative_regulation of Pik3r1 1 0.30 0.77 0
171 INT240985 Positive_regulation of Binding of Agtr2 1 0.07 0.83 0
172 INT103887 Positive_regulation of Negative_regulation of Agtr2 1 0.08 0.1 0
173 INT240996 Protein_catabolism of Agtr2 1 0.12 0.18 0
174 INT240990 Positive_regulation of Protein_catabolism of Agtr2 1 0.07 0.18 0
175 INT141560 Positive_regulation of Uts2 1 0.50 0 0
176 INT241016 Negative_regulation of Protein_catabolism of Agtr2 1 0.06 0.18 0
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