GO:0010507

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Name negative regulation of autophagy
Categary Process
Go Slim No
Go Link GO:0010507
Unique Molecular Interactions 126
Total Molecular Interactions 151
Total Single Events 1038
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of autophagy. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of autophagy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
2 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
3 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
4 INT209040 Il3 Positive_regulation of Cxcl1 1 0.04 0.38 0.73
5 INT209061 Il3 Positive_regulation of Elf1 1 0.06 0.38 0.73
6 INT209048 Il3 Positive_regulation of Il17a 1 0.03 0.38 0.73
7 INT209065 Il3 Positive_regulation of Ccr1 1 0.00 0.38 0.73
8 INT209062 Il3 Positive_regulation of Csf2 1 0.02 0.38 0.73
9 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
10 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
11 INT109065 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.00 0 0.58
12 INT273111 Bdnf Positive_regulation of Positive_regulation of Mtor 1 0.44 0.07 0.42
13 INT277353 VEGFA Regulation of Mtor 1 0.02 1.11 0.37
14 INT277354 Gene_expression of VEGFA Regulation of Mtor 1 0.02 1.1 0.37
15 INT273118 Bdnf Positive_regulation of Mtor 1 0.66 0 0.33
16 INT150050 Mtor Positive_regulation of Rps6kb1 3 0.49 1.44 0.3
17 INT305533 Runx1 Positive_regulation of Il3 1 0.03 0.28 0.19
18 INT327327 Ttpa Negative_regulation of Il3 1 0.01 0.4 0.17
19 INT349560 Olr779 Negative_regulation of Mtor 1 0.02 0.5 0.16
20 INT273902 Mtor Positive_regulation of Eif4ebp1 1 0.50 0.56 0.15
21 INT349559 Mtor Regulation of Pdpk1 1 0.03 0.42 0.14
22 INT273901 Mtor Positive_regulation of Eif4e 1 0.50 0.54 0.14
23 INT273103 Binding of Mtor and Rps6kb1 1 0.44 0 0.11
24 INT261762 Il3 Positive_regulation of Stat6 1 0.15 0 0.11
25 INT273112 Positive_regulation of Binding of Mtor and Rps6kb1 1 0.46 0.05 0.11
26 INT313482 Binding of MTOR and SST 1 0.01 0 0.1
27 INT249126 Binding of Ephb1 and Mtor 1 0.02 0 0.08
28 INT273104 Mtor Negative_regulation of Gene_expression of Gria1 1 0.46 0.15 0.08
29 INT184097 Cish Negative_regulation of Il3 1 0.10 0.62 0.07
30 INT273107 Bdnf Regulation of Positive_regulation of Mtor 1 0.26 0.09 0.07
31 INT273098 Binding of Bdnf and Positive_regulation of Mtor 1 0.47 0 0.06
32 INT244641 PDGFA Regulation of MTOR 1 0.07 2.55 0.06
33 INT273096 Mtor Positive_regulation of Gene_expression of Grip2 1 0.05 0.07 0.05
34 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
35 INT329216 Prkag1 Regulation of Mtor 1 0.01 0.35 0.04
36 INT253376 Lep Regulation of Mtor 1 0.17 0.08 0.04
37 INT257874 Agt Positive_regulation of Mtor 1 0.04 0.37 0.04
38 INT257881 Ins1 Positive_regulation of Mtor 1 0.05 0.37 0.04
39 INT332286 PIK3CD Positive_regulation of MTOR 1 0.14 0.73 0.03
40 INT298878 Binding of MTOR and RAB7A 1 0.07 0.35 0.03
41 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
42 INT313485 MTOR Positive_regulation of Gene_expression of P2RX1 1 0.16 0 0.03
43 INT273105 Mtor Regulation of Gria1 1 0.29 0.07 0.03
44 INT198009 MTOR Regulation of HCC 1 0.09 1.1 0
45 INT253359 Positive_regulation of Prkaa2 Negative_regulation of Mtor 1 0.26 0.27 0
46 INT295980 Dap Positive_regulation of Lipg 1 0.17 0.48 0
47 INT292137 Regulation of Mtor Regulation of Gene_expression of VEGFA 1 0.01 0.75 0
48 INT150051 Mtor Positive_regulation of Eif4ebp1 1 0.50 0.46 0
49 INT198024 CDCP1 Negative_regulation of MTOR 1 0.00 0.97 0
50 INT233506 Tlr4 Positive_regulation of Htr2b 1 0.06 0.09 0
51 INT251780 RRAD Negative_regulation of MTOR 1 0.00 0.62 0
52 INT273106 Binding of Mtor and Cby1 1 0.01 0 0
53 INT303331 Mtor Positive_regulation of Rps6kb1 1 0.07 0.07 0
54 INT273116 Binding of Fkbp1a and Mtor 1 0.37 0 0
55 INT223575 AKT1 Regulation of MTOR 1 0.12 0.37 0
56 INT276887 MTOR Regulation of Ppargc1a 1 0.23 0.33 0
57 INT250668 AKT1 Positive_regulation of MTOR 1 0.16 1.26 0
58 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0
59 INT292136 Mtor Regulation of Gene_expression of VEGFA 1 0.01 0.75 0
60 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0
61 INT250663 Phosphorylation of AKT1 Positive_regulation of MTOR 1 0.16 1.26 0
62 INT223582 Negative_regulation of MTOR Positive_regulation of Phosphorylation of ESR1 1 0.31 0.67 0
63 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0
64 INT198007 MTOR Regulation of Gene_expression of GOPC 1 0.08 1.33 0
65 INT296867 Binding of B4galnt2 and Mtor 1 0.00 0.51 0
66 INT253369 Prkaa2 Negative_regulation of Mtor 1 0.24 0.27 0
67 INT198013 MTOR Regulation of Gene_expression of MCL1 1 0.29 1.3 0
68 INT274434 Binding of Gata4 and Zfpm2 1 0.12 0.56 0
69 INT341227 Mtor Regulation of Phosphorylation of Eif4ebp1 1 0.02 0.19 0
70 INT290435 Positive_regulation of Binding of Mtor and Utp3 1 0.01 0.26 0
71 INT272016 Mtor Negative_regulation of INS 1 0.00 0.61 0
72 INT253373 Binding of Mtor and Prkaa2 1 0.20 0.26 0
73 INT290436 Binding of Mtor and Utp3 1 0.00 0.26 0
74 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0
75 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0
76 INT253372 Prkaa2 Regulation of Mtor 1 0.13 0.09 0
77 INT351098 MTOR Regulation of Binding of EPAS1 1 0.08 0.95 0
78 INT295199 Tlr4 Positive_regulation of Positive_regulation of Mtor 1 0.01 0 0
79 INT296869 Mtor Positive_regulation of Gene_expression of B4galnt2 1 0.01 1.56 0
80 INT286564 Pkd1 Regulation of Mtor 1 0.00 0.51 0
81 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0
82 INT276868 MTOR Regulation of Gene_expression of MTUS1 1 0.01 0.33 0
83 INT341228 Binding of tor and Mtor 1 0.00 0 0
84 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0
85 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0
86 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0
87 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0
88 INT223576 PIK3CG Regulation of MTOR 1 0.15 0.37 0
89 INT198010 KDR Negative_regulation of MTOR 1 0.11 0.95 0
90 INT223580 Positive_regulation of PIK3CG Regulation of MTOR 1 0.25 0.42 0
91 INT256605 FPR1 Positive_regulation of MTOR 1 0.01 2.18 0
92 INT253371 Akt1 Regulation of Mtor 1 0.05 0.19 0
93 INT271978 Positive_regulation of Racgap1 Regulation of Mtor 1 0.00 0.54 0
94 INT260264 Binding of MTOR and FKBP7 1 0.26 0.87 0
95 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of autophagy. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of autophagy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15305 Positive_regulation of Mtor 51 0.67 8.28 11
2 INT20166 Negative_regulation of Mtor 32 0.56 10.64 10.25
3 INT15307 Regulation of Mtor 27 0.48 4.7 9.34
4 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19
5 INT23611 Gene_expression of Mtor 23 0.66 3.57 5.02
6 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
7 INT45132 Positive_regulation of Dap 14 0.69 0.62 3.5
8 INT11245 Negative_regulation of Dap 15 0.59 1.95 3.18
9 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83
10 INT228678 Phosphorylation of Mtor 15 0.78 3.18 2.76
11 INT55470 Regulation of Mtor 16 0.24 12.51 2.07
12 INT36293 Gene_expression of Mtor 24 0.25 14.5 2.04
13 INT184077 Positive_regulation of Il3 7 0.06 3.69 2
14 INT20377 Gene_expression of Il3 8 0.65 0.82 1.77
15 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
16 INT89871 Gene_expression of Gata4 11 0.69 1.05 1.53
17 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44
18 INT59725 Regulation of Dap 6 0.45 0.83 1.42
19 INT166764 Localization of Mtor 2 0.75 1.28 1.42
20 INT37436 Localization of Dap 3 0.71 0 1.31
21 INT228671 Negative_regulation of Phosphorylation of Mtor 8 0.50 1.77 1.2
22 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
23 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
24 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01
25 INT109069 Transcription of Gata4 4 0.64 0.52 1.01
26 INT109070 Positive_regulation of Transcription of Gata4 1 0.03 0 1.01
27 INT76004 Negative_regulation of Localization of Dap 1 0.43 0 0.97
28 INT30157 Gene_expression of Htr2b 2 0.48 0 0.94
29 INT271917 Phosphorylation of Mtor 11 0.13 6.76 0.78
30 INT20383 Localization of Il3 2 0.43 0.75 0.72
31 INT213923 Positive_regulation of MTOR 16 0.65 9.28 0.7
32 INT15303 Transcription of Mtor 1 0.47 0.17 0.66
33 INT15302 Regulation of Transcription of Mtor 1 0.31 0.17 0.66
34 INT57127 Binding of Htr2b 2 0.36 0.05 0.63
35 INT89867 Negative_regulation of Gene_expression of Gata4 3 0.38 0.17 0.61
36 INT89868 Negative_regulation of Gata4 1 0.38 0 0.57
37 INT161248 Positive_regulation of Gene_expression of Mtor 2 0.06 6.47 0.51
38 INT70720 Negative_regulation of Positive_regulation of Dap 1 0.24 0 0.51
39 INT223599 Regulation of MTOR 14 0.42 8.52 0.49
40 INT253391 Positive_regulation of Positive_regulation of Mtor 7 0.48 0.39 0.46
41 INT59724 Binding of Dap 1 0.32 0 0.46
42 INT59726 Positive_regulation of Binding of Dap 1 0.44 0 0.46
43 INT161218 Positive_regulation of Positive_regulation of Htr2b 1 0.67 0.69 0.43
44 INT37434 Gene_expression of Dap 6 0.62 1.22 0.42
45 INT76874 Negative_regulation of Htr2b 1 0.07 0 0.41
46 INT136180 Binding of MTOR 9 0.35 5.01 0.38
47 INT228668 Positive_regulation of Localization of Mtor 1 0.39 0.62 0.38
48 INT156201 Negative_regulation of Gene_expression of MTOR 6 0.58 7.7 0.36
49 INT37433 Protein_catabolism of Dap 1 0.33 0 0.35
50 INT109058 Positive_regulation of Gene_expression of Gata4 2 0.29 0 0.33
51 INT209026 Transcription of Il3 1 0.17 0.53 0.31
52 INT249123 Binding of Mtor 9 0.36 0.57 0.3
53 INT41720 Positive_regulation of Gene_expression of MTOR 2 0.49 1.54 0.28
54 INT41722 Positive_regulation of Negative_regulation of MTOR 1 0.45 0.73 0.28
55 INT156207 Negative_regulation of Phosphorylation of MTOR 5 0.58 2.33 0.25
56 INT90335 Transcription of Dap 2 0.20 0 0.25
57 INT57126 Transcription of Htr2b 1 0.33 0 0.24
58 INT327033 Negative_regulation of Phosphorylation of Mtor 3 0.07 1.38 0.23
59 INT156204 Phosphorylation of MTOR 15 0.82 3.99 0.21
60 INT282732 Positive_regulation of Phosphorylation of Mtor 4 0.06 2.09 0.2
61 INT349553 Negative_regulation of Negative_regulation of Mtor 1 0.40 0.67 0.19
62 INT257861 Positive_regulation of Gene_expression of Mtor 5 0.48 0.9 0.18
63 INT332297 Negative_regulation of Binding of MTOR 2 0.40 1.6 0.18
64 INT38976 Positive_regulation of Negative_regulation of Mtor 2 0.48 0 0.17
65 INT249124 Regulation of Regulation of Mtor 1 0.11 0 0.15
66 INT253392 Positive_regulation of Phosphorylation of Mtor 2 0.42 0.26 0.13
67 INT327256 Regulation of Il3 1 0.05 0.41 0.13
68 INT277350 Negative_regulation of Localization of Mtor 1 0.03 1.39 0.11
69 INT257855 Regulation of Positive_regulation of Mtor 3 0.35 0.54 0.1
70 INT277345 Localization of Mtor 3 0.08 1.89 0.09
71 INT327035 Regulation of Phosphorylation of Mtor 1 0.07 0.3 0.09
72 INT296856 Negative_regulation of Gene_expression of Mtor 1 0.05 2.08 0.09
73 INT249121 Positive_regulation of Binding of Mtor 1 0.20 0 0.08
74 INT273094 Regulation of Negative_regulation of Mtor 1 0.43 0.15 0.08
75 INT290430 Regulation of Positive_regulation of Mtor 1 0.03 0.42 0.05
76 INT257852 Negative_regulation of Positive_regulation of Mtor 2 0.46 0.21 0.04
77 INT217732 Localization of MTOR 11 0.56 3.19 0.03
78 INT212458 Binding of Mtor 8 0.04 6.77 0.03
79 INT248540 Positive_regulation of Gata4 2 0.23 0.95 0.03
80 INT282729 Regulation of Binding of Mtor 2 0.05 1.48 0.03
81 INT117637 Positive_regulation of Negative_regulation of Dap 1 0.13 0.09 0.03
82 INT217730 Positive_regulation of Localization of MTOR 4 0.33 0.86 0
83 INT217731 Positive_regulation of Phosphorylation of MTOR 3 0.40 0.54 0
84 INT246194 Regulation of Phosphorylation of MTOR 2 0.34 0.31 0
85 INT274404 Binding of Gata4 2 0.16 0.89 0
86 INT284329 Regulation of Gene_expression of MTOR 2 0.20 1.63 0
87 INT239157 Positive_regulation of Negative_regulation of Mtor 2 0.11 0.89 0
88 INT155583 Negative_regulation of Positive_regulation of Mtor 2 0.37 0.42 0
89 INT279178 Negative_regulation of Positive_regulation of MTOR 1 0.24 0.8 0
90 INT246204 Transcription of MTOR 1 0.25 0 0
91 INT313888 Negative_regulation of Binding of Mtor 1 0.14 0.07 0
92 INT233451 Negative_regulation of Htr2b 1 0.33 0.09 0
93 INT296849 Positive_regulation of Positive_regulation of Mtor 1 0.05 1.24 0
94 INT223608 Negative_regulation of Negative_regulation of MTOR 1 0.32 0.74 0
95 INT256614 Positive_regulation of Binding of MTOR 1 0.18 0.07 0
96 INT298932 Negative_regulation of Localization of MTOR 1 0.08 0.42 0
97 INT223613 Regulation of Negative_regulation of MTOR 1 0.34 1.25 0
98 INT337052 Regulation of Negative_regulation of Mtor 1 0.03 0.37 0
99 INT347593 Negative_regulation of Gene_expression of Htr2b 1 0.01 0.16 0
100 INT296858 Regulation of Gene_expression of Mtor 1 0.04 0 0
101 INT181811 Localization of Gata4 1 0.54 0.3 0
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