GO:0010613

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Name positive regulation of cardiac muscle hypertrophy
Categary Process
Go Slim No
Go Link GO:0010613
Unique Molecular Interactions 958
Total Molecular Interactions 1287
Total Single Events 9775
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cardiac muscle hypertrophy. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cardiac muscle hypertrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
3 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
4 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
5 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
6 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
7 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
8 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
9 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
10 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
11 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
12 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
13 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
14 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
15 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
16 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
17 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
18 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
19 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
20 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
21 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
22 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
23 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
24 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
25 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
26 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
27 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
28 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
29 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
30 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
31 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
32 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
33 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
34 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
35 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
36 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
37 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
38 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
39 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
40 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
41 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
42 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
43 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
44 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
45 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
46 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
47 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
48 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
49 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
50 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
51 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
52 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
53 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
54 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
55 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
56 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
57 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
58 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
59 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
60 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
61 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83
62 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
63 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
64 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
65 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
66 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
67 INT190869 Binding of Prkca and Ltp 1 0.03 0.86 0.81
68 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
69 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
70 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
71 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
72 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
73 INT282063 Ngf Positive_regulation of Positive_regulation of Prkca 1 0.09 0.18 0.8
74 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
75 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8
76 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
77 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
78 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78
79 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
80 INT157917 TRPV1 Regulation of Prkca 1 0.04 0.55 0.78
81 INT190867 Binding of Marcks and Prkca 1 0.17 0.8 0.77
82 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75
83 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
84 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
85 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
86 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72
87 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71
88 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
89 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
90 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
91 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7
92 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
93 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
94 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
95 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
96 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
97 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
98 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
99 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
100 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
101 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
102 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66
103 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
104 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
105 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
106 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
107 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
108 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
109 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
110 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
111 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
112 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
113 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
114 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
115 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6
116 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
117 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
118 INT81606 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.29 0 0.6
119 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
120 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
121 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
122 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
123 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
124 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
125 INT81605 PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.43 0 0.57
126 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
127 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
128 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
129 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
130 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
131 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
132 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
133 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55
134 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55
135 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
136 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
137 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
138 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
139 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
140 INT182553 Ptger2 Regulation of Localization of Prkca 1 0.08 0.69 0.53
141 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
142 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
143 INT137685 Phosphorylation of Prkca Negative_regulation of Binding of Srpx2 1 0.18 0 0.53
144 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
145 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
146 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
147 INT106346 Mtpn Regulation of Chat 1 0.06 0 0.52
148 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52
149 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
150 INT151220 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Prkca 1 0.00 0.13 0.51
151 INT151219 Negative_regulation of SIGMAR1 Negative_regulation of Prkca 1 0.00 0.13 0.51
152 INT189688 PRKCA Regulation of Transcription of TERT 1 0.13 0.2 0.5
153 INT189696 PRKCA Negative_regulation of Negative_regulation of TEP1 1 0.02 0.15 0.5
154 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
155 INT189680 PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
156 INT189675 Negative_regulation of PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
157 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
158 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
159 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
160 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
161 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
162 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
163 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
164 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
165 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48
166 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
167 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
168 INT261648 BDKRB1 Regulation of PRKCA 1 0.03 1.9 0.47
169 INT296466 Prkca Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
170 INT153658 PRKCA Negative_regulation of GEM 1 0.01 0.22 0.46
171 INT153657 PRKCA Negative_regulation of MED23 1 0.01 0.22 0.46
172 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
173 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
174 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
175 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
176 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
177 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
178 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
179 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44
180 INT151958 Negative_regulation of Agt Positive_regulation of Agtrap 1 0.39 0 0.44
181 INT191896 Pbsn Positive_regulation of Prkca 1 0.04 0.85 0.44
182 INT151959 Agt Positive_regulation of Agtrap 1 0.63 0 0.44
183 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
184 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
185 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
186 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
187 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
188 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
189 INT196881 Ly6 Positive_regulation of Prkca 2 0.01 0.25 0.42
190 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
191 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42
192 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
193 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
194 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
195 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41
196 INT189681 Negative_regulation of PRKCA Negative_regulation of Gene_expression of METTL3 1 0.00 0.16 0.41
197 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
198 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
199 INT189689 CHKB Negative_regulation of Positive_regulation of PRKCA 1 0.11 0 0.4
200 INT124799 PRKCA Positive_regulation of Localization of ADCY6 1 0.19 0 0.4

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cardiac muscle hypertrophy. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cardiac muscle hypertrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
2 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
3 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
4 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
5 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
6 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
7 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
8 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
9 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
10 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
11 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
12 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
13 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
14 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
15 INT1158 Regulation of Agt 106 0.61 29.4 30.29
16 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
17 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
18 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
19 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
20 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
21 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
22 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
23 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
24 INT117527 Binding of Prkca 25 0.48 6.43 21.05
25 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
26 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09
27 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
28 INT5048 Binding of Edn1 55 0.47 18.86 19.16
29 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
30 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
31 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
32 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
33 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
34 INT2066 Localization of Agt 56 0.80 9.95 16.25
35 INT79458 Localization of Prkca 30 0.81 11.13 15.78
36 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
37 INT9191 Localization of EDN1 94 0.81 57.01 14.78
38 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
39 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
40 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
41 INT6365 Localization of Edn1 56 0.81 18.84 13.83
42 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
43 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
44 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
45 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
46 INT3962 Regulation of AGT 50 0.62 20.96 13.01
47 INT4199 Binding of Agt 76 0.48 21.06 12.66
48 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
49 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
50 INT398 Localization of AGT 45 0.78 16.97 11.54
51 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
52 INT8065 Binding of AGT 54 0.48 20.54 10.85
53 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
54 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
55 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
56 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
57 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
58 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
59 INT6361 Localization of Edn1 30 0.81 19.09 9.7
60 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
61 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
62 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
63 INT34777 Localization of IGF1 82 0.80 42.68 8.62
64 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62
65 INT10237 Binding of EDN1 40 0.48 16 8.48
66 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
67 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
68 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
69 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
70 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
71 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
72 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
73 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
74 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
75 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
76 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
77 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
78 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
79 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
80 INT151032 Localization of Igf1 49 0.76 26.32 5.71
81 INT94862 Positive_regulation of Gene_expression of Pde5a 10 0.20 4.23 5.18
82 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17
83 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
84 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
85 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
86 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
87 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
88 INT166678 Negative_regulation of Phosphorylation of PRKCA 12 0.38 5.77 4.59
89 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
90 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
91 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
92 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27
93 INT49360 Localization of Igf1 22 0.76 6.96 4.26
94 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91
95 INT118154 Positive_regulation of Binding of Prkca 2 0.50 0.58 3.81
96 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
97 INT50295 Regulation of Mtpn 13 0.26 7.54 3.77
98 INT154225 Negative_regulation of Binding of Prkca 2 0.30 0.06 3.71
99 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46
100 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
101 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31
102 INT72216 Regulation of Positive_regulation of PRKCA 9 0.37 1.36 3.26
103 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
104 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23
105 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18
106 INT190860 Regulation of Localization of Prkca 4 0.21 1.61 3.11
107 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06
108 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
109 INT53374 Binding of Edn1 17 0.43 11.66 2.98
110 INT16130 Binding of IGF1 67 0.48 27.43 2.95
111 INT133144 Localization of Mtpn 18 0.24 7.88 2.77
112 INT171682 Positive_regulation of Phosphorylation of PRKCA 3 0.43 1.04 2.72
113 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
114 INT136675 Transcription of Pde5a 6 0.63 4.74 2.71
115 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7
116 INT143841 Positive_regulation of Mtpn 17 0.17 5.46 2.68
117 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
118 INT105598 Negative_regulation of Mtpn 15 0.16 11.83 2.65
119 INT94860 Negative_regulation of Gene_expression of Pde5a 2 0.33 3.2 2.64
120 INT257298 Regulation of Positive_regulation of Pde5a 1 0.19 2.03 2.54
121 INT184583 Regulation of Phosphorylation of Prkca 3 0.21 1.76 2.5
122 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
123 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
124 INT257299 Binding of Pde5a 14 0.27 4.31 2.45
125 INT66544 Binding of Igf1 23 0.46 8.33 2.44
126 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
127 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
128 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
129 INT257301 Protein_catabolism of Pde5a 5 0.30 1.97 2.26
130 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
131 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
132 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
133 INT108422 Binding of Pde5a 11 0.36 3.07 2.07
134 INT12005 Negative_regulation of Localization of Agt 6 0.57 1.49 2.06
135 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96
136 INT12801 Negative_regulation of Regulation of Agt 4 0.43 1.2 1.96
137 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
138 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
139 INT102866 Regulation of Negative_regulation of Prkca 2 0.43 1.27 1.95
140 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
141 INT106636 Binding of PRKCA 7 0.28 3.06 1.93
142 INT43944 Negative_regulation of Positive_regulation of Agt 4 0.42 1.44 1.93
143 INT165648 Negative_regulation of Transcription of Pde5a 1 0.41 3.6 1.93
144 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
145 INT170345 Negative_regulation of Localization of Prkca 5 0.23 0.88 1.88
146 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
147 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
148 INT79569 Protein_catabolism of PRKCA 3 1.00 0.44 1.78
149 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
150 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76
151 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
152 INT228445 Transcription of Mtpn 1 0.03 0.35 1.72
153 INT97571 Positive_regulation of Gene_expression of PRKCA 13 0.43 1.61 1.7
154 INT3152 Transcription of Agt 7 0.72 5.09 1.68
155 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
156 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
157 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
158 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
159 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
160 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
161 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
162 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
163 INT291576 Positive_regulation of Protein_catabolism of Pde5a 1 0.12 1.15 1.43
164 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
165 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
166 INT52713 Regulation of Negative_regulation of PRKCA 5 0.36 1.23 1.41
167 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
168 INT90491 Binding of Igf1 25 0.44 9.75 1.36
169 INT239215 Binding of Agt 9 0.38 6.75 1.35
170 INT11306 Regulation of Gene_expression of Agt 7 0.45 3.29 1.31
171 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31
172 INT242945 Localization of PDE5A 9 0.75 4.57 1.28
173 INT11241 Transcription of AGT 4 0.52 1.83 1.27
174 INT19319 Negative_regulation of Binding of Agt 9 0.42 3.42 1.24
175 INT87157 Regulation of Gene_expression of Mtpn 4 0.49 0.78 1.24
176 INT79916 Negative_regulation of Agt 14 0.47 6 1.22
177 INT139261 Positive_regulation of Gene_expression of Mtpn 8 0.05 5.95 1.22
178 INT220763 Regulation of Phosphorylation of PRKCA 3 0.29 0.84 1.22
179 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
180 INT47644 Positive_regulation of Localization of AGT 4 0.45 1.24 1.2
181 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
182 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17
183 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
184 INT28594 Positive_regulation of Transcription of Agt 2 0.47 1.3 1.15
185 INT115621 Positive_regulation of Binding of AGT 1 0.02 0 1.15
186 INT103043 Binding of PDE5A 16 0.37 7.79 1.12
187 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
188 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
189 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
190 INT228437 Regulation of Transcription of Mtpn 1 0.03 0.08 1.02
191 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
192 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
193 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
194 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
195 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
196 INT257200 Phosphorylation of Pde5a 1 0.25 0 0.94
197 INT165644 Regulation of Transcription of Pde5a 1 0.44 1.65 0.91
198 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
199 INT164144 Phosphorylation of Pde5a 4 0.19 1.15 0.87
200 INT317485 Regulation of Binding of Prkca 1 0.17 0.17 0.87
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