GO:0010737

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Name protein kinase A signaling cascade
Categary Process
Go Slim No
Go Link GO:0010737
Unique Molecular Interactions 77
Total Molecular Interactions 95
Total Single Events 1433
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein kinase A signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported for protein kinase A signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT30905 SST Negative_regulation of Localization of GCG 2 0.12 1.56 1.04
2 INT101443 Penk Positive_regulation of Localization of Gcg 1 0.50 1.21 1.04
3 INT31642 POMC Regulation of GCG 1 0.41 0.62 0.73
4 INT101676 Sst Negative_regulation of Localization of Gcg 1 0.03 0 0.72
5 INT101444 Penk Regulation of Localization of Gcg 1 0.45 0.77 0.71
6 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
7 INT31418 Positive_regulation of Adra2c Positive_regulation of Gcg 1 0.22 0 0.65
8 INT30902 GCG Positive_regulation of Localization of SST 1 0.11 0.05 0.62
9 INT108467 GCG Positive_regulation of Cck 1 0.02 0.16 0.51
10 INT7849 Man2a2 Positive_regulation of Localization of Gcg 1 0.08 0 0.51
11 INT25524 Oprd1 Regulation of Localization of GCG 1 0.01 0.52 0.48
12 INT43956 GCG Regulation of ALB 1 0.16 0.15 0.38
13 INT207823 SSTR2 Negative_regulation of Localization of GCG 1 0.06 0 0.29
14 INT26175 POMC Positive_regulation of GCG 2 0.47 0.57 0.28
15 INT7850 Adra2c Regulation of Localization of Gcg 1 0.08 0 0.27
16 INT233784 Binding of GCG and SCT 1 0.06 0 0.27
17 INT37309 Ins1 Negative_regulation of Localization of Gcg 1 0.12 0 0.27
18 INT36292 GCG Positive_regulation of MIA3 1 0.01 1.06 0.26
19 INT115875 Col5a1 Positive_regulation of Localization of Gcg 1 0.08 0 0.23
20 INT29257 Pomc Positive_regulation of Gcg 1 0.17 0.23 0.21
21 INT75355 Negative_regulation of GCG Regulation of Gh 1 0.01 1.26 0.18
22 INT75356 GCG Regulation of Gh 1 0.01 1.25 0.18
23 INT98775 Abhd5 Regulation of Localization of Gcg 1 0.24 0 0.17
24 INT71547 ADRA2C Positive_regulation of Localization of GCG 1 0.01 0.14 0.17
25 INT125770 GLP1R Negative_regulation of Localization of GCG 2 0.29 0.65 0.16
26 INT15524 GCG Negative_regulation of FFAR1 1 0.07 0.35 0.16
27 INT1233 Gcg Positive_regulation of Pdpk1 1 0.27 0 0.14
28 INT321983 Glp1r Negative_regulation of Localization of Gcg 1 0.09 1.36 0.11
29 INT242203 GLP1R Regulation of GCG 1 0.04 0.64 0.1
30 INT43284 Binding of Npr1 and Gcg 1 0.05 0 0.1
31 INT207822 ABAT Positive_regulation of Localization of GCG 1 0.02 0 0.1
32 INT354077 Avpr1b Positive_regulation of Localization of Gcg 1 0.12 0.05 0.1
33 INT52894 Gcg Negative_regulation of Ins1 1 0.16 0.18 0.09
34 INT332639 Glp1r Negative_regulation of Localization of Gcg 1 0.03 0.87 0.07
35 INT46528 Binding of Ins1 and Gcg 1 0.25 0.07 0.06
36 INT46529 Gcg Positive_regulation of Ins1 1 0.34 0.07 0.06
37 INT32621 POMC Positive_regulation of Positive_regulation of GCG 1 0.35 0.05 0.06
38 INT332631 Negative_regulation of Dpp4 Negative_regulation of Gcg 1 0.05 1 0.05
39 INT43283 Gcg Positive_regulation of Npr1 1 0.07 0 0.05
40 INT32622 POMC Negative_regulation of Negative_regulation of GCG 1 0.30 0.05 0.05
41 INT332628 Negative_regulation of Dpp4 Negative_regulation of Positive_regulation of Gcg 1 0.05 1 0.05
42 INT332633 Glp1r Negative_regulation of Gcg 1 0.04 1.13 0.05
43 INT332632 Gip Negative_regulation of Localization of Gcg 1 0.05 0.47 0.04
44 INT332635 Glp1r Regulation of Localization of Gcg 1 0.03 0.94 0.04
45 INT240894 Gcg Positive_regulation of Creb1 1 0.14 0.06 0.03
46 INT331875 Binding of GCG and Mst1r 1 0.08 0 0
47 INT332629 Binding of Glp1r and Positive_regulation of Localization of Gcg 1 0.03 0.47 0
48 INT311223 GLP1R Regulation of Localization of GCG 1 0.16 0.74 0
49 INT331874 Positive_regulation of Binding of GCG and Mst1r 1 0.11 0 0
50 INT238870 INS Positive_regulation of Gene_expression of GCG 1 0.39 1.06 0
51 INT331880 Binding of GCG and Mest 1 0.08 0 0
52 INT310276 Gcg Positive_regulation of Localization of Ins1 1 0.25 0 0
53 INT314624 Ex Regulation of GCG 1 0.01 0.67 0
54 INT230763 GCG Positive_regulation of Localization of INS 1 0.17 0.26 0
55 INT313572 GLP1R Negative_regulation of GCG 1 0.29 0.54 0
56 INT256400 GLP1R Positive_regulation of Localization of GCG 1 0.02 0.15 0
57 INT253213 Negative_regulation of Dpp4 Positive_regulation of Localization of GCG 1 0.05 0.4 0
58 INT331879 Positive_regulation of Binding of GCG and Mest 1 0.11 0 0
59 INT321976 Dpp4 Regulation of Gcg 1 0.13 1.06 0
60 INT253214 Negative_regulation of Dpp4 Negative_regulation of Gene_expression of GCG 1 0.04 0.43 0
61 INT321977 Dpp4 Regulation of Negative_regulation of Gcg 1 0.13 1.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein kinase A signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported in protein kinase A signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1473 Localization of Gcg 95 0.80 17.35 30.31
2 INT17625 Localization of GCG 210 0.80 55.69 24.97
3 INT6575 Positive_regulation of Localization of Gcg 33 0.69 3.48 13.31
4 INT2586 Positive_regulation of Gcg 35 0.70 9.25 11.75
5 INT8740 Localization of Gcg 65 0.78 19 9.81
6 INT4494 Regulation of GCG 41 0.45 18.38 9.68
7 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48
8 INT3658 Regulation of Gcg 28 0.53 12.89 8.58
9 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35
10 INT2587 Regulation of Localization of Gcg 22 0.60 1.73 7.59
11 INT3659 Negative_regulation of Gcg 26 0.51 10.08 7.39
12 INT15528 Positive_regulation of GCG 38 0.63 20.47 6.14
13 INT3894 Negative_regulation of Localization of Gcg 18 0.52 2.7 5.77
14 INT31227 Regulation of Localization of GCG 28 0.48 4.86 5.72
15 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98
16 INT8743 Positive_regulation of Gcg 19 0.65 10.63 4.43
17 INT1634 Gene_expression of Gcg 25 0.75 14.98 4.42
18 INT8744 Regulation of Localization of Gcg 14 0.60 2.06 4.3
19 INT17626 Positive_regulation of Localization of GCG 36 0.69 13.94 4.06
20 INT8748 Positive_regulation of Localization of Gcg 24 0.67 9.74 3.46
21 INT31414 Gene_expression of Gcg 25 0.73 7.28 3.25
22 INT43282 Binding of Gcg 5 0.32 0.61 2.18
23 INT56705 Negative_regulation of Positive_regulation of Gcg 1 0.51 0 2.17
24 INT15983 Regulation of Gcg 6 0.58 1.67 2.16
25 INT8745 Negative_regulation of Gcg 13 0.40 4.84 1.91
26 INT28954 Binding of GCG 7 0.36 3.14 1.68
27 INT26180 Regulation of Regulation of GCG 3 0.39 1.43 1.65
28 INT98773 Negative_regulation of Localization of Gcg 10 0.53 9.59 1.5
29 INT10264 Regulation of Regulation of Gcg 2 0.39 0 1.05
30 INT43857 Regulation of Gene_expression of GCG 2 0.25 0.64 0.76
31 INT31413 Regulation of Regulation of Gcg 1 0.25 0 0.73
32 INT87717 Negative_regulation of Regulation of Gcg 1 0.02 0 0.67
33 INT238450 Transcription of Gcg 2 0.52 0.37 0.62
34 INT18168 Protein_catabolism of Gcg 4 0.99 1.17 0.56
35 INT15526 Positive_regulation of Gene_expression of GCG 3 0.38 1.64 0.53
36 INT83550 Negative_regulation of Gene_expression of Gcg 2 0.42 1.52 0.52
37 INT238453 Positive_regulation of Gene_expression of Gcg 5 0.38 1.99 0.48
38 INT83548 Negative_regulation of Positive_regulation of GCG 1 0.42 1.06 0.46
39 INT238452 Binding of Gcg 1 0.32 0.38 0.46
40 INT43909 Positive_regulation of Gene_expression of Gcg 3 0.48 1.45 0.45
41 INT43910 Regulation of Gene_expression of Gcg 3 0.27 3.71 0.41
42 INT238449 Negative_regulation of Gene_expression of Gcg 5 0.37 1.94 0.37
43 INT45708 Positive_regulation of Positive_regulation of GCG 1 0.48 0.76 0.35
44 INT47340 Regulation of Positive_regulation of GCG 1 0.45 0 0.34
45 INT113894 Positive_regulation of Protein_catabolism of Gcg 1 0.25 0.32 0.32
46 INT50750 Transcription of Gcg 1 0.53 0.85 0.25
47 INT310936 Phosphorylation of GCG 1 0.10 1 0.24
48 INT303671 Negative_regulation of Regulation of GCG 1 0.13 1.44 0.22
49 INT264796 Regulation of Binding of GCG 1 0.04 0.16 0.21
50 INT26178 Negative_regulation of Gene_expression of GCG 4 0.35 1.43 0.19
51 INT3895 Positive_regulation of Positive_regulation of Gcg 2 0.49 0.8 0.18
52 INT26179 Regulation of Negative_regulation of GCG 2 0.38 1.04 0.14
53 INT213998 Phosphorylation of Gcg 3 0.17 0.94 0.12
54 INT213994 Negative_regulation of Phosphorylation of Gcg 1 0.09 0.1 0.1
55 INT46471 Positive_regulation of Regulation of Gcg 1 0.39 0.27 0.09
56 INT3893 Positive_regulation of Regulation of Gcg 1 0.46 0.8 0.09
57 INT21668 Regulation of Positive_regulation of Gcg 1 0.34 0.58 0.06
58 INT26182 Negative_regulation of Negative_regulation of GCG 1 0.27 0.07 0.06
59 INT238447 Regulation of Gene_expression of Gcg 1 0.39 0.47 0.05
60 INT332621 Negative_regulation of Positive_regulation of Gcg 1 0.12 1.68 0.04
61 INT291466 Phosphorylation of Gcg 1 0.15 0.73 0.03
62 INT305496 Positive_regulation of Positive_regulation of Gcg 1 0.17 0.43 0.03
63 INT207840 Positive_regulation of Negative_regulation of GCG 1 0.36 0.1 0
64 INT325678 Negative_regulation of Protein_catabolism of Gcg 1 0.02 0.8 0
65 INT238873 Positive_regulation of Regulation of GCG 1 0.38 0.95 0
66 INT110597 Positive_regulation of Protein_catabolism of GCG 1 0.15 0 0
67 INT110596 Protein_catabolism of GCG 1 0.30 0 0
68 INT332605 Negative_regulation of Negative_regulation of Gcg 1 0.12 0.57 0
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