GO:0010739

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Name positive regulation of protein kinase A signaling cascade
Categary Process
Go Slim No
Go Link GO:0010739
Unique Molecular Interactions 250
Total Molecular Interactions 479
Total Single Events 2878
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein kinase A signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of protein kinase A signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
3 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
4 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
5 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
6 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
7 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
8 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
9 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
10 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
11 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
12 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
13 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
14 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
15 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
16 INT276282 Binding of Atrn and Mc1r 1 0.32 0.41 1.29
17 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
18 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22
19 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
20 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
21 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
22 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
23 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 0.05 0.5 1.05
24 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
25 INT201614 Mc1r Regulation of Uvbi1 1 0.04 1.42 0.98
26 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
27 INT40636 Mif Negative_regulation of Pomc 1 0.25 0.07 0.9
28 INT253992 Cxcl12 Positive_regulation of Mif 1 0.46 1.31 0.88
29 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 0.00 1.56 0.87
30 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
31 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
32 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
33 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
34 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
35 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
36 INT99335 Binding of Agrp and Mc1r 1 0.30 0 0.77
37 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
38 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
39 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
40 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
41 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
42 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
43 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7
44 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69
45 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69
46 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68
47 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
48 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 0.52 0.31 0.68
49 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 0.52 0.31 0.68
50 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
51 INT110526 OCA2 Regulation of MC1R 1 0.49 0.43 0.65
52 INT99170 Binding of Mc1r and Tyr 1 0.11 0.2 0.64
53 INT104973 SGCG Regulation of Gene_expression of MC1R 1 0.67 0.17 0.63
54 INT148352 Binding of MC1R and XRCC3 1 0.36 0.34 0.62
55 INT164990 Mif Positive_regulation of Gene_expression of Grina 1 0.24 0.53 0.6
56 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
57 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
58 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
59 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
60 INT71110 Binding of MC1R and NDP 1 0.10 0 0.57
61 INT66020 Binding of Mc1r and RBM25 1 0.00 0.42 0.57
62 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
63 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55
64 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
65 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
66 INT155958 Binding of Kcnk2 and Akap5 1 0.15 0.64 0.48
67 INT195769 MIF Regulation of Gene_expression of TP53I11 1 0.19 1.24 0.47
68 INT93508 Binding of ASIP and Mc1r 1 0.02 0 0.47
69 INT253997 Binding of Cd200r1 and Mif 1 0.03 1.02 0.46
70 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
71 INT73831 Binding of Mc1r and Pld1 1 0.00 0.16 0.45
72 INT147404 NDP Positive_regulation of MC1R 1 0.22 0.25 0.45
73 INT288370 a Positive_regulation of Mc1r 1 0.39 0 0.44
74 INT355571 MIF Positive_regulation of IL8 1 0.04 1.05 0.44
75 INT355568 MIF Positive_regulation of IL6 1 0.05 1.05 0.44
76 INT121364 ZNF398 Negative_regulation of Transcription of MIF 1 0.00 0.9 0.43
77 INT121378 Fancl Positive_regulation of MIF 1 0.01 0.92 0.42
78 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42
79 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
80 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
81 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4
82 INT235887 CALM1 Regulation of Akap5 1 0.00 0 0.39
83 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
84 INT121365 ZNF398 Negative_regulation of Gene_expression of MIF 1 0.00 0.73 0.38
85 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
86 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37
87 INT355570 MIF Positive_regulation of Gene_expression of IL8 1 0.07 1.11 0.36
88 INT235861 Binding of Prkaca and Akap5 1 0.20 0 0.35
89 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
90 INT235862 Binding of Ppp3r2 and Akap5 1 0.01 0 0.35
91 INT32212 POMC Regulation of Gene_expression of Mif 1 0.00 1.01 0.35
92 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
93 INT72953 Mif Positive_regulation of Localization of Prl 1 0.42 0 0.34
94 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
95 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
96 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
97 INT108637 Binding of MC1R and NCOR2 1 0.00 0.1 0.32
98 INT72951 Mif Regulation of Prl 1 0.41 0 0.32
99 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
100 INT112193 MC1R Regulation of Localization of Tnf 1 0.06 0.15 0.31
101 INT353335 F2r Regulation of Positive_regulation of Mif 1 0.27 0.11 0.31
102 INT337085 Binding of Cxcr4 and Mif 1 0.21 1.89 0.3
103 INT97543 Gtf3a Negative_regulation of Mc1r 1 0.05 0.15 0.3
104 INT97549 KITLG Negative_regulation of Mc1r 1 0.01 0.15 0.3
105 INT97546 Pomc Negative_regulation of Mc1r 1 0.40 0.15 0.3
106 INT154194 Binding of KCNK2 and Akap5 1 0.08 0.19 0.29
107 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
108 INT81791 AGRP Negative_regulation of MC1R 2 0.47 0 0.28
109 INT353336 F2r Regulation of Localization of Mif 1 0.23 0.24 0.28
110 INT154674 Binding of MC1R and SNRPE 1 0.38 0.27 0.28
111 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28
112 INT72952 Mif Regulation of Localization of Prl 1 0.28 0 0.27
113 INT254000 Regulation of Binding of Cxcr4 and Mif 1 0.29 0.56 0.27
114 INT353330 F2r Positive_regulation of Positive_regulation of Mif 1 0.46 0 0.26
115 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
116 INT355567 IRF6 Positive_regulation of MIF 1 0.01 0.29 0.25
117 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
118 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
119 INT100280 TXN Positive_regulation of Gene_expression of MC1R 1 0.33 0.22 0.24
120 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
121 INT179492 Binding of Ins1 and Adipoq 1 0.16 1.16 0.23
122 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23
123 INT249760 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Adipoq 1 0.20 0.81 0.22
124 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
125 INT242996 Adipoq Negative_regulation of Transcription of Cd68 1 0.22 0.6 0.21
126 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
127 INT155702 MC1R Positive_regulation of CAMP 1 0.48 0 0.2
128 INT332304 Binding of Il6 and Adipoq 1 0.03 0.4 0.2
129 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2
130 INT352518 Binding of FAT1 and Adipoq 1 0.01 2.79 0.2
131 INT83585 Trh Positive_regulation of Mc1r 1 0.50 0.35 0.2
132 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
133 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
134 INT68852 MC1R Positive_regulation of Localization of POMC 1 0.31 0.47 0.19
135 INT68853 MC1R Regulation of Localization of POMC 1 0.30 0.47 0.19
136 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18
137 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18
138 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
139 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17
140 INT201609 Uvbi1 Positive_regulation of Gene_expression of Mc1r 1 0.05 0.57 0.17
141 INT201608 Binding of Mc1r and Uvbi1 1 0.03 0.93 0.15
142 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15
143 INT201622 Binding of Mark3 and Mc1r 1 0.33 0.74 0.15
144 INT201619 Binding of Cdk11b and Mc1r 1 0.28 0.74 0.15
145 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
146 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
147 INT161095 Agrp Regulation of MC1R 1 0.45 0 0.15
148 INT195770 Binding of CPB1 and MIF 1 0.01 0.47 0.15
149 INT128499 KLK7 Regulation of Gene_expression of MC1R 1 0.01 0.09 0.15
150 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
151 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
152 INT81789 Binding of MC1R and GIPC1 1 0.01 0 0.13
153 INT254002 Binding of Cyp3a23/3a1 and Positive_regulation of Gene_expression of Mif 1 0.08 0.56 0.13
154 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
155 INT77873 Uvbi1 Positive_regulation of MC1R 1 0.01 0.34 0.12
156 INT270663 Adipoq Positive_regulation of Il6 1 0.02 1.05 0.12
157 INT179493 Adipoq Positive_regulation of Ins1 1 0.20 0.99 0.12
158 INT270669 Adipoq Positive_regulation of IL8 1 0.01 1.06 0.12
159 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
160 INT77857 TNF Negative_regulation of MC1R 1 0.35 0.34 0.12
161 INT77858 IL1B Positive_regulation of MC1R 1 0.55 0.34 0.12
162 INT81790 Regulation of Binding of AGRP and MC1R 1 0.26 0 0.12
163 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
164 INT77861 IL1B Regulation of Gene_expression of MC1R 1 0.49 0.31 0.12
165 INT270665 Adipoq Positive_regulation of Ccl2 1 0.07 1.06 0.12
166 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
167 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12
168 INT257467 Fat1 Regulation of Gene_expression of Adipoq 1 0.08 0.56 0.11
169 INT83584 Binding of Mc1r and Trh 1 0.36 0.17 0.1
170 INT240624 Binding of ADIPOQ and Hdl1 1 0.02 0.85 0.1
171 INT151136 MC1R Regulation of Mchr1 1 0.00 0.43 0.1
172 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1
173 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09
174 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09
175 INT222425 Mif Regulation of Tlr4 1 0.01 0.24 0.09
176 INT157274 Adipoq Positive_regulation of ADIPOR1 1 0.00 1.2 0.09
177 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09
178 INT228174 RNU1-1 Positive_regulation of Gene_expression of Adipoq 1 0.12 0.55 0.08
179 INT337090 Mif Positive_regulation of Gene_expression of Mapk1 1 0.10 1.11 0.08
180 INT337087 Negative_regulation of Binding of Mif and Cops5 1 0.13 1.64 0.08
181 INT257466 Psd Negative_regulation of Gene_expression of Adipoq 1 0.22 0.66 0.08
182 INT222514 Mif Regulation of Localization of Il6 1 0.04 0.23 0.08
183 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08
184 INT337088 Binding of Mif and Cops5 1 0.12 1.63 0.08
185 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08
186 INT352517 Binding of INS and Adipoq 1 0.09 1.32 0.07
187 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07
188 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
189 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07
190 INT293973 Binding of POMC and Mc1r 1 0.37 1.8 0.07
191 INT140813 Binding of Retn and Adipoq 1 0.03 1.18 0.06
192 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
193 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05
194 INT353341 F2r Positive_regulation of Negative_regulation of Mif 1 0.49 0 0.05
195 INT228169 Gm2733 Regulation of Adipoq 1 0.00 0.51 0.05
196 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
197 INT236590 Binding of Adipoq and Ncoa2 1 0.15 0.2 0.03
198 INT236587 Binding of Adipoq and Ncoa1 1 0.17 0.2 0.03
199 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03
200 INT236592 Positive_regulation of Binding of Adipoq and Ncoa2 1 0.19 0.2 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein kinase A signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of protein kinase A signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
2 INT21737 Binding of MC1R 129 0.48 45.45 56.54
3 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
4 INT116737 Localization of Mif 63 0.81 52.97 28.11
5 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
6 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28
7 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
8 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
9 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37
10 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
11 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91
12 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78
13 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
14 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
15 INT71030 Binding of Mc1r 39 0.48 10.27 12.02
16 INT72949 Binding of Mif 31 0.46 23.12 11.65
17 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
18 INT117553 Regulation of MIF 10 0.56 12.76 8.67
19 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01
20 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79
21 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
22 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
23 INT517 Regulation of Mif 16 0.62 5.43 6.55
24 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5
25 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
26 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
27 INT121370 Positive_regulation of MIF 22 0.70 17.79 6.08
28 INT516 Negative_regulation of Mif 13 0.59 6.69 6.08
29 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93
30 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
31 INT83442 Negative_regulation of MIF 18 0.57 9.51 5.12
32 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
33 INT174339 Positive_regulation of Localization of Mif 7 0.61 8.27 4.95
34 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92
35 INT121372 Positive_regulation of Gene_expression of MIF 17 0.60 14.78 4.73
36 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54
37 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
38 INT116738 Positive_regulation of Gene_expression of Mif 14 0.68 10.99 3.8
39 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
40 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
41 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
42 INT130226 Positive_regulation of Gene_expression of Mif 4 0.58 15.75 3.03
43 INT61136 Localization of MC1R 8 0.75 2.8 2.85
44 INT163290 Binding of MIF 9 0.31 7.57 2.8
45 INT203137 Binding of Mif 6 0.31 9.46 2.71
46 INT162074 Negative_regulation of Transcription of MC1R 1 0.42 1.05 2.65
47 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
48 INT120011 Localization of MIF 6 0.58 5.72 2.6
49 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
50 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
51 INT40748 Negative_regulation of Mif 6 0.56 8.33 2.46
52 INT155045 Negative_regulation of Gene_expression of Mc1r 7 0.43 1.04 2.33
53 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
54 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
55 INT103304 Positive_regulation of Mif 6 0.48 8.66 2.05
56 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
57 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
58 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91
59 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85
60 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
61 INT162871 Localization of Mc1r 6 0.75 0.61 1.72
62 INT44149 Regulation of Gene_expression of Mif 6 0.54 2.45 1.63
63 INT353326 Negative_regulation of Localization of Mif 1 0.45 1.28 1.59
64 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
65 INT93505 Positive_regulation of Positive_regulation of Mc1r 2 0.70 0.33 1.45
66 INT128003 Negative_regulation of Gene_expression of MC1R 4 0.59 1.56 1.41
67 INT253987 Regulation of Localization of Mif 3 0.43 1.65 1.27
68 INT69875 Negative_regulation of Binding of MC1R 2 0.39 0.37 1.26
69 INT41418 Regulation of Mif 2 0.40 3.86 1.24
70 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15
71 INT121368 Transcription of Mif 5 0.72 2.71 1.15
72 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
73 INT121375 Transcription of MIF 4 0.62 2.85 1.1
74 INT85626 Positive_regulation of Transcription of Mc1r 2 0.50 1.12 1.1
75 INT331103 Regulation of Transcription of Mc1r 1 0.61 1.1 1.09
76 INT102827 Protein_catabolism of Mif 1 0.33 0 1.06
77 INT106860 Regulation of Transcription of MC1R 1 0.45 0 1
78 INT121369 Negative_regulation of Gene_expression of MIF 3 0.50 2.48 0.92
79 INT160140 Regulation of Binding of Adipoq 1 0.37 0.87 0.92
80 INT107474 Positive_regulation of Negative_regulation of Mc1r 1 0.61 0.41 0.89
81 INT121376 Negative_regulation of Transcription of MIF 3 0.37 2.26 0.87
82 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85
83 INT151927 Regulation of Gene_expression of Adipoq 3 0.43 3.32 0.81
84 INT353328 Regulation of Positive_regulation of Mif 1 0.40 0.89 0.81
85 INT125413 Regulation of Regulation of MC1R 1 0.45 0.09 0.78
86 INT142013 Positive_regulation of Regulation of Adipoq 1 0.03 0.65 0.78
87 INT100833 Transcription of Akap12 1 0.64 0.28 0.78
88 INT28020 Binding of Adipoq 10 0.36 11.49 0.77
89 INT2108 Localization of Mif 5 0.77 2.7 0.73
90 INT153419 Regulation of Binding of MC1R 1 0.40 1.38 0.7
91 INT148756 Regulation of Adipoq 10 0.60 7.83 0.67
92 INT32209 Regulation of Gene_expression of Mif 3 0.59 3.41 0.66
93 INT130229 Regulation of Negative_regulation of Mif 1 0.39 1.36 0.66
94 INT353322 Negative_regulation of Positive_regulation of Mif 1 0.38 0.35 0.66
95 INT44148 Negative_regulation of Gene_expression of Mif 6 0.41 0.95 0.64
96 INT118310 Negative_regulation of Positive_regulation of Adipoq 2 0.34 2.47 0.61
97 INT179488 Positive_regulation of Transcription of Adipoq 3 0.37 0.5 0.6
98 INT69701 Positive_regulation of Transcription of MC1R 5 0.46 2 0.51
99 INT337079 Negative_regulation of Gene_expression of Mif 1 0.41 4.17 0.51
100 INT113978 Positive_regulation of Localization of MC1R 1 0.24 1.2 0.51
101 INT227272 Transcription of Adipoq 8 0.64 8.29 0.49
102 INT83430 Positive_regulation of Binding of ADIPOQ 2 0.21 0.85 0.49
103 INT83434 Negative_regulation of Binding of ADIPOQ 1 0.39 1.14 0.45
104 INT308980 Positive_regulation of Negative_regulation of Adipoq 3 0.33 2.3 0.4
105 INT100832 Regulation of Akap12 1 0.25 0.08 0.4
106 INT116735 Positive_regulation of Positive_regulation of Mif 1 0.70 0.61 0.38
107 INT211706 Negative_regulation of Localization of Mc1r 1 0.42 0 0.37
108 INT179491 Transcription of Adipoq 4 0.51 0.98 0.32
109 INT253977 Positive_regulation of Binding of Mif 1 0.48 0.97 0.32
110 INT227268 Negative_regulation of Transcription of Adipoq 4 0.52 4.93 0.3
111 INT121374 Regulation of Gene_expression of MIF 2 0.39 1.01 0.29
112 INT117115 Regulation of Positive_regulation of MC1R 1 0.33 0.38 0.29
113 INT142717 Positive_regulation of Negative_regulation of MC1R 1 0.47 0.36 0.28
114 INT121366 Regulation of Transcription of Mif 1 0.02 0.61 0.24
115 INT121367 Negative_regulation of Transcription of Mif 1 0.02 0.59 0.24
116 INT253941 Positive_regulation of Localization of Adipoq 5 0.24 2.59 0.21
117 INT337077 Positive_regulation of Localization of Mif 1 0.58 0.96 0.21
118 INT288358 Positive_regulation of Binding of Mc1r 1 0.41 0 0.19
119 INT150529 Positive_regulation of Negative_regulation of Adipoq 2 0.37 1.76 0.18
120 INT197872 Regulation of Regulation of Adipoq 3 0.35 1.11 0.17
121 INT28026 Positive_regulation of Binding of Adipoq 1 0.27 0 0.17
122 INT137455 Protein_catabolism of ADIPOQ 1 0.66 0.25 0.17
123 INT228162 Negative_regulation of Localization of Adipoq 1 0.38 1.29 0.17
124 INT308978 Negative_regulation of Regulation of Adipoq 1 0.28 0.92 0.17
125 INT263001 Regulation of Gene_expression of ADIPOQ 5 0.45 3.77 0.16
126 INT163262 Transcription of ADIPOQ 5 0.52 2.81 0.14
127 INT323165 Regulation of Akap5 1 0.10 0.08 0.14
128 INT262999 Negative_regulation of Gene_expression of ADIPOQ 7 0.43 9.52 0.12
129 INT337076 Positive_regulation of Negative_regulation of Mif 1 0.48 1.44 0.12
130 INT157267 Negative_regulation of Localization of Adipoq 1 0.24 0.94 0.09
131 INT327816 Regulation of Positive_regulation of ADIPOQ 1 0.04 1.2 0.09
132 INT323163 Negative_regulation of Akap5 1 0.16 0.1 0.07
133 INT323162 Transcription of Akap5 1 0.19 0.1 0.07
134 INT85629 Regulation of Regulation of Mc1r 1 0.34 0.39 0.07
135 INT353069 Positive_regulation of Positive_regulation of ADIPOQ 1 0.13 1.75 0.05
136 INT245905 Negative_regulation of Transcription of ADIPOQ 1 0.42 1.26 0.05
137 INT228584 Phosphorylation of Adipoq 1 0.38 0.61 0.04
138 INT174340 Protein_catabolism of Mif 1 0.89 0.09 0.04
139 INT251940 Positive_regulation of Transcription of ADIPOQ 1 0.01 0 0.04
140 INT240621 Negative_regulation of Localization of ADIPOQ 1 0.39 0.64 0.03
141 INT353329 Positive_regulation of Regulation of Mif 1 0.36 0 0
142 INT257464 Negative_regulation of Transcription of Adipoq 1 0.41 0.45 0
143 INT263530 Negative_regulation of Positive_regulation of ADIPOQ 1 0.31 1.43 0
144 INT337082 Phosphorylation of Mif 1 0.68 0.97 0
145 INT335614 Positive_regulation of Regulation of MC1R 1 0.23 0 0
146 INT227262 Regulation of Transcription of Adipoq 1 0.35 0.47 0
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