GO:0010812

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Name negative regulation of cell-substrate adhesion
Categary Process
Go Slim No
Go Link GO:0010812
Unique Molecular Interactions 236
Total Molecular Interactions 305
Total Single Events 1952
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cell-substrate adhesion. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of cell-substrate adhesion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
2 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
3 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
4 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
5 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
6 INT111924 Cpb2 Negative_regulation of Positive_regulation of Plg 1 0.02 1.29 0.9
7 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
8 INT153516 PLG Positive_regulation of Pas5a 1 0.57 0.05 0.83
9 INT114844 Lgals1 Positive_regulation of TACR1 1 0.16 0.95 0.82
10 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
11 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 0.06 0.84 0.66
12 INT114845 RET Regulation of Gene_expression of Lgals1 1 0.02 0.84 0.65
13 INT99728 Binding of F13A1 and PLG 4 0.02 2.51 0.63
14 INT12610 IAPP Positive_regulation of LGALS1 1 0.07 0.09 0.61
15 INT12611 IAPP Positive_regulation of Localization of LGALS1 1 0.06 0.09 0.61
16 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
17 INT99736 Binding of PLG and Serpinf2 1 0.01 0.73 0.55
18 INT132372 Lgals1 Positive_regulation of Ephb1 1 0.37 0.25 0.54
19 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
20 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
21 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
22 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
23 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42
24 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
25 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
26 INT181893 TNF Regulation of ANGPT2 1 0.04 1.22 0.33
27 INT128885 Lgals1 Regulation of Pscs 2 0.10 0.6 0.32
28 INT142286 Binding of PLG and Plat 2 0.52 0.7 0.31
29 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
30 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
31 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
32 INT132365 Lgals1 Positive_regulation of Mapk1 1 0.03 0.13 0.28
33 INT137014 Positive_regulation of Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
34 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
35 INT171050 Negative_regulation of F13A1 Regulation of PLG 1 0.02 0.55 0.28
36 INT298348 ANGPT2 Positive_regulation of Phosphorylation of Stat3 1 0.18 0.14 0.28
37 INT137012 Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
38 INT171048 F13A1 Regulation of PLG 1 0.02 0.55 0.27
39 INT132371 Lgals1 Positive_regulation of Positive_regulation of Nfkb1 1 0.34 0.12 0.27
40 INT132374 Lgals1 Positive_regulation of Jun 1 0.15 0.13 0.27
41 INT132363 Lgals1 Positive_regulation of Gene_expression of Ccl2 1 0.26 0.14 0.27
42 INT132362 Lgals1 Positive_regulation of Nfkb1 1 0.47 0.13 0.27
43 INT132366 Lgals1 Positive_regulation of Mapk8 1 0.38 0.13 0.27
44 INT76081 Plg Positive_regulation of Gene_expression of IL6 1 0.03 0.18 0.26
45 INT76082 Plg Regulation of Gene_expression of IL6 1 0.01 0.19 0.26
46 INT180964 PLG Positive_regulation of MMP13 1 0.24 0.45 0.25
47 INT271446 Thy1 Regulation of Col1a1 1 0.05 0.61 0.25
48 INT31097 Binding of Penk and Plg 1 0.29 0.07 0.24
49 INT252784 ROS1 Positive_regulation of Gene_expression of COL1A1 1 0.05 1.86 0.24
50 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
51 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22
52 INT316810 Sparc Regulation of Col1a1 1 0.13 0.48 0.21
53 INT225099 ZNF630 Positive_regulation of Gene_expression of COL1A1 1 0.00 0.17 0.2
54 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
55 INT255259 Binding of Plg and Tsp1 1 0.05 0.84 0.2
56 INT27675 Plg Positive_regulation of Protein_catabolism of F13A1 1 0.00 0.75 0.2
57 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19
58 INT99735 Binding of PLG and Ppp1r1a 1 0.00 0.24 0.19
59 INT99727 Binding of SERPINE1 and PLG 1 0.02 0.24 0.19
60 INT46306 Asrgl1 Positive_regulation of Negative_regulation of Plg 1 0.01 1.07 0.19
61 INT355504 ANGPT2 Positive_regulation of CYBB 1 0.01 0.81 0.18
62 INT265827 ACE Negative_regulation of ANGPT2 1 0.09 0.59 0.17
63 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
64 INT270416 PLAT Negative_regulation of Positive_regulation of PLG 1 0.00 0.48 0.15
65 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
66 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
67 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
68 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15
69 INT188249 PLAT Positive_regulation of PLG 2 0.10 0.86 0.14
70 INT174917 Negative_regulation of PLG Negative_regulation of Positive_regulation of FUT1 1 0.01 0.68 0.13
71 INT157602 Binding of COL1A1 and COL3A1 1 0.04 0 0.13
72 INT99732 Serpinf2 Negative_regulation of PLG 1 0.01 0.24 0.12
73 INT316813 Sparc Negative_regulation of Gene_expression of Col1a1 1 0.13 0.67 0.12
74 INT307075 Tbxas1 Negative_regulation of Negative_regulation of PLG 1 0.01 1.22 0.11
75 INT232017 F12 Positive_regulation of PLG 1 0.03 0.52 0.11
76 INT294445 KLK4 Negative_regulation of COL1A1 1 0.01 0 0.1
77 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1
78 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
79 INT179869 COL1A1 Positive_regulation of SOCS3 1 0.04 0.99 0.1
80 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
81 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
82 INT348686 Plg Positive_regulation of Protein_catabolism of Ecm1 1 0.02 0.17 0.09
83 INT232010 PLG Positive_regulation of TRGC1 1 0.08 0.51 0.09
84 INT58630 Calca Negative_regulation of Positive_regulation of COL1A1 1 0.02 0.23 0.08
85 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
86 INT222983 TNF Positive_regulation of Positive_regulation of COL1A1 1 0.01 0.71 0.08
87 INT218710 MMP1 Regulation of Positive_regulation of Col1a1 1 0.00 0.15 0.07
88 INT247079 Gene_expression of PLAT Positive_regulation of Gene_expression of PLG 1 0.36 0.3 0.07
89 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
90 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07
91 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
92 INT189557 Binding of NOTCH1 and ROBO4 1 0.01 0.22 0.06
93 INT259635 Plau Positive_regulation of PLG 1 0.13 0.22 0.06
94 INT58586 IFNG Positive_regulation of Gene_expression of PLG 1 0.41 0.38 0.06
95 INT355577 ANGPT2 Positive_regulation of MMP1 1 0.04 0.79 0.05
96 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05
97 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
98 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05
99 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05
100 INT220081 Binding of COL1A1 and MMRN1 1 0.00 0.36 0.05
101 INT355605 ANGPT2 Positive_regulation of Mmp9 1 0.10 0.79 0.05
102 INT245833 Plg Negative_regulation of VEGFA 1 0.05 2.21 0.04
103 INT240769 Positive_regulation of Binding of F13A1 and PLG 1 0.02 0.9 0.04
104 INT245826 Plg Regulation of Gene_expression of Serpinf1 1 0.09 1.57 0.04
105 INT328498 Sumo1 Positive_regulation of Plg 1 0.07 0.61 0.04
106 INT180955 PLG Regulation of Positive_regulation of TIMP1 1 0.21 0.38 0.04
107 INT180956 PLG Regulation of Positive_regulation of MMP13 1 0.32 0.38 0.04
108 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04
109 INT349314 Binding of Notch1 and Notch3 1 0.11 0.67 0.04
110 INT245825 Plg Positive_regulation of Gene_expression of Serpinf1 1 0.21 1.01 0.04
111 INT207997 Bel Regulation of Gene_expression of Plg 1 0.00 0 0.04
112 INT180957 Binding of PLG and Regulation of Positive_regulation of MMP13 1 0.14 0.38 0.04
113 INT294217 Binding of PLG and Ldlr 1 0.33 0.06 0.04
114 INT222980 TNF Positive_regulation of Localization of COL1A1 1 0.01 0.56 0.04
115 INT266074 LGALS1 Regulation of Gene_expression of PAEP 1 0.14 0.43 0.03
116 INT276377 Binding of Lgals1 and KRT20 1 0.00 1.11 0.03
117 INT199526 Ceacam1 Negative_regulation of Col1a1 1 0.01 0.06 0.03
118 INT347165 Binding of NOTCH1 and PAX5 1 0.05 0.86 0.03
119 INT222977 Positive_regulation of COL1A1 Positive_regulation of MMP1 1 0.01 0.61 0.03
120 INT57787 Binding of PLG and SGCG 1 0.02 0.13 0.03
121 INT266072 LGALS1 Regulation of Gene_expression of LIF 1 0.17 0.43 0.03
122 INT222987 Positive_regulation of COL1A1 Positive_regulation of Protein_catabolism of MMP1 1 0.01 0.61 0.03
123 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03
124 INT276305 Binding of LGALS1 and KRT20 1 0.01 1.11 0.03
125 INT347163 NOTCH1 Positive_regulation of MSC 1 0.03 0.85 0.03
126 INT266076 LIF Regulation of Gene_expression of LGALS1 1 0.17 0.43 0.03
127 INT170329 Binding of Col4a1 and Col1a1 1 0.03 0.14 0.03
128 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03
129 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03
130 INT266081 PAPPA Regulation of Gene_expression of LGALS1 1 0.24 0.49 0.03
131 INT266077 LGALS1 Regulation of Gene_expression of PAPPA 1 0.24 0.49 0.03
132 INT347164 NOTCH1 Negative_regulation of Gene_expression of EBF1 1 0.03 0.85 0.03
133 INT170331 Binding of Col7a1 and Col1a1 1 0.00 0.14 0.03
134 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
135 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0
136 INT79163 Binding of PLG and CLEC3B 2 0.29 3.18 0
137 INT79164 CLEC3B Positive_regulation of Positive_regulation of PLG 2 0.78 2.67 0
138 INT252820 ELANE Positive_regulation of Gene_expression of COL1A1 1 0.01 0.58 0
139 INT312224 INPP5K Regulation of Negative_regulation of COL1A1 1 0.08 0 0
140 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0
141 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
142 INT245834 Plg Regulation of Gene_expression of VEGFA 1 0.04 1.11 0
143 INT120661 Positive_regulation of Plg Positive_regulation of Serpine1 1 0.00 0 0
144 INT294202 Binding of Plat and Plg 1 0.11 0 0
145 INT272300 Binding of LPA and PLG 1 0.09 0.66 0
146 INT294065 ANGPT2 Positive_regulation of VEGFA 1 0.02 0.1 0
147 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0
148 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
149 INT272301 Negative_regulation of Binding of LPA and PLG 1 0.08 0.68 0
150 INT327873 Postn Regulation of Notch1 1 0.41 0 0
151 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0
152 INT252796 ELANE Regulation of COL1A1 1 0.01 0.57 0
153 INT47482 PRL Regulation of Gene_expression of LGALS1 1 0.19 0 0
154 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
155 INT356083 Binding of App and Notch1 1 0.02 0.2 0
156 INT245823 Binding of Plg and Plg 1 0.03 1.41 0
157 INT180847 Binding of COL1A1 and NID2 1 0.05 0.91 0
158 INT297848 Binding of Fzd4 and Ndp 1 0.04 1.19 0
159 INT193949 Alph1 Positive_regulation of Notch1 1 0.01 0.08 0
160 INT337630 Binding of PLAT and PLG 1 0.07 0.69 0
161 INT57794 Binding of PLAT and Plg 1 0.00 0.15 0
162 INT337627 Binding of CLEC3B and Positive_regulation of Positive_regulation of PLG 1 0.52 1.22 0
163 INT294219 PLG Positive_regulation of Grin1 1 0.44 0 0
164 INT337628 Binding of HGF and PLG 1 0.17 0.69 0
165 INT193950 Alph1 Positive_regulation of Positive_regulation of Notch1 1 0.01 0.07 0
166 INT312214 INPP5K Regulation of Gene_expression of COL1A1 1 0.08 0 0
167 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0
168 INT342910 LPA Negative_regulation of PLG 1 0.15 0.44 0
169 INT268521 Binding of WNT1 and MIR221 1 0.02 1.36 0
170 INT297855 Binding of Ndp and Wnt1 1 0.38 1.18 0
171 INT252773 ROS1 Positive_regulation of COL1A1 1 0.05 0.57 0
172 INT57792 Binding of Plg and Plat 1 0.00 0.07 0
173 INT245822 Plg Negative_regulation of Phosphorylation of Mapk3 1 0.10 2.09 0
174 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
175 INT264727 Binding of Notch1 and Mir199b 1 0.00 0.86 0
176 INT252800 ROS1 Regulation of COL1A1 1 0.05 0.57 0
177 INT252813 ELANE Positive_regulation of COL1A1 1 0.01 0.57 0
178 INT118660 Binding of COL1A1 and GAPDH 1 0.16 0.09 0
179 INT79162 Binding of TNC and PLG 1 0.28 0.23 0
180 INT245827 Plg Negative_regulation of Vegfa 1 0.14 1.3 0
181 INT264728 Mir199b Regulation of Notch1 1 0.01 0.85 0
182 INT96782 FAM176C Regulation of Gene_expression of COL1A1 1 0.32 0.05 0
183 INT180859 Binding of COL1A1 and NID1 1 0.01 0.9 0
184 INT251891 Serpine1 Negative_regulation of Plg 1 0.12 3.13 0
185 INT172839 Binding of ANGPT2 and T2dm2 1 0.00 1.72 0
186 INT337632 PLAU Positive_regulation of PLG 1 0.07 0.36 0
187 INT307074 Binding of Plg and Tbxas1 1 0.00 0.14 0
188 INT285770 Binding of NOTCH1 and Das 1 0.00 1.14 0
189 INT35139 SPANXC Regulation of PLG 1 0.01 0 0
190 INT264726 Binding of Notch1 and Gtf3a 1 0.00 1.68 0
191 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0
192 INT252802 ROS1 Regulation of Gene_expression of COL1A1 1 0.05 0.58 0
193 INT285769 Das Regulation of NOTCH1 1 0.00 0.78 0
194 INT252776 ELANE Regulation of Gene_expression of COL1A1 1 0.01 0.58 0
195 INT206621 Col1a1 Positive_regulation of Col3a1 1 0.00 0.28 0
196 INT120660 Plg Positive_regulation of Serpine1 1 0.00 0 0
197 INT193947 Notch1 Positive_regulation of Alph1 1 0.01 0.07 0
198 INT245835 Plg Negative_regulation of Gene_expression of VEGFA 1 0.05 3.51 0
199 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0
200 INT57795 Binding of F13A1 and Plg 1 0.00 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cell-substrate adhesion. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of cell-substrate adhesion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
2 INT10145 Gene_expression of Plg 28 0.62 12.68 7.46
3 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74
4 INT10610 Negative_regulation of Plg 22 0.40 11.81 6.74
5 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21
6 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
7 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
8 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82
9 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81
10 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
11 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
12 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38
13 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07
14 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05
15 INT54886 Negative_regulation of ANGPT2 25 0.42 9.33 3.79
16 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
17 INT16644 Positive_regulation of Plg 16 0.60 6.38 3.62
18 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
19 INT81229 Binding of COL1A1 24 0.35 12.07 3.3
20 INT25344 Localization of Plg 10 0.57 5 3.27
21 INT16390 Regulation of Plg 13 0.48 6.72 3.2
22 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
23 INT21610 Positive_regulation of ANGPT2 23 0.41 13.28 3.03
24 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
25 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
26 INT68091 Localization of COL1A1 19 0.66 9.13 2.56
27 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
28 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45
29 INT4560 Protein_catabolism of PLG 18 0.96 11.64 2.32
30 INT4398 Regulation of LGALS1 7 0.44 2.16 2.31
31 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3
32 INT12622 Localization of LGALS1 9 0.78 0.55 2.19
33 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18
34 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
35 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1
36 INT17268 Localization of PLG 9 0.78 11.71 2.06
37 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01
38 INT29035 Negative_regulation of Wnt1 3 0.41 1.47 2
39 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98
40 INT59283 Positive_regulation of Gene_expression of Plg 6 0.25 2.36 1.97
41 INT17326 Binding of Plg 14 0.43 11.72 1.94
42 INT114840 Gene_expression of Lgals1 9 0.76 3.94 1.94
43 INT90219 Gene_expression of Lgals1 6 0.20 3.47 1.94
44 INT120857 Localization of Col1a1 10 0.71 2.33 1.93
45 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
46 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
47 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81
48 INT90217 Positive_regulation of Lgals1 1 0.15 2.06 1.78
49 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
50 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52
51 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
52 INT90218 Localization of Lgals1 3 0.18 1.77 1.51
53 INT142719 Binding of Col1a1 7 0.34 5.83 1.47
54 INT16388 Protein_catabolism of Plg 6 0.79 3.46 1.4
55 INT17325 Negative_regulation of Protein_catabolism of Plg 1 0.32 0 1.37
56 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34
57 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
58 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
59 INT41381 Positive_regulation of Gene_expression of Plg 8 0.44 3.29 1.3
60 INT112650 Positive_regulation of Col1a1 3 0.30 5.96 1.3
61 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24
62 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23
63 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
64 INT18422 Regulation of Plg 6 0.45 1.71 1.22
65 INT140033 Positive_regulation of Gene_expression of Col1a1 6 0.14 3.68 1.2
66 INT141834 Negative_regulation of Gene_expression of WNT1 3 0.57 1.31 1.2
67 INT110780 Localization of Notch1 2 0.06 0.47 1.19
68 INT12621 Positive_regulation of Localization of LGALS1 2 0.08 0.07 1.17
69 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
70 INT3046 Gene_expression of LGALS1 20 0.75 12.48 1.11
71 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
72 INT114838 Positive_regulation of Lgals1 2 0.54 0.89 1.01
73 INT156614 Regulation of Gene_expression of COL1A1 6 0.33 2.51 0.99
74 INT94393 Localization of ANGPT2 8 0.17 5.02 0.96
75 INT129997 Protein_catabolism of Col1a1 5 0.96 3.43 0.96
76 INT6833 Binding of Notch1 4 0.36 0.05 0.94
77 INT97768 Positive_regulation of Gene_expression of PLG 5 0.49 2.49 0.89
78 INT56972 Regulation of ANGPT2 6 0.44 3.48 0.86
79 INT8888 Regulation of Col1a1 4 0.13 1.97 0.86
80 INT35141 Regulation of PLG 6 0.44 2.64 0.85
81 INT141835 Negative_regulation of WNT1 2 0.41 1.02 0.83
82 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82
83 INT58765 Positive_regulation of Gene_expression of ANGPT2 11 0.38 8.2 0.81
84 INT228046 Negative_regulation of Lgals1 1 0.10 0.45 0.81
85 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8
86 INT30926 Regulation of Gene_expression of Plg 11 0.45 2.14 0.78
87 INT154877 Binding of LGALS1 3 0.19 2.73 0.78
88 INT79169 Binding of PLG 10 0.47 5.88 0.72
89 INT37544 Binding of ANGPT2 9 0.19 6.51 0.69
90 INT58764 Negative_regulation of Gene_expression of ANGPT2 7 0.34 2.64 0.69
91 INT13702 Protein_catabolism of Plg 4 0.12 0.88 0.69
92 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
93 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66
94 INT114839 Regulation of Gene_expression of Lgals1 1 0.35 0.83 0.65
95 INT4394 Positive_regulation of LGALS1 6 0.50 0.46 0.64
96 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
97 INT114841 Localization of Lgals1 1 0.58 0.72 0.6
98 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
99 INT90216 Transcription of Lgals1 1 0.11 0.67 0.59
100 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
101 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55
102 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
103 INT46340 Positive_regulation of Negative_regulation of Plg 2 0.15 1.71 0.54
104 INT68092 Negative_regulation of Localization of COL1A1 1 0.48 0 0.53
105 INT58591 Negative_regulation of Positive_regulation of PLG 4 0.42 2.46 0.51
106 INT149297 Protein_catabolism of NOTCH1 2 0.15 0.87 0.51
107 INT8886 Regulation of Transcription of Col1a1 1 0.04 0 0.5
108 INT96864 Localization of Plg 7 0.67 2.07 0.48
109 INT151903 Positive_regulation of Positive_regulation of PLG 3 0.45 1.53 0.48
110 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45
111 INT17269 Negative_regulation of Localization of PLG 1 0.03 0.54 0.45
112 INT228057 Positive_regulation of WNT1 1 0.49 1.8 0.44
113 INT158577 Negative_regulation of Gene_expression of Plg 7 0.17 3.36 0.43
114 INT128882 Negative_regulation of Lgals1 2 0.42 0.96 0.41
115 INT320812 Positive_regulation of Localization of COL1A1 1 0.05 1.04 0.4
116 INT39640 Negative_regulation of Gene_expression of Plg 2 0.25 1.13 0.39
117 INT92242 Binding of Plg 2 0.32 1.09 0.37
118 INT96865 Regulation of Positive_regulation of Plg 1 0.01 0.05 0.36
119 INT216379 Positive_regulation of Gene_expression of WNT1 5 0.30 3.1 0.34
120 INT163709 Regulation of Negative_regulation of COL1A1 1 0.29 0.93 0.34
121 INT152276 Regulation of Positive_regulation of PLG 2 0.44 1.53 0.32
122 INT132361 Binding of Lgals1 1 0.35 0.36 0.32
123 INT51230 Negative_regulation of Localization of LGALS1 1 0.02 0 0.31
124 INT254811 Localization of Col1a1 3 0.29 1.39 0.3
125 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3
126 INT291615 Negative_regulation of Localization of Col1a1 1 0.06 1.28 0.3
127 INT128883 Positive_regulation of Gene_expression of Lgals1 1 0.68 0.77 0.29
128 INT126512 Negative_regulation of Gene_expression of Col1a1 3 0.39 2.2 0.27
129 INT180969 Positive_regulation of Protein_catabolism of PLG 1 0.36 0.47 0.27
130 INT56971 Negative_regulation of Negative_regulation of ANGPT2 1 0.31 0 0.26
131 INT176464 Protein_catabolism of Col1a1 1 0.19 0.83 0.26
132 INT200522 Negative_regulation of Negative_regulation of PLG 2 0.41 1.53 0.24
133 INT271432 Positive_regulation of Regulation of Col1a1 1 0.10 0.61 0.24
134 INT265833 Negative_regulation of Binding of ANGPT2 1 0.08 0.82 0.24
135 INT153877 Positive_regulation of Binding of Plg 1 0.44 0.41 0.23
136 INT316049 Regulation of Regulation of Notch1 1 0.03 0.92 0.23
137 INT225109 Regulation of Localization of COL1A1 1 0.05 0.41 0.23
138 INT146397 Regulation of Gene_expression of ANGPT2 2 0.28 0.49 0.22
139 INT216887 Positive_regulation of Localization of Plg 1 0.04 0.13 0.22
140 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21
141 INT218694 Binding of Col1a1 2 0.21 1.52 0.21
142 INT276320 Binding of Lgals1 2 0.03 1.51 0.21
143 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2
144 INT193945 Binding of Notch1 7 0.15 1.28 0.19
145 INT53833 Negative_regulation of Positive_regulation of LGALS1 1 0.39 0 0.19
146 INT25345 Negative_regulation of Localization of Plg 1 0.08 0.81 0.19
147 INT279261 Positive_regulation of Gene_expression of LGALS1 1 0.45 0.78 0.19
148 INT130096 Positive_regulation of Positive_regulation of NOTCH1 2 0.50 1.15 0.18
149 INT120859 Positive_regulation of Localization of Col1a1 1 0.16 0.05 0.18
150 INT45721 Transcription of Plg 1 0.20 0.16 0.18
151 INT353965 Negative_regulation of Gene_expression of Wnt1 1 0.41 0 0.18
152 INT47484 Regulation of Gene_expression of LGALS1 2 0.38 0.73 0.17
153 INT187816 Positive_regulation of Transcription of Col1a1 1 0.06 0.82 0.17
154 INT217569 Binding of Wnt1 2 0.36 1.07 0.15
155 INT265834 Negative_regulation of Localization of ANGPT2 1 0.08 0.96 0.15
156 INT130000 Positive_regulation of Protein_catabolism of Col1a1 1 0.49 1.15 0.15
157 INT187815 Transcription of Col1a1 1 0.09 0.76 0.15
158 INT73297 Positive_regulation of Transcription of Col1a1 2 0.32 3.12 0.14
159 INT4396 Negative_regulation of LGALS1 2 0.51 6.32 0.14
160 INT39633 Negative_regulation of Positive_regulation of Plg 2 0.22 0.4 0.14
161 INT146398 Transcription of ANGPT2 1 0.32 0.15 0.14
162 INT257290 Negative_regulation of Transcription of COL1A1 3 0.27 1.64 0.13
163 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13
164 INT338718 Positive_regulation of Localization of NOTCH1 1 0.04 0.6 0.13
165 INT316042 Negative_regulation of Gene_expression of Notch1 1 0.27 1.7 0.12
166 INT265832 Regulation of Localization of ANGPT2 1 0.08 0.39 0.12
167 INT216835 Positive_regulation of Localization of Plg 1 0.03 0.27 0.11
168 INT200599 Positive_regulation of Positive_regulation of Plg 3 0.07 2.11 0.1
169 INT266241 Regulation of Wnt1 1 0.26 0.59 0.09
170 INT141999 Regulation of Gene_expression of NOTCH1 2 0.04 0.97 0.08
171 INT39641 Regulation of Gene_expression of Plg 1 0.26 0 0.08
172 INT327728 Regulation of Gene_expression of Notch1 2 0.27 0.73 0.07
173 INT35144 Negative_regulation of Gene_expression of PLG 3 0.29 0.98 0.06
174 INT97920 Negative_regulation of Angpt2 1 0.26 0 0.06
175 INT97918 Localization of Angpt2 1 0.31 0 0.06
176 INT97921 Negative_regulation of Localization of Angpt2 1 0.19 0 0.06
177 INT193845 Localization of Notch1 2 0.78 0.32 0.05
178 INT193850 Regulation of Localization of Notch1 1 0.14 0.33 0.05
179 INT179886 Negative_regulation of Negative_regulation of COL1A1 1 0.05 0.5 0.05
180 INT304937 Transcription of Wnt1 1 0.22 0.65 0.05
181 INT287956 Regulation of WNT1 2 0.26 2.38 0.04
182 INT298336 Phosphorylation of Notch1 1 0.02 0.13 0.04
183 INT328495 Positive_regulation of Binding of Plg 1 0.13 0.62 0.04
184 INT311648 Regulation of Gene_expression of Wnt1 1 0.39 0.09 0.04
185 INT287936 Regulation of Gene_expression of WNT1 1 0.20 1.06 0.04
186 INT180589 Phosphorylation of COL1A1 3 0.34 0.37 0.03
187 INT350959 Transcription of NOTCH1 2 0.05 0.84 0.03
188 INT328496 Positive_regulation of Protein_catabolism of Plg 1 0.14 0.68 0.03
189 INT222999 Positive_regulation of Positive_regulation of COL1A1 1 0.04 0.61 0.03
190 INT180582 Negative_regulation of Phosphorylation of COL1A1 1 0.07 0 0.03
191 INT180579 Negative_regulation of Protein_catabolism of COL1A1 1 0.07 0 0.03
192 INT202633 Positive_regulation of Gene_expression of Wnt1 3 0.43 0.85 0
193 INT232397 Protein_catabolism of Notch1 3 0.64 1.56 0
194 INT206617 Regulation of Gene_expression of Col1a1 2 0.06 0.49 0
195 INT257285 Positive_regulation of Transcription of COL1A1 2 0.29 1.23 0
196 INT331173 Negative_regulation of Localization of Plg 1 0.02 0.67 0
197 INT297242 Transcription of Notch1 1 0.19 0.25 0
198 INT264724 Negative_regulation of Positive_regulation of Notch1 1 0.03 0.77 0
199 INT116543 Regulation of Negative_regulation of ANGPT2 1 0.09 0 0
200 INT245725 Positive_regulation of Negative_regulation of Col1a1 1 0.21 0.7 0
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