GO:0010841

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Name positive regulation of circadian sleep/wake cycle, wakefulness
Categary Process
Go Slim No
Go Link GO:0010841
Unique Molecular Interactions 90
Total Molecular Interactions 123
Total Single Events 829
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of circadian sleep/wake cycle, wakefulness. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of circadian sleep/wake cycle, wakefulness. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
2 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
3 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
4 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
5 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
6 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
7 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
8 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
9 INT18247 Binding of CRH and GNRH1 1 0.51 1.57 0.95
10 INT5451 CRH Regulation of POMC 2 0.28 0.39 0.85
11 INT260894 CRH Regulation of Localization of MMP3 1 0.21 0.36 0.85
12 INT90382 Binding of CRH and GH1 1 0.34 0.05 0.81
13 INT260895 CRH Regulation of MMP1 1 0.11 0.31 0.74
14 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64
15 INT120206 Binding of UTS2R and Il1 1 0.17 1.28 0.59
16 INT34311 Regulation of CRH Positive_regulation of POMC 1 0.24 0 0.59
17 INT120207 Binding of UTS2R and Il1f5 1 0.09 1.28 0.59
18 INT61505 ABAT Negative_regulation of Localization of CRH 1 0.09 0 0.57
19 INT55872 Binding of ADRA1D and CRH 1 0.26 0 0.54
20 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
21 INT25027 CRH Negative_regulation of Negative_regulation of FSHR 1 0.25 0 0.42
22 INT105771 CRH Negative_regulation of Localization of GNRH1 1 0.35 0.56 0.39
23 INT37249 CRH Positive_regulation of PPY 1 0.04 0.34 0.39
24 INT260893 CRH Positive_regulation of Gene_expression of IL8 1 0.28 0.05 0.31
25 INT111813 CREM Regulation of Regulation of CRH 1 0.12 0 0.3
26 INT107747 CRH Negative_regulation of HSD17B1 1 0.40 0.41 0.3
27 INT260896 CRH Positive_regulation of Localization of MMP9 1 0.15 0.15 0.3
28 INT35080 CRH Negative_regulation of Localization of FSHR 1 0.03 0 0.29
29 INT35079 CRH Negative_regulation of Localization of PLOD1 1 0.06 0 0.29
30 INT264782 Binding of CRH and CRHR1 1 0.02 0.06 0.28
31 INT31508 FEM1B Positive_regulation of Gene_expression of CRH 1 0.54 0 0.28
32 INT31505 CRH Positive_regulation of Gene_expression of FEM1B 1 0.54 0 0.28
33 INT180194 CRH Positive_regulation of CRHR2 1 0.02 0.24 0.27
34 INT180195 CRH Regulation of CRHR2 1 0.01 0.24 0.27
35 INT81252 Uts2r Regulation of Gene_expression of Oprm1 1 0.01 0.07 0.24
36 INT139271 Binding of CRH and POMC 1 0.35 1.1 0.22
37 INT148995 Uts2 Positive_regulation of CDNF 1 0.00 0.41 0.2
38 INT100084 Binding of CRH and CRHR2 1 0.32 1.11 0.19
39 INT153322 CRH Positive_regulation of Positive_regulation of CRHR1 1 0.31 0.12 0.19
40 INT25495 AVP Positive_regulation of CRH 1 0.14 0 0.19
41 INT297393 TRIM6-TRIM34 Regulation of CRH 1 0.01 1.42 0.19
42 INT25497 AVP Positive_regulation of Localization of CRH 1 0.14 0 0.19
43 INT34346 CRH Regulation of DBI 1 0.01 0.25 0.17
44 INT107750 CRH Regulation of Transcription of HSD17B1 1 0.19 0.21 0.17
45 INT328379 Ghrl Positive_regulation of CRH 1 0.16 1.17 0.16
46 INT206212 UTS2R Positive_regulation of CD24 1 0.09 0.71 0.15
47 INT57500 CREM Positive_regulation of Regulation of CRH 1 0.39 0 0.14
48 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
49 INT276767 NR3C1 Regulation of Gene_expression of UTS2R 1 0.00 1.09 0.13
50 INT12830 Regulation of CRH Regulation of PENK 1 0.10 0.41 0.12
51 INT311399 Binding of Celf1 and Uts2r 1 0.08 0.26 0.12
52 INT12828 CRH Regulation of PENK 1 0.10 0.41 0.12
53 INT327704 Uts2r Positive_regulation of 4930579C15Rik 1 0.03 0.48 0.1
54 INT350694 Uts2r Negative_regulation of Negative_regulation of Rc3h1 1 0.05 0.79 0.1
55 INT327709 Uts2r Positive_regulation of Comt 1 0.14 0.47 0.1
56 INT198620 CRH Negative_regulation of GH1 1 0.05 0.47 0.05
57 INT198619 CRH Negative_regulation of TRH 1 0.18 0.47 0.05
58 INT321651 Binding of Slc6a3 and Uts2r 1 0.04 0.06 0.05
59 INT270568 Binding of UTS2R and STAT6 1 0.04 2 0.05
60 INT328308 CRH Negative_regulation of KISS1 1 0.02 0 0.05
61 INT198618 CRH Negative_regulation of Localization of SST 1 0.07 0.53 0.05
62 INT317181 Binding of Htt and Uts2r 1 0.04 0 0.05
63 INT321654 Binding of Slc6a4 and Uts2r 1 0.05 0.07 0.05
64 INT327710 Binding of Gopc and Uts2r 1 0.03 0.41 0.04
65 INT327711 Binding of Drd2 and Uts2r 1 0.07 0.41 0.04
66 INT221952 UTS2R Regulation of Protein_catabolism of CDK5R1 1 0.10 0.3 0.04
67 INT221953 UTS2R Positive_regulation of Gene_expression of CDK5R1 1 0.16 0.23 0.04
68 INT247080 Binding of CRH and CRHBP 1 0.11 0.2 0.03
69 INT221962 UTS2R Regulation of Gene_expression of CDK5R1 1 0.09 0.43 0.03
70 INT221961 Binding of ELAVL1 and UTS2R 1 0.00 0.26 0.03
71 INT328304 POMC Positive_regulation of Localization of CRH 1 0.07 0.22 0.03
72 INT328369 Ghrl Negative_regulation of CRH 1 0.16 0.15 0
73 INT121541 Positive_regulation of Binding of CRH and CCL7 1 0.09 0.07 0
74 INT337404 Binding of UTS2R and WG 1 0.01 0.2 0
75 INT343701 Binding of UTS2R and LOC100364739 1 0.00 0 0
76 INT144261 CRH Positive_regulation of SEMA6A 1 0.56 0 0
77 INT350710 Uts2r Negative_regulation of Gene_expression of MIR21 1 0.01 0 0
78 INT121542 Binding of CRH and CCL7 1 0.07 0.07 0
79 INT262706 Uts2r Positive_regulation of Bace1 1 0.10 0.39 0
80 INT111768 IL2 Positive_regulation of Localization of CRH 1 0.02 0 0
81 INT350707 Uts2r Negative_regulation of Gene_expression of Foxp3 1 0.03 0 0
82 INT221442 Binding of UTS2R and CREG1 1 0.01 0.92 0
83 INT327705 Binding of Sugt1 and Uts2r 1 0.00 0.19 0
84 INT221957 Binding of UTS2R and GOPC 1 0.02 0.08 0
85 INT233400 COPD Regulation of CRH 1 0.11 1.67 0
86 INT237461 Binding of UTS2R and TTPA 1 0.01 0.63 0
87 INT51878 CCBE1 Regulation of CRH 1 0.01 1.06 0
88 INT274433 Binding of Zfpm2 and Uts2r 1 0.08 0.17 0
89 INT262700 Uts2r Regulation of Gene_expression of Bace1 1 0.12 0.21 0
90 INT263319 Binding of Gsk3b and Uts2r 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of circadian sleep/wake cycle, wakefulness. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of circadian sleep/wake cycle, wakefulness. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5454 Localization of CRH 124 0.79 79.18 41.53
2 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74
3 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12
4 INT5452 Regulation of CRH 56 0.62 15.32 12.42
5 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37
6 INT20922 Positive_regulation of Localization of CRH 18 0.67 11.12 6.79
7 INT5455 Negative_regulation of Localization of CRH 16 0.49 7.31 6.41
8 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7
9 INT7559 Transcription of CRH 37 0.69 4.84 3.61
10 INT25029 Positive_regulation of Positive_regulation of CRH 7 0.49 6.77 3.52
11 INT63534 Binding of CRH 23 0.47 6.84 3.43
12 INT23763 Regulation of Localization of CRH 6 0.48 0.22 3.04
13 INT12835 Negative_regulation of Positive_regulation of CRH 6 0.42 3.15 1.76
14 INT115963 Negative_regulation of Gene_expression of CRH 9 0.59 4.53 1.48
15 INT34312 Regulation of Gene_expression of CRH 6 0.46 1.97 1.48
16 INT16854 Gene_expression of Uts2r 17 0.26 3.1 1.31
17 INT51744 Regulation of Uts2 8 0.56 0.23 0.86
18 INT184678 Regulation of Uts2r 7 0.14 2.57 0.85
19 INT244897 Binding of Uts2r 7 0.11 1.8 0.84
20 INT31046 Negative_regulation of Uts2 6 0.42 0.44 0.76
21 INT97763 Negative_regulation of Binding of CRH 2 0.42 0 0.76
22 INT317151 Transcription of Uts2r 4 0.24 1.16 0.51
23 INT194127 Negative_regulation of Transcription of CRH 2 0.41 0.16 0.51
24 INT12833 Regulation of Regulation of CRH 2 0.27 1.32 0.44
25 INT7558 Regulation of Transcription of CRH 1 0.60 0.06 0.35
26 INT51743 Gene_expression of Uts2 5 0.76 0.3 0.33
27 INT53854 Regulation of Negative_regulation of Uts2 3 0.44 0 0.29
28 INT67420 Negative_regulation of Negative_regulation of CRH 2 0.43 0.81 0.28
29 INT310382 Positive_regulation of Binding of Uts2r 1 0.03 0.19 0.27
30 INT317149 Localization of Uts2r 1 0.07 0 0.25
31 INT28717 Regulation of Positive_regulation of CRH 2 0.29 1.4 0.24
32 INT327694 Positive_regulation of Transcription of Uts2r 1 0.17 0.26 0.21
33 INT12834 Positive_regulation of Transcription of CRH 3 0.67 1 0.2
34 INT208039 Gene_expression of UTS2R 14 0.43 4.95 0.13
35 INT183206 Regulation of UTS2R 5 0.13 3.17 0.12
36 INT264799 Regulation of Binding of CRH 1 0.04 0 0.11
37 INT53855 Positive_regulation of Gene_expression of Uts2 1 0.49 0 0.11
38 INT51742 Binding of Uts2 1 0.34 0 0.08
39 INT208046 Positive_regulation of UTS2R 3 0.45 0.7 0.07
40 INT311337 Positive_regulation of Uts2r 3 0.12 1.34 0.05
41 INT183205 Binding of UTS2R 3 0.11 1.33 0.05
42 INT222268 Transcription of UTS2R 2 0.44 0.21 0.05
43 INT222265 Regulation of Transcription of UTS2R 1 0.29 0 0.05
44 INT327271 Negative_regulation of Uts2r 2 0.13 0.42 0.04
45 INT263258 Protein_catabolism of Uts2r 1 0.05 0.47 0.04
46 INT274423 Positive_regulation of Gene_expression of Uts2r 3 0.09 0.58 0
47 INT208049 Regulation of Gene_expression of UTS2R 2 0.16 0.24 0
48 INT265296 Negative_regulation of Gene_expression of UTS2R 1 0.04 0.16 0
49 INT263261 Regulation of Gene_expression of Uts2r 1 0.04 0 0
50 INT208042 Localization of UTS2R 1 0.06 0.45 0
51 INT208041 Positive_regulation of Localization of UTS2R 1 0.04 0.45 0
52 INT141560 Positive_regulation of Uts2 1 0.50 0 0
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