GO:0010862

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Name positive regulation of pathway-restricted SMAD protein phosphorylation
Categary Process
Go Slim No
Go Link GO:0010862
Unique Molecular Interactions 447
Total Molecular Interactions 580
Total Single Events 3790
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of pathway-restricted SMAD protein phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of pathway-restricted SMAD protein phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
2 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
3 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
4 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
5 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
6 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
7 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
8 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
9 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
10 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
11 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
12 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
13 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
14 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
15 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
16 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
17 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
18 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
19 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
20 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
21 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
22 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
23 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
24 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
25 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
26 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
27 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
28 INT169477 TGFB3 Positive_regulation of Spink3 1 0.02 1.83 0.89
29 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
30 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
31 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
32 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
33 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
34 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
35 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
36 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
37 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
38 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
39 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77
40 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
41 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
42 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
43 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
44 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
45 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
46 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67
47 INT32719 ENG Regulation of LH 2 0.00 0 0.64
48 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
49 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
50 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
51 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
52 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
53 INT89144 TGFB1 Regulation of Gene_expression of Tcstv1 1 0.00 0.53 0.53
54 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
55 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
56 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
57 INT92918 Atp6v0a2 Negative_regulation of Gene_expression of Tgfb1 1 0.01 0.83 0.52
58 INT171897 Binding of Bmpr2 and Il1 1 0.03 0.84 0.52
59 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
60 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
61 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
62 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
63 INT138151 Tgfb1 Regulation of IL1B 1 0.01 0.29 0.49
64 INT89145 TGFB1 Positive_regulation of Tcstv1 1 0.00 0.49 0.49
65 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
66 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
67 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
68 INT138153 Tgfb1 Regulation of IL6 1 0.01 0.29 0.49
69 INT302643 ARSA Positive_regulation of Localization of TGFB1 1 0.08 0.12 0.49
70 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
71 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
72 INT102213 Binding of ENG and HP 1 0.01 0 0.47
73 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
74 INT138146 Tgfb1 Regulation of Mmp3 1 0.00 0.23 0.46
75 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
76 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45
77 INT169478 TGFB3 Positive_regulation of Tgfa 1 0.01 0.9 0.44
78 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43
79 INT169465 TGFB3 Positive_regulation of MTG1 1 0.03 0.89 0.43
80 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
81 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
82 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
83 INT81991 Bmpr2 Positive_regulation of Gene_expression of ODF1 1 0.03 1.59 0.41
84 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
85 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
86 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
87 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39
88 INT336340 Glp2r Positive_regulation of Gene_expression of TGFB1 1 0.14 0.67 0.39
89 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 0.06 0.57 0.38
90 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
91 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34
92 INT137018 Tgfb1 Positive_regulation of Pscs 1 0.01 0.43 0.34
93 INT137013 Tgfb1 Positive_regulation of Gene_expression of Pscs 1 0.01 0.43 0.34
94 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
95 INT333457 Binding of PPARA and TGFB1 1 0.04 0 0.34
96 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
97 INT299549 Binding of TGFB1 and Egf 1 0.02 0.32 0.32
98 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
99 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
100 INT55404 Binding of ENG and Th 1 0.02 0 0.3
101 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
102 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
103 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
104 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
105 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29
106 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
107 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
108 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
109 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
110 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
111 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
112 INT137032 Il6 Positive_regulation of Localization of Tgfb1 1 0.04 0.51 0.27
113 INT83395 Binding of IL1RN and Tgfb1 1 0.01 0.17 0.26
114 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
115 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
116 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
117 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
118 INT139094 Csf2 Regulation of Tgfb1 1 0.42 0.58 0.26
119 INT271450 Thy1 Regulation of TGFB1 1 0.00 0.62 0.25
120 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
121 INT222981 TGFB1 Positive_regulation of Gene_expression of MMRN1 1 0.09 1.62 0.25
122 INT225098 ZNF630 Regulation of Localization of TGFB1 1 0.01 0.44 0.24
123 INT225105 ZNF630 Regulation of TGFB1 1 0.01 0.44 0.24
124 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
125 INT9720 Binding of TGFB1 and Egf 1 0.01 0 0.23
126 INT168710 Ifng Regulation of TGFB1 1 0.00 0.3 0.23
127 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
128 INT112596 Tgfb1 Negative_regulation of Negative_regulation of Mptp1 1 0.26 0.72 0.22
129 INT112595 Tgfb1 Negative_regulation of Gene_expression of Mptp1 1 0.27 0.72 0.22
130 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
131 INT346458 ROS1 Regulation of Localization of TGFB1 1 0.00 1.71 0.21
132 INT114905 TGFB1 Positive_regulation of Transcription of COL7A1 1 0.02 0.08 0.21
133 INT92691 Tgfb1 Positive_regulation of Ctgf 1 0.16 0.91 0.2
134 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
135 INT92692 Tgfb1 Positive_regulation of Gene_expression of Fn1 1 0.27 0.91 0.2
136 INT92693 Tgfb1 Positive_regulation of Fgf2 1 0.32 0.9 0.2
137 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19
138 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19
139 INT14869 Binding of EGF and TGFB3 1 0.14 0.69 0.19
140 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
141 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19
142 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
143 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19
144 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19
145 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19
146 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19
147 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19
148 INT350718 Mir106b Regulation of TGFB1 1 0.00 0.42 0.18
149 INT350603 MIR25 Regulation of TGFB1 1 0.01 0.42 0.18
150 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
151 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
152 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
153 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
154 INT296037 TGFB1 Positive_regulation of IL17A 1 0.02 0 0.17
155 INT160083 TGFB1 Positive_regulation of Gene_expression of L1CAM 1 0.16 1.53 0.16
156 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16
157 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
158 INT123180 Bmp6 Positive_regulation of Lamtor1 1 0.01 0.61 0.14
159 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
160 INT239323 Binding of Nr1h2 and Positive_regulation of Positive_regulation of Tgfb1 1 0.00 3.71 0.14
161 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
162 INT123194 Bmp6 Positive_regulation of TAF9 1 0.18 0.61 0.14
163 INT299550 TGFB1 Negative_regulation of Glul 1 0.01 0.34 0.14
164 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
165 INT123193 Bmp6 Positive_regulation of Negative_regulation of TAF9 1 0.18 0.61 0.14
166 INT254855 Agt Positive_regulation of Tgfb1 1 0.03 0.18 0.13
167 INT296031 Negative_regulation of TGFB1 Regulation of IL10 1 0.01 1.01 0.13
168 INT296027 TGFB1 Regulation of TH1L 1 0.02 1 0.13
169 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
170 INT299547 Negative_regulation of Binding of TGFB1 and Egf 1 0.02 0.1 0.13
171 INT69687 Tgfb1 Positive_regulation of Gene_expression of Il4 1 0.23 0 0.12
172 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
173 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12
174 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
175 INT296028 TGFB1 Regulation of IL10 1 0.01 1 0.12
176 INT69688 Tgfb1 Positive_regulation of Rel 1 0.50 0 0.12
177 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
178 INT296038 TGFB1 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11
179 INT299551 Regulation of Binding of TGFB1 and Egf 1 0.03 0.21 0.11
180 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11
181 INT269788 Binding of FN1 and TGFB1 1 0.00 0.29 0.1
182 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
183 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
184 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
185 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
186 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
187 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
188 INT116789 Bsg Positive_regulation of Gene_expression of Tgfb1 1 0.00 0.18 0.09
189 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
190 INT127143 Binding of IL6 and TGFB1 2 0.01 0.16 0.08
191 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
192 INT296041 Binding of TGFB1 and IL21 1 0.01 0.05 0.08
193 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
194 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
195 INT134832 TGFB1 Regulation of YAP1 1 0.16 0.68 0.08
196 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
197 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
198 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
199 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
200 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of pathway-restricted SMAD protein phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of pathway-restricted SMAD protein phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
2 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
3 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
4 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
5 INT10799 Localization of ENG 63 0.78 18.67 27.28
6 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
7 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
8 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
9 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
10 INT7674 Regulation of ENG 42 0.30 11.41 14.44
11 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
12 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
13 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
14 INT23375 Binding of ENG 17 0.47 6.02 6.46
15 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
16 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
17 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
18 INT89104 Binding of TGFB1 29 0.44 13.67 5.12
19 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37
20 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
21 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
22 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6
23 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53
24 INT56300 Negative_regulation of Gene_expression of TGFB1 13 0.41 4.87 3.5
25 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
26 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
27 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
28 INT69216 Positive_regulation of Tgfb1 14 0.49 5.84 3.29
29 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24
30 INT85149 Negative_regulation of Gene_expression of Tgfb1 11 0.42 4.73 3.19
31 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
32 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
33 INT39990 Negative_regulation of BMP6 1 0.59 0 3.05
34 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
35 INT112667 Negative_regulation of Tgfb1 9 0.58 2.72 2.97
36 INT14872 Gene_expression of TGFB3 15 0.55 12.45 2.96
37 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92
38 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
39 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74
40 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
41 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46
42 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
43 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
44 INT12086 Regulation of Localization of TGFB1 4 0.43 1.65 2.09
45 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
46 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
47 INT74824 Positive_regulation of Transcription of TGFB1 6 0.67 2.58 1.84
48 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
49 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
50 INT86712 Regulation of Gene_expression of Tgfb1 2 0.15 2.03 1.65
51 INT84310 Regulation of Gene_expression of Tgfb1 7 0.29 6.6 1.63
52 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55
53 INT120071 Negative_regulation of Positive_regulation of Tgfb1 4 0.16 4.06 1.55
54 INT110992 Positive_regulation of Positive_regulation of TGFB1 4 0.50 3.01 1.51
55 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
56 INT228040 Negative_regulation of Transcription of Tgfb1 1 0.04 0.49 1.42
57 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4
58 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
59 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
60 INT173892 Phosphorylation of TGFB1 8 0.79 2.63 1.3
61 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
62 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27
63 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
64 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24
65 INT39991 Negative_regulation of Negative_regulation of BMP6 1 0.43 0 1.24
66 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
67 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
68 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
69 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
70 INT120858 Positive_regulation of Localization of Tgfb1 7 0.68 1.46 1.03
71 INT128717 Regulation of Tgfb1 6 0.61 1.94 0.94
72 INT123852 Negative_regulation of Positive_regulation of Tgfb1 3 0.28 1.69 0.94
73 INT52213 Regulation of Localization of Bmp6 1 0.44 0.39 0.93
74 INT114664 Binding of BMP2 12 0.37 6.54 0.91
75 INT52215 Localization of Bmp6 1 0.73 0.37 0.88
76 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
77 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
78 INT139322 Negative_regulation of Negative_regulation of Tgfb1 1 0.53 0 0.86
79 INT85148 Transcription of Tgfb1 5 0.52 1.91 0.84
80 INT102848 Negative_regulation of Localization of Tgfb1 3 0.10 1.81 0.83
81 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
82 INT139323 Positive_regulation of Negative_regulation of Tgfb1 1 0.45 0 0.79
83 INT14871 Binding of TGFB3 3 0.13 1.2 0.78
84 INT141150 Localization of BMP7 4 0.56 2.84 0.76
85 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
86 INT291617 Negative_regulation of Transcription of TGFB1 2 0.15 0.61 0.76
87 INT90790 Regulation of Localization of Tgfb1 2 0.29 0.46 0.75
88 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
89 INT337046 Positive_regulation of Binding of Tgfb1 1 0.30 1.1 0.69
90 INT121302 Positive_regulation of Localization of Tgfb1 5 0.07 1.91 0.67
91 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66
92 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
93 INT111891 Regulation of Transcription of Tgfb1 1 0.04 0.68 0.64
94 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
95 INT39994 Positive_regulation of BMP6 1 0.50 0 0.63
96 INT39992 Positive_regulation of Negative_regulation of BMP6 1 0.47 0 0.62
97 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
98 INT114910 Negative_regulation of Positive_regulation of TGFB1 3 0.34 0.92 0.6
99 INT39993 Regulation of BMP6 2 0.39 0.29 0.6
100 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
101 INT173891 Positive_regulation of Phosphorylation of TGFB1 4 0.49 2 0.59
102 INT138140 Protein_catabolism of Tgfb1 2 0.09 0.87 0.59
103 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
104 INT90939 Positive_regulation of Eng 9 0.64 4.62 0.57
105 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
106 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
107 INT110924 Regulation of BMPR2 3 0.17 1.75 0.54
108 INT69683 Positive_regulation of Transcription of Tgfb1 1 0.67 0 0.53
109 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
110 INT85808 Localization of BMP2 7 0.77 1.94 0.51
111 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
112 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
113 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
114 INT52214 Regulation of Gene_expression of Bmp6 1 0.37 0.19 0.46
115 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
116 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
117 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
118 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
119 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
120 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
121 INT27659 Localization of TGFB3 3 0.29 0.52 0.4
122 INT292484 Negative_regulation of TGFBR1 3 0.19 0.75 0.39
123 INT123185 Positive_regulation of Gene_expression of Bmp6 2 0.24 1.28 0.38
124 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
125 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
126 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
127 INT69680 Positive_regulation of Positive_regulation of Tgfb1 3 0.67 1.04 0.35
128 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34
129 INT150330 Gene_expression of BMPR2 7 0.29 4.22 0.34
130 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34
131 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34
132 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
133 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
134 INT92100 Binding of Smad4 5 0.31 2.23 0.3
135 INT14873 Positive_regulation of Gene_expression of TGFB3 2 0.25 1.14 0.29
136 INT311881 Regulation of Positive_regulation of Tgfbr1 1 0.22 0.97 0.29
137 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28
138 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28
139 INT251327 Regulation of Binding of Bmpr2 1 0.20 2.27 0.27
140 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25
141 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
142 INT251228 Phosphorylation of Tgfb1 4 0.15 1.18 0.24
143 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
144 INT299545 Positive_regulation of Binding of TGFB1 2 0.06 1.08 0.22
145 INT81981 Negative_regulation of Bmpr2 4 0.27 2.88 0.21
146 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
147 INT61823 Positive_regulation of TGFB3 2 0.01 1.64 0.2
148 INT150332 Negative_regulation of Gene_expression of BMPR2 1 0.01 0 0.2
149 INT150331 Positive_regulation of Gene_expression of BMPR2 2 0.02 0.59 0.19
150 INT311886 Phosphorylation of Tgfbr1 1 0.40 0.7 0.19
151 INT123935 Positive_regulation of BMPR2 3 0.26 1.65 0.18
152 INT131558 Protein_catabolism of ENG 1 0.01 0 0.18
153 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
154 INT277935 Binding of SMAD4 4 0.28 1.12 0.17
155 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
156 INT339267 Negative_regulation of BMP7 1 0.43 0.55 0.17
157 INT85330 Positive_regulation of Regulation of Tgfb1 1 0.41 0.67 0.17
158 INT122201 Binding of Tgfb1 1 0.16 0.17 0.17
159 INT118459 Regulation of Bmp7 3 0.43 0.25 0.15
160 INT189604 Negative_regulation of BMPR2 2 0.26 0.95 0.15
161 INT133100 Negative_regulation of Localization of Tgfb1 2 0.28 1.48 0.15
162 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
163 INT139977 Regulation of Smad4 1 0.16 1.41 0.15
164 INT192082 Localization of BMPR2 1 0.32 0.55 0.15
165 INT297455 Positive_regulation of Gdf2 1 0.01 0.75 0.15
166 INT201968 Positive_regulation of Bmp7 2 0.43 1.11 0.14
167 INT90940 Binding of Eng 5 0.35 1.92 0.13
168 INT302662 Negative_regulation of Negative_regulation of TGFBR1 1 0.14 0 0.13
169 INT166623 Binding of BMPR2 1 0.29 0.35 0.13
170 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
171 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
172 INT81940 Regulation of TGFB3 3 0.14 0.45 0.1
173 INT149266 Gene_expression of BMP6 2 0.77 0.56 0.1
174 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
175 INT287912 Localization of BMP4 1 0.18 1.13 0.1
176 INT201962 Transcription of Bmpr2 6 0.37 3.51 0.09
177 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
178 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
179 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
180 INT14738 Negative_regulation of Regulation of TGFB1 2 0.41 0.81 0.09
181 INT26064 Regulation of Positive_regulation of ENG 1 0.01 0.1 0.09
182 INT254819 Regulation of Negative_regulation of Tgfbr1 1 0.15 1.2 0.09
183 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
184 INT90941 Negative_regulation of Eng 1 0.31 0.25 0.09
185 INT325510 Transcription of Smad4 1 0.67 0.16 0.09
186 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
187 INT331623 Negative_regulation of Binding of TGFB1 1 0.02 1.02 0.08
188 INT149264 Positive_regulation of Gene_expression of BMP6 1 0.69 0.34 0.08
189 INT355332 Localization of Bmp7 1 0.09 1.92 0.08
190 INT254332 Negative_regulation of Gene_expression of Bmpr2 3 0.22 2.41 0.07
191 INT316570 Binding of BMP7 3 0.37 0.95 0.07
192 INT149265 Localization of BMP6 1 0.74 0.31 0.07
193 INT287244 Transcription of BMP7 1 0.66 0.15 0.07
194 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
195 INT287242 Positive_regulation of Transcription of BMP7 1 0.64 0.15 0.07
196 INT311885 Positive_regulation of Gene_expression of Tgfbr1 2 0.44 0.35 0.06
197 INT254790 Localization of Smad4 2 0.37 0.54 0.06
198 INT139093 Regulation of Negative_regulation of Tgfb1 1 0.27 0.44 0.06
199 INT153022 Negative_regulation of Bmp7 1 0.01 0.27 0.06
200 INT265338 Regulation of Eng 2 0.42 0.94 0.05
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