GO:0010870

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Name positive regulation of receptor biosynthetic process
Categary Process
Go Slim No
Go Link GO:0010870
Unique Molecular Interactions 368
Total Molecular Interactions 498
Total Single Events 3644
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of receptor biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of receptor biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
3 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
4 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
5 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
6 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
7 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
8 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
9 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
10 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
11 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
12 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
13 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
14 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
15 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
16 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
17 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
18 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
19 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
20 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
21 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
22 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
23 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
24 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
25 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
26 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
27 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
28 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
29 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
30 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
31 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
32 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
33 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
34 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
35 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
36 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
37 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
38 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
39 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
40 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
41 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
42 INT135176 Myst2 Regulation of Gene_expression of Hif1a 1 0.24 0.47 0.47
43 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
44 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
45 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
46 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
47 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
48 INT135178 Myst2 Regulation of Hif1a 1 0.24 0.44 0.44
49 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
50 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
51 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
52 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
53 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
54 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
55 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
56 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
57 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
58 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
59 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
60 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
61 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34
62 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
63 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
64 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
65 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
66 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
67 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
68 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
69 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
70 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
71 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
72 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
73 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
74 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
75 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
76 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
77 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
78 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
79 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
80 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
81 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
82 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
83 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
84 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
85 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
86 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
87 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23
88 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
89 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
90 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
91 INT162850 ISYNA1 Positive_regulation of Localization of HIF1A 1 0.05 0.25 0.21
92 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
93 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
94 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
95 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
96 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
97 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
98 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
99 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
100 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
101 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
102 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18
103 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
104 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
105 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
106 INT143440 HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.52 0.45 0.17
107 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
108 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
109 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
110 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
111 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
112 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
113 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
114 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
115 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
116 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
117 INT181898 Binding of ROS1 and Positive_regulation of HIF1A 1 0.02 0.82 0.15
118 INT181897 ROS1 Negative_regulation of HIF1A 1 0.03 0.83 0.15
119 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15
120 INT181895 ROS1 Positive_regulation of HIF1A 1 0.03 0.78 0.15
121 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
122 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
123 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
124 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
125 INT181894 ROS1 Regulation of HIF1A 1 0.02 0.82 0.13
126 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
127 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
128 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
129 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
130 INT323434 Osr1 Regulation of Hif1a 1 0.01 0.79 0.13
131 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13
132 INT323433 Osr1 Regulation of Protein_catabolism of Hif1a 1 0.01 0.8 0.13
133 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
134 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
135 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
136 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
137 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
138 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12
139 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
140 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
141 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
142 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
143 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
144 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
145 INT323431 Binding of Hif1a and Vhl 1 0.07 0.68 0.12
146 INT249923 Binding of Pah and Hif1a 1 0.31 1.16 0.12
147 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
148 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
149 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11
150 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1
151 INT102244 IL36RN Positive_regulation of Binding of HIF1A 1 0.06 1.07 0.1
152 INT102245 TNF Positive_regulation of Binding of HIF1A 1 0.18 1.09 0.1
153 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
154 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
155 INT102248 INS Positive_regulation of Binding of HIF1A 1 0.13 0.96 0.1
156 INT181570 Binding of Edn1 and Mapk1 1 0.13 2.72 0.1
157 INT294455 KLK4 Negative_regulation of HIF1A 1 0.01 0 0.1
158 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
159 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
160 INT102246 Binding of HIF1A and INS 1 0.07 0.96 0.1
161 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
162 INT173061 Binding of HIF1A and LILRA3 1 0.03 1.24 0.09
163 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
164 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09
165 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09
166 INT173062 Binding of HIF1A and VHLL 1 0.04 1.26 0.09
167 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
168 INT173057 Positive_regulation of HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.24 1.49 0.08
169 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
170 INT249920 Negative_regulation of Binding of Pah and Hif1a 1 0.37 0.76 0.08
171 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08
172 INT181583 Binding of Edn1 and Positive_regulation of NOS1 1 0.02 0.86 0.08
173 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
174 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08
175 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
176 INT178078 Positive_regulation of Binding of DBP and HIF1A 1 0.00 1 0.08
177 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
178 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
179 INT178103 Binding of DBP and HIF1A 1 0.00 0.99 0.07
180 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07
181 INT182269 EDN1 Positive_regulation of Localization of MMP1 1 0.17 0.31 0.07
182 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
183 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07
184 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
185 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
186 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
187 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07
188 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07
189 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
190 INT247578 Hif1a Regulation of VEGFA 1 0.02 1.59 0.07
191 INT192907 Edn1 Positive_regulation of Ednrb 1 0.10 0.35 0.07
192 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
193 INT191219 Edn1 Positive_regulation of Amigo2 1 0.06 1.26 0.07
194 INT324896 Ece1 Positive_regulation of Negative_regulation of Edn1 1 0.19 0.42 0.07
195 INT172381 AVP Positive_regulation of Localization of EDN1 1 0.01 0.34 0.07
196 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07
197 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
198 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07
199 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
200 INT191216 Binding of Edn1 and Cotl1 1 0.14 0.63 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of receptor biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of receptor biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
6 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
7 INT5048 Binding of Edn1 55 0.47 18.86 19.16
8 INT9191 Localization of EDN1 94 0.81 57.01 14.78
9 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
10 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
11 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
12 INT6365 Localization of Edn1 56 0.81 18.84 13.83
13 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
14 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
15 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
16 INT6361 Localization of Edn1 30 0.81 19.09 9.7
17 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
18 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
19 INT10237 Binding of EDN1 40 0.48 16 8.48
20 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
21 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
22 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
23 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07
24 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
25 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45
26 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44
27 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
28 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
29 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23
30 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
31 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05
32 INT53374 Binding of Edn1 17 0.43 11.66 2.98
33 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88
34 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
35 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68
36 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
37 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17
38 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13
39 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
40 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
41 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
42 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
43 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
44 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
45 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
46 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63
47 INT153723 Negative_regulation of Gene_expression of Hif1a 2 0.41 1.25 1.58
48 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51
49 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
50 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5
51 INT143443 Localization of HIF1A 14 0.78 10.93 1.49
52 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
53 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
54 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
55 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
56 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
57 INT232785 Localization of Hif1a 8 0.46 10.37 1.33
58 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
59 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
60 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
61 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
62 INT68339 Gene_expression of HDAC2 3 0.51 1.71 1.1
63 INT102249 Binding of HIF1A 39 0.36 30.47 1.04
64 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
65 INT317791 Localization of HDAC2 2 0.50 2.31 0.99
66 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
67 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
68 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
69 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
70 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
71 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
72 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83
73 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
74 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8
75 INT135169 Binding of Hif1a 22 0.47 12.48 0.79
76 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
77 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
78 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
79 INT169731 Negative_regulation of Localization of HIF1A 1 0.57 0.57 0.73
80 INT100380 Negative_regulation of Positive_regulation of HIF1A 2 0.57 1.6 0.72
81 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
82 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
83 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
84 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
85 INT176184 Positive_regulation of Gene_expression of Nr1h3 2 0.49 0 0.68
86 INT128795 Regulation of Positive_regulation of HIF1A 2 0.61 0.95 0.67
87 INT176218 Gene_expression of Nr1h3 2 0.65 0 0.67
88 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
89 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
90 INT233837 Negative_regulation of Hif1a 9 0.26 12.72 0.65
91 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
92 INT112708 Negative_regulation of Hif1a 5 0.38 2.7 0.64
93 INT100382 Positive_regulation of Protein_catabolism of HIF1A 2 0.45 1.75 0.64
94 INT312882 Negative_regulation of Hdac6 1 0.52 1.86 0.63
95 INT100377 Negative_regulation of Protein_catabolism of HIF1A 1 0.57 0.9 0.63
96 INT136465 Regulation of Hif1a 5 0.39 7.05 0.62
97 INT112363 Regulation of Gene_expression of HIF1A 6 0.60 2.28 0.61
98 INT155353 Positive_regulation of Phosphorylation of HIF1A 1 0.49 2.58 0.61
99 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
100 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
101 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
102 INT135173 Regulation of Gene_expression of Hif1a 3 0.44 2.49 0.53
103 INT134758 Positive_regulation of Transcription of Hif1a 2 0.33 2.44 0.53
104 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
105 INT153065 Regulation of Hif1a 8 0.28 8.57 0.51
106 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
107 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5
108 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49
109 INT153067 Positive_regulation of Positive_regulation of Hif1a 10 0.49 11.83 0.47
110 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
111 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
112 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
113 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
114 INT247549 Transcription of Hif1a 7 0.42 8.77 0.36
115 INT333916 Negative_regulation of HDAC2 2 0.18 1.38 0.36
116 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
117 INT320784 Protein_catabolism of Hif1a 3 0.61 2.41 0.34
118 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
119 INT272882 Positive_regulation of Binding of Hdac2 2 0.20 1.12 0.32
120 INT335077 Regulation of Nr1h3 1 0.44 0.1 0.32
121 INT335072 Regulation of Regulation of Nr1h3 1 0.44 0.1 0.32
122 INT247563 Negative_regulation of Positive_regulation of Hif1a 1 0.16 9.12 0.32
123 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
124 INT177856 Negative_regulation of Gene_expression of HDAC2 1 0.19 0.12 0.3
125 INT312879 Regulation of Hdac6 1 0.55 0.76 0.29
126 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
127 INT173105 Transcription of HIF1A 6 0.67 4.47 0.28
128 INT232786 Positive_regulation of Localization of Hif1a 2 0.31 2.63 0.27
129 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
130 INT312887 Gene_expression of Hdac6 1 0.60 1.28 0.25
131 INT312883 Regulation of Regulation of Hdac6 1 0.40 0.38 0.24
132 INT173103 Positive_regulation of Transcription of HIF1A 3 0.49 2.11 0.21
133 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
134 INT176207 Positive_regulation of Nr1h3 2 0.45 0 0.2
135 INT247564 Positive_regulation of Transcription of Hif1a 1 0.19 2.05 0.2
136 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
137 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
138 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
139 INT266991 Regulation of Hdac2 2 0.07 0.74 0.15
140 INT312881 Positive_regulation of Hdac6 1 0.45 0.67 0.15
141 INT249919 Regulation of Regulation of Hif1a 2 0.29 1.81 0.14
142 INT249908 Binding of Hif1a 2 0.31 1.48 0.14
143 INT249913 Regulation of Gene_expression of Hif1a 2 0.32 1.82 0.13
144 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
145 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
146 INT196934 Negative_regulation of Hdac1 4 0.39 1.41 0.11
147 INT331783 Regulation of Negative_regulation of Hdac1 1 0.04 0.98 0.11
148 INT105392 Positive_regulation of Binding of HIF1A 5 0.45 3.83 0.1
149 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
150 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
151 INT153064 Positive_regulation of Regulation of Hif1a 1 0.45 1.52 0.1
152 INT260478 Negative_regulation of Positive_regulation of Hif1a 2 0.30 1.23 0.09
153 INT260462 Negative_regulation of Binding of Hif1a 1 0.30 1.13 0.09
154 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
155 INT260451 Positive_regulation of Positive_regulation of Hif1a 1 0.36 1.01 0.08
156 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
157 INT331786 Negative_regulation of Binding of Hdac2 1 0.11 1.2 0.08
158 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08
159 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08
160 INT297157 Negative_regulation of Negative_regulation of Hif1a 1 0.03 0.54 0.07
161 INT247560 Negative_regulation of Negative_regulation of Hif1a 1 0.16 2.06 0.07
162 INT143444 Positive_regulation of Localization of HIF1A 3 0.45 1.26 0.06
163 INT247553 Regulation of Negative_regulation of Hif1a 1 0.17 1.36 0.06
164 INT297158 Regulation of Localization of Hif1a 1 0.03 0.32 0.06
165 INT247559 Regulation of Positive_regulation of Hif1a 2 0.23 1.64 0.05
166 INT247555 Positive_regulation of Binding of Hif1a 2 0.31 1.15 0.05
167 INT331784 Negative_regulation of Positive_regulation of Hdac2 1 0.11 0.52 0.05
168 INT312877 Positive_regulation of Negative_regulation of Hdac6 1 0.45 0 0.05
169 INT297156 Localization of Hif1a 1 0.06 0.32 0.05
170 INT322464 Regulation of Localization of Hif1a 1 0.28 0.59 0.05
171 INT155174 Regulation of Regulation of HIF1A 3 0.24 1.57 0.04
172 INT173079 Positive_regulation of Regulation of HIF1A 1 0.26 0.64 0.04
173 INT249918 Regulation of Protein_catabolism of Hif1a 1 0.29 0.4 0.04
174 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04
175 INT249916 Protein_catabolism of Hif1a 1 0.64 0.39 0.04
176 INT105389 Negative_regulation of Binding of HIF1A 4 0.42 3.2 0.03
177 INT312888 Phosphorylation of Hdac6 1 0.73 0 0.03
178 INT328554 Regulation of HDAC1 1 0.26 1.12 0.03
179 INT331778 Regulation of Phosphorylation of Hdac2 1 0.11 0.49 0.03
180 INT331787 Phosphorylation of Hdac2 1 0.20 0.49 0.03
181 INT277595 Localization of Hdac1 4 0.73 0.81 0
182 INT189607 Regulation of Binding of HIF1A 2 0.06 1.49 0
183 INT261751 Regulation of Hdac1 2 0.41 0 0
184 INT298673 Gene_expression of HOXA5 2 0.49 2.33 0
185 INT312873 Negative_regulation of Gene_expression of Hdac6 1 0.38 0 0
186 INT350509 Phosphorylation of HDAC1 1 0.25 0.62 0
187 INT337478 Binding of HDAC2 1 0.14 0.07 0
188 INT312885 Binding of Hdac6 1 0.43 0 0
189 INT319154 Transcription of Hdac1 1 0.66 0 0
190 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0
191 INT320543 Positive_regulation of Gene_expression of HOXA5 1 0.44 0.57 0
192 INT312874 Regulation of Phosphorylation of Hdac6 1 0.40 0 0
193 INT189594 Negative_regulation of Transcription of HIF1A 1 0.05 0.94 0
194 INT249915 Regulation of Positive_regulation of Hif1a 1 0.29 0.85 0
195 INT277596 Phosphorylation of Hdac1 1 0.61 0.59 0
196 INT112706 Negative_regulation of Gene_expression of Hif1a 1 0.08 0 0
197 INT319169 Negative_regulation of Transcription of Hdac1 1 0.54 0 0
198 INT312876 Negative_regulation of Transcription of Hdac6 1 0.38 0 0
199 INT322450 Negative_regulation of Binding of Hif1a 1 0.26 0.32 0
200 INT280682 Positive_regulation of Transcription of Edn1 1 0.34 0 0
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