GO:0010951

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Name negative regulation of endopeptidase activity
Categary Process
Go Slim No
Go Link GO:0010951
Unique Molecular Interactions 835
Total Molecular Interactions 1152
Total Single Events 9802
Pain Genes Associated 73

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02
2 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
3 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
4 INT275398 Binding of ITIH4 and Htatsf1 1 0.02 5.05 2.24
5 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
6 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
7 INT113550 Binding of FN1 and VTN 6 0.30 5.24 1.91
8 INT128654 ITIH4 Regulation of Gene_expression of CCL16 1 0.02 2.69 1.79
9 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
10 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
11 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
12 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
13 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
14 INT351366 LPA Positive_regulation of Rab38 1 0.00 0.95 1.53
15 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
16 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
17 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
18 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
19 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
20 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
21 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
22 INT343949 SERPINE2 Positive_regulation of Positive_regulation of Slco1c1 1 0.00 0.59 1.27
23 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
24 INT46022 tp Positive_regulation of SERPINB1 1 0.04 0 1.26
25 INT123260 Binding of Gabrg2 and Serpini1 1 0.02 0.63 1.16
26 INT123261 Gabrg2 Regulation of Serpini1 1 0.01 0.63 1.16
27 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
28 INT348398 LPA Positive_regulation of Pik3cb 1 0.04 0.88 1.14
29 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
30 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
31 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
32 INT343950 SERPINE2 Positive_regulation of Slco1c1 1 0.00 1.63 1.07
33 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
34 INT106810 ZNF398 Positive_regulation of RECK 1 0.02 0.5 1.01
35 INT106809 ZNF398 Positive_regulation of Transcription of RECK 1 0.02 0.5 1.01
36 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
37 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
38 INT275409 Binding of ITIH4 and Cxcr4 1 0.09 2.87 0.97
39 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
40 INT128655 ITIH4 Regulation of Gene_expression of CCR3 1 0.36 1.45 0.92
41 INT128653 ITIH4 Regulation of Gene_expression of MIP 1 0.23 1.44 0.92
42 INT156989 LPA Positive_regulation of Gene_expression of EFNB1 1 0.00 0.91 0.92
43 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
44 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
45 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
46 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84
47 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
48 INT106808 RECK Negative_regulation of MMP2 1 0.40 0.5 0.83
49 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
50 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
51 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
52 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
53 INT16507 Binding of LPA and Crp 1 0.00 0.78 0.78
54 INT16488 Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
55 INT16491 Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
56 INT16494 Binding of LPA and Serpinf2 1 0.00 0.78 0.78
57 INT351364 LPA Positive_regulation of Trpv1 1 0.02 1.15 0.78
58 INT16492 Positive_regulation of Binding of LPA and Serpinf2 1 0.00 0.78 0.78
59 INT16506 Positive_regulation of Binding of LPA and Crp 1 0.00 0.78 0.78
60 INT16498 Binding of ADRA1D and LPA 1 0.10 0.78 0.78
61 INT16493 Positive_regulation of Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
62 INT16497 Positive_regulation of Binding of ADRA1D and LPA 1 0.10 0.78 0.78
63 INT16489 Positive_regulation of Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
64 INT113549 Binding of VTN and alphavbeta3 integrin receptor 1 0.09 2.05 0.76
65 INT168507 Binding of SPINK1 and Ctrc 1 0.03 0.93 0.76
66 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76
67 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
68 INT117639 Serpini1 Negative_regulation of Cpox 1 0.00 0.64 0.72
69 INT137139 ITIH4 Positive_regulation of OPRM1 1 0.37 0.67 0.72
70 INT177359 Serpinc1 Positive_regulation of CSRP1 1 0.00 0.97 0.72
71 INT224580 Gene_expression of IL18 Positive_regulation of SERPINH1 1 0.00 1.34 0.7
72 INT126779 Binding of Serpinc1 and F8 1 0.00 1.52 0.69
73 INT126781 Binding of F10 and Serpinc1 1 0.00 1.51 0.69
74 INT351367 LPA Regulation of Trpv1 1 0.01 0.83 0.69
75 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
76 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
77 INT120484 ITIH4 Positive_regulation of Il1 1 0.01 0.62 0.68
78 INT130355 spc Regulation of Serpine1 1 0.14 0.2 0.66
79 INT137142 Binding of ITIH4 and Positive_regulation of Localization of TNF 1 0.40 0.71 0.66
80 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
81 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
82 INT130354 Adcy10 Regulation of Serpine1 1 0.17 0.2 0.66
83 INT329589 Serpina5 Positive_regulation of PTX3 1 0.03 1.52 0.66
84 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
85 INT92045 Binding of ALB and SERPINA1 1 0.30 1.37 0.64
86 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
87 INT167795 Negative_regulation of LPA Negative_regulation of Mag 1 0.01 0.84 0.64
88 INT167794 LPA Negative_regulation of Mag 1 0.01 0.77 0.63
89 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
90 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
91 INT299286 VEGFA Positive_regulation of PI3 1 0.16 0.46 0.6
92 INT137138 ITIH4 Positive_regulation of Positive_regulation of OPRM1 1 0.42 0.55 0.59
93 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
94 INT142990 Serpinc1 Positive_regulation of Phosphorylation of S1pr1 1 0.03 0.05 0.59
95 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
96 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
97 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
98 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
99 INT223924 Cux1 Regulation of Gene_expression of Serpina1 1 0.04 0.15 0.57
100 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
101 INT137141 Binding of HIVEP1 and ITIH4 2 0.16 1.44 0.56
102 INT139429 LPA Positive_regulation of Negative_regulation of MBP 1 0.00 0.78 0.56
103 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
104 INT227911 Binding of VTN and MMRN1 1 0.01 1.16 0.56
105 INT137897 Binding of SERPINH1 and IL36B 1 0.00 0.64 0.55
106 INT99736 Binding of PLG and Serpinf2 1 0.01 0.73 0.55
107 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54
108 INT125086 LPA Positive_regulation of Rtn4 1 0.00 0.36 0.54
109 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
110 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
111 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
112 INT129869 SERPINA6 Regulation of AVP 1 0.25 2.33 0.54
113 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
114 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
115 INT130561 NCKIPSD Regulation of SERPINF2 1 0.22 0 0.52
116 INT223925 Drd1a Positive_regulation of Gene_expression of Serpina1 1 0.01 0 0.51
117 INT167583 ENPP2 Positive_regulation of Gene_expression of LPA 1 0.08 0.93 0.51
118 INT63512 Vip Positive_regulation of Localization of SERPINE2 1 0.63 1.84 0.5
119 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
120 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
121 INT55553 Avp Regulation of Serpina6 1 0.02 0 0.49
122 INT36143 Binding of SERPINH1 and HLA-B 1 0.00 0.66 0.49
123 INT175326 SERPINH1 Regulation of Pnlip 1 0.00 0.53 0.49
124 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
125 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49
126 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
127 INT348402 LPA Positive_regulation of Gene_expression of Ptgs2 1 0.01 0.62 0.48
128 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
129 INT229127 SPINK1 Positive_regulation of PRSS1 1 0.53 1.59 0.48
130 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
131 INT173293 LPA Positive_regulation of OR1S1 1 0.03 0.15 0.47
132 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
133 INT341625 Binding of SPINK1 and CTRC 1 0.41 1.22 0.46
134 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
135 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45
136 INT106001 Binding of PLAUR and VTN 2 0.23 1.5 0.45
137 INT159538 SERPINB1 Regulation of Gene_expression of CALCA 1 0.01 0.8 0.45
138 INT262815 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Gfap 1 0.39 2.73 0.44
139 INT151958 Negative_regulation of Agt Positive_regulation of Agtrap 1 0.39 0 0.44
140 INT48715 PTGER2 Regulation of Gene_expression of SERPINE1 1 0.21 0.6 0.44
141 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 0.42 0.59 0.44
142 INT151959 Agt Positive_regulation of Agtrap 1 0.63 0 0.44
143 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
144 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
145 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
146 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
147 INT262819 Gene_expression of Serpinf1 Negative_regulation of Binding of 1190002H23Rik 1 0.05 2.66 0.43
148 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
149 INT54135 Binding of F13A1 and LPA 2 0.00 0.71 0.42
150 INT161654 Gsr Regulation of Gpx1 1 0.14 0.85 0.42
151 INT54136 Negative_regulation of Binding of F13A1 and LPA 1 0.00 0.42 0.42
152 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42
153 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42
154 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42
155 INT83915 Il1b Positive_regulation of SERPINA3 1 0.02 0.5 0.41
156 INT69109 Acot1 Regulation of Gene_expression of Serpine2 1 0.04 0 0.4
157 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
158 INT153116 Binding of SPINK1 and Abpa 1 0.01 1.32 0.4
159 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
160 INT346148 Binding of ADM and VTN 1 0.15 0.93 0.39
161 INT4975 Binding of ITIH4 and MAG 1 0.44 2.24 0.39
162 INT64384 Agt Negative_regulation of Son 1 0.26 0 0.39
163 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
164 INT346142 Positive_regulation of Binding of ADM and VTN 1 0.20 0.93 0.39
165 INT113551 Binding of ITGA3 and VTN 1 0.02 1.03 0.38
166 INT48714 PTGER2 Negative_regulation of Gene_expression of SERPINE1 1 0.15 0.28 0.38
167 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
168 INT281154 ITIH4 Positive_regulation of Cxcr4 1 0.09 0.71 0.37
169 INT99738 Binding of F13A1 and Serpinf2 1 0.00 0.49 0.37
170 INT262824 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Il18 1 0.39 1.56 0.37
171 INT113555 Negative_regulation of Binding of FN1 and VTN 1 0.23 0.87 0.37
172 INT113559 Binding of PLAU and VTN 1 0.28 0.82 0.37
173 INT113554 Negative_regulation of Binding of PLAU and VTN 1 0.32 0.87 0.37
174 INT281155 Binding of ITIH4 and Ddc 1 0.09 1.27 0.37
175 INT113547 Negative_regulation of Binding of PLAUR and VTN 1 0.26 0.87 0.37
176 INT281153 Binding of ITIH4 and Cd4 1 0.10 0.91 0.37
177 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
178 INT21828 Binding of POMC and Serpinb1a 1 0.02 0 0.36
179 INT53257 CALCRL Negative_regulation of Binding of Agt 1 0.00 0 0.36
180 INT44112 Agt Regulation of Penk 1 0.08 0 0.35
181 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
182 INT4638 Binding of Agt and Adarb1 3 0.01 0 0.34
183 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
184 INT193784 ITIH4 Positive_regulation of YWHAZ 1 0.04 1.21 0.34
185 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34
186 INT330119 Agt Positive_regulation of Gene_expression of Bdkrb1 1 0.37 0.63 0.34
187 INT162157 Binding of SGCG and Agt 1 0.33 0.35 0.33
188 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33
189 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
190 INT311265 RENBP Regulation of IL8 1 0.03 1.59 0.33
191 INT311263 RENBP Regulation of TNF 1 0.01 1.59 0.33
192 INT147436 Agt Positive_regulation of Gene_expression of Ros1 1 0.02 0.5 0.33
193 INT56090 TNF Regulation of SERPINE1 1 0.43 0.41 0.33
194 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33
195 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
196 INT298472 LPA Positive_regulation of Gene_expression of CXCL16 1 0.05 0.41 0.32
197 INT311266 RENBP Regulation of IL6 1 0.02 1.59 0.32
198 INT44127 Agt Negative_regulation of DSPP 1 0.02 0 0.32
199 INT330182 Binding of ITIH2 and BRD4 1 0.05 0.37 0.32
200 INT56115 Agt Regulation of Lhb 1 0.16 0 0.32

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
2 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
3 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
4 INT1158 Regulation of Agt 106 0.61 29.4 30.29
5 INT9650 Gene_expression of LPA 141 0.75 104.57 29
6 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
7 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05
8 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
9 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
10 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
11 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
12 INT2066 Localization of Agt 56 0.80 9.95 16.25
13 INT4977 Binding of ITIH4 60 0.46 42.48 15.65
14 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
15 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78
16 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18
17 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89
18 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67
19 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
20 INT3962 Regulation of AGT 50 0.62 20.96 13.01
21 INT4199 Binding of Agt 76 0.48 21.06 12.66
22 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61
23 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
24 INT398 Localization of AGT 45 0.78 16.97 11.54
25 INT23654 Binding of SPINK1 27 0.48 30.85 11.53
26 INT8065 Binding of AGT 54 0.48 20.54 10.85
27 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93
28 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
29 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7
30 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04
31 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
32 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82
33 INT82743 Gene_expression of SPINK1 48 0.78 44.28 8.77
34 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
35 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44
36 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35
37 INT10065 Positive_regulation of Serpina6 12 0.70 1.48 8.22
38 INT44816 Regulation of Serpina6 16 0.62 3.63 8.02
39 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
40 INT153814 Localization of LPA 19 0.65 18.25 7.68
41 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24
42 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17
43 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84
44 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56
45 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48
46 INT10131 Gene_expression of Serpinf1 53 0.76 35.57 6.42
47 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
48 INT677 Positive_regulation of CST3 20 0.67 17.47 6
49 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92
50 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
51 INT10147 Gene_expression of Serpinc1 28 0.76 17.73 5.77
52 INT29821 Gene_expression of Serpina1 18 0.60 2.98 5.75
53 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68
54 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
55 INT63507 Gene_expression of SERPINE2 8 0.70 8.35 5.56
56 INT157802 Negative_regulation of Timp2 7 0.54 5.75 5.51
57 INT106813 Positive_regulation of RECK 1 0.69 2.39 5.38
58 INT12039 Localization of TFPI 22 0.68 9.88 5.35
59 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16
60 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05
61 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98
62 INT15941 Negative_regulation of Serpine1 42 0.58 21.07 4.95
63 INT28703 Negative_regulation of TFPI 29 0.38 19.81 4.93
64 INT84057 Positive_regulation of Gene_expression of ITIH4 12 0.50 10.5 4.92
65 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
66 INT2947 Regulation of TFPI 10 0.44 5.81 4.86
67 INT11030 Binding of LPA 70 0.48 40.35 4.81
68 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77
69 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75
70 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75
71 INT6005 Gene_expression of Serpini1 5 0.58 1.62 4.74
72 INT35254 Negative_regulation of SERPINB1 22 0.48 11.42 4.7
73 INT210885 Regulation of SLPI 8 0.44 7.15 4.61
74 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43
75 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42
76 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41
77 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
78 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3
79 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26
80 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26
81 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
82 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93
83 INT51312 Positive_regulation of Gene_expression of SERPINA1 4 0.46 9.41 3.84
84 INT179261 Gene_expression of SERPINA6 12 0.14 3.53 3.82
85 INT55093 Negative_regulation of SPINK1 13 0.42 15.11 3.8
86 INT181922 Binding of RENBP 16 0.36 13.92 3.71
87 INT57644 Regulation of SPINK1 7 0.47 15.19 3.64
88 INT106817 Gene_expression of RECK 8 0.77 2.78 3.62
89 INT24231 Localization of SERPINB1 13 0.61 3.1 3.61
90 INT16263 Regulation of Serpine1 13 0.45 5.24 3.6
91 INT54102 Positive_regulation of Gene_expression of TFPI 14 0.49 6.67 3.54
92 INT228465 Positive_regulation of Timp2 4 0.64 6.29 3.54
93 INT53584 Regulation of Gpx1 19 0.62 14.38 3.48
94 INT3889 Regulation of Serpinc1 13 0.61 8.6 3.46
95 INT76399 Binding of Serpina6 4 0.34 3.81 3.46
96 INT8539 Negative_regulation of Serpina1a 21 0.58 12.65 3.39
97 INT14397 Gene_expression of Serpinc1 27 0.46 14.54 3.32
98 INT43985 Regulation of LPA 29 0.62 20.79 3.29
99 INT7773 Localization of SERPINF1 18 0.55 8.54 3.25
100 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16
101 INT37811 Negative_regulation of SERPINB6 8 0.47 4.65 3.15
102 INT10132 Negative_regulation of Serpinf1 14 0.58 11.72 3.14
103 INT14086 Binding of SERPINB1 18 0.34 4.32 3.13
104 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13
105 INT107962 Gene_expression of Pttg1 34 0.53 34.05 3.11
106 INT90289 Positive_regulation of Gene_expression of Gpx1 10 0.17 8.07 3.05
107 INT14960 Positive_regulation of Serpinc1 17 0.68 12.71 3.02
108 INT24821 Binding of VTN 14 0.47 5.83 3
109 INT45673 Gene_expression of Serpina6 10 0.53 3.47 3
110 INT27243 Positive_regulation of SPINK1 13 0.68 26.71 2.92
111 INT69099 Gene_expression of Serpine2 22 0.78 7.89 2.87
112 INT64843 Gene_expression of Serping1 19 0.67 8.88 2.72
113 INT76099 Positive_regulation of ITIH4 8 0.69 5.71 2.66
114 INT127552 Gene_expression of Pcsk1n 8 0.78 1.11 2.66
115 INT103977 Positive_regulation of Gene_expression of SPINK1 7 0.50 7.38 2.66
116 INT71794 Binding of SERPINC1 17 0.39 10.5 2.64
117 INT29818 Regulation of Serpina1 8 0.27 0.08 2.64
118 INT61904 Gene_expression of CST7 3 0.53 3.22 2.53
119 INT156130 Binding of SERPING1 29 0.42 26.16 2.52
120 INT120483 Localization of ITIH4 11 0.69 12.05 2.51
121 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51
122 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47
123 INT60142 Negative_regulation of Serpinb1a 2 0.42 0.59 2.46
124 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
125 INT10044 Positive_regulation of Serpina1 5 0.69 0.99 2.45
126 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
127 INT10048 Positive_regulation of SERPINA1 11 0.68 8.59 2.43
128 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
129 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36
130 INT38871 Binding of TFPI 12 0.32 5.9 2.36
131 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35
132 INT75756 Phosphorylation of LPA 5 0.68 0.67 2.35
133 INT12384 Positive_regulation of PI3 7 0.38 5.73 2.33
134 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
135 INT71490 Positive_regulation of Positive_regulation of Serpina6 3 0.70 0.16 2.27
136 INT640 Regulation of CST3 9 0.60 4.04 2.26
137 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23
138 INT40565 Gene_expression of SLPI 15 0.75 7.25 2.21
139 INT43612 Regulation of SERPINB1 12 0.11 3.26 2.21
140 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
141 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17
142 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16
143 INT70962 Positive_regulation of SERPING1 33 0.69 27.32 2.14
144 INT37809 Gene_expression of SERPINB6 7 0.77 6.58 2.12
145 INT106814 Positive_regulation of Gene_expression of RECK 2 0.69 1.04 2.1
146 INT45672 Negative_regulation of Serpina6 5 0.43 1.66 2.08
147 INT10045 Negative_regulation of Serpina1 7 0.43 1.01 2.07
148 INT83911 Negative_regulation of Gene_expression of SERPINA1 3 0.43 5.2 2.07
149 INT12005 Negative_regulation of Localization of Agt 6 0.57 1.49 2.06
150 INT46109 Binding of SERPINF2 6 0.37 1.08 2.06
151 INT63542 Positive_regulation of Serpini1 3 0.20 0.51 1.98
152 INT71115 Positive_regulation of Gene_expression of Serpine1 20 0.70 15.32 1.97
153 INT64709 Gene_expression of VTN 11 0.67 11.01 1.97
154 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96
155 INT23188 Localization of Serpine1 22 0.79 16.06 1.96
156 INT12801 Negative_regulation of Regulation of Agt 4 0.43 1.2 1.96
157 INT130560 Negative_regulation of Gene_expression of Serpinf1 17 0.58 13.39 1.94
158 INT43944 Negative_regulation of Positive_regulation of Agt 4 0.42 1.44 1.93
159 INT40954 Regulation of Serping1 5 0.32 3.71 1.88
160 INT14500 Positive_regulation of Gene_expression of CST3 9 0.67 7.46 1.87
161 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85
162 INT68522 Localization of Pcsk1n 2 0.56 1.19 1.85
163 INT64787 Regulation of ITIH4 7 0.38 5.61 1.82
164 INT16391 Regulation of Serpinf2 5 0.03 4.22 1.82
165 INT6006 Positive_regulation of Gene_expression of Serpini1 1 0.00 0 1.82
166 INT96797 Negative_regulation of ITIH4 5 0.42 3.21 1.8
167 INT63029 Gene_expression of Vtn 4 0.14 2.8 1.8
168 INT37810 Positive_regulation of Negative_regulation of SERPINB6 2 0.41 1.84 1.78
169 INT67183 Binding of Serpinb1a 4 0.37 4 1.77
170 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76
171 INT211200 Regulation of SERPINH1 2 0.03 3.8 1.75
172 INT41639 Positive_regulation of A2m 7 0.46 4.52 1.74
173 INT9648 Positive_regulation of Gene_expression of LPA 15 0.59 11.31 1.72
174 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72
175 INT94848 Negative_regulation of Gene_expression of Gpx1 11 0.30 4.91 1.7
176 INT156671 Gene_expression of Vcsa1 22 0.75 23.32 1.69
177 INT108252 Positive_regulation of Renbp 16 0.24 11.66 1.68
178 INT3152 Transcription of Agt 7 0.72 5.09 1.68
179 INT48720 Transcription of SERPINE1 11 0.68 4.76 1.67
180 INT223923 Positive_regulation of Gene_expression of Serpina1 1 0.08 0.27 1.67
181 INT215928 Binding of Timp2 1 0.23 0.79 1.66
182 INT14405 Gene_expression of SERPINF2 14 0.65 3 1.64
183 INT20982 Positive_regulation of SERPINB1 7 0.28 7.27 1.61
184 INT193809 Regulation of Binding of ITIH4 2 0.31 1.82 1.59
185 INT60975 Localization of CST3 6 0.78 2.4 1.58
186 INT73330 Positive_regulation of SERPINB2 6 0.47 5.33 1.57
187 INT223920 Regulation of Gene_expression of Serpina1 1 0.05 0.4 1.57
188 INT67869 Transcription of Gpx1 3 0.68 0.67 1.56
189 INT77314 Gene_expression of Lxn 3 0.76 5.67 1.55
190 INT202935 Gene_expression of SERPINF1 12 0.50 7.53 1.54
191 INT64821 Positive_regulation of SLPI 11 0.67 5.08 1.48
192 INT14404 Negative_regulation of SERPINF2 11 0.47 3.15 1.47
193 INT11710 Positive_regulation of SERPINC1 6 0.59 6.15 1.47
194 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
195 INT189948 Gene_expression of Pttg1 106 0.76 104.68 1.41
196 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
197 INT263023 Gene_expression of PI3 6 0.75 2.68 1.39
198 INT72359 Binding of Serpini1 3 0.32 1.02 1.39
199 INT179644 Gene_expression of RENBP 26 0.35 13.74 1.38
200 INT239215 Binding of Agt 9 0.38 6.75 1.35
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