GO:0010957

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Name negative regulation of vitamin D biosynthetic process
Categary Process
Go Slim No
Go Link GO:0010957
Unique Molecular Interactions 140
Total Molecular Interactions 205
Total Single Events 1106
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of vitamin D biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of vitamin D biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
2 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
3 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
4 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
5 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
6 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
7 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
8 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
9 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
10 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
11 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
12 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
13 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
14 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
15 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
16 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
17 INT63594 Snai1 Negative_regulation of Binding of Ugt1a2 1 0.05 0.32 0.82
18 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
19 INT63596 Snai1 Negative_regulation of ITS 1 0.00 0.31 0.81
20 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
21 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
22 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
23 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
24 INT103134 DCSTAMP Positive_regulation of NFKB1 2 0.07 1.43 0.7
25 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
26 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
27 INT66207 Positive_regulation of TNF Positive_regulation of NFKB1 1 0.42 0.08 0.61
28 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
29 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
30 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
31 INT113548 NFKB1 Regulation of Localization of PLAU 1 0.26 1.93 0.55
32 INT156246 NFKB1 Regulation of Gene_expression of TNF 1 0.17 0.35 0.54
33 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54
34 INT105110 Cxcl12 Positive_regulation of NFKB1 1 0.06 0.54 0.53
35 INT105108 Negative_regulation of Cxcl12 Positive_regulation of NFKB1 1 0.05 0.54 0.53
36 INT139834 NFKB1 Regulation of Gene_expression of SELE 1 0.18 0.49 0.5
37 INT139835 NFKB1 Regulation of SELE 1 0.41 0.49 0.5
38 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
39 INT135588 Positive_regulation of IKBKE Positive_regulation of NFKB1 1 0.18 1.29 0.48
40 INT135587 IKBKE Positive_regulation of NFKB1 1 0.18 1.28 0.48
41 INT191948 NFKB1 Regulation of Gene_expression of NOS2 1 0.38 1 0.47
42 INT106073 IL1B Positive_regulation of Positive_regulation of NFKB1 1 0.41 0.7 0.47
43 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
44 INT103128 Positive_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.07 0.73 0.43
45 INT107699 IL1B Positive_regulation of Localization of NFKB1 1 0.03 0.13 0.41
46 INT84516 NFKB1 Positive_regulation of Gene_expression of TF 1 0.10 0.09 0.41
47 INT103131 Positive_regulation of NFKB1 Regulation of Gene_expression of IL8 1 0.27 0.68 0.4
48 INT166788 HRAS Negative_regulation of Phosphorylation of NFKB1 1 0.08 0.5 0.39
49 INT103795 Negative_regulation of SLC9A1 Negative_regulation of Positive_regulation of NFKB1 1 0.12 0.47 0.37
50 INT107705 DCSTAMP Positive_regulation of Localization of NFKB1 1 0.07 0.07 0.36
51 INT54570 Positive_regulation of NFKB1 Positive_regulation of Gene_expression of IL8 1 0.24 0.77 0.35
52 INT90388 NFKB1 Positive_regulation of CPOX 1 0.32 0.18 0.35
53 INT83347 GSR Negative_regulation of NFKB1 1 0.25 0.72 0.33
54 INT144251 TNF Positive_regulation of Gene_expression of NFKB1 1 0.43 0.65 0.3
55 INT80029 Binding of FAS and Positive_regulation of NFKB1 1 0.34 0.92 0.3
56 INT140386 Spp1 Positive_regulation of NFKB1 1 0.21 1.29 0.3
57 INT166789 HRAS Regulation of Positive_regulation of NFKB1 1 0.05 0.31 0.3
58 INT80031 FAS Positive_regulation of Positive_regulation of NFKB1 1 0.50 0.93 0.3
59 INT113558 Negative_regulation of NFKB1 Negative_regulation of Localization of PLAU 1 0.41 0.97 0.29
60 INT196631 PTGER2 Negative_regulation of NFKB1 1 0.00 0.32 0.28
61 INT144237 Negative_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.06 0.72 0.28
62 INT144255 EGF Regulation of Positive_regulation of NFKB1 1 0.41 0.66 0.27
63 INT144239 CTSG Regulation of Positive_regulation of NFKB1 1 0.00 0.67 0.27
64 INT56071 NFKB1 Positive_regulation of Gene_expression of IL1B 1 0.36 0.4 0.27
65 INT125514 Positive_regulation of PRKDC Positive_regulation of Positive_regulation of NFKB1 1 0.07 0.44 0.26
66 INT125512 Gene_expression of NFKB1 Positive_regulation of GDF15 1 0.32 0.42 0.25
67 INT321224 TLR4 Positive_regulation of NFKB1 1 0.04 1.02 0.25
68 INT120849 PRL Positive_regulation of NFKB1 1 0.07 0.49 0.25
69 INT321223 CXCR1 Positive_regulation of NFKB1 1 0.00 1.02 0.25
70 INT321222 Binding of NFKB1 and NFKBIZ 1 0.02 1.11 0.24
71 INT125518 Binding of NFKB1 and GDF15 1 0.33 0.41 0.24
72 INT125519 Regulation of PLAT Positive_regulation of NFKB1 1 0.07 0.44 0.24
73 INT143950 Negative_regulation of NFKB1 Positive_regulation of Gene_expression of RELA 1 0.45 0.46 0.23
74 INT144238 TNF Positive_regulation of Protein_catabolism of NFKB1 1 0.40 0.35 0.22
75 INT104838 Binding of NFKB1 and IGKV2OR2-1 1 0.01 0 0.22
76 INT55164 Binding of NFKB1 and WRAP53 1 0.02 0.11 0.19
77 INT102805 NFKB1 Regulation of TCEAL1 1 0.25 0.77 0.17
78 INT116442 CD8B Negative_regulation of Positive_regulation of NFKB1 1 0.02 0 0.17
79 INT144252 CGA Positive_regulation of Positive_regulation of NFKB1 1 0.17 0.38 0.17
80 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
81 INT116443 LY9 Negative_regulation of Positive_regulation of NFKB1 1 0.12 0 0.17
82 INT102806 NFKB1 Regulation of Gene_expression of TCEAL1 1 0.25 0.77 0.17
83 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
84 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
85 INT296030 Binding of NFKB1 and FOXP3 1 0.17 1.18 0.16
86 INT350013 ARID1B Regulation of Positive_regulation of NFKB1 1 0.00 1.77 0.16
87 INT296078 Binding of NFKB1 and Gtf3a 1 0.00 1.18 0.16
88 INT104832 Binding of IL10 and NFKB1 1 0.15 0 0.15
89 INT316479 Il6 Positive_regulation of Snai1 1 0.24 0.33 0.15
90 INT139822 ZNF833P Negative_regulation of Transcription of NFKB1 1 0.03 0.11 0.15
91 INT61360 Regulation of TNF Positive_regulation of NFKB1 2 0.21 1.34 0.14
92 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14
93 INT214480 SELPLG Negative_regulation of Positive_regulation of NFKB1 1 0.00 0.6 0.14
94 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14
95 INT139791 PRSS53 Negative_regulation of NFKB1 1 0.09 0.71 0.13
96 INT128281 Binding of JUND and NFKB1 1 0.36 0.39 0.13
97 INT306262 NFKB1 Positive_regulation of Transcription of PTGS2 1 0.42 0.31 0.12
98 INT306265 Binding of NFKB1 and NFKBIA 1 0.21 0.48 0.11
99 INT147073 NFKB1 Regulation of PTGS2 1 0.37 0 0.11
100 INT147072 NFKB1 Regulation of PTGES 1 0.36 0 0.11
101 INT139784 PRSS53 Negative_regulation of Positive_regulation of NFKB1 1 0.09 0.9 0.11
102 INT139785 TNFAIP8 Positive_regulation of Positive_regulation of NFKB1 1 0.19 0.89 0.11
103 INT294681 Tlr4 Positive_regulation of Positive_regulation of NFKB1 1 0.02 0.27 0.1
104 INT208218 NFKB1 Regulation of IRF6 1 0.01 0.07 0.07
105 INT1226 Fabp6 Negative_regulation of Snai1 1 0.03 0.49 0.07
106 INT269214 SNAI1 Positive_regulation of Positive_regulation of CDH1 1 0.35 0.71 0.04
107 INT269211 SNAI1 Positive_regulation of Gene_expression of CDH1 1 0.40 0.73 0.04
108 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
109 INT233848 Zeb1 Positive_regulation of Snai1 1 0.07 0.58 0.04
110 INT233853 Zeb1 Positive_regulation of Snai2 1 0.09 0.58 0.04
111 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
112 INT172716 Binding of BCL3 and NFKB1 1 0.06 0.15 0.03
113 INT139004 Mtpn Regulation of NFKB1 1 0.33 0.55 0
114 INT103286 Negative_regulation of IRF6 Positive_regulation of NFKB1 1 0.18 0 0
115 INT103287 IRF6 Positive_regulation of NFKB1 1 0.19 0 0
116 INT165509 CYBB Regulation of Gene_expression of NFKB1 1 0.02 0 0
117 INT156450 ANGPTL5 Positive_regulation of Positive_regulation of NFKB1 1 0.03 0 0
118 INT155918 NFKB1 Positive_regulation of Gene_expression of TNF 1 0.34 0 0
119 INT155173 NFKB1 Regulation of Gene_expression of NOS1 1 0.12 0.08 0
120 INT150957 STK16 Positive_regulation of Positive_regulation of NFKB1 1 0.04 0.08 0
121 INT298451 Binding of SNAI1 and Vim 1 0.07 1.45 0
122 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0
123 INT298437 Binding of ITK and SNAI1 1 0.05 1.16 0
124 INT269209 SNAI1 Regulation of Gene_expression of LOXL2 1 0.07 1.14 0
125 INT155926 PARP1 Regulation of Binding of NFKB1 1 0.24 0.16 0
126 INT315070 Binding of IL8 and NFKB1 1 0.26 0.34 0
127 INT165510 HSPG2 Negative_regulation of Gene_expression of NFKB1 1 0.01 0.06 0
128 INT269213 Binding of SNAI1 and Positive_regulation of Gene_expression of CDH1 1 0.37 1.03 0
129 INT298436 Binding of KNG1 and SNAI1 1 0.09 0.53 0
130 INT335513 EDIL3 Regulation of NFKB1 1 0.26 0.2 0
131 INT170589 NFKB1 Regulation of Gene_expression of ICAM1 1 0.27 0 0
132 INT156451 Negative_regulation of NFKB1 Negative_regulation of Gene_expression of ANGPTL5 1 0.03 0 0
133 INT292152 Binding of NFKB1 and REL 1 0.03 0.4 0
134 INT155922 PARP1 Positive_regulation of Binding of NFKB1 1 0.42 0.06 0
135 INT155924 Binding of PARP1 and NFKB1 1 0.34 0.23 0
136 INT164070 AKT1 Positive_regulation of NFKB1 1 0.32 0.09 0
137 INT164071 AKT1 Regulation of Positive_regulation of NFKB1 1 0.17 0.09 0
138 INT155917 NFKB1 Positive_regulation of Gene_expression of IL6 1 0.29 0 0
139 INT155925 PARP1 Positive_regulation of NFKB1 1 0.42 0.06 0
140 INT298438 Binding of CDH1 and SNAI1 1 0.14 1.16 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of vitamin D biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of vitamin D biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
2 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
3 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
4 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
5 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
6 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
7 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
8 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
9 INT1223 Negative_regulation of Snai1 15 0.38 2.05 8.46
10 INT20914 Positive_regulation of Snai1 13 0.41 3.41 7.69
11 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
12 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39
13 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31
14 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01
15 INT56077 Protein_catabolism of NFKB1 16 0.98 8.03 3.94
16 INT56075 Transcription of NFKB1 13 0.71 9.03 3.83
17 INT79231 Positive_regulation of Gene_expression of NFKB1 18 0.67 9.16 3.66
18 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63
19 INT139801 Phosphorylation of NFKB1 9 0.66 5.2 3.13
20 INT1225 Regulation of Snai1 10 0.30 1.05 2.72
21 INT71305 Regulation of Gene_expression of NFKB1 9 0.61 5.41 2.44
22 INT269217 Gene_expression of SNAI1 81 0.76 80.49 2.26
23 INT56078 Negative_regulation of Protein_catabolism of NFKB1 7 0.42 4.44 1.83
24 INT76608 Regulation of Negative_regulation of NFKB1 1 0.33 0.53 1.75
25 INT32024 Positive_regulation of Positive_regulation of Snai1 2 0.25 0.32 1.7
26 INT165446 Positive_regulation of Phosphorylation of NFKB1 3 0.56 1.88 1.66
27 INT55302 Binding of Snai1 2 0.31 1.94 1.63
28 INT66214 Regulation of Binding of NFKB1 2 0.35 0.55 1.28
29 INT97032 Gene_expression of Snai1 3 0.52 0.58 1.04
30 INT88600 Positive_regulation of Binding of NFKB1 9 0.59 2.1 0.88
31 INT76609 Regulation of Regulation of NFKB1 2 0.20 0.97 0.79
32 INT56073 Positive_regulation of Transcription of NFKB1 4 0.46 1.88 0.77
33 INT56074 Negative_regulation of Transcription of NFKB1 3 0.58 1.53 0.64
34 INT54000 Positive_regulation of SNAI1 7 0.49 5.37 0.58
35 INT107106 Positive_regulation of Negative_regulation of NFKB1 1 0.33 1.26 0.54
36 INT166794 Regulation of Localization of NFKB1 2 0.36 0.49 0.38
37 INT166795 Regulation of Phosphorylation of NFKB1 1 0.36 0.49 0.38
38 INT123578 Negative_regulation of Gene_expression of Snai1 1 0.33 0.5 0.36
39 INT123579 Negative_regulation of Positive_regulation of Snai1 1 0.33 0.51 0.36
40 INT135495 Regulation of Positive_regulation of Snai1 1 0.23 0 0.33
41 INT269225 Negative_regulation of Gene_expression of SNAI1 4 0.58 9.11 0.28
42 INT58734 Regulation of SNAI1 3 0.60 1.26 0.2
43 INT143955 Negative_regulation of Negative_regulation of NFKB1 1 0.35 0.48 0.2
44 INT162483 Localization of Snai1 1 0.43 0 0.19
45 INT162484 Regulation of Localization of Snai1 1 0.33 0 0.19
46 INT269228 Binding of SNAI1 1 0.47 2.28 0.18
47 INT181783 Transcription of SNAI1 3 0.71 2.44 0.17
48 INT58735 Negative_regulation of Regulation of SNAI1 1 0.33 0.24 0.17
49 INT307932 Localization of Snai1 3 0.78 2.28 0.13
50 INT316436 Positive_regulation of Snai1 1 0.22 0.35 0.13
51 INT269218 Localization of SNAI1 4 0.79 3.1 0.07
52 INT298445 Positive_regulation of Gene_expression of SNAI1 4 0.59 5.07 0.04
53 INT269219 Phosphorylation of SNAI1 1 0.62 0.38 0.04
54 INT269222 Regulation of Gene_expression of SNAI1 2 0.27 2.24 0
55 INT298444 Negative_regulation of SNAI1 1 0.41 0.77 0
56 INT308354 Gene_expression of Snai2 1 0.58 1.14 0
57 INT308358 Positive_regulation of Gene_expression of Snai2 1 0.45 1.14 0
58 INT326136 Binding of Snai1 1 0.04 1.23 0
59 INT305345 Positive_regulation of Snai2 1 0.16 1.4 0
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