GO:0012501

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Name programmed cell death
Categary Process
Go Slim No
Go Link GO:0012501
Unique Molecular Interactions 134
Total Molecular Interactions 159
Total Single Events 960
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for programmed cell death. They are ordered first by their pain relevance and then by number of times they were reported for programmed cell death. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
2 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
3 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
4 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
5 INT161191 CRX Regulation of Gene_expression of Trib3 1 0.00 2 1.38
6 INT50706 Phax Positive_regulation of Localization of Trib3 1 0.04 0.28 1.38
7 INT161185 NMS Regulation of Gene_expression of Trib3 1 0.03 2 1.38
8 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
9 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
10 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
11 INT228681 Fkbp4 Negative_regulation of Trib3 1 0.00 0.57 1.2
12 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
13 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
14 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
15 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
16 INT186431 Trib3 Regulation of Creb1 1 0.03 0.23 0.92
17 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
18 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
19 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84
20 INT80793 Prkcg Regulation of Pkm2 1 0.29 0.2 0.83
21 INT186428 Trib3 Regulation of Prkcg 1 0.02 0.09 0.81
22 INT128041 Bdnf Positive_regulation of Trib3 1 0.10 0.29 0.79
23 INT50708 Phax Positive_regulation of Trib3 1 0.03 0.07 0.77
24 INT50707 Phax Positive_regulation of Positive_regulation of Trib3 1 0.04 0.16 0.74
25 INT161298 Ppp1r1b Negative_regulation of Trib3 1 0.05 0.16 0.7
26 INT82022 Binding of Trib3 and Ngf 1 0.08 0.31 0.68
27 INT249485 Trib3 Negative_regulation of Phosphorylation of Grin2b 1 0.02 0.64 0.68
28 INT82020 Negative_regulation of Binding of Trib3 and Ngf 1 0.07 0.31 0.68
29 INT134028 Olr696 Regulation of Trib3 1 0.00 0.15 0.68
30 INT112515 Binding of Ephb1 and Trib3 1 0.06 0.41 0.65
31 INT112516 Binding of Prkce and Trib3 1 0.01 0.4 0.64
32 INT165048 Trib3 Positive_regulation of Gene_expression of Tnf 1 0.08 0.8 0.63
33 INT249484 Trib3 Positive_regulation of Phosphorylation of Grin2b 1 0.01 0.57 0.61
34 INT186434 Trib3 Positive_regulation of Phosphorylation of Creb1 1 0.05 0.26 0.58
35 INT118003 Trib3 Regulation of Trpv1 1 0.03 0.09 0.58
36 INT282142 Grm1 Positive_regulation of Positive_regulation of Trib3 1 0.01 0.27 0.57
37 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
38 INT161250 Trib3 Regulation of Mapk14 1 0.04 0.81 0.54
39 INT149321 Amph Positive_regulation of Trib3 1 0.16 0 0.54
40 INT330545 Bcl2l11 Negative_regulation of Trib3 1 0.00 0.38 0.52
41 INT162993 Binding of Trib3 and Fadd 1 0.05 0.1 0.46
42 INT162990 Binding of Trib3 and Pea15a 1 0.04 0.09 0.46
43 INT128043 Positive_regulation of Ntrk2 Positive_regulation of Phosphorylation of Trib3 1 0.07 0.34 0.45
44 INT283731 Trib3 Positive_regulation of Creb1 2 0.01 0.16 0.44
45 INT313377 Trib3 Regulation of Gene_expression of Gfap 1 0.01 0.37 0.44
46 INT313378 Trib3 Regulation of Phosphorylation of Mapk14 1 0.01 0.37 0.44
47 INT114599 Positive_regulation of Il1rap Positive_regulation of Trib3 1 0.03 0.07 0.43
48 INT95403 Ephb1 Regulation of Positive_regulation of Trib3 1 0.07 0.19 0.41
49 INT95402 Mapk14 Regulation of Positive_regulation of Trib3 1 0.06 0.19 0.41
50 INT114598 Positive_regulation of Il1b Positive_regulation of Trib3 1 0.08 0.08 0.4
51 INT114594 Il1b Positive_regulation of Positive_regulation of Trib3 1 0.08 0.08 0.4
52 INT114596 Il1b Positive_regulation of Trib3 1 0.08 0.08 0.4
53 INT114597 Positive_regulation of Trib3 Regulation of Gene_expression of Tac4 1 0.01 0.09 0.4
54 INT151698 Binding of RNF130 and Vwf 1 0.04 0.29 0.37
55 INT140869 Binding of Gdnf and Trib3 1 0.04 0.15 0.37
56 INT118000 Trpv1 Regulation of Phosphorylation of Trib3 1 0.01 0.08 0.36
57 INT151694 Binding of FBL and RNF130 1 0.40 0.23 0.36
58 INT117999 Trpv1 Positive_regulation of Phosphorylation of Trib3 1 0.02 0.08 0.36
59 INT224285 BDNF Positive_regulation of Trib3 1 0.06 0.22 0.36
60 INT122757 Helt Positive_regulation of Trib3 1 0.00 0.2 0.35
61 INT263383 Abl1 Regulation of Trib3 1 0.01 0.28 0.35
62 INT249492 Trib3 Regulation of Phosphorylation of Grin2b 1 0.01 0.23 0.35
63 INT304495 Trib3 Positive_regulation of Mapk1 1 0.02 1.4 0.35
64 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
65 INT309132 Edc4 Negative_regulation of Positive_regulation of Trib3 1 0.00 0.69 0.33
66 INT356288 Egf Positive_regulation of Trib3 1 0.00 0.17 0.3
67 INT186430 Creb1 Positive_regulation of Trib3 1 0.04 0.17 0.3
68 INT356283 Ngf Positive_regulation of Trib3 1 0.00 0.17 0.3
69 INT356282 Gdnf Positive_regulation of Trib3 1 0.00 0.17 0.3
70 INT283733 Trib3 Positive_regulation of Creb1 1 0.00 0 0.28
71 INT53951 Negative_regulation of Trib3 Negative_regulation of Gene_expression of Ptgs1 1 0.01 0.43 0.26
72 INT149357 Trib3 Negative_regulation of Raf1 1 0.01 0.08 0.25
73 INT51432 Gria1 Positive_regulation of Trib3 1 0.04 0 0.25
74 INT177661 Binding of Trib3 and Myo1f 1 0.00 0.54 0.24
75 INT187485 Trib3 Positive_regulation of Prkag1 1 0.00 0.97 0.22
76 INT285979 Ros1 Positive_regulation of Trib3 2 0.02 2.18 0.2
77 INT179937 Trib3 Regulation of TNF 1 0.00 0.59 0.2
78 INT345209 Repin1 Positive_regulation of Positive_regulation of Trib3 1 0.00 0.88 0.18
79 INT140870 Binding of Trib3 and Gtf3a 1 0.00 0.07 0.18
80 INT152019 Gene_expression of Pdcd2 Negative_regulation of Localization of TNF 1 0.42 0.38 0.17
81 INT164790 Cdk5r1 Positive_regulation of Trib3 1 0.02 0.25 0.17
82 INT146841 Tnf Positive_regulation of Trib3 1 0.03 0.77 0.16
83 INT309125 Trib3 Positive_regulation of Rorb 1 0.00 0.16 0.16
84 INT146845 Tnf Positive_regulation of Positive_regulation of Trib3 1 0.03 0.77 0.16
85 INT153185 Prok2 Regulation of Trib3 1 0.02 0 0.15
86 INT352450 Tnc Regulation of Trib3 1 0.00 0.22 0.13
87 INT133349 Positive_regulation of Trib3 Positive_regulation of Gene_expression of Qrfp 1 0.02 0 0.12
88 INT177675 Binding of CALM1 and Positive_regulation of Trib3 1 0.00 0.27 0.12
89 INT177674 CALM1 Positive_regulation of Trib3 1 0.00 0.27 0.12
90 INT332685 Trib3 Positive_regulation of Binding of Ros1 1 0.01 0.74 0.12
91 INT285981 Ros1 Regulation of Positive_regulation of Trib3 1 0.01 0.95 0.12
92 INT278156 Negative_regulation of Trib3 Negative_regulation of Akt1 1 0.00 0.45 0.1
93 INT321299 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Nr0b2 1 0.02 0.31 0.1
94 INT248704 Trib3 Positive_regulation of Phosphorylation of Rxrb 1 0.00 0.49 0.08
95 INT285982 Ros1 Positive_regulation of Binding of Trib3 1 0.02 1.41 0.08
96 INT285602 Trib3 Regulation of Gene_expression of Nos2 1 0.00 0.48 0.07
97 INT263430 Binding of Wasf1 and Trib3 1 0.01 0.06 0.07
98 INT215693 Trib3 Regulation of Gene_expression of Ccnd1 1 0.00 0.09 0.07
99 INT300308 Positive_regulation of Mapk14 Positive_regulation of Trib3 1 0.03 1.42 0.07
100 INT292812 Zfp787 Negative_regulation of Trib3 1 0.00 0.48 0.06
101 INT213001 Hdl1 Positive_regulation of Trib3 1 0.00 2 0.06
102 INT179932 Trib3 Negative_regulation of Positive_regulation of Mmp9 1 0.01 0.41 0.05
103 INT308328 Hif1a Regulation of Positive_regulation of Trib3 1 0.02 0.89 0.05
104 INT179933 Trib3 Negative_regulation of Gene_expression of Mmp9 1 0.01 0.41 0.05
105 INT148095 Vasp Regulation of Trib3 1 0.00 0.12 0.04
106 INT263378 Trib3 Regulation of Bmx 1 0.00 0 0.04
107 INT263431 Trib3 Regulation of Pdgfra 1 0.00 0 0.04
108 INT263381 Trib3 Regulation of Src 1 0.01 0 0.04
109 INT263432 Trib3 Regulation of Abl1 1 0.00 0 0.04
110 INT213002 Binding of Scarb1 and Trib3 1 0.00 1.02 0.03
111 INT53100 Trib3 Regulation of Gene_expression of Penk 1 0.06 0 0.03
112 INT277745 Trib3 Regulation of Ccnd1 1 0.00 0.41 0.03
113 INT277223 Trib3 Regulation of Regulation of aicda 1 0.01 0.42 0.03
114 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
115 INT355435 Trib3 Positive_regulation of Eif2ak2 1 0.01 0.61 0
116 INT205985 Ptn Positive_regulation of Trib3 1 0.00 0.73 0
117 INT266533 Trib3 Positive_regulation of Phosphorylation of Olr447 1 0.00 0 0
118 INT315057 Binding of TOP1 and PAR4 1 0.16 1.23 0
119 INT214902 Binding of Pcna and Trib3 1 0.00 1.51 0
120 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
121 INT234145 Fig4 Negative_regulation of Gene_expression of Trib3 1 0.01 0.31 0
122 INT257871 Binding of Ins1 and Positive_regulation of Trib3 1 0.01 0.49 0
123 INT225001 Binding of Mtpn and Trib3 1 0.00 0.15 0
124 INT330226 Positive_regulation of Prkaa2 Positive_regulation of Trib3 1 0.00 0.07 0
125 INT238624 Binding of Sdc2 and Trib3 1 0.00 0.08 0
126 INT234141 Fig4 Negative_regulation of Trib3 1 0.01 0.13 0
127 INT259016 Positive_regulation of Binding of TNFSF18 and Relt 1 0.06 0.67 0
128 INT351977 Binding of Tp53 and Trib3 1 0.01 0.79 0
129 INT229807 Fos Regulation of Casp2 1 0.04 0.32 0
130 INT205986 Mapk8 Positive_regulation of Trib3 1 0.02 0.73 0
131 INT310240 INS Positive_regulation of Trib3 1 0.00 0.98 0
132 INT180673 Trib3 Regulation of Ecm1 1 0.02 0 0
133 INT259015 Binding of TNFSF18 and Relt 1 0.04 0.67 0
134 INT238620 Binding of Cadm1 and Trib3 1 0.00 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for programmed cell death. They are ordered first by their pain relevance and then by number of times they were reported in programmed cell death. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01
2 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48
3 INT12681 Regulation of Trib3 76 0.53 23.92 26.58
4 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27
5 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58
6 INT38253 Localization of Trib3 35 0.63 10.28 15.42
7 INT33127 Positive_regulation of Phosphorylation of Trib3 26 0.17 14.04 10
8 INT10533 Positive_regulation of Positive_regulation of Trib3 24 0.42 6.59 9.2
9 INT38254 Positive_regulation of Localization of Trib3 14 0.45 6.14 6.99
10 INT48270 Negative_regulation of RNF130 44 0.57 21.31 6.14
11 INT50704 Binding of Trib3 13 0.31 6.33 5.46
12 INT51734 Negative_regulation of Localization of Trib3 10 0.19 2.53 4.97
13 INT24813 Negative_regulation of Positive_regulation of Trib3 10 0.16 1.3 4.48
14 INT32205 Regulation of Positive_regulation of Trib3 9 0.11 2.82 4.1
15 INT10535 Positive_regulation of Gene_expression of Trib3 13 0.59 4.93 3.74
16 INT15327 Negative_regulation of Phosphorylation of Trib3 7 0.30 4.95 2.99
17 INT33492 Negative_regulation of Negative_regulation of Trib3 5 0.30 0.51 2.67
18 INT32469 Regulation of Gene_expression of Trib3 5 0.07 2.33 1.7
19 INT48752 Regulation of Negative_regulation of Trib3 3 0.39 0.89 1.65
20 INT81222 Binding of RNF130 9 0.47 5.38 1.54
21 INT99639 Regulation of Phosphorylation of Trib3 6 0.14 0.44 1.36
22 INT83061 Regulation of Localization of Trib3 2 0.07 0.11 1.17
23 INT48931 Regulation of Regulation of Trib3 2 0.04 0.06 0.89
24 INT235746 Positive_regulation of Casp2 2 0.04 2.67 0.67
25 INT79870 Regulation of RNF130 3 0.44 1.12 0.56
26 INT71157 Positive_regulation of RNF130 7 0.67 2.77 0.5
27 INT152016 Positive_regulation of Gene_expression of Pdcd2 1 0.62 1.08 0.48
28 INT152013 Gene_expression of Pdcd2 1 0.69 1.08 0.48
29 INT296651 Negative_regulation of Casp2 2 0.21 1.75 0.35
30 INT92101 Regulation of Negative_regulation of RNF130 1 0.44 0.83 0.22
31 INT310369 Protein_catabolism of Trib3 2 0.01 0.43 0.2
32 INT259005 Positive_regulation of Gene_expression of Relt 1 0.12 0.95 0.2
33 INT258999 Gene_expression of Relt 1 0.16 0.94 0.2
34 INT188059 Transcription of Trib3 3 0.05 1.07 0.18
35 INT296650 Gene_expression of Casp2 2 0.30 1.49 0.17
36 INT67625 Positive_regulation of Regulation of Trib3 1 0.10 0.24 0.17
37 INT296646 Transcription of Casp2 1 0.03 0.71 0.17
38 INT152015 Negative_regulation of Pdcd2 1 0.52 0.37 0.16
39 INT152012 Positive_regulation of Pdcd2 1 0.62 0.36 0.15
40 INT289345 Positive_regulation of Negative_regulation of Trib3 2 0.03 0.54 0.13
41 INT188062 Regulation of Transcription of Trib3 1 0.02 0.25 0.12
42 INT126661 Gene_expression of RNF130 6 0.65 0.59 0.11
43 INT172100 Binding of TOP1 2 0.14 1.31 0.11
44 INT112381 Negative_regulation of Positive_regulation of RNF130 1 0.41 0.37 0.1
45 INT78478 Negative_regulation of TOP1 3 0.21 1.75 0.06
46 INT234134 Positive_regulation of Transcription of Trib3 1 0.03 0.12 0.06
47 INT322341 Binding of Relt 1 0.08 1.3 0.05
48 INT349837 Regulation of Casp2 1 0.13 0.56 0.04
49 INT290912 Positive_regulation of Pkm2 1 0.10 0.14 0.04
50 INT290924 Negative_regulation of Gene_expression of Pkm2 1 0.06 0.08 0.03
51 INT290921 Gene_expression of Pkm2 1 0.10 0.08 0.03
52 INT234133 Negative_regulation of Gene_expression of Trib3 1 0.03 0.13 0
53 INT290919 Regulation of Pkm2 1 0.04 0 0
54 INT229840 Localization of Casp2 1 0.12 0.32 0
55 INT258998 Positive_regulation of Relt 1 0.18 1.33 0
56 INT290925 Negative_regulation of Pkm2 1 0.06 0 0
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