GO:0014032

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Name neural crest cell development
Categary Process
Go Slim No
Go Link GO:0014032
Unique Molecular Interactions 373
Total Molecular Interactions 506
Total Single Events 3610
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neural crest cell development. They are ordered first by their pain relevance and then by number of times they were reported for neural crest cell development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
3 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
4 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
5 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
6 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
7 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
8 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
9 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
10 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
11 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
12 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
13 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
14 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
15 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
16 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
17 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
18 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
19 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
20 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
21 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
22 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
23 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
24 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
25 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
26 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
27 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
28 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
29 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
30 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
31 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
32 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
33 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
34 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
35 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
36 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
37 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
38 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
39 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
40 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
41 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
42 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
43 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
44 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
45 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
46 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
47 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
48 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
49 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
50 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
51 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
52 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
53 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
54 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
55 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
56 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
57 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
58 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
59 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
60 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
61 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
62 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
63 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
64 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
65 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
66 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
67 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
68 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
69 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
70 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
71 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
72 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
73 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
74 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
75 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
76 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
77 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
78 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
79 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
80 INT334763 Ednra Positive_regulation of Gabrg1 1 0.01 0 0.4
81 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
82 INT77683 Ednra Negative_regulation of LH 1 0.03 0.23 0.39
83 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
84 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
85 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
86 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
87 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
88 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
89 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
90 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
91 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
92 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
93 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
94 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
95 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
96 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
97 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
98 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
99 INT303030 Binding of Ednra and MCPH1 1 0.00 1.02 0.32
100 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
101 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
102 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
103 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
104 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
105 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
106 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
107 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
108 INT303005 Binding of Ednra and Pah 1 0.06 1.02 0.32
109 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
110 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
111 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
112 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
113 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31
114 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
115 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
116 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
117 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
118 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
119 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
120 INT117588 Binding of C5AR1 and EDNRA 1 0.40 0.38 0.3
121 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
122 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
123 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28
124 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
125 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
126 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28
127 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
128 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
129 INT214594 Binding of FOXC1 and IBD9 1 0.00 1.81 0.28
130 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
131 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
132 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
133 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
134 INT124117 Apcs Negative_regulation of Ednra 1 0.09 0 0.26
135 INT219918 Positive_regulation of EDNRA Positive_regulation of Trpv1 1 0.13 0 0.26
136 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
137 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
138 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
139 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
140 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
141 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
142 INT36875 Binding of EDNRA and SYNCRIP 1 0.01 0 0.24
143 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
144 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
145 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
146 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
147 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
148 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
149 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
150 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 0.12 0.45 0.22
151 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
152 INT36876 EDNRA Regulation of Negative_regulation of PRB1 1 0.00 0 0.21
153 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
154 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
155 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
156 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
157 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
158 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
159 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
160 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
161 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
162 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
163 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
164 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
165 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
166 INT214591 FOXC1 Regulation of ICAM1 1 0.05 0.29 0.19
167 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
168 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
169 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
170 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
171 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
172 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
173 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
174 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
175 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
176 INT334769 Ednra Positive_regulation of Car2 1 0.02 0.49 0.18
177 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
178 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
179 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
180 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
181 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
182 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
183 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
184 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
185 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
186 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
187 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
188 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
189 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
190 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
191 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
192 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
193 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
194 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
195 INT115205 Positive_regulation of Ednra Positive_regulation of Localization of Avp 1 0.36 0 0.14
196 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
197 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
198 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
199 INT334765 Ednra Positive_regulation of Positive_regulation of Car2 1 0.02 0.24 0.14
200 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14

Single Events

The table below shows the top 100 pain related interactions that have been reported for neural crest cell development. They are ordered first by their pain relevance and then by number of times they were reported in neural crest cell development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
3 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
4 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
5 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
6 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
7 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
8 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
9 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
10 INT5048 Binding of Edn1 55 0.47 18.86 19.16
11 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
12 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
13 INT9191 Localization of EDN1 94 0.81 57.01 14.78
14 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
15 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
16 INT6365 Localization of Edn1 56 0.81 18.84 13.83
17 INT173505 Localization of Hand2 63 0.57 45.32 13.66
18 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
19 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
20 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
21 INT6361 Localization of Edn1 30 0.81 19.09 9.7
22 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
23 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
24 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
25 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
26 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
27 INT10237 Binding of EDN1 40 0.48 16 8.48
28 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
29 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
30 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
31 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
32 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
33 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
34 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
35 INT167049 Binding of Ednra 3 0.07 3.47 6.84
36 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
37 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
38 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
39 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
40 INT246315 Localization of Ednra 22 0.15 2.73 4.64
41 INT21953 Binding of Ednra 12 0.33 4.72 4.56
42 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
43 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
44 INT156131 Binding of Hand2 14 0.25 10.35 3.99
45 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
46 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32
47 INT49971 Regulation of Ednra 10 0.35 2.4 3.06
48 INT53374 Binding of Edn1 17 0.43 11.66 2.98
49 INT93058 Positive_regulation of Gene_expression of Ednra 8 0.28 4.11 2.88
50 INT76836 Positive_regulation of Ednra 6 0.55 2.65 2.72
51 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
52 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
53 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
54 INT156677 Regulation of Gene_expression of Ednra 4 0.15 0.25 2.05
55 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
56 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
57 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
58 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
59 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
60 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
61 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
62 INT72021 Localization of Ednra 7 0.58 3.13 1.53
63 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
64 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
65 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
66 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
67 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
68 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
69 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
70 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
71 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
72 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
73 INT39711 Negative_regulation of FOXC1 4 0.41 4.29 1.2
74 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18
75 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
76 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
77 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12
78 INT156427 Localization of FOXC1 2 0.73 1.36 1.07
79 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
80 INT214609 Positive_regulation of Gene_expression of FOXC1 1 0.08 1.78 1
81 INT46334 Binding of FOXC1 2 0.36 2.66 0.99
82 INT43131 Regulation of FOXC1 3 0.36 1.09 0.98
83 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
84 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
85 INT72024 Localization of EDNRA 11 0.57 8.22 0.96
86 INT19084 Negative_regulation of NRG1 5 0.42 4.9 0.96
87 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
88 INT76835 Negative_regulation of Gene_expression of Ednra 2 0.10 0.89 0.96
89 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
90 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
91 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
92 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
93 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
94 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
95 INT178133 Negative_regulation of Positive_regulation of EDNRA 2 0.35 2.18 0.88
96 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
97 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
98 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
99 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
100 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
101 INT186579 Positive_regulation of Gene_expression of Ednra 5 0.07 0.89 0.76
102 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
103 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
104 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
105 INT169421 Positive_regulation of FOXC1 4 0.49 2.42 0.7
106 INT313697 Phosphorylation of Ednra 1 0.18 0 0.7
107 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
108 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
109 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
110 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
111 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
112 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
113 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
114 INT290081 Regulation of NRG1 7 0.26 5.24 0.59
115 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
116 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
117 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
118 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
119 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
120 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
121 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
122 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
123 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
124 INT186686 Regulation of Positive_regulation of EDNRA 5 0.22 2.35 0.51
125 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
126 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
127 INT126442 Negative_regulation of Gene_expression of Ednra 3 0.33 1.94 0.51
128 INT115202 Positive_regulation of Positive_regulation of Ednra 2 0.39 2.88 0.49
129 INT19083 Positive_regulation of NRG1 3 0.20 0.65 0.48
130 INT120405 Phosphorylation of EDNRA 1 0.61 0.38 0.48
131 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
132 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
133 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
134 INT324888 Transcription of Ednra 2 0.13 0.66 0.43
135 INT158057 Positive_regulation of Positive_regulation of EDNRA 2 0.15 0 0.41
136 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
137 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
138 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
139 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
140 INT290096 Regulation of Gene_expression of NRG1 2 0.06 2.21 0.35
141 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
142 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
143 INT283698 Gene_expression of Sox11 1 0.68 4.6 0.33
144 INT128754 Binding of Foxc1 1 0.01 0.43 0.32
145 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
146 INT72022 Positive_regulation of Localization of Ednra 2 0.32 0.07 0.3
147 INT350970 Negative_regulation of Binding of EDNRA 1 0.41 0.86 0.29
148 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
149 INT334747 Regulation of Binding of Ednra 1 0.06 0.05 0.28
150 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
151 INT214611 Positive_regulation of Localization of FOXC1 1 0.07 0.34 0.26
152 INT203557 Transcription of NRG1 2 0.31 0.7 0.24
153 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
154 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
155 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
156 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
157 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
158 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
159 INT334746 Positive_regulation of Localization of Ednra 1 0.07 0 0.2
160 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
161 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
162 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
163 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
164 INT324881 Regulation of Transcription of Ednra 1 0.08 0.66 0.19
165 INT72023 Positive_regulation of Localization of EDNRA 1 0.02 0.07 0.18
166 INT72025 Negative_regulation of Localization of EDNRA 1 0.01 0.07 0.18
167 INT72020 Negative_regulation of Localization of Ednra 1 0.24 0.07 0.18
168 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
169 INT173335 Negative_regulation of Gene_expression of EDNRA 2 0.19 0.71 0.17
170 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
171 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
172 INT162941 Negative_regulation of Binding of Tfap2a 1 0.32 0.34 0.17
173 INT54093 Protein_catabolism of NRG1 1 0.26 0 0.16
174 INT185203 Regulation of Regulation of FOXC1 1 0.16 0 0.15
175 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
176 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
177 INT70908 Transcription of EDNRA 1 0.08 0.33 0.12
178 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
179 INT70906 Negative_regulation of Transcription of EDNRA 1 0.05 0.33 0.12
180 INT203559 Positive_regulation of Transcription of NRG1 1 0.22 0 0.11
181 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
182 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
183 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
184 INT143835 Gene_expression of Foxc1 2 0.39 1.17 0.09
185 INT143833 Positive_regulation of Foxc1 2 0.42 1.02 0.09
186 INT54092 Regulation of Protein_catabolism of NRG1 1 0.13 0 0.09
187 INT143836 Negative_regulation of Foxc1 1 0.35 0.92 0.09
188 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
189 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
190 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
191 INT283695 Binding of Sox11 1 0.32 0.18 0.08
192 INT334742 Negative_regulation of Transcription of Ednra 1 0.06 0 0.08
193 INT334749 Positive_regulation of Transcription of Ednra 1 0.07 0 0.08
194 INT54094 Positive_regulation of Protein_catabolism of NRG1 1 0.14 0 0.07
195 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
196 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
197 INT290102 Localization of NRG1 1 0.15 0.76 0.06
198 INT283696 Localization of Sox11 1 0.65 0.37 0.05
199 INT283233 Regulation of Regulation of EDNRA 1 0.04 2.22 0.05
200 INT246353 Protein_catabolism of EDNRA 1 0.01 0.48 0.04
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