GO:0014033

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Name neural crest cell differentiation
Categary Process
Go Slim No
Go Link GO:0014033
Unique Molecular Interactions 28
Total Molecular Interactions 31
Total Single Events 265
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neural crest cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for neural crest cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
2 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
3 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
4 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
5 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
6 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
7 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06
8 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
9 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
10 INT280263 Binding of Smad4 and Proc 1 0.00 1.26 0.03
11 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
12 INT277927 WIF1 Negative_regulation of SMAD4 1 0.23 0.37 0
13 INT233506 Tlr4 Positive_regulation of Htr2b 1 0.06 0.09 0
14 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
15 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
16 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
17 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
18 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
19 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
20 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
21 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
22 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
23 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
24 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
25 INT172981 PAN3 Negative_regulation of SMAD4 1 0.01 0.98 0
26 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neural crest cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in neural crest cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
2 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
3 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
4 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
5 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
6 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
7 INT30157 Gene_expression of Htr2b 2 0.48 0 0.94
8 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
9 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
10 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
11 INT57127 Binding of Htr2b 2 0.36 0.05 0.63
12 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
13 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
14 INT161218 Positive_regulation of Positive_regulation of Htr2b 1 0.67 0.69 0.43
15 INT76874 Negative_regulation of Htr2b 1 0.07 0 0.41
16 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
17 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
18 INT92100 Binding of Smad4 5 0.31 2.23 0.3
19 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
20 INT57126 Transcription of Htr2b 1 0.33 0 0.24
21 INT202355 Transcription of Mef2c 3 0.69 0.6 0.21
22 INT248543 Positive_regulation of Mef2c 7 0.69 2.82 0.18
23 INT277935 Binding of SMAD4 4 0.28 1.12 0.17
24 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
25 INT277602 Binding of Mef2c 10 0.39 4.35 0.16
26 INT139977 Regulation of Smad4 1 0.16 1.41 0.15
27 INT325510 Transcription of Smad4 1 0.67 0.16 0.09
28 INT290404 Positive_regulation of Negative_regulation of Mef2c 1 0.50 0.72 0.08
29 INT277578 Regulation of Negative_regulation of Mef2c 2 0.45 1.17 0.07
30 INT254790 Localization of Smad4 2 0.37 0.54 0.06
31 INT290417 Positive_regulation of Gene_expression of Mef2c 1 0.50 1.25 0.06
32 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
33 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
34 INT290407 Positive_regulation of Binding of Mef2c 1 0.44 0.93 0.04
35 INT334291 Positive_regulation of Gene_expression of SMAD4 1 0.18 0 0.04
36 INT268360 Positive_regulation of SMAD4 3 0.55 1.55 0.03
37 INT290419 Regulation of Gene_expression of Mef2c 1 0.62 0.41 0.03
38 INT290399 Negative_regulation of Gene_expression of Mef2c 1 0.59 0.59 0.03
39 INT117563 Negative_regulation of Gene_expression of SMAD4 6 0.54 3.87 0
40 INT334327 Regulation of SMAD4 2 0.35 1.73 0
41 INT268368 Transcription of SMAD4 1 0.54 1.7 0
42 INT233451 Negative_regulation of Htr2b 1 0.33 0.09 0
43 INT290400 Regulation of Regulation of Mef2c 1 0.45 0.24 0
44 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
45 INT173000 Negative_regulation of Localization of SMAD4 1 0.22 0.98 0
46 INT173008 Localization of SMAD4 1 0.38 0.97 0
47 INT290429 Negative_regulation of Negative_regulation of Mef2c 1 0.37 0.05 0
48 INT290425 Negative_regulation of Binding of Mef2c 1 0.37 0 0
49 INT334289 Regulation of Binding of SMAD4 1 0.16 0 0
50 INT290409 Negative_regulation of Transcription of Mef2c 1 0.43 0.08 0
51 INT334288 Regulation of Negative_regulation of SMAD4 1 0.16 0 0
52 INT228250 Positive_regulation of Smad4 1 0.45 1.93 0
53 INT347593 Negative_regulation of Gene_expression of Htr2b 1 0.01 0.16 0
54 INT347117 Negative_regulation of Binding of Lrp6 1 0.28 0.5 0
55 INT335866 Regulation of Transcription of Lrp6 1 0.42 0.25 0
56 INT335881 Gene_expression of Lrp6 1 0.62 0.09 0
57 INT277587 Localization of Mef2c 1 0.65 0.43 0
58 INT228247 Regulation of Positive_regulation of Smad4 1 0.26 0.97 0
59 INT335873 Transcription of Lrp6 1 0.64 0.25 0
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