GO:0014044

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Name Schwann cell development
Categary Process
Go Slim No
Go Link GO:0014044
Unique Molecular Interactions 79
Total Molecular Interactions 101
Total Single Events 752
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Schwann cell development. They are ordered first by their pain relevance and then by number of times they were reported for Schwann cell development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
2 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
3 INT106707 POMC Regulation of Binding of LAMB2 1 0.03 0.7 0.94
4 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
5 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
6 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
7 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
8 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
9 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
10 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
11 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
12 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
13 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
14 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32
15 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32
16 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3
17 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
18 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29
19 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29
20 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28
21 INT337113 Ppp1r1b Negative_regulation of Phosphorylation of Cdk5 1 0.11 0.28 0.27
22 INT273232 Negative_regulation of Binding of Cdk5 and Cdk5r1 1 0.28 3.16 0.23
23 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22
24 INT326834 Cdk5r2 Positive_regulation of Cdk5 1 0.02 0.96 0.21
25 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
26 INT103197 Nf1 Negative_regulation of ras 1 0.04 1.19 0.17
27 INT298998 Il18 Positive_regulation of Cdk5 1 0.11 0.36 0.17
28 INT164791 Cdk5r1 Positive_regulation of Cdk5 1 0.30 0.25 0.17
29 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
30 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
31 INT103198 NF1 Negative_regulation of ras 1 0.05 1.19 0.16
32 INT203591 Positive_regulation of PIK3CG Positive_regulation of Protein_catabolism of LAMB2 1 0.00 0.46 0.14
33 INT273233 Negative_regulation of Cdk5 Negative_regulation of Positive_regulation of Ltp 1 0.20 0.39 0.13
34 INT273239 Cdk5 Positive_regulation of Positive_regulation of GRIN1 1 0.51 0.37 0.12
35 INT191612 Nf1 Positive_regulation of ras 1 0.25 2.6 0.11
36 INT243996 Binding of Dag1 and Dmd 1 0.04 0.08 0.11
37 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1
38 INT273236 Cdk5 Positive_regulation of Car2 1 0.13 0.45 0.1
39 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1
40 INT312841 Pou3f1 Regulation of Gene_expression of Plp1 1 0.24 0.16 0.09
41 INT201751 Car2 Positive_regulation of Cdk5 1 0.00 0.67 0.09
42 INT312844 Pou3f1 Regulation of Gene_expression of Pmp22 1 0.27 0.16 0.09
43 INT312842 Pou3f1 Regulation of Gene_expression of Mag 1 0.24 0.16 0.09
44 INT221954 Binding of CDK5 and CDK5R2 1 0.02 0.36 0.09
45 INT312845 Pou3f1 Regulation of Gene_expression of Mbp 1 0.25 0.16 0.09
46 INT191617 Binding of Nf1 and Rtcd1 1 0.01 0.95 0.08
47 INT244027 Binding of Dag1 and Helt 1 0.00 0.05 0.08
48 INT283126 Dag1 Positive_regulation of Localization of Aqp4 1 0.47 0.2 0.07
49 INT247948 Positive_regulation of Cdk5r1 Positive_regulation of Cdk5 1 0.26 0.16 0.07
50 INT332329 Binding of Cdk5 and P2rx3 1 0.22 0.05 0.05
51 INT332331 Binding of Cdk5 and Rbm39 1 0.00 0.05 0.05
52 INT326830 Cdk5r1 Positive_regulation of Positive_regulation of Cdk5 1 0.09 0.16 0.04
53 INT336638 Binding of LAMB2 and Fn1 1 0.00 0.58 0.04
54 INT221639 Fyn Positive_regulation of Phosphorylation of Cdk5 1 0.14 0.28 0.03
55 INT221661 Sema3a Positive_regulation of Phosphorylation of Cdk5 1 0.19 0.28 0.03
56 INT332330 Cdk5 Negative_regulation of Pirt 1 0.00 0 0.03
57 INT219352 CDK5 Negative_regulation of PAK1 1 0.22 0.72 0.03
58 INT221613 Binding of Cdk5 and Fyn 1 0.10 0.29 0.03
59 INT191613 Binding of Nf1 and Rasa1 1 0.06 0.88 0.03
60 INT221617 Fyn Positive_regulation of Cdk5 1 0.13 0.28 0.03
61 INT292450 LAMB2 Positive_regulation of CALM1 1 0.00 0.4 0
62 INT292515 LAMB2 Positive_regulation of Birc5 1 0.01 0.7 0
63 INT292463 LAMB2 Positive_regulation of Phosphorylation of PTK2 1 0.01 0.7 0
64 INT232715 Binding of LAMB2 and SAFB 1 0.00 0.29 0
65 INT89432 Binding of LAMB2 and IGSF11 1 0.01 0.47 0
66 INT292462 LAMB2 Positive_regulation of BAD 1 0.00 0.7 0
67 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
68 INT201734 Binding of Akt1 and Cdk5 1 0.01 0.31 0
69 INT201738 Positive_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
70 INT89431 Binding of LAMB2 and BCAM 1 0.05 0.47 0
71 INT283122 Binding of Dag1 and Sptbn1 1 0.00 0.07 0
72 INT245828 Binding of VEGFA and Tfap2a 1 0.01 0.64 0
73 INT267229 Binding of LAMB2 and SCFV 1 0.00 0.59 0
74 INT180836 Binding of CTD and NF1 1 0.15 0.2 0
75 INT201731 Negative_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
76 INT268446 Cdk5 Positive_regulation of Cdk5r1 1 0.02 0.58 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Schwann cell development. They are ordered first by their pain relevance and then by number of times they were reported in Schwann cell development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
2 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
3 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
4 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
5 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
6 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
7 INT68216 Binding of NF1 40 0.48 51.24 4.59
8 INT148495 Regulation of Cdk5 6 0.58 5.42 3.95
9 INT196733 Gene_expression of Cdk5 25 0.76 18.25 2.64
10 INT138789 Gene_expression of Cdk5 6 0.76 5.19 2.62
11 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
12 INT60765 Gene_expression of LAMB2 28 0.49 13.93 2.38
13 INT148494 Binding of Cdk5 6 0.40 5.97 2.31
14 INT112905 Phosphorylation of Cdk5 15 0.82 2.78 2.3
15 INT64700 Binding of Nf1 14 0.45 15.24 2.29
16 INT157579 Binding of Cdk5 3 0.35 0.47 2.13
17 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
18 INT68181 Binding of Nf1 6 0.48 8.14 1.88
19 INT148492 Positive_regulation of Binding of Cdk5 1 0.47 0.51 1.86
20 INT158710 Negative_regulation of Binding of Cdk5 1 0.40 0 1.84
21 INT109222 Positive_regulation of Negative_regulation of Cdk5 2 0.50 0.23 1.39
22 INT158709 Negative_regulation of Phosphorylation of Cdk5 1 0.40 0 1.39
23 INT202817 Gene_expression of Dag1 16 0.75 7.82 1.3
24 INT106709 Binding of LAMB2 13 0.06 4.89 1.26
25 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
26 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
27 INT190198 Protein_catabolism of LAMB2 3 0.06 1.39 1.11
28 INT211095 Negative_regulation of Dag1 14 0.57 7.18 1.07
29 INT273221 Positive_regulation of Negative_regulation of Cdk5 8 0.49 9.89 1.03
30 INT106708 Regulation of Binding of LAMB2 2 0.06 0.92 0.94
31 INT203893 Positive_regulation of Gene_expression of Cdk5 2 0.49 7.12 0.92
32 INT138788 Positive_regulation of Gene_expression of Cdk5 1 0.49 0.44 0.91
33 INT127452 Positive_regulation of CDK5 5 0.32 1.88 0.87
34 INT203892 Positive_regulation of Positive_regulation of Cdk5 4 0.49 4.02 0.85
35 INT219358 Gene_expression of CDK5 9 0.58 5.65 0.81
36 INT138787 Positive_regulation of Positive_regulation of Cdk5 1 0.49 0.38 0.81
37 INT201216 Negative_regulation of LAMB2 6 0.04 3.75 0.71
38 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
39 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68
40 INT179133 Localization of Nf1 2 0.80 2.18 0.68
41 INT196790 Localization of Cdk5 6 0.74 2.6 0.67
42 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67
43 INT283119 Regulation of Dag1 4 0.44 1.98 0.65
44 INT283110 Localization of Dag1 5 0.73 3.14 0.61
45 INT127557 Positive_regulation of Phosphorylation of Cdk5 2 0.50 0.43 0.56
46 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51
47 INT316933 Transcription of Nf1 1 0.18 0.49 0.47
48 INT316939 Positive_regulation of Transcription of Nf1 1 0.16 0.49 0.47
49 INT283120 Regulation of Gene_expression of Dag1 4 0.52 1.32 0.38
50 INT232743 Positive_regulation of LAMB2 5 0.06 1.94 0.37
51 INT273218 Negative_regulation of Negative_regulation of Cdk5 1 0.42 3.06 0.37
52 INT221973 Negative_regulation of CDK5 4 0.57 2.26 0.36
53 INT112334 Regulation of NF1 18 0.52 15.85 0.34
54 INT326820 Negative_regulation of Positive_regulation of Cdk5 1 0.36 1.27 0.28
55 INT298972 Transcription of Cdk5 1 0.15 1.63 0.28
56 INT164788 Regulation of Gene_expression of Cdk5 1 0.27 0.31 0.24
57 INT129342 Positive_regulation of Positive_regulation of Nf1 1 0.50 0.79 0.23
58 INT68180 Regulation of Nf1 2 0.27 2.02 0.22
59 INT286203 Protein_catabolism of Dag1 2 0.26 1.56 0.22
60 INT316917 Negative_regulation of Protein_catabolism of Dag1 1 0.12 0.44 0.21
61 INT283102 Positive_regulation of Dag1 1 0.49 1.31 0.21
62 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2
63 INT129341 Negative_regulation of Gene_expression of Nf1 2 0.43 1.67 0.2
64 INT219375 Localization of CDK5 4 0.52 2.8 0.19
65 INT243937 Binding of Dag1 1 0.05 0.13 0.19
66 INT221974 Phosphorylation of CDK5 1 0.56 0.99 0.19
67 INT273226 Negative_regulation of Gene_expression of Cdk5 2 0.42 0.79 0.17
68 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
69 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
70 INT155285 Positive_regulation of Nf1 1 0.16 0.55 0.17
71 INT283105 Positive_regulation of Gene_expression of Dag1 1 0.67 1.19 0.17
72 INT162941 Negative_regulation of Binding of Tfap2a 1 0.32 0.34 0.17
73 INT157582 Regulation of Phosphorylation of Cdk5 1 0.26 0.25 0.16
74 INT103196 Negative_regulation of Gene_expression of Nf1 1 0.57 1.21 0.16
75 INT221972 Regulation of CDK5 1 0.42 1.87 0.16
76 INT175646 Negative_regulation of Gene_expression of LAMB2 2 0.02 1.41 0.14
77 INT312823 Gene_expression of Pou3f1 2 0.38 0.45 0.12
78 INT326822 Negative_regulation of Phosphorylation of Cdk5 1 0.36 0.43 0.12
79 INT334842 Positive_regulation of Positive_regulation of Pou3f1 1 0.15 0.28 0.11
80 INT341559 Positive_regulation of Gene_expression of CDK5 1 0.23 0.25 0.11
81 INT334847 Positive_regulation of Pou3f1 1 0.21 0.28 0.11
82 INT312824 Transcription of Pou3f1 1 0.39 0.16 0.09
83 INT283103 Regulation of Localization of Dag1 1 0.44 0.32 0.09
84 INT250143 Positive_regulation of Gene_expression of LAMB2 1 0.07 0.43 0.09
85 INT201655 Negative_regulation of Binding of Cdk5 1 0.06 0.9 0.09
86 INT61991 Negative_regulation of Gene_expression of NF1 1 0.59 1.67 0.08
87 INT190026 Positive_regulation of Gene_expression of Nf1 3 0.53 2.45 0.07
88 INT341567 Negative_regulation of Gene_expression of CDK5 1 0.27 0.24 0.07
89 INT219355 Binding of CDK5 3 0.35 2.02 0.06
90 INT334844 Negative_regulation of Pou3f1 1 0.13 0.31 0.04
91 INT169558 Positive_regulation of NF1 13 0.59 13.58 0
92 INT232746 Negative_regulation of Binding of LAMB2 2 0.06 0.7 0
93 INT112333 Localization of NF1 2 0.51 0.63 0
94 INT216268 Positive_regulation of Positive_regulation of NF1 2 0.40 2.08 0
95 INT292477 Phosphorylation of LAMB2 1 0.01 0.64 0
96 INT283107 Transcription of Dag1 1 0.61 0.44 0
97 INT267237 Localization of LAMB2 1 0.02 0.9 0
98 INT268444 Regulation of Positive_regulation of Cdk5 1 0.08 0.66 0
99 INT286141 Negative_regulation of Negative_regulation of NF1 1 0.01 0.66 0
100 INT237279 Regulation of Binding of NF1 1 0.38 0.79 0
101 INT283101 Negative_regulation of Gene_expression of Dag1 1 0.57 0.96 0
102 INT177934 Regulation of Gene_expression of NF1 1 0.19 1.23 0
103 INT283113 Regulation of Transcription of Dag1 1 0.52 0.44 0
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