GO:0014062

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Name regulation of serotonin secretion
Categary Process
Go Slim No
Go Link GO:0014062
Unique Molecular Interactions 230
Total Molecular Interactions 408
Total Single Events 2681
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of serotonin secretion. They are ordered first by their pain relevance and then by number of times they were reported for regulation of serotonin secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
2 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
3 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
4 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
5 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
6 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
7 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
8 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
9 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
10 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
11 INT29716 Crh Negative_regulation of Localization of Gnrh1 5 0.44 0 2.35
12 INT18791 Crh Regulation of Penk 2 0.49 0 2.15
13 INT356313 Crh Positive_regulation of Localization of Helt 1 0.02 0 2.11
14 INT30954 Crh Negative_regulation of LH 5 0.46 1.4 2.06
15 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
16 INT163266 Crh Negative_regulation of Tyr 1 0.01 0.45 1.98
17 INT165284 Positive_regulation of Nts Positive_regulation of Crh 1 0.40 1.86 1.93
18 INT165285 Nts Positive_regulation of Crh 1 0.40 1.84 1.91
19 INT149469 Oxt Regulation of Gene_expression of Crh 1 0.45 1.2 1.91
20 INT29715 Crh Negative_regulation of Localization of LH 5 0.43 0 1.78
21 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
22 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
23 INT341372 CRX Positive_regulation of Gene_expression of Crh 1 0.04 1.81 1.7
24 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
25 INT151020 Binding of Pdyn and Crh 1 0.14 0.42 1.59
26 INT356327 Crh Positive_regulation of Localization of Gabrg1 1 0.17 0 1.58
27 INT209087 Crh Positive_regulation of Ceacam3 1 0.24 1.45 1.54
28 INT59547 Avp Positive_regulation of Crh 2 0.14 1.13 1.47
29 INT199494 Crh Positive_regulation of Localization of Pdyn 1 0.02 0.43 1.4
30 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
31 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
32 INT62448 Il2 Positive_regulation of Crh 1 0.59 0.36 1.3
33 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28
34 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
35 INT142431 Cp Positive_regulation of Crh 1 0.31 1.49 1.26
36 INT29714 Crh Regulation of Localization of LH 2 0.26 0 1.19
37 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
38 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
39 INT29713 Crh Negative_regulation of Localization of Gnrhr 1 0.39 0 1.12
40 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
41 INT356316 Crh Positive_regulation of Localization of Cea 1 0.34 0 1.06
42 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04
43 INT210015 Binding of Adcyap1 and Crh 1 0.47 0.88 1
44 INT5612 Cck Positive_regulation of Localization of Crh 1 0.65 0.16 1
45 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
46 INT31494 Pomc Regulation of Crh 2 0.12 0.13 0.97
47 INT36002 Negative_regulation of Crh Negative_regulation of LH 2 0.29 0.66 0.96
48 INT149471 Avp Regulation of Gene_expression of Crh 1 0.45 0.6 0.96
49 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91
50 INT62449 Gnrh1 Regulation of Crh 1 0.40 0.34 0.91
51 INT66371 Pomc Regulation of Gene_expression of Crh 2 0.49 0 0.88
52 INT21006 Oprl1 Regulation of Localization of Crh 1 0.19 0 0.84
53 INT64629 Binding of Gal and Crh 1 0.18 0.1 0.83
54 INT64627 Binding of Oxt and Crh 1 0.07 0.1 0.83
55 INT122191 Binding of Crh and Ucn 4 0.36 0.79 0.82
56 INT36003 Crh Positive_regulation of Localization of LH 2 0.45 0 0.79
57 INT79532 Crh Regulation of Ugt1a10 1 0.00 0 0.76
58 INT28620 Penk Regulation of Crh 2 0.40 0.25 0.75
59 INT30838 Crh Negative_regulation of D230030E09Rik 1 0.17 0.1 0.73
60 INT290551 Crh Positive_regulation of Etf1 1 0.01 0.38 0.73
61 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
62 INT290553 Positive_regulation of Oprk1 Positive_regulation of Crh 1 0.33 0.39 0.72
63 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
64 INT313778 Gene_expression of Crhq1 Negative_regulation of Localization of Crh 1 0.05 0.66 0.71
65 INT12022 Crh Positive_regulation of Localization of Prl 1 0.02 0.14 0.7
66 INT26198 Positive_regulation of Crh Positive_regulation of Localization of POMC 1 0.38 0 0.7
67 INT55205 Prl Positive_regulation of Localization of Crh 1 0.47 0 0.69
68 INT55209 Prl Positive_regulation of Crh 1 0.51 0 0.69
69 INT253825 Cck Positive_regulation of Crh 1 0.74 0 0.69
70 INT253830 Cck Positive_regulation of Crh 1 0.38 0 0.68
71 INT135119 Binding of Pomc and Crh 1 0.35 0 0.67
72 INT103905 Gh Positive_regulation of Positive_regulation of Crh 1 0.08 0.9 0.66
73 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
74 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64
75 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
76 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
77 INT34212 PSG2 Regulation of Localization of Crh 1 0.02 0.09 0.63
78 INT34211 DNM2 Regulation of Localization of Crh 1 0.01 0.09 0.63
79 INT142432 Regulation of Cp Positive_regulation of Crh 1 0.18 0.75 0.63
80 INT23576 Binding of Penk and Crh 2 0.18 0 0.62
81 INT20162 Crh Regulation of GNRH1 2 0.02 0.07 0.62
82 INT27067 Crh Positive_regulation of Localization of Avp 3 0.18 0.46 0.61
83 INT91391 Crh Regulation of Localization of Gnrh1 2 0.36 1.78 0.61
84 INT356328 Crh Positive_regulation of Cea 1 0.26 0.28 0.6
85 INT57246 Crh Positive_regulation of Positive_regulation of Caprin2 1 0.01 0.55 0.6
86 INT104050 Binding of Crh and Nts 1 0.40 0 0.6
87 INT59540 Crh Regulation of Gnrh1 2 0.36 2.61 0.58
88 INT356315 Crh Regulation of Cea 1 0.16 0.08 0.58
89 INT91393 Crh Positive_regulation of SST 1 0.01 0.73 0.58
90 INT54620 IL1B Positive_regulation of Crh 1 0.01 0.39 0.58
91 INT62445 Pomc Negative_regulation of Localization of Crh 1 0.12 0.07 0.58
92 INT30268 Binding of Gnrh1 and Crh 1 0.45 0.65 0.57
93 INT356311 Crh Regulation of Gabrg1 1 0.08 0.08 0.57
94 INT77367 IFNA1 Positive_regulation of Positive_regulation of Crh 1 0.05 0.76 0.57
95 INT30267 Binding of Crh and Gnrhr 1 0.33 0.65 0.57
96 INT94499 Tnf Positive_regulation of Gene_expression of Crh 1 0.27 0.97 0.56
97 INT141020 Crh Positive_regulation of Gene_expression of Pomc 1 0.05 0.17 0.55
98 INT60627 Crh Positive_regulation of Localization of Mc2r 2 0.11 0.44 0.53
99 INT87557 Crh Positive_regulation of Prkaca 1 0.27 0 0.52
100 INT205030 Crh Positive_regulation of Crhr1 2 0.54 1.33 0.51
101 INT55208 Prl Negative_regulation of Localization of Crh 1 0.43 0 0.51
102 INT127337 Crh Regulation of LOC308670 1 0.01 0 0.51
103 INT62446 Il6 Positive_regulation of Crh 1 0.22 0.05 0.5
104 INT27066 Crh Positive_regulation of Localization of Oxt 1 0.40 0 0.48
105 INT59546 Avp Positive_regulation of Localization of Crh 1 0.05 0.08 0.47
106 INT59548 Negative_regulation of Avp Positive_regulation of Crh 1 0.04 0.08 0.47
107 INT28619 Negative_regulation of Penk Regulation of Crh 1 0.41 0 0.46
108 INT62447 Gnrh1 Regulation of Localization of Crh 1 0.40 0.17 0.45
109 INT57983 Il1b Regulation of Crh 1 0.37 0.09 0.44
110 INT57981 Regulation of Il1b Positive_regulation of Crh 1 0.22 0.1 0.44
111 INT30083 Binding of Crh and Lvp1 1 0.00 0.35 0.44
112 INT290543 Binding of Crh and Pdyn 1 0.25 1.04 0.43
113 INT273945 Crh Positive_regulation of Gene_expression of Crem 1 0.20 0.52 0.43
114 INT139486 Oprm1 Positive_regulation of Crh 1 0.27 0.1 0.42
115 INT55202 Crh Positive_regulation of Negative_regulation of Prl 1 0.51 0 0.41
116 INT91107 Positive_regulation of Ptgs1 Positive_regulation of Localization of Crh 1 0.00 0.56 0.41
117 INT273939 Positive_regulation of Crem Negative_regulation of Transcription of Crh 1 0.18 0.99 0.39
118 INT273956 Binding of Crem and Negative_regulation of Transcription of Crh 1 0.18 0.99 0.39
119 INT122188 Binding of Crh and Ucn2 2 0.22 0.29 0.38
120 INT73772 NR3C1 Regulation of Regulation of Crh 1 0.02 0.68 0.38
121 INT356319 ORF61 Regulation of Crh 1 0.00 0.1 0.38
122 INT25763 Crh Positive_regulation of Prkacb 1 0.56 0.07 0.37
123 INT41460 Crh Regulation of Pomc 1 0.10 0.1 0.36
124 INT26197 Qrfp Regulation of Localization of Crh 1 0.02 0 0.36
125 INT41461 Crh Regulation of Localization of Pomc 1 0.10 0.1 0.36
126 INT66368 Pomc Regulation of Positive_regulation of Crh 1 0.36 0 0.35
127 INT37552 Crh Regulation of Avp 1 0.22 0 0.34
128 INT37551 Positive_regulation of Crh Regulation of Avp 1 0.38 0 0.34
129 INT37553 Crh Regulation of FDX1 1 0.03 0 0.34
130 INT280838 Binding of Crh and gr 1 0.06 0 0.33
131 INT30418 Crh Negative_regulation of Localization of Gh1 1 0.41 0.72 0.33
132 INT273955 Creb1 Positive_regulation of Transcription of Crh 1 0.14 0.96 0.33
133 INT30524 Crh Regulation of Oprl1 1 0.15 0.15 0.33
134 INT82904 Crh Negative_regulation of ge 1 0.00 1.3 0.33
135 INT26196 Npy Positive_regulation of Localization of Crh 1 0.40 0 0.33
136 INT60628 Crh Positive_regulation of Pomc 1 0.52 0.17 0.32
137 INT26071 Adarb1 Regulation of Localization of Crh 1 0.01 0.21 0.32
138 INT30420 Crh Positive_regulation of Localization of Gh1 1 0.67 0.47 0.32
139 INT107944 Crh Regulation of Adarb1 1 0.06 0 0.32
140 INT115597 Avp Positive_regulation of Crh 1 0.56 0.79 0.31
141 INT141019 Crh Positive_regulation of Gene_expression of Pomc 1 0.20 0.1 0.31
142 INT290552 Crh Positive_regulation of Positive_regulation of Pdyn 1 0.38 0.23 0.3
143 INT126696 Binding of Crhr1 and Crh 3 0.50 0.44 0.29
144 INT74331 Crh Regulation of Transcription of Penk 1 0.40 0.25 0.29
145 INT74335 Penk Regulation of Transcription of Crh 1 0.40 0.25 0.29
146 INT74336 Crh Regulation of Transcription of Egr1 1 0.49 0.24 0.28
147 INT74330 Crh Regulation of Transcription of Fos 1 0.49 0.24 0.28
148 INT280832 Binding of Crh and Ucn3 1 0.16 0.07 0.27
149 INT273953 Crem Regulation of Transcription of Crh 1 0.26 0.99 0.27
150 INT280822 Jun Regulation of Regulation of Crh 1 0.20 0.08 0.27
151 INT56978 Crh Positive_regulation of Localization of Gnrh1 1 0.10 0 0.24
152 INT154523 Binding of Oxt and Crh 1 0.11 0 0.24
153 INT121050 Crh Regulation of Localization of Pomc 4 0.43 0.6 0.22
154 INT137611 Crh Positive_regulation of Vegfa 1 0.43 0.49 0.21
155 INT137612 Crh Positive_regulation of Positive_regulation of Vegfa 1 0.43 0.43 0.21
156 INT92205 Crh Positive_regulation of Localization of SST 1 0.30 0.87 0.21
157 INT137610 Crh Positive_regulation of Localization of Vegfa 1 0.43 0.49 0.21
158 INT177479 Negative_regulation of Crh Regulation of POMC 1 0.05 0.84 0.21
159 INT33560 Binding of POMC and Crh 1 0.24 0.22 0.2
160 INT62451 Il2 Regulation of Localization of Crh 1 0.53 0.19 0.2
161 INT143394 Ucn Regulation of Crh 1 0.44 0.19 0.2
162 INT280820 S100a8 Positive_regulation of Gene_expression of Crh 1 0.01 0.65 0.19
163 INT280839 Il6 Positive_regulation of Gene_expression of Crh 1 0.09 0.1 0.19
164 INT25053 Crh Regulation of PLOD1 1 0.11 0 0.19
165 INT25052 Crh Regulation of FSHR 1 0.08 0 0.19
166 INT59589 Npy Regulation of Crh 1 0.27 0 0.18
167 INT121045 Crh Regulation of Gene_expression of Pomc 1 0.03 0.16 0.18
168 INT55988 POMC Positive_regulation of Negative_regulation of Crh 1 0.01 0 0.18
169 INT342647 Negative_regulation of Binding of Avp and Crh 1 0.37 0.64 0.18
170 INT59588 Npy Positive_regulation of Crh 1 0.41 0 0.18
171 INT121046 Crh Regulation of Localization of Pomc 1 0.03 0.16 0.18
172 INT59587 Npy Regulation of Gene_expression of Crh 1 0.27 0 0.18
173 INT33694 Crh Negative_regulation of Rhd 1 0.08 1.41 0.18
174 INT124236 Crh Regulation of Localization of BTF3 1 0.00 0.32 0.18
175 INT34351 Crh Regulation of DBI 1 0.00 0.25 0.17
176 INT280833 Il1 Positive_regulation of Gene_expression of Crh 1 0.05 0.09 0.17
177 INT222505 Gene_expression of Crh Negative_regulation of Gene_expression of Hpse 1 0.02 0.55 0.17
178 INT25050 Crh Negative_regulation of PLOD1 1 0.11 0 0.17
179 INT25054 Crh Negative_regulation of FSHR 1 0.07 0 0.17
180 INT17922 Positive_regulation of Crh Positive_regulation of Fos 1 0.23 0.19 0.17
181 INT5520 Negative_regulation of Dbi Negative_regulation of Gene_expression of Crh 1 0.21 0.44 0.16
182 INT280846 Crh Positive_regulation of Localization of POMC 1 0.03 0.37 0.16
183 INT5521 Oprd1 Negative_regulation of Gene_expression of Crh 1 0.11 0.43 0.16
184 INT5517 Negative_regulation of Dbi Negative_regulation of Crh 1 0.27 0.44 0.16
185 INT5522 Pomc Negative_regulation of Gene_expression of Crh 1 0.27 0.39 0.16
186 INT5516 Oprd1 Negative_regulation of Crh 1 0.15 0.43 0.16
187 INT30084 Lvp1 Regulation of Localization of Crh 1 0.00 0.14 0.16
188 INT121047 Crh Regulation of Gene_expression of Pomc 1 0.58 0.29 0.15
189 INT30421 Gnrhr Regulation of Crh 1 0.11 0.27 0.15
190 INT39154 Crh Positive_regulation of Avp 2 0.11 0.15 0.14
191 INT177480 Positive_regulation of Crh Positive_regulation of Regulation of POMC 1 0.06 0.46 0.14
192 INT293119 Agtr1a Regulation of Positive_regulation of Crh 1 0.12 0.37 0.14
193 INT293115 Agt Regulation of Positive_regulation of Crh 1 0.16 0.37 0.14
194 INT121049 Crh Regulation of Gene_expression of Mc2r 1 0.10 0.29 0.14
195 INT33749 Crh Positive_regulation of Localization of Agt 1 0.31 0 0.13
196 INT8162 Fos Regulation of Gene_expression of Crh 1 0.35 0.31 0.13
197 INT62748 Crh Regulation of Gal 1 0.27 0.36 0.12
198 INT168578 Crh Positive_regulation of Hrasls 1 0.06 0 0.12
199 INT205031 Crh Positive_regulation of Crhr2 1 0.45 1.11 0.11
200 INT280836 Gene_expression of Fos Positive_regulation of Crh 1 0.09 0.17 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of serotonin secretion. They are ordered first by their pain relevance and then by number of times they were reported in regulation of serotonin secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1562 Localization of Crh 499 0.81 126.74 236.68
2 INT438 Gene_expression of Crh 376 0.78 159.11 169.17
3 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14
4 INT1898 Regulation of Crh 220 0.62 61.33 102.64
5 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28
6 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92
7 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23
8 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26
9 INT5514 Negative_regulation of Localization of Crh 64 0.58 8.12 29.29
10 INT16879 Binding of Crh 72 0.48 21.65 28.43
11 INT21379 Transcription of Crh 65 0.72 15.64 27.92
12 INT7584 Gene_expression of Crh 112 0.78 39.15 25.33
13 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34
14 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73
15 INT8075 Localization of Crh 64 0.81 25.41 19.45
16 INT21177 Positive_regulation of Crh 39 0.70 17.5 15.28
17 INT7585 Regulation of Crh 24 0.58 9.88 12.97
18 INT5498 Positive_regulation of Positive_regulation of Crh 19 0.70 9.82 7.97
19 INT21179 Negative_regulation of Crh 22 0.58 8.03 7.87
20 INT22336 Positive_regulation of Transcription of Crh 18 0.68 4.61 6.91
21 INT22485 Negative_regulation of Positive_regulation of Crh 13 0.59 4.49 5.46
22 INT18244 Regulation of Positive_regulation of Crh 11 0.45 3.87 5.41
23 INT22338 Negative_regulation of Transcription of Crh 11 0.43 2.09 5.24
24 INT97894 Positive_regulation of Gene_expression of Crh 27 0.70 11.82 4.82
25 INT19777 Binding of Crh 16 0.40 6.65 4.36
26 INT134008 Transcription of Crh 8 0.59 6.12 3.95
27 INT63441 Regulation of Transcription of Crh 9 0.60 4.51 3.9
28 INT103739 Negative_regulation of Gene_expression of Crh 19 0.59 10.19 3.17
29 INT28715 Negative_regulation of Regulation of Crh 7 0.43 0.97 3.06
30 INT54740 Positive_regulation of Localization of Crh 10 0.47 7.27 3.01
31 INT235853 Regulation of Gene_expression of Crh 7 0.51 1.98 2.66
32 INT5510 Negative_regulation of Negative_regulation of Crh 8 0.43 1.05 2.61
33 INT22339 Positive_regulation of Negative_regulation of Crh 5 0.67 1.36 2.59
34 INT30834 Regulation of Negative_regulation of Crh 3 0.45 0.62 1.81
35 INT29084 Regulation of Localization of Crh 4 0.29 1.24 1.72
36 INT18710 Regulation of Regulation of Crh 6 0.60 0.79 1.6
37 INT21178 Positive_regulation of Negative_regulation of Crh 1 0.37 0.13 1.28
38 INT25043 Positive_regulation of Regulation of Crh 5 0.50 1 1.06
39 INT58050 Regulation of Binding of Crh 2 0.42 0.84 0.86
40 INT280771 Positive_regulation of Positive_regulation of Crh 2 0.41 0.21 0.76
41 INT140282 Negative_regulation of Positive_regulation of Crh 3 0.39 1.09 0.71
42 INT142429 Positive_regulation of Transcription of Crh 1 0.47 0.73 0.67
43 INT134009 Regulation of Transcription of Crh 2 0.37 1.1 0.66
44 INT25761 Regulation of Positive_regulation of Crh 1 0.45 0.15 0.65
45 INT19776 Positive_regulation of Binding of Crh 1 0.43 0 0.44
46 INT83897 Protein_catabolism of Crh 2 0.86 1.75 0.39
47 INT290535 Negative_regulation of Negative_regulation of Crh 1 0.32 0.19 0.28
48 INT280775 Regulation of Regulation of Crh 1 0.37 0.08 0.27
49 INT55986 Positive_regulation of Binding of Crh 1 0.48 0.76 0.19
50 INT92090 Negative_regulation of Protein_catabolism of Crh 1 0.04 0.99 0.12
51 INT53238 Negative_regulation of Binding of Crh 1 0.48 0.8 0.03
52 INT280784 Negative_regulation of Transcription of Crh 1 0.48 0.25 0
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