GO:0014065

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Name phosphatidylinositol 3-kinase cascade
Categary Process
Go Slim No
Go Link GO:0014065
Unique Molecular Interactions 626
Total Molecular Interactions 874
Total Single Events 6686
Pain Genes Associated 29

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol 3-kinase cascade. They are ordered first by their pain relevance and then by number of times they were reported for phosphatidylinositol 3-kinase cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
3 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
4 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
5 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
6 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
7 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41
8 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
9 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
10 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
11 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
12 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
13 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
14 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
15 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
16 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
17 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
18 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
19 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
20 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
21 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
22 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
23 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
24 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
25 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
26 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
27 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
28 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
29 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
30 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
31 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
32 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
33 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
34 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
35 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
36 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
37 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
38 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
39 INT129313 HTR2A Positive_regulation of Oxt 1 0.41 0.22 0.67
40 INT261517 Binding of HTR2A and USH1C 1 0.01 0 0.66
41 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
42 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
43 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
44 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
45 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
46 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
47 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
48 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
49 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
50 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
51 INT36511 Binding of Htr2a and Eef1a1 1 0.22 0 0.62
52 INT36512 Binding of Htr2a and Man2a2 1 0.19 0 0.62
53 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
54 INT117707 Oprm1 Positive_regulation of PIK3CG 1 0.00 0.08 0.6
55 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
56 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
57 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
58 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
59 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
60 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
61 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
62 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
63 INT47745 Binding of Slc6a4 and Htr2a 1 0.33 0.09 0.52
64 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
65 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
66 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
67 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
68 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
69 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
70 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
71 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
72 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
73 INT74085 Binding of Htr1d and Htr2a 1 0.40 0.65 0.45
74 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
75 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
76 INT118136 Binding of HTR1A and HTR2A 1 0.36 0.77 0.45
77 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
78 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
79 INT337325 PIK3CD Positive_regulation of Phosphorylation of IL2RG 1 0.00 0 0.43
80 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
81 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
82 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
83 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
84 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
85 INT166157 Ccr9 Positive_regulation of Pik3r1 1 0.55 2.14 0.39
86 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
87 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
88 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
89 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
90 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
91 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
92 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
93 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
94 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
95 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
96 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
97 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
98 INT168779 Binding of Pik3r1 and Tnf 1 0.01 0.73 0.33
99 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
100 INT80205 HTR1B Positive_regulation of Positive_regulation of HTR2A 1 0.54 0 0.33
101 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
102 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32
103 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
104 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32
105 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
106 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
107 INT326090 Binding of Erbb2 and Mmp2 1 0.09 1.39 0.31
108 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
109 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3
110 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
111 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
112 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
113 INT185141 Pik3r1 Positive_regulation of Snrpd1 1 0.00 0.16 0.29
114 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
115 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
116 INT144434 Gene_expression of Erbb2 Positive_regulation of ras 1 0.16 0.6 0.28
117 INT303948 LEPR Positive_regulation of PIK3CG 1 0.02 0.22 0.28
118 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
119 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
120 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
121 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
122 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
123 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
124 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
125 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
126 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
127 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
128 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
129 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
130 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
131 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
132 INT66681 Positive_regulation of HTR2A Positive_regulation of Localization of SFTPA1 1 0.22 0.07 0.24
133 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
134 INT121581 Negative_regulation of PIK3CG Positive_regulation of GDF15 1 0.36 0.59 0.24
135 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
136 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
137 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
138 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
139 INT144433 Gene_expression of Erbb2 Positive_regulation of Positive_regulation of Mapk3 1 0.41 0.56 0.21
140 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
141 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
142 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
143 INT50886 HTR2A Positive_regulation of HTR1D 1 0.54 0.07 0.2
144 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
145 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
146 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
147 INT280621 Il6 Negative_regulation of Transcription of Irs1 1 0.25 0.4 0.19
148 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
149 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
150 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
151 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
152 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18
153 INT314038 THL Negative_regulation of Pik3r1 1 0.14 0.78 0.18
154 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
155 INT121580 PIK3CG Regulation of Gene_expression of GDF15 1 0.48 0.4 0.18
156 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
157 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
158 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17
159 INT103197 Nf1 Negative_regulation of ras 1 0.04 1.19 0.17
160 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
161 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
162 INT115610 Binding of ERBB2 and KLF1 1 0.02 2.12 0.17
163 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
164 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
165 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
166 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
167 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
168 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
169 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
170 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
171 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
172 INT246843 Positive_regulation of Binding of Irs1 and Ppp1r13b 1 0.18 0.28 0.16
173 INT103198 NF1 Negative_regulation of ras 1 0.05 1.19 0.16
174 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
175 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
176 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
177 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
178 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
179 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
180 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
181 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
182 INT350081 Pik3r1 Positive_regulation of Hmox1 1 0.07 0.2 0.15
183 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
184 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
185 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
186 INT203591 Positive_regulation of PIK3CG Positive_regulation of Protein_catabolism of LAMB2 1 0.00 0.46 0.14
187 INT261520 Binding of DLG4 and HTR2A 1 0.06 0 0.14
188 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
189 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
190 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13
191 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
192 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
193 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
194 INT335460 FPR1 Positive_regulation of PIK3CD 1 0.17 0 0.13
195 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
196 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
197 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
198 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
199 INT129094 Binding of GRP and Pik3r1 1 0.00 0.49 0.12
200 INT129091 Binding of PIK3CG and Lyn 1 0.00 0.47 0.12

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol 3-kinase cascade. They are ordered first by their pain relevance and then by number of times they were reported in phosphatidylinositol 3-kinase cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
6 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
7 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
8 INT5048 Binding of Edn1 55 0.47 18.86 19.16
9 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7
10 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
11 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
12 INT9191 Localization of EDN1 94 0.81 57.01 14.78
13 INT5324 Binding of Htr2a 23 0.47 7.14 14.66
14 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
15 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14
16 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
17 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87
18 INT6365 Localization of Edn1 56 0.81 18.84 13.83
19 INT30961 Binding of HTR2A 33 0.47 11.44 12.86
20 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
21 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
22 INT27258 Regulation of Htr2a 18 0.60 6.37 11.06
23 INT11669 Gene_expression of Htr2a 17 0.75 6.78 10.75
24 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
25 INT35835 Positive_regulation of Htr2a 17 0.67 10.68 9.81
26 INT6361 Localization of Edn1 30 0.81 19.09 9.7
27 INT16580 Negative_regulation of Htr2a 18 0.57 3.8 9.63
28 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07
29 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
30 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
31 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
32 INT10237 Binding of EDN1 40 0.48 16 8.48
33 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25
34 INT59276 Transcription of Htr2a 12 0.69 10.47 8.25
35 INT27785 Regulation of HTR2A 11 0.44 8 8.18
36 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
37 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37
38 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
39 INT35452 Gene_expression of Htr2a 11 0.65 5.11 6.1
40 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
41 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
42 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
43 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
44 INT118274 Positive_regulation of Positive_regulation of PIK3CG 8 0.64 4.81 4.62
45 INT68216 Binding of NF1 40 0.48 51.24 4.59
46 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
47 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
48 INT98057 Regulation of Htr2a 9 0.44 5.06 4.28
49 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
50 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2
51 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
52 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
53 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
54 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97
55 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
56 INT60667 Transcription of HTR2A 5 0.67 0.44 3.71
57 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
58 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
59 INT59275 Positive_regulation of Transcription of Htr2a 6 0.49 4.65 3.34
60 INT35450 Negative_regulation of Htr2a 7 0.47 3.46 3.33
61 INT66617 Localization of HTR2A 6 0.80 1.35 3.32
62 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
63 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
64 INT53374 Binding of Edn1 17 0.43 11.66 2.98
65 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89
66 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
67 INT54754 Localization of Htr2a 6 0.73 0.73 2.85
68 INT49843 Positive_regulation of Gene_expression of Htr2a 3 0.49 1.53 2.84
69 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
70 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
71 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
72 INT20593 Positive_regulation of Positive_regulation of Htr2a 6 0.49 1.29 2.55
73 INT62141 Positive_regulation of Gene_expression of HTR2A 8 0.67 2.47 2.42
74 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
75 INT20072 Positive_regulation of Positive_regulation of HTR2A 5 0.67 2.96 2.33
76 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
77 INT64700 Binding of Nf1 14 0.45 15.24 2.29
78 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
79 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
80 INT264967 Positive_regulation of Positive_regulation of PIK3CD 4 0.18 1.97 2.13
81 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
82 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
83 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
84 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
85 INT68181 Binding of Nf1 6 0.48 8.14 1.88
86 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
87 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
88 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
89 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
90 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
91 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
92 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
93 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
94 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
95 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
96 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
97 INT243799 Gene_expression of PIK3CD 15 0.45 6.63 1.5
98 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
99 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
100 INT189286 Regulation of Gene_expression of Htr2a 1 0.01 1.12 1.49
101 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
102 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
103 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
104 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
105 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
106 INT116008 Binding of Gata3 2 0.34 1.37 1.41
107 INT189290 Positive_regulation of Positive_regulation of Htr2a 1 0.02 2.51 1.41
108 INT286696 Binding of Htr2a 2 0.35 0.71 1.4
109 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
110 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
111 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
112 INT250707 Gene_expression of PIK3CB 15 0.31 5.4 1.34
113 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
114 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
115 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
116 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
117 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
118 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
119 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
120 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
121 INT264969 Localization of PIK3CD 5 0.50 0.64 1.13
122 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
123 INT59274 Positive_regulation of Binding of Htr2a 2 0.67 0.93 1.12
124 INT133079 Positive_regulation of Gene_expression of GATA3 3 0.50 1.03 1.11
125 INT293487 Regulation of Gene_expression of Erbb2 4 0.61 3.4 1.06
126 INT35451 Negative_regulation of Gene_expression of Htr2a 2 0.35 0.34 1.04
127 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02
128 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
129 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
130 INT83857 Negative_regulation of Binding of HTR2A 1 0.42 0.52 0.97
131 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
132 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
133 INT250708 Negative_regulation of PIK3CB 17 0.30 3.09 0.94
134 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
135 INT30157 Gene_expression of Htr2b 2 0.48 0 0.94
136 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
137 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
138 INT49842 Regulation of Gene_expression of Htr2a 2 0.44 0.18 0.88
139 INT7001 Negative_regulation of Positive_regulation of Htr2a 2 0.41 0.44 0.86
140 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
141 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
142 INT88718 Negative_regulation of Erbb2 11 0.58 12.98 0.84
143 INT71649 Localization of ERBB2 23 0.78 13.63 0.83
144 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
145 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81
146 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
147 INT288191 Positive_regulation of Localization of Pik3r1 4 0.15 1.27 0.81
148 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
149 INT159982 Negative_regulation of ERBB3 11 0.26 8.44 0.75
150 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75
151 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
152 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
153 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74
154 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
155 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
156 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
157 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
158 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
159 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68
160 INT179133 Localization of Nf1 2 0.80 2.18 0.68
161 INT280678 Transcription of Irs1 1 0.45 0.87 0.68
162 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67
163 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
164 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
165 INT242655 Binding of Irs1 1 0.29 1.45 0.66
166 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
167 INT190187 Regulation of Gene_expression of PIK3CG 1 0.13 0 0.65
168 INT166456 Negative_regulation of Gene_expression of Pik3r1 4 0.41 1.72 0.64
169 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
170 INT17840 Negative_regulation of GATA3 3 0.41 1.96 0.63
171 INT57127 Binding of Htr2b 2 0.36 0.05 0.63
172 INT264964 Positive_regulation of Localization of PIK3CD 1 0.13 0.05 0.62
173 INT205470 Positive_regulation of GATA3 4 0.33 2.53 0.61
174 INT135666 Negative_regulation of Negative_regulation of Pik3r1 2 0.29 0.3 0.6
175 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
176 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59
177 INT11431 Gene_expression of LTK 2 0.75 0.16 0.58
178 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
179 INT226481 Negative_regulation of Gene_expression of GATA3 1 0.06 1.41 0.57
180 INT286691 Transcription of Htr2a 1 0.08 0 0.57
181 INT115255 Negative_regulation of Phosphorylation of Irs1 6 0.45 3.71 0.56
182 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
183 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55
184 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
185 INT144053 Transcription of GATA3 1 0.67 0.89 0.54
186 INT132781 Phosphorylation of PIK3CG 8 0.52 4.83 0.53
187 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
188 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
189 INT202196 Transcription of Erbb2 3 0.69 3.87 0.51
190 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51
191 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51
192 INT158517 Regulation of Irs1 2 0.39 1.02 0.5
193 INT73215 Negative_regulation of Gene_expression of HTR2A 1 0.41 0.45 0.49
194 INT299799 Negative_regulation of Negative_regulation of GATA3 1 0.09 1.32 0.47
195 INT316933 Transcription of Nf1 1 0.18 0.49 0.47
196 INT316939 Positive_regulation of Transcription of Nf1 1 0.16 0.49 0.47
197 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
198 INT154565 Regulation of Positive_regulation of PIK3CD 2 0.09 1.59 0.45
199 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
200 INT161218 Positive_regulation of Positive_regulation of Htr2b 1 0.67 0.69 0.43
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