GO:0014076

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Name response to fluoxetine
Categary Process
Go Slim No
Go Link GO:0014076
Unique Molecular Interactions 168
Total Molecular Interactions 228
Total Single Events 2447
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to fluoxetine. They are ordered first by their pain relevance and then by number of times they were reported for response to fluoxetine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69229 Ngf Positive_regulation of Gene_expression of Bdnf 6 0.76 8.19 6.66
2 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
3 INT240653 Ngf Positive_regulation of Positive_regulation of Bdnf 1 0.55 2.97 4.23
4 INT132862 Ngf Positive_regulation of Bdnf 4 0.46 4.05 3.65
5 INT152699 Bdnf Positive_regulation of Ltp 5 0.05 1.22 2.95
6 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
7 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
8 INT122964 FSCN1 Positive_regulation of Bdnf 1 0.01 1.14 1.79
9 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
10 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
11 INT180804 Bdnf Positive_regulation of Gene_expression of Sorbs1 1 0.01 0 1.44
12 INT180768 Bdnf Regulation of Localization of Trpv1 1 0.13 1.21 1.43
13 INT180771 Calca Regulation of Positive_regulation of Bdnf 1 0.18 0 1.32
14 INT96708 Bdnf Positive_regulation of Localization of SST 1 0.01 0 1.3
15 INT50386 Bdnf Regulation of Npy 1 0.21 0.47 1.24
16 INT50385 Bdnf Positive_regulation of Pomc 1 0.22 0.47 1.23
17 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2
18 INT148437 Binding of Bdnf and Ngf 2 0.32 1.9 1.17
19 INT148435 Binding of Bdnf and Gdnf 2 0.35 1.9 1.17
20 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
21 INT132683 Bdnf Positive_regulation of Phosphorylation of Grin2a 1 0.00 0.93 1.11
22 INT87320 Ngf Regulation of Gene_expression of Bdnf 2 0.38 0.97 1.06
23 INT134534 Binding of Bdnf and Psds1 1 0.01 0 1.05
24 INT224856 Binding of Bdnf and Eef2 1 0.14 0 1.02
25 INT147506 Binding of Ncam1 and Gtf3a 1 0.03 0.88 0.99
26 INT147504 Binding of Ncam1 and Gdnf 1 0.31 0.87 0.98
27 INT219037 Creb1 Positive_regulation of Transcription of Bdnf 2 0.43 1.07 0.9
28 INT180772 Bdnf Regulation of Trpv1 1 0.11 0.29 0.9
29 INT180777 Bdnf Regulation of Gene_expression of Trpv1 1 0.18 0.29 0.9
30 INT152700 Negative_regulation of Nfkb1 Negative_regulation of Bdnf 1 0.04 0.15 0.89
31 INT152701 Nfkb1 Negative_regulation of Bdnf 1 0.04 0.15 0.89
32 INT152694 Negative_regulation of Nfkb1 Negative_regulation of Bdnf 1 0.24 0.15 0.88
33 INT48463 Bdnf Positive_regulation of Gene_expression of Sst 1 0.25 0 0.88
34 INT152695 Nfkb1 Negative_regulation of Bdnf 1 0.24 0.15 0.88
35 INT261783 Bdnf Regulation of Gene_expression of Slc12a5 1 0.09 0 0.87
36 INT215596 Bdnf Positive_regulation of Negative_regulation of Slc12a5 1 0.14 0.76 0.86
37 INT261786 Bdnf Negative_regulation of Slc12a5 1 0.14 0.05 0.85
38 INT271193 Creb1 Regulation of Bdnf 1 0.15 0.28 0.81
39 INT128042 Bdnf Positive_regulation of Phosphorylation of Ephb1 1 0.22 0.2 0.8
40 INT180782 Bdnf Positive_regulation of Calca 1 0.16 0.77 0.8
41 INT128041 Bdnf Positive_regulation of Trib3 1 0.10 0.29 0.79
42 INT224280 Bdnf Positive_regulation of Creb1 3 0.30 0.62 0.77
43 INT224281 Bdnf Regulation of Gene_expression of Gap43 1 0.36 0.4 0.77
44 INT224283 Bdnf Regulation of Gene_expression of Calca 1 0.19 0.35 0.76
45 INT180765 Calca Regulation of Binding of Bdnf 1 0.15 0.15 0.72
46 INT219035 Nkx1-1 Regulation of Gene_expression of Bdnf 1 0.13 0.88 0.7
47 INT224892 Bdnf Regulation of Localization of Ltp 1 0.03 0.17 0.69
48 INT224893 Bdnf Regulation of Ltp 1 0.03 0.17 0.69
49 INT161186 Bdnf Regulation of Gene_expression of Ntrk2 1 0.44 1.05 0.68
50 INT180805 Bdnf Regulation of Sorbs1 1 0.01 0.14 0.67
51 INT161183 NMS Positive_regulation of Gene_expression of Bdnf 1 0.40 1.3 0.67
52 INT82306 Bdnf Positive_regulation of Gene_expression of Fos 1 0.68 0.64 0.65
53 INT93690 Bdnf Regulation of Localization of Tacr1 1 0.10 0.28 0.61
54 INT257717 Binding of Bdnf and Vgf 1 0.25 0.86 0.61
55 INT271194 Binding of Bdnf and Gopc 1 0.03 0.49 0.6
56 INT59201 ecs Positive_regulation of Ncam1 1 0.01 0.98 0.59
57 INT164455 Ngf Negative_regulation of Bdnf 1 0.05 0.59 0.59
58 INT257715 Bdnf Positive_regulation of Transcription of Vgf 1 0.35 0.66 0.57
59 INT145718 Positive_regulation of Plat Positive_regulation of Bdnf 1 0.20 0 0.56
60 INT147273 Bdnf Regulation of Syp 1 0.24 0 0.56
61 INT261481 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.02 0.21 0.56
62 INT147274 Bdnf Regulation of Gap43 1 0.37 0 0.55
63 INT143854 Ngf Regulation of Transcription of Bdnf 1 0.09 0.61 0.53
64 INT143862 Bdnf Positive_regulation of Gene_expression of NUP214 1 0.27 0.61 0.52
65 INT143859 Bdnf Positive_regulation of Gene_expression of Nfatc1 1 0.00 0.61 0.52
66 INT271191 Bdnf Regulation of Slc6a4 1 0.03 0.29 0.51
67 INT224853 Binding of Bdnf and Eif4e 1 0.10 0 0.5
68 INT114543 Bdnf Positive_regulation of Prkcg 1 0.21 0 0.49
69 INT257720 Bdnf Regulation of Vgf 1 0.19 0.64 0.49
70 INT219038 Creb1 Regulation of Gene_expression of Bdnf 1 0.25 0.25 0.49
71 INT273110 Bdnf Regulation of Positive_regulation of Gria1 1 0.43 0 0.47
72 INT309127 Edc4 Positive_regulation of Bdnf 1 0.04 0.37 0.47
73 INT224282 Binding of Bdnf and Il6 1 0.08 0.26 0.45
74 INT261782 Bdnf Positive_regulation of Gene_expression of Slc12a5 1 0.18 0 0.44
75 INT180781 Bdnf Positive_regulation of Zbtb38 1 0.00 0.93 0.44
76 INT132863 Positive_regulation of Ngf Positive_regulation of Bdnf 1 0.23 1.11 0.43
77 INT127075 Bdnf Regulation of Gene_expression of Jun 1 0.11 0.28 0.43
78 INT127073 Bdnf Regulation of Gene_expression of Fos 1 0.42 0.28 0.43
79 INT55829 Bdnf Positive_regulation of Gene_expression of Qrfp 1 0.09 0 0.42
80 INT237471 Ltp Regulation of Bdnf 1 0.02 0.13 0.42
81 INT309157 Aqp1 Positive_regulation of Bdnf 1 0.00 0.74 0.42
82 INT127078 Bdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
83 INT127076 Gene_expression of Bdnf Positive_regulation of Gene_expression of IER3 1 0.03 0.26 0.42
84 INT273111 Bdnf Positive_regulation of Positive_regulation of Mtor 1 0.44 0.07 0.42
85 INT224894 Bdnf Positive_regulation of Positive_regulation of IER3 1 0.00 0.36 0.41
86 INT148438 Binding of Bdnf and Ntf3 1 0.33 1.14 0.4
87 INT309115 Edc4 Positive_regulation of Gene_expression of Bdnf 1 0.04 0.77 0.39
88 INT261788 Bdnf Regulation of Slc12a5 1 0.10 0.07 0.38
89 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
90 INT340607 Bdnf Regulation of Gene_expression of Creb1 1 0.36 0.31 0.36
91 INT144060 Bdnf Regulation of Regulation of Abat 1 0.14 0 0.35
92 INT112283 Bdnf Regulation of Gene_expression of Ngfr 1 0.14 0.28 0.34
93 INT330794 Positive_regulation of Gabrd Positive_regulation of Localization of Bdnf 1 0.02 0.78 0.33
94 INT152112 Binding of NTSR1 and Bdnf 1 0.08 0.27 0.33
95 INT273118 Bdnf Positive_regulation of Mtor 1 0.66 0 0.33
96 INT158708 Positive_regulation of P2RX4 Positive_regulation of Localization of Bdnf 1 0.09 0.48 0.3
97 INT118655 Bdnf Positive_regulation of Phosphorylation of Creb1 1 0.44 0.16 0.3
98 INT144210 Bdnf Regulation of Ntf3 1 0.20 0.78 0.3
99 INT118653 Binding of Bdnf and Creb1 1 0.39 0.19 0.3
100 INT118652 Positive_regulation of Bdnf Positive_regulation of Ntrk1 1 0.31 0.24 0.29
101 INT309119 Edc4 Positive_regulation of Regulation of Bdnf 1 0.04 0.58 0.29
102 INT158707 P2RX4 Positive_regulation of Localization of Bdnf 1 0.40 0.59 0.29
103 INT118654 Bdnf Positive_regulation of Ntrk1 1 0.43 0.24 0.28
104 INT355734 Pdgfb Regulation of Bdnf 1 0.22 1.5 0.27
105 INT315393 Bdnf Positive_regulation of Gene_expression of IFNA1 1 0.01 0.37 0.26
106 INT146211 Binding of Ngf and Bdnf 1 0.04 0.11 0.24
107 INT273109 Bdnf Positive_regulation of Gene_expression of Gria1 1 0.66 0.07 0.24
108 INT154590 Bdnf Positive_regulation of Gene_expression of Kcna3 1 0.07 0.07 0.23
109 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22
110 INT55828 Bdnf Negative_regulation of Negative_regulation of Tac4 1 0.09 0 0.21
111 INT55827 Bdnf Negative_regulation of Negative_regulation of Tac1 1 0.45 0 0.21
112 INT47695 sps Regulation of Bdnf 1 0.00 0.98 0.2
113 INT55826 Bdnf Positive_regulation of Transcription of Qrfp 1 0.09 0 0.2
114 INT261787 Positive_regulation of Bdnf Positive_regulation of Fig4 1 0.02 0.77 0.2
115 INT165657 Lilrb3 Regulation of Regulation of Bdnf 1 0.07 0.72 0.2
116 INT261784 Positive_regulation of Bdnf Positive_regulation of Slc12a5 1 0.15 0.77 0.2
117 INT355733 Pdgfb Regulation of Transcription of Bdnf 1 0.10 0.86 0.19
118 INT307453 Bdnf Positive_regulation of Phosphorylation of Gsk3a 1 0.06 0.16 0.18
119 INT273099 Bdnf Positive_regulation of Localization of Dlg4 1 0.21 0.07 0.18
120 INT316072 Binding of Cd3e and Ncam1 1 0.01 0.4 0.18
121 INT355732 Pdgfb Negative_regulation of Bdnf 1 0.13 0.87 0.17
122 INT307651 Gabbr1 Regulation of Gene_expression of Bdnf 1 0.00 0 0.16
123 INT307652 Gabbr1 Regulation of Localization of Bdnf 1 0.00 0 0.16
124 INT273097 Binding of Bdnf and Gria1 1 0.39 0.17 0.16
125 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
126 INT307650 Gabrg1 Regulation of Bdnf 1 0.06 0 0.15
127 INT307459 P2rx4 Positive_regulation of Localization of Bdnf 1 0.15 0.1 0.15
128 INT151925 Bdnf Negative_regulation of Ntrk1 1 0.10 0 0.14
129 INT193550 Ephb1 Positive_regulation of Gene_expression of Bdnf 1 0.29 0.3 0.14
130 INT349345 Bdnf Negative_regulation of Positive_regulation of Casp3 1 0.13 1.02 0.12
131 INT261390 Binding of Nsdhl and Bdnf 1 0.05 1.33 0.12
132 INT317162 Binding of Bdnf and Htt 1 0.51 0.2 0.12
133 INT259815 Ltp Positive_regulation of Bdnf 1 0.02 0.4 0.1
134 INT261371 Nsdhl Negative_regulation of Positive_regulation of Bdnf 1 0.06 1.18 0.09
135 INT133661 Bdnf Regulation of Gene_expression of STMN2 1 0.14 0 0.09
136 INT249465 Positive_regulation of Slc6a4 Positive_regulation of Gene_expression of Bdnf 1 0.31 0.3 0.08
137 INT326382 Binding of Gdnf and Ncam1 1 0.01 0.3 0.08
138 INT273115 Bdnf Negative_regulation of Gene_expression of Gria1 1 0.47 0.15 0.08
139 INT267014 Bdnf Negative_regulation of Gene_expression of Pdp1 1 0.07 0.08 0.07
140 INT267016 Bdnf Positive_regulation of Egr1 1 0.12 0.09 0.07
141 INT267017 Bdnf Positive_regulation of Dusp6 1 0.13 0.1 0.07
142 INT273107 Bdnf Regulation of Positive_regulation of Mtor 1 0.26 0.09 0.07
143 INT273098 Binding of Bdnf and Positive_regulation of Mtor 1 0.47 0 0.06
144 INT355735 Bdnf Regulation of Positive_regulation of Ltp 1 0.02 1.03 0.05
145 INT133662 Bdnf Positive_regulation of Gene_expression of STMN2 1 0.20 0 0.05
146 INT307456 Bdnf Positive_regulation of Transcription of Ntrk2 1 0.14 0.25 0.04
147 INT307461 Bdnf Positive_regulation of Ntrk2 1 0.19 0.25 0.04
148 INT307450 Bdnf Positive_regulation of Transcription of Creb1 1 0.07 0.25 0.04
149 INT307455 Gsk3a Regulation of Bdnf 1 0.06 0.09 0.04
150 INT267003 Bdnf Positive_regulation of Elk1 1 0.03 0.09 0.03
151 INT317161 Htt Regulation of Transcription of Bdnf 1 0.48 0.41 0.03
152 INT273102 Bdnf Regulation of Gria1 1 0.30 0.08 0.03
153 INT267038 NOS1 Regulation of Bdnf 1 0.05 0.07 0.03
154 INT267011 Pik3cg Regulation of Bdnf 1 0.06 0.07 0.03
155 INT267036 CAMK4 Regulation of Bdnf 1 0.03 0.07 0.03
156 INT267006 Bdnf Positive_regulation of Mdk 1 0.07 0.18 0.03
157 INT116407 Binding of Bdnf and Cntf 1 0.19 0.05 0
158 INT266999 Mdk Positive_regulation of Regulation of Bdnf 1 0.07 0.05 0
159 INT267018 Bdnf Positive_regulation of Gene_expression of Creb1 1 0.10 0 0
160 INT216283 Bdnf Negative_regulation of Positive_regulation of Ephb1 1 0.04 0.99 0
161 INT267015 Ephb1 Regulation of Bdnf 1 0.05 0.07 0
162 INT216284 Bdnf Negative_regulation of Phosphorylation of Mapk14 1 0.04 0.97 0
163 INT317163 Htt Regulation of Bdnf 1 0.29 0.19 0
164 INT267002 Bdnf Positive_regulation of Gopc 1 0.02 0.1 0
165 INT65173 Negative_regulation of Ntrk2 Negative_regulation of Bdnf 1 0.37 0 0
166 INT267037 Regulation of Bdnf Regulation of CAMK4 1 0.02 0.08 0
167 INT216285 Bdnf Negative_regulation of Phosphorylation of Ephb1 1 0.04 1.31 0
168 INT267039 Bdnf Regulation of CAMK4 1 0.02 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to fluoxetine. They are ordered first by their pain relevance and then by number of times they were reported in response to fluoxetine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1
2 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82
3 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01
4 INT67682 Localization of Bdnf 204 0.81 72.36 88.92
5 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5
6 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24
7 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55
8 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64
9 INT67620 Negative_regulation of Gene_expression of Bdnf 53 0.59 22.45 28.5
10 INT47685 Positive_regulation of Positive_regulation of Bdnf 32 0.70 20.05 27.03
11 INT96557 Binding of Bdnf 46 0.47 21.74 24.26
12 INT18672 Gene_expression of Ncam1 54 0.78 36.64 18.79
13 INT96299 Positive_regulation of Localization of Bdnf 35 0.70 15.67 16.09
14 INT47692 Negative_regulation of Positive_regulation of Bdnf 18 0.59 9.64 13.14
15 INT56048 Positive_regulation of Transcription of Bdnf 24 0.70 8.33 11.83
16 INT91065 Regulation of Transcription of Bdnf 13 0.62 12.48 6.13
17 INT56047 Negative_regulation of Transcription of Bdnf 16 0.59 8.02 5.67
18 INT110666 Phosphorylation of Bdnf 12 0.69 5.67 5.21
19 INT67681 Negative_regulation of Localization of Bdnf 12 0.50 4.37 5.07
20 INT133905 Gene_expression of Ncam1 24 0.78 10.2 4.62
21 INT137691 Positive_regulation of Gene_expression of Ncam1 9 0.68 2.3 4.24
22 INT56027 Positive_regulation of Ncam1 12 0.69 4.96 4.1
23 INT137688 Regulation of Gene_expression of Ncam1 1 0.60 1.21 3.65
24 INT82305 Regulation of Localization of Bdnf 10 0.40 3 3.62
25 INT48462 Positive_regulation of Negative_regulation of Bdnf 8 0.70 1 3.2
26 INT183212 Positive_regulation of Regulation of Bdnf 4 0.45 1.57 3.14
27 INT119516 Positive_regulation of Phosphorylation of Bdnf 3 0.21 2.81 2.68
28 INT137690 Negative_regulation of Gene_expression of Ncam1 3 0.50 3.37 2.18
29 INT168945 Positive_regulation of Binding of Bdnf 4 0.50 1.7 2.14
30 INT133906 Positive_regulation of Gene_expression of Ncam1 6 0.70 1.9 2
31 INT92622 Regulation of Positive_regulation of Bdnf 4 0.39 2.16 1.81
32 INT56028 Regulation of Ncam1 6 0.38 3.6 1.78
33 INT133904 Positive_regulation of Ncam1 7 0.50 4.01 1.57
34 INT112314 Regulation of Binding of Bdnf 3 0.38 0.61 1.34
35 INT148432 Negative_regulation of Binding of Bdnf 2 0.38 1.74 0.99
36 INT83229 Regulation of Regulation of Bdnf 6 0.45 4.62 0.92
37 INT78800 Negative_regulation of Ncam1 2 0.36 0.58 0.69
38 INT47684 Negative_regulation of Negative_regulation of Bdnf 2 0.59 1.66 0.66
39 INT95163 Binding of Ncam1 3 0.32 1.02 0.5
40 INT95161 Localization of Ncam1 5 0.80 1.01 0.45
41 INT171223 Regulation of Ncam1 5 0.20 3.81 0.43
42 INT89620 Phosphorylation of Ncam1 1 0.19 0.52 0.28
43 INT273090 Protein_catabolism of Bdnf 1 0.56 0.08 0.25
44 INT95162 Negative_regulation of Localization of Ncam1 2 0.37 0.17 0.24
45 INT56026 Positive_regulation of Regulation of Ncam1 1 0.37 0.24 0.22
46 INT260506 Binding of Ncam1 2 0.20 0.1 0.2
47 INT202816 Negative_regulation of Ncam1 3 0.30 0.64 0.14
48 INT252012 Negative_regulation of Positive_regulation of Ncam1 1 0.22 1.3 0.14
49 INT208202 Localization of Ncam1 2 0.42 0.56 0.11
50 INT273091 Regulation of Negative_regulation of Bdnf 1 0.44 0.15 0.08
51 INT151924 Regulation of Phosphorylation of Bdnf 1 0.23 0 0.07
52 INT247634 Negative_regulation of Localization of Ncam1 1 0.05 0.1 0.05
53 INT326360 Phosphorylation of Ncam1 1 0.44 0.28 0
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