GO:0014806

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Name smooth muscle hyperplasia
Categary Process
Go Slim No
Go Link GO:0014806
Unique Molecular Interactions 132
Total Molecular Interactions 176
Total Single Events 2189
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for smooth muscle hyperplasia. They are ordered first by their pain relevance and then by number of times they were reported for smooth muscle hyperplasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
2 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
3 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
4 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
5 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
6 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
7 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
8 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
9 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73
10 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
11 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
12 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59
13 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
14 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
15 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49
16 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
17 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46
18 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
19 INT95276 Obfc2a Negative_regulation of Nos3 1 0.02 1.02 0.46
20 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46
21 INT165677 NFE2L2 Negative_regulation of Positive_regulation of HMOX1 1 0.40 0.32 0.44
22 INT165678 NFE2L2 Negative_regulation of HMOX1 1 0.40 0.31 0.43
23 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
24 INT333158 asa Positive_regulation of Nos3 1 0.11 0.18 0.32
25 INT333166 Tlx2 Positive_regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
26 INT333155 Tlx2 Regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
27 INT333152 Tlx2 Positive_regulation of Nos3 1 0.08 0.18 0.32
28 INT333169 asa Positive_regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
29 INT333164 asa Regulation of Nos3 1 0.11 0.18 0.32
30 INT333149 asa Regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
31 INT333167 Tlx2 Regulation of Nos3 1 0.08 0.18 0.32
32 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
33 INT141871 Binding of Nos3 and Slc2a4 1 0.25 0.51 0.28
34 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22
35 INT122576 Pik3cd Positive_regulation of Phosphorylation of Nos3 1 0.28 0.45 0.21
36 INT239227 Prkca Regulation of Nos3 1 0.02 0.97 0.2
37 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19
38 INT137417 MAPK7 Regulation of Gene_expression of NOS3 1 0.00 0.5 0.19
39 INT269333 Binding of BDKRB2 and NOS3 1 0.02 0 0.17
40 INT231757 TLR4 Positive_regulation of Negative_regulation of HMOX1 1 0.26 1.37 0.15
41 INT231761 TNF Negative_regulation of HMOX1 1 0.19 1.2 0.12
42 INT269332 Binding of NOS3 and TMPO 1 0.01 0 0.12
43 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12
44 INT213042 Apoa1 Positive_regulation of Nos3 1 0.10 2.17 0.11
45 INT288616 EPO Positive_regulation of Nos3 1 0.08 0.69 0.11
46 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11
47 INT231768 Binding of HMOX1 and TLR4 1 0.23 0.95 0.11
48 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
49 INT231772 TNF Positive_regulation of Gene_expression of HMOX1 1 0.21 0.96 0.1
50 INT302511 Binding of OPA1 and Nos3 1 0.02 1.57 0.1
51 INT172816 Crp Positive_regulation of Transcription of Nos3 1 0.06 0.91 0.1
52 INT172817 Crp Positive_regulation of Regulation of Nos3 1 0.09 0.84 0.1
53 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1
54 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
55 INT252790 Binding of NOS1 and NOS3 1 0.03 0.37 0.1
56 INT249848 Fgf2 Positive_regulation of Gene_expression of Nos3 1 0.33 0.44 0.1
57 INT172819 Crp Positive_regulation of Gene_expression of Nos3 1 0.06 0.91 0.1
58 INT249851 VEGFA Positive_regulation of Gene_expression of Nos3 1 0.05 0.44 0.1
59 INT172821 Crp Positive_regulation of Negative_regulation of Nos3 1 0.06 0.84 0.1
60 INT213023 Hdl1 Regulation of Nos3 2 0.09 4.06 0.09
61 INT231773 IRF6 Negative_regulation of Gene_expression of HMOX1 1 0.06 1.27 0.09
62 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
63 INT252803 Binding of NOS3 and ISYNA1 1 0.02 0.32 0.09
64 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
65 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
66 INT309390 Gene_expression of Sod2 Negative_regulation of Nos3 1 0.31 0.2 0.08
67 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
68 INT231760 TNF Positive_regulation of Protein_catabolism of HMOX1 1 0.31 0.41 0.06
69 INT250015 Binding of FLNA and Nos3 1 0.05 1.09 0.06
70 INT246691 Ide Positive_regulation of Gene_expression of Nos3 1 0.03 0.26 0.05
71 INT231758 IRF6 Regulation of Gene_expression of HMOX1 1 0.08 0.23 0.05
72 INT231766 TLR4 Negative_regulation of Gene_expression of HMOX1 1 0.28 0.71 0.05
73 INT249954 Cpa1 Positive_regulation of Nos3 1 0.04 0.36 0.05
74 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04
75 INT231759 IL10 Positive_regulation of Gene_expression of HMOX1 1 0.06 0.7 0.04
76 INT213047 Hdl1 Positive_regulation of Gene_expression of Nos3 1 0.14 0.94 0.04
77 INT213031 Positive_regulation of Pik3r1 Positive_regulation of Gene_expression of Nos3 1 0.10 0.8 0.04
78 INT231775 TLR4 Regulation of Gene_expression of HMOX1 1 0.29 0.68 0.04
79 INT231774 Gene_expression of TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
80 INT231762 TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
81 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03
82 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03
83 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03
84 INT281908 VEGFA Positive_regulation of NOS3 1 0.14 0.14 0
85 INT249953 Cpa1 Regulation of Nos3 1 0.03 0.08 0
86 INT183248 LPA Positive_regulation of NOS3 1 0.02 0 0
87 INT98710 Pdyn Negative_regulation of Nos3 1 0.02 0 0
88 INT249935 Nos3 Regulation of Nos2 1 0.25 0.19 0
89 INT133825 TNF Negative_regulation of NOS3 1 0.28 0.06 0
90 INT305265 Obsty1 Negative_regulation of Phosphorylation of Nos3 1 0.05 0.78 0
91 INT249937 Nos1 Regulation of Nos3 1 0.23 0.19 0
92 INT268013 Binding of Nos3 and Acot1 1 0.02 1.48 0
93 INT340178 Car2 Positive_regulation of Positive_regulation of Nos3 1 0.01 0.26 0
94 INT305254 Obsty1 Regulation of Gene_expression of Nos3 1 0.03 0.97 0
95 INT98711 Regulation of Pdyn Negative_regulation of Nos3 1 0.02 0 0
96 INT351165 Binding of CAV1 and Nos3 1 0.09 1.46 0
97 INT330735 GSTK1 Regulation of HMOX1 1 0.08 0.25 0
98 INT260134 CGA Positive_regulation of Gene_expression of Nos3 1 0.16 0.13 0
99 INT334102 Nos3 Positive_regulation of Gene_expression of ISYNA1 1 0.01 0.59 0
100 INT133824 IL1B Negative_regulation of NOS3 1 0.48 0.06 0
101 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0
102 INT333560 NOS3 Regulation of HCK 1 0.01 0.2 0
103 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
104 INT227796 Binding of Acsl1 and Nos3 1 0.16 1.16 0
105 INT343716 Nos3 Positive_regulation of Pde6b 1 0.20 0 0
106 INT260564 Binding of Nos3 and T2dm2 1 0.05 3.96 0
107 INT305262 Obsty1 Positive_regulation of Phosphorylation of Nos3 1 0.05 0.96 0
108 INT260563 Hdl1 Positive_regulation of Positive_regulation of Nos3 1 0.05 1.55 0
109 INT301906 Binding of HMOX1 and HSD11B1 1 0.05 2.41 0
110 INT343718 Nos3 Regulation of Pde6b 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for smooth muscle hyperplasia. They are ordered first by their pain relevance and then by number of times they were reported in smooth muscle hyperplasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
2 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
3 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
4 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
5 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
6 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
7 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
8 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
9 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
10 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
11 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
12 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86
13 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62
14 INT83712 Transcription of Nos3 19 0.69 13.09 6.31
15 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74
16 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87
17 INT83991 Regulation of Nos3 25 0.44 9.89 4.06
18 INT102515 Binding of Nos3 19 0.45 9.41 4.01
19 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32
20 INT70958 Binding of NOS3 19 0.37 11.84 3.29
21 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
22 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
23 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73
24 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7
25 INT145101 Transcription of Nos3 8 0.70 6.04 2.47
26 INT73809 Regulation of Nos3 18 0.45 10.05 2.27
27 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17
28 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
29 INT91594 Localization of NOS3 12 0.78 5.39 2.02
30 INT76532 Binding of Nos3 13 0.37 9.32 1.87
31 INT60999 Localization of Nos3 12 0.74 5.28 1.75
32 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
33 INT100420 Regulation of HMOX1 10 0.35 6.68 1.48
34 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
35 INT165680 Transcription of HMOX1 7 0.71 11.2 1.41
36 INT83713 Positive_regulation of Transcription of Nos3 3 0.67 2.92 1.38
37 INT89785 Regulation of Transcription of Nos3 1 0.32 0.85 1.36
38 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
39 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28
40 INT136612 Positive_regulation of Positive_regulation of Nos3 5 0.43 4.22 1.26
41 INT212983 Positive_regulation of Positive_regulation of Nos3 9 0.51 7.08 1.23
42 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
43 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
44 INT116529 Binding of HMOX1 10 0.47 15.38 1.04
45 INT105445 Localization of HMOX1 5 0.71 3.11 0.98
46 INT122572 Phosphorylation of Nos3 37 0.65 25.23 0.75
47 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
48 INT193486 Negative_regulation of Negative_regulation of Nos3 3 0.34 2.21 0.68
49 INT181576 Phosphorylation of Nos3 7 0.59 1.35 0.6
50 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
51 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56
52 INT165681 Positive_regulation of Transcription of HMOX1 2 0.69 4.29 0.53
53 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
54 INT145100 Regulation of Transcription of Nos3 4 0.44 2.05 0.46
55 INT144095 Localization of Nos3 8 0.57 4.5 0.43
56 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
57 INT193491 Negative_regulation of Positive_regulation of Nos3 2 0.36 1.67 0.4
58 INT95273 Regulation of Negative_regulation of Nos3 2 0.20 0.85 0.37
59 INT157157 Negative_regulation of Localization of HMOX1 1 0.37 0.74 0.37
60 INT281659 Regulation of Transcription of HMOX1 2 0.27 2.12 0.33
61 INT135772 Regulation of Positive_regulation of HMOX1 3 0.39 1.52 0.29
62 INT212933 Regulation of Binding of Nos3 2 0.34 0.88 0.24
63 INT172796 Regulation of Negative_regulation of Nos3 1 0.16 1.4 0.23
64 INT316565 Negative_regulation of Regulation of Nos3 1 0.32 1.01 0.22
65 INT73810 Negative_regulation of Regulation of Nos3 2 0.36 1.01 0.21
66 INT118276 Regulation of Positive_regulation of Nos3 1 0.09 0 0.21
67 INT269409 Regulation of Phosphorylation of NOS3 1 0.18 0 0.2
68 INT163997 Positive_regulation of Negative_regulation of Nos3 1 0.49 1.15 0.2
69 INT92815 Positive_regulation of Negative_regulation of NOS3 1 0.12 1.03 0.2
70 INT141866 Regulation of Localization of Nos3 1 0.42 0.24 0.18
71 INT257201 Positive_regulation of Negative_regulation of Nos3 1 0.12 0 0.18
72 INT269403 Regulation of Positive_regulation of NOS3 1 0.18 0 0.17
73 INT145102 Positive_regulation of Transcription of Nos3 1 0.45 0.46 0.14
74 INT201467 Protein_catabolism of HMOX1 2 0.77 0.83 0.13
75 INT290701 Protein_catabolism of Nos3 1 0.54 0.42 0.13
76 INT212996 Negative_regulation of Positive_regulation of Nos3 3 0.35 2.11 0.12
77 INT269395 Regulation of Binding of NOS3 2 0.39 1.84 0.12
78 INT323261 Positive_regulation of Binding of Nos3 1 0.18 0.25 0.12
79 INT186558 Negative_regulation of Positive_regulation of NOS3 2 0.37 0.26 0.1
80 INT172791 Negative_regulation of Transcription of Nos3 1 0.17 0.9 0.1
81 INT309385 Positive_regulation of Phosphorylation of Nos3 5 0.48 2.98 0.09
82 INT305235 Negative_regulation of Phosphorylation of Nos3 5 0.41 4.17 0.09
83 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09
84 INT293311 Positive_regulation of Positive_regulation of HMOX1 3 0.69 1.99 0.04
85 INT175698 Positive_regulation of Localization of Nos3 2 0.27 1.19 0.04
86 INT343710 Positive_regulation of Localization of Nos3 1 0.38 0.22 0.03
87 INT269496 Regulation of Binding of Nos3 3 0.25 0.46 0
88 INT355212 Positive_regulation of Phosphorylation of Nos3 1 0.23 0.18 0
89 INT336827 Regulation of Regulation of NOS3 1 0.23 0.51 0
90 INT309384 Regulation of Phosphorylation of Nos3 1 0.31 0.39 0
91 INT249944 Positive_regulation of Regulation of Nos3 1 0.35 0.07 0
92 INT174535 Negative_regulation of Negative_regulation of NOS3 1 0.11 0.32 0
93 INT343712 Regulation of Positive_regulation of Nos3 1 0.50 0.93 0
94 INT140156 Positive_regulation of Transcription of NOS3 1 0.31 0 0
95 INT159478 Negative_regulation of Phosphorylation of NOS3 1 0.51 0 0
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