GO:0014808

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Name release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Categary Process
Go Slim No
Go Link GO:0014808
Unique Molecular Interactions 96
Total Molecular Interactions 146
Total Single Events 1037
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. They are ordered first by their pain relevance and then by number of times they were reported for release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
2 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
3 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
4 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
5 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03
6 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
7 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
8 INT275390 Binding of Ccr5 and Htatsf1 1 0.01 3.26 0.97
9 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
10 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
11 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
12 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86
13 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86
14 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
15 INT120018 VEGFA Positive_regulation of CCL3 1 0.01 1 0.7
16 INT120017 CCL2 Positive_regulation of CCL3 1 0.01 0.99 0.7
17 INT120019 IL8 Positive_regulation of CCL3 1 0.02 0.99 0.7
18 INT297307 Negative_regulation of Binding of Ccr1 and Ccl3 1 0.27 0.73 0.67
19 INT106247 Binding of CCR5 and CCL4 1 0.54 0.06 0.64
20 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55
21 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
22 INT275387 Binding of Lamp1 and Ccr5 1 0.01 1.45 0.52
23 INT275405 Binding of GOLPH3 and Ccr5 1 0.00 1.46 0.52
24 INT275407 Binding of ERVW-1 and Ccr5 1 0.00 1.74 0.46
25 INT181447 Ccl3 Positive_regulation of Csf2 1 0.06 1.89 0.45
26 INT178664 Binding of CCR5 and TH1L 1 0.04 1.04 0.44
27 INT149221 Binding of Ryr1 and Trpc3 5 0.40 0 0.37
28 INT123511 TIAF1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0.6 0.37
29 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
30 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
31 INT187219 Vip Negative_regulation of Gene_expression of Ccl3 1 0.32 0.65 0.35
32 INT325221 Il13 Regulation of Ccl3 1 0.08 0.17 0.32
33 INT189494 Negative_regulation of Ccr5 Negative_regulation of Gene_expression of Hand1 1 0.16 0.66 0.32
34 INT284229 Binding of ITIH4 and Ccr5 1 0.10 0.27 0.31
35 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31
36 INT181446 Csf2 Positive_regulation of Ccl3 1 0.05 0.81 0.29
37 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26
38 INT237087 Binding of Cxcl9 and Ccl3 1 0.30 1.51 0.26
39 INT181445 Binding of Ccr5 and Hand1 1 0.12 1.01 0.22
40 INT283373 Pcbd1 Regulation of RYR1 1 0.00 1.45 0.21
41 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2
42 INT244243 Regulation of Binding of IL8 and Ccl3 1 0.04 0.05 0.18
43 INT244240 Binding of IL8 and Ccr5 1 0.03 0.05 0.18
44 INT244241 Binding of IL8 and Ccl3 1 0.05 0.05 0.18
45 INT244242 Negative_regulation of Binding of IL8 and Ccl3 1 0.06 0.05 0.18
46 INT244235 Binding of Cxcl1 and Ccl3 1 0.14 0.23 0.17
47 INT284230 Positive_regulation of Binding of ITIH4 and Ccr5 1 0.10 0 0.17
48 INT88311 ITIH4 Positive_regulation of CCR5 1 0.49 1.57 0.16
49 INT221019 ELANE Positive_regulation of CCL3 1 0.00 0.24 0.15
50 INT284226 Negative_regulation of Binding of Ccr5 and Hivan1 1 0.01 0.27 0.14
51 INT284217 Binding of Ccr5 and Hivan1 1 0.01 0.27 0.14
52 INT148532 Binding of CCL3 and Tnfsf11 1 0.03 0.71 0.14
53 INT352417 Ccl2 Positive_regulation of Ccr5 1 0.06 0.26 0.14
54 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
55 INT333652 Binding of Ccr5 and Msc 1 0.10 0.07 0.13
56 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13
57 INT284219 Binding of Ccr5 and Avpr1b 1 0.01 0.46 0.12
58 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
59 INT284208 Binding of Ccr5 and Eclc 1 0.08 0.3 0.12
60 INT241748 CCR5 Regulation of CD4 1 0.21 0.39 0.11
61 INT351427 Binding of PIK3C3 and RYR1 1 0.00 0 0.11
62 INT149219 Binding of Ryr1 and Trpc1 1 0.35 0 0.11
63 INT225740 RYR1 Positive_regulation of Binding of Entpd1 1 0.08 0.08 0.1
64 INT284220 Binding of Ccr5 and Mela 1 0.12 0.23 0.1
65 INT294444 KLK4 Negative_regulation of CCL3 1 0.00 0 0.1
66 INT284222 Binding of Ccr5 and Musd1 1 0.01 0.5 0.07
67 INT265983 Homer1 Regulation of Ryr1 1 0.37 0.15 0.07
68 INT284216 Binding of Ccr5 and Arhgap4 1 0.02 0.31 0.07
69 INT170517 Binding of Ryr1 and Qdpr 2 0.15 0.36 0.05
70 INT284209 Negative_regulation of Binding of Ccr5 and Mela 1 0.14 0.12 0.05
71 INT251296 Binding of CCR5 and ITIH4 1 0.16 0.08 0.04
72 INT284225 Binding of Cd4 and Ccr5 1 0.30 0.26 0.04
73 INT241749 ITIH4 Negative_regulation of Binding of CCR5 1 0.16 0.71 0.04
74 INT183767 Csf2 Negative_regulation of Transcription of CCR5 1 0.17 0.92 0.03
75 INT183758 INCENP Negative_regulation of Transcription of CCR5 1 0.00 0.93 0.03
76 INT192046 Negative_regulation of Binding of RYR2 and Cbx5 1 0.01 1.12 0
77 INT121652 Binding of CCR5 and CXCL12 1 0.33 0.2 0
78 INT328477 Mkrn1 Positive_regulation of CCR5 1 0.01 0.69 0
79 INT266704 Binding of RYR1 and TRDN 1 0.34 0 0
80 INT316647 Ryr1 Regulation of Qdpr 1 0.19 0.68 0
81 INT192049 Negative_regulation of Binding of RYR2 and Cbx1 1 0.01 1.12 0
82 INT192045 Jup Positive_regulation of RYR2 1 0.11 0.29 0
83 INT283372 Binding of RYR1 and Pcbd1 1 0.00 0.28 0
84 INT192047 Binding of RYR2 and Cbx1 1 0.01 1.12 0
85 INT192043 Binding of RYR2 and Cbx5 1 0.01 1.12 0
86 INT271027 Binding of RYR1 and Car2 1 0.03 0.46 0
87 INT266703 Binding of RYR1 and DIXDC1 1 0.26 0.1 0
88 INT336168 Binding of CCR5 and HIVEP1 1 0.01 0.44 0
89 INT296930 Casq1 Negative_regulation of RYR1 1 0.00 0.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. They are ordered first by their pain relevance and then by number of times they were reported in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
2 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16
3 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
4 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15
5 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
6 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
7 INT87393 Gene_expression of Ccr5 19 0.65 11 10.51
8 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59
9 INT18393 Negative_regulation of Ryr1 15 0.43 3.63 7.57
10 INT153271 Localization of Ccl3 7 0.81 11.29 7.14
11 INT91758 Binding of CCR5 28 0.45 20.16 7.07
12 INT153268 Positive_regulation of Ccr5 25 0.66 19 7.02
13 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11
14 INT120089 Negative_regulation of Ccr5 7 0.58 10.36 5.91
15 INT103847 Positive_regulation of Ccr5 11 0.55 6.04 5.79
16 INT181406 Binding of Ccr5 16 0.45 17 5.78
17 INT59555 Binding of RYR1 39 0.42 8.65 4.92
18 INT166878 Regulation of Ccl3 9 0.44 8.21 4.81
19 INT153269 Binding of Ccl3 10 0.48 8.87 4.69
20 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15
21 INT103843 Positive_regulation of Gene_expression of Ccr5 5 0.42 2.31 3.89
22 INT144083 Positive_regulation of Gene_expression of Ccl3 10 0.50 8.16 3.81
23 INT181357 Negative_regulation of Ccl3 12 0.59 13.09 3.38
24 INT18396 Positive_regulation of Ryr1 10 0.58 2.45 3.38
25 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26
26 INT18394 Regulation of Ryr1 6 0.60 0.28 3.26
27 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11
28 INT166879 Localization of Ccr5 4 0.71 3.62 2.97
29 INT110233 Regulation of Gene_expression of CCR5 6 0.34 7.14 2.76
30 INT106433 Regulation of CCR5 11 0.59 6.93 2.75
31 INT87395 Binding of Ccr5 5 0.29 2.5 2.6
32 INT71681 Positive_regulation of Gene_expression of CCL3 8 0.54 8.21 2.41
33 INT113775 Negative_regulation of Gene_expression of CCR5 6 0.43 3.97 2.28
34 INT181356 Positive_regulation of Gene_expression of Ccr5 11 0.66 8.3 2.24
35 INT96743 Transcription of Ccr5 2 0.54 2.72 2.17
36 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04
37 INT120014 Transcription of CCL3 5 0.69 3.03 1.82
38 INT87394 Negative_regulation of Ccr5 3 0.32 1.3 1.74
39 INT11713 Localization of RYR1 22 0.76 10.42 1.64
40 INT55305 Regulation of RYR1 14 0.45 5.27 1.33
41 INT65699 Localization of CCL3 7 0.78 2.56 1.25
42 INT123828 Regulation of CCL3 3 0.60 0.79 1.25
43 INT241757 Localization of CCR5 6 0.71 5.7 1.14
44 INT153267 Negative_regulation of Binding of Ccl3 2 0.43 2.06 1.14
45 INT181410 Regulation of Gene_expression of Ccl3 2 0.33 3.52 1.06
46 INT166880 Negative_regulation of Gene_expression of Ccl3 1 0.57 0.81 1.01
47 INT87396 Negative_regulation of Gene_expression of Ccr5 1 0.12 1.02 0.92
48 INT116831 Binding of Ryr1 11 0.47 0.12 0.9
49 INT202174 Negative_regulation of CCL3 2 0.26 1.77 0.9
50 INT79235 Binding of CCL3 3 0.36 2.2 0.88
51 INT189482 Regulation of Gene_expression of Ccr5 4 0.44 3.38 0.86
52 INT38446 Localization of Ryr1 3 0.64 0.28 0.86
53 INT160410 Positive_regulation of Positive_regulation of Ccr5 2 0.38 1.31 0.83
54 INT153272 Positive_regulation of Localization of Ccl3 2 0.50 2.02 0.79
55 INT120013 Negative_regulation of Transcription of CCL3 1 0.41 1 0.72
56 INT153270 Positive_regulation of Binding of Ccl3 1 0.47 1.44 0.69
57 INT171946 Positive_regulation of Binding of CCR5 1 0.47 3.86 0.66
58 INT115892 Positive_regulation of Phosphorylation of Ccr5 1 0.00 0 0.66
59 INT115896 Phosphorylation of Ccr5 1 0.01 0 0.65
60 INT181364 Regulation of Ccr5 3 0.32 1.81 0.62
61 INT18395 Negative_regulation of Negative_regulation of Ryr1 1 0.00 0 0.59
62 INT128360 Negative_regulation of Positive_regulation of Ccl3 2 0.41 1.86 0.55
63 INT221040 Negative_regulation of Gene_expression of CCL3 2 0.20 1.19 0.53
64 INT260124 Positive_regulation of Positive_regulation of CCR5 1 0.14 0.84 0.51
65 INT103844 Regulation of Gene_expression of Ccr5 1 0.22 0.55 0.51
66 INT181376 Negative_regulation of Gene_expression of Ccr5 3 0.41 2.12 0.49
67 INT181397 Transcription of Ccr5 2 0.62 1.33 0.46
68 INT87392 Regulation of Ccr5 1 0.17 0.53 0.46
69 INT15647 Regulation of Positive_regulation of RYR1 1 0.26 0.23 0.45
70 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44
71 INT222240 Positive_regulation of Transcription of Ccr5 1 0.37 0.7 0.4
72 INT322707 Protein_catabolism of Ccr5 1 0.22 0.32 0.37
73 INT221044 Positive_regulation of Negative_regulation of CCR5 1 0.19 0.62 0.35
74 INT80636 Positive_regulation of Localization of RYR1 2 0.47 0.78 0.29
75 INT79236 Positive_regulation of Positive_regulation of CCL3 1 0.49 1.22 0.28
76 INT301314 Regulation of Binding of CCL3 1 0.04 0 0.24
77 INT59650 Regulation of Binding of RYR1 1 0.04 0 0.23
78 INT181399 Transcription of Ccl3 2 0.60 0.41 0.22
79 INT120216 Regulation of RYR2 2 0.28 1.03 0.22
80 INT104449 Transcription of CCR5 4 0.53 2.73 0.21
81 INT49908 Regulation of Gene_expression of RYR1 3 0.45 0.32 0.19
82 INT284203 Positive_regulation of Negative_regulation of Ccr5 1 0.41 0.41 0.18
83 INT107316 Negative_regulation of Positive_regulation of CCR5 2 0.41 1.96 0.17
84 INT329819 Phosphorylation of CCL3 1 0.23 0.61 0.17
85 INT285899 Positive_regulation of Localization of CCL3 1 0.12 1.08 0.17
86 INT60209 Transcription of RYR1 3 0.69 3.06 0.16
87 INT312718 Protein_catabolism of CCL3 1 0.31 0.44 0.16
88 INT158175 Positive_regulation of Gene_expression of RYR1 2 0.48 1.35 0.13
89 INT170514 Gene_expression of Ryr1 4 0.49 0.56 0.12
90 INT284206 Negative_regulation of Negative_regulation of Ccr5 1 0.40 0 0.12
91 INT241759 Negative_regulation of Binding of CCR5 2 0.41 0.94 0.11
92 INT165787 Positive_regulation of RYR2 2 0.23 1.3 0.11
93 INT322703 Negative_regulation of Binding of Ccr5 1 0.32 0.41 0.09
94 INT192016 Localization of RYR2 5 0.25 4.18 0.05
95 INT192012 Binding of RYR2 2 0.30 3.61 0.05
96 INT221865 Positive_regulation of Localization of RYR2 2 0.15 4.56 0.05
97 INT271024 Negative_regulation of Binding of RYR1 3 0.05 1.07 0.04
98 INT284205 Phosphorylation of Ccr5 1 0.59 0.08 0.04
99 INT316641 Positive_regulation of Localization of Ryr1 1 0.42 0 0.04
100 INT192023 Negative_regulation of RYR2 1 0.15 1.86 0.04
101 INT183763 Negative_regulation of Transcription of CCR5 1 0.15 0.92 0.03
102 INT211904 Negative_regulation of Localization of RYR1 1 0.37 0.64 0
103 INT192020 Regulation of Localization of RYR2 1 0.15 0.27 0
104 INT80635 Regulation of Localization of RYR1 1 0.04 0.1 0
105 INT211903 Negative_regulation of Gene_expression of RYR1 1 0.37 0.06 0
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