GO:0014826

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Name vein smooth muscle contraction
Categary Process
Go Slim No
Go Link GO:0014826
Unique Molecular Interactions 327
Total Molecular Interactions 476
Total Single Events 2953
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vein smooth muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported for vein smooth muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
3 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
4 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
5 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
6 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
7 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
8 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
9 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
10 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
11 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
12 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
13 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
14 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
15 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
16 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
17 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
18 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
19 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
20 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
21 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
22 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
23 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
24 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
25 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
26 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
27 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
28 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
29 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
30 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
31 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
32 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
33 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
34 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
35 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
36 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
37 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
38 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
39 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
40 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
41 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
42 INT130157 Pomc Regulation of Gene_expression of Ednrb 1 0.14 0 0.52
43 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
44 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
45 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
46 INT94018 Binding of EDN2 and EDN3 1 0.19 0 0.48
47 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
48 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
49 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
50 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
51 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
52 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
53 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
54 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
55 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
56 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
57 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
58 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
59 INT152315 Ifng Regulation of Ednrb 1 0.19 0.22 0.36
60 INT152313 Il18 Regulation of Ednrb 1 0.30 0.22 0.36
61 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
62 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
63 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
64 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
65 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
66 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
67 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
68 INT201484 Negative_regulation of Prkcg Negative_regulation of Positive_regulation of Ednrb 1 0.34 0.96 0.32
69 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
70 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
71 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
72 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
73 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
74 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
75 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
76 INT54639 Edn3 Negative_regulation of Edn2 1 0.00 0 0.28
77 INT72820 EDN3 Positive_regulation of Avp 1 0.31 0.64 0.27
78 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
79 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
80 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
81 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
82 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
83 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
84 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
85 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
86 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
87 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
88 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
89 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
90 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
91 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 0.12 0.45 0.22
92 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
93 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
94 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
95 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
96 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
97 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
98 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
99 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
100 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
101 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
102 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
103 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
104 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
105 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
106 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
107 INT94017 Binding of EDN3 and INSRR 1 0.03 0 0.16
108 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
109 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
110 INT264276 Binding of Ednrb and P2rx1 1 0.00 0.17 0.16
111 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
112 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
113 INT94013 Positive_regulation of Binding of EDN2 and INSRR 1 0.04 0 0.16
114 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
115 INT94023 Positive_regulation of Binding of EDN2 and EDN3 1 0.25 0 0.16
116 INT94019 Positive_regulation of Binding of EDN3 and INSRR 1 0.04 0 0.16
117 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
118 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
119 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
120 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
121 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
122 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
123 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
124 INT89940 Ednrb Positive_regulation of Positive_regulation of TNF 1 0.01 0.09 0.14
125 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
126 INT72818 Edn3 Negative_regulation of Avp 1 0.08 0.34 0.14
127 INT72819 Regulation of EDN3 Positive_regulation of Avp 1 0.28 0.32 0.13
128 INT89939 Ednrb Regulation of Gene_expression of TNF 1 0.00 0.09 0.13
129 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
130 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
131 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
132 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
133 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
134 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
135 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
136 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
137 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
138 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
139 INT284140 Binding of EDNRB and PAH 1 0.08 0.1 0.1
140 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
141 INT181570 Binding of Edn1 and Mapk1 1 0.13 2.72 0.1
142 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
143 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
144 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
145 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
146 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09
147 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09
148 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
149 INT178072 Gene_expression of EDNRB Positive_regulation of EDN3 1 0.05 1.11 0.08
150 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
151 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08
152 INT137632 Rasa1 Regulation of Ednrb 1 0.05 0 0.08
153 INT181583 Binding of Edn1 and Positive_regulation of NOS1 1 0.02 0.86 0.08
154 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
155 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08
156 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
157 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
158 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07
159 INT182269 EDN1 Positive_regulation of Localization of MMP1 1 0.17 0.31 0.07
160 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
161 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
162 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
163 INT178093 EDN3 Positive_regulation of Gene_expression of EDNRB 1 0.05 1.01 0.07
164 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07
165 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
166 INT192907 Edn1 Positive_regulation of Ednrb 1 0.10 0.35 0.07
167 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
168 INT191219 Edn1 Positive_regulation of Amigo2 1 0.06 1.26 0.07
169 INT324896 Ece1 Positive_regulation of Negative_regulation of Edn1 1 0.19 0.42 0.07
170 INT172381 AVP Positive_regulation of Localization of EDN1 1 0.01 0.34 0.07
171 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07
172 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
173 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
174 INT191216 Binding of Edn1 and Cotl1 1 0.14 0.63 0.05
175 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05
176 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
177 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05
178 INT180667 Edn1 Regulation of Ecm1 1 0.04 0 0.05
179 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04
180 INT178091 EDN1 Positive_regulation of Gene_expression of PTGER2 1 0.01 0.74 0.04
181 INT353314 Edn1 Positive_regulation of Kalrn 1 0.03 0.21 0.04
182 INT229371 Positive_regulation of Pparg Negative_regulation of Gene_expression of Edn1 1 0.01 0.92 0.04
183 INT178098 EDN1 Positive_regulation of Transcription of VEGFA 1 0.08 0.76 0.04
184 INT332684 Binding of Edn1 and Lep 1 0.09 1.11 0.04
185 INT306513 EDN3 Positive_regulation of EDNRB 1 0.14 0.98 0.04
186 INT306514 EDN1 Positive_regulation of EDNRB 1 0.11 0.98 0.04
187 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04
188 INT178082 EDN1 Positive_regulation of VEGFA 1 0.08 0.77 0.04
189 INT246450 Lta Positive_regulation of Ednrb 1 0.00 0 0.04
190 INT323623 Binding of Adm and Edn1 1 0.04 0.77 0.03
191 INT239229 Regulation of Binding of Edn1 and Ednra 1 0.01 0.37 0.03
192 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
193 INT345298 NLRP3 Positive_regulation of Localization of Edn1 1 0.01 0.94 0.03
194 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03
195 INT239225 Binding of Edn1 and Ednrb 1 0.02 0.36 0.03
196 INT292081 Binding of EDN1 and NCOR2 1 0.00 0.98 0.03
197 INT239228 Regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03
198 INT239224 Positive_regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03
199 INT213030 Hdl1 Regulation of Gene_expression of Edn1 1 0.06 0.88 0
200 INT10901 Edn1 Positive_regulation of Localization of Nppb 1 0.39 0.68 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for vein smooth muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported in vein smooth muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
6 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
7 INT5048 Binding of Edn1 55 0.47 18.86 19.16
8 INT9191 Localization of EDN1 94 0.81 57.01 14.78
9 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
10 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
11 INT6365 Localization of Edn1 56 0.81 18.84 13.83
12 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
13 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
14 INT6361 Localization of Edn1 30 0.81 19.09 9.7
15 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68
16 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
17 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
18 INT10237 Binding of EDN1 40 0.48 16 8.48
19 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
20 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
21 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37
22 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75
23 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
24 INT29519 Gene_expression of Ednrb 8 0.66 1.99 4.55
25 INT92133 Negative_regulation of Ednrb 8 0.42 1.7 4.44
26 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
27 INT152312 Positive_regulation of Ednrb 7 0.49 1.46 4.04
28 INT5782 Gene_expression of Edn3 17 0.67 3.38 3.65
29 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
30 INT84222 Regulation of Ednrb 4 0.45 2.24 3.25
31 INT55033 Localization of Edn3 7 0.80 1.4 3.05
32 INT53374 Binding of Edn1 17 0.43 11.66 2.98
33 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
34 INT128774 Regulation of Gene_expression of Ednrb 3 0.46 1 2.56
35 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
36 INT78177 Negative_regulation of Gene_expression of Ednrb 4 0.41 1.04 2.16
37 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
38 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
39 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
40 INT178130 Binding of EDNRB 12 0.36 6.18 1.84
41 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
42 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
43 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
44 INT201475 Negative_regulation of Positive_regulation of Ednrb 6 0.42 3.74 1.66
45 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
46 INT139514 Localization of EDNRB 7 0.73 4.63 1.52
47 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
48 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
49 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
50 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
51 INT114298 Positive_regulation of Gene_expression of Ednrb 4 0.36 0.79 1.42
52 INT60772 Negative_regulation of Ednrb 8 0.41 4.56 1.39
53 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
54 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
55 INT61123 Localization of Edn2 1 0.55 0.27 1.05
56 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
57 INT78181 Negative_regulation of EDNRB 6 0.57 4.46 0.95
58 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
59 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
60 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
61 INT139515 Positive_regulation of EDNRB 15 0.67 10.35 0.93
62 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
63 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
64 INT6243 Regulation of Edn3 2 0.35 0.2 0.83
65 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
66 INT178127 Positive_regulation of Gene_expression of EDNRB 7 0.51 5.24 0.78
67 INT186681 Gene_expression of Edn2 2 0.09 1.01 0.76
68 INT61122 Regulation of Regulation of Edn3 1 0.35 0.2 0.75
69 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
70 INT8614 Negative_regulation of Edn2 3 0.06 0.07 0.73
71 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
72 INT63556 Binding of Edn3 1 0.24 0.63 0.7
73 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
74 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
75 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
76 INT50061 Negative_regulation of Edn3 4 0.58 0.77 0.65
77 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
78 INT139513 Negative_regulation of Localization of EDNRB 2 0.41 0 0.62
79 INT114299 Transcription of Ednrb 2 0.19 0.32 0.59
80 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
81 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
82 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
83 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
84 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
85 INT8663 Positive_regulation of EDN2 3 0.38 0.65 0.5
86 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
87 INT55370 Positive_regulation of Localization of Edn3 2 0.47 1.13 0.44
88 INT201478 Regulation of Positive_regulation of Ednrb 1 0.35 0.68 0.44
89 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
90 INT92195 Negative_regulation of Edn3 3 0.43 1.92 0.43
91 INT131106 Positive_regulation of Positive_regulation of Ednrb 1 0.15 0.91 0.4
92 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
93 INT168066 Transcription of Edn3 1 0.38 0.87 0.38
94 INT8664 Positive_regulation of EDN3 2 0.38 0 0.37
95 INT201476 Positive_regulation of Negative_regulation of Ednrb 1 0.49 0.62 0.36
96 INT129487 Negative_regulation of EDN3 1 0.38 0.35 0.35
97 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
98 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
99 INT53375 Binding of Edn3 1 0.36 0 0.32
100 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
101 INT131110 Localization of EDN3 1 0.03 0.74 0.31
102 INT131109 Positive_regulation of Localization of EDN3 1 0.02 0.76 0.31
103 INT16366 Gene_expression of Edn3 4 0.49 1.35 0.29
104 INT350971 Negative_regulation of Binding of EDNRB 1 0.13 0.86 0.29
105 INT139512 Positive_regulation of Localization of EDNRB 3 0.37 0.69 0.26
106 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
107 INT8660 Positive_regulation of Positive_regulation of EDN2 2 0.38 0.23 0.22
108 INT8665 Positive_regulation of Positive_regulation of EDN3 1 0.38 0 0.22
109 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
110 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
111 INT53376 Positive_regulation of Regulation of Edn3 1 0.48 0 0.19
112 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
113 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
114 INT53373 Regulation of Edn3 2 0.45 1.38 0.18
115 INT55013 Localization of Ednrb 2 0.16 0.98 0.18
116 INT274098 Regulation of EDNRB 1 0.33 2.41 0.18
117 INT26353 Binding of Edn2 1 0.01 0 0.17
118 INT242342 Regulation of Ednrb 1 0.09 2.03 0.15
119 INT256229 Protein_catabolism of EDNRB 3 0.64 0.96 0.14
120 INT55371 Positive_regulation of Edn3 1 0.69 0.38 0.14
121 INT323040 Gene_expression of EDN2 1 0.32 0.13 0.13
122 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
123 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
124 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
125 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
126 INT323038 Regulation of Positive_regulation of EDN2 1 0.21 0 0.1
127 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
128 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
129 INT178109 Binding of EDN3 1 0.06 1.65 0.07
130 INT324892 Binding of Ednrb 1 0.06 0.32 0.06
131 INT264273 Localization of Ednrb 1 0.01 0 0.03
132 INT270323 Gene_expression of EDN3 1 0.01 0.76 0.03
133 INT323037 Negative_regulation of EDN2 1 0.20 0.23 0
134 INT226251 Protein_catabolism of EDN3 1 0.02 0 0
135 INT22196 Positive_regulation of Gene_expression of Edn3 1 0.17 0.15 0
136 INT280682 Positive_regulation of Transcription of Edn1 1 0.34 0 0
137 INT49261 Negative_regulation of Protein_catabolism of EDN1 1 0.58 0 0
138 INT284148 Positive_regulation of Positive_regulation of EDNRB 1 0.29 0.54 0
139 INT323036 Regulation of EDN2 1 0.13 0 0
140 INT323041 Binding of EDN2 1 0.18 0.12 0
141 INT323039 Regulation of Binding of EDN2 1 0.21 0.12 0
142 INT181578 Negative_regulation of Phosphorylation of Edn1 1 0.37 0.1 0
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