GO:0015026

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Name coreceptor activity
Categary Function
Go Slim No
Go Link GO:0015026
Unique Molecular Interactions 337
Total Molecular Interactions 645
Total Single Events 3735
Pain Genes Associated 26

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for coreceptor activity. They are ordered first by their pain relevance and then by number of times they were reported for coreceptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
2 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
3 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8
4 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
5 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
6 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
7 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
8 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
9 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
10 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
11 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
12 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
13 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
14 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12
15 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
16 INT182190 Binding of IL8 and CXCR4 1 0.26 1.25 0.95
17 INT182210 Binding of CXCR4 and CXCL13 1 0.32 1.25 0.95
18 INT182205 Binding of CXCL5 and CXCR4 1 0.29 1.24 0.94
19 INT182195 Binding of CXCL1 and CXCR4 1 0.13 1.25 0.94
20 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
21 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85
22 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
23 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
24 INT141963 Binding of CALCRL and RAMP1 2 0.43 0.81 0.78
25 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78
26 INT142507 Binding of Calca and Ramp1 1 0.31 0.48 0.73
27 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72
28 INT182201 Binding of CXCR5 and CXCR4 1 0.36 1.15 0.72
29 INT182202 Binding of CXCR2 and CXCR4 1 0.31 1.15 0.72
30 INT239538 Binding of CXCR4 and CALCRL 1 0.00 0.35 0.71
31 INT209956 Binding of CD8A and RDBP 1 0.01 0.3 0.7
32 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
33 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66
34 INT106247 Binding of CCR5 and CCL4 1 0.54 0.06 0.64
35 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63
36 INT299792 Positive_regulation of Binding of CD80 and CTLA4 1 0.17 1.63 0.63
37 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
38 INT316882 Binding of Cd22 and Cr2 1 0.02 1.71 0.61
39 INT249624 Negative_regulation of Binding of CD86 and CTLA4 1 0.47 0.57 0.55
40 INT62299 Binding of CD4 and SGCG 1 0.39 1.23 0.51
41 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5
42 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
43 INT158400 Binding of CD80 and CD86 3 0.36 0.76 0.48
44 INT330522 Binding of CD8A and TNFSF10 1 0.17 1.24 0.48
45 INT141964 Binding of ADM and RAMP1 1 0.30 2.63 0.47
46 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47
47 INT138424 Binding of RAMP1 and Calca 1 0.01 0.08 0.47
48 INT149121 Binding of CD80 and Cd28 2 0.04 0.95 0.46
49 INT178664 Binding of CCR5 and TH1L 1 0.04 1.04 0.44
50 INT148611 Binding of CD8A and Cr2 1 0.02 0.81 0.44
51 INT194405 DCLK3 Positive_regulation of Gene_expression of RAMP1 1 0.16 0.09 0.43
52 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
53 INT208461 Binding of CD4 and IL16 1 0.05 3.04 0.41
54 INT188572 CD14 Regulation of Gene_expression of CD28 1 0.11 0.6 0.4
55 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4
56 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4
57 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4
58 INT287819 Binding of CD80 and Cd28 1 0.25 0.7 0.4
59 INT287818 Negative_regulation of Binding of CD80 and Cd28 1 0.29 0.7 0.4
60 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39
61 INT330519 Binding of CD8A and DICER1 1 0.08 0.99 0.38
62 INT330516 Binding of CD8A and CCR6 1 0.07 0.99 0.38
63 INT330517 Binding of CD8A and HLA-DRB4 1 0.08 0.99 0.38
64 INT117184 GOLPH3 Regulation of CXCR4 1 0.30 0.29 0.37
65 INT273172 Negative_regulation of PDE4A Negative_regulation of Localization of CD4 1 0.11 0.74 0.37
66 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37
67 INT226374 Negative_regulation of Binding of CD4 and IFNA1 1 0.03 0.66 0.37
68 INT117182 GOLPH3 Regulation of Binding of CXCR4 1 0.50 0.29 0.37
69 INT306254 Binding of TLR2 and LY96 1 0.25 1.29 0.36
70 INT343857 Binding of ABCC8 and LY96 1 0.02 0.96 0.34
71 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34
72 INT27029 HERPUD1 Regulation of Gene_expression of CD8A 1 0.41 0 0.34
73 INT27030 HERPUD1 Regulation of CD4 1 0.41 0 0.34
74 INT27035 HERPUD1 Regulation of CD8A 1 0.18 0 0.34
75 INT188391 Binding of CD4 and HLA-DRB1 1 0.05 0.96 0.34
76 INT27037 HERPUD1 Regulation of Gene_expression of CD4 1 0.55 0 0.34
77 INT138423 Binding of RAMP3 and Calca 1 0.01 0 0.32
78 INT299791 Negative_regulation of Binding of CD28 and CTLA4 1 0.18 0.77 0.32
79 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32
80 INT316883 Positive_regulation of Binding of Cd19 and Cd22 1 0.02 0.86 0.31
81 INT316886 Positive_regulation of Binding of Cd22 and Cr2 1 0.02 0.86 0.31
82 INT278693 ERAL1 Positive_regulation of CD4 1 0.05 1.1 0.31
83 INT278692 ERAL1 Positive_regulation of Positive_regulation of CD4 1 0.05 1.1 0.31
84 INT316887 Binding of Cd19 and Cd22 1 0.02 0.85 0.31
85 INT119333 Binding of Ramp2 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
86 INT119332 Binding of Ramp3 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
87 INT194406 Binding of RAMP1 and RPL34P34 1 0.00 0 0.29
88 INT355038 NRP1 Negative_regulation of CKAP4 1 0.02 1.23 0.29
89 INT141882 Binding of CD8A and HLA-A 1 0.32 0.9 0.29
90 INT174499 Binding of CD4 and HLA-E 1 0.04 1.08 0.29
91 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
92 INT245072 PPARA Regulation of Gene_expression of CXCR4 1 0.07 0.68 0.26
93 INT194670 CREB1 Regulation of Gene_expression of CD4 1 0.05 0.07 0.25
94 INT330521 Binding of CD4 and TNFSF10 1 0.20 0.73 0.24
95 INT352081 Binding of CD4 and ADAM11 1 0.09 0.33 0.24
96 INT88310 ITIH4 Positive_regulation of CXCR4 2 0.27 1.98 0.23
97 INT63195 INS Positive_regulation of CD8A 1 0.19 0.3 0.23
98 INT63202 POMC Positive_regulation of CD8A 1 0.30 0.3 0.23
99 INT289959 Negative_regulation of Binding of CD28 and CD80 1 0.07 0.24 0.23
100 INT289953 Binding of CD80 and KLF1 1 0.00 0.21 0.23
101 INT63201 PTH Positive_regulation of CD8A 1 0.45 0.29 0.22
102 INT194404 Binding of RAMP2 and DCLK3 1 0.07 0 0.22
103 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21
104 INT337168 DCPS Negative_regulation of CD86 1 0.02 1.54 0.21
105 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
106 INT330520 Positive_regulation of Binding of CD8A and TNFSF10 1 0.19 0.62 0.21
107 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2
108 INT252366 Binding of RUNX1 and CD80 1 0.01 0.54 0.2
109 INT288006 Binding of CD28 and LRRC23 1 0.02 0.54 0.19
110 INT188568 Negative_regulation of IRF6 Positive_regulation of CD28 1 0.05 0.19 0.19
111 INT252821 Binding of CD4 and IL12A 1 0.02 1.36 0.19
112 INT188570 Negative_regulation of IRF6 Positive_regulation of CD4 1 0.04 0.19 0.19
113 INT171127 Binding of CD28 and IFN1@ 1 0.39 0.36 0.19
114 INT252817 Binding of CD8A and IL12A 1 0.02 1.36 0.19
115 INT353298 IFNA1 Positive_regulation of CD8A 1 0.04 0.75 0.19
116 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19
117 INT188573 IRF6 Positive_regulation of CD4 1 0.05 0.19 0.19
118 INT188571 IRF6 Positive_regulation of CD28 1 0.06 0.19 0.19
119 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
120 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18
121 INT172246 TAS2R14 Positive_regulation of Gene_expression of RAMP1 1 0.01 0.07 0.18
122 INT274386 Binding of CD4 and ERVW-1 1 0.05 3.07 0.18
123 INT226380 Gene_expression of IL15 Negative_regulation of Positive_regulation of CD8A 1 0.02 1.59 0.18
124 INT350149 SH2B3 Regulation of CD8A 1 0.13 0.86 0.17
125 INT172251 CALCRL Positive_regulation of Gene_expression of RAMP1 1 0.04 0.07 0.17
126 INT116442 CD8B Negative_regulation of Positive_regulation of NFKB1 1 0.02 0 0.17
127 INT302553 Binding of CD8A and MID1 1 0.01 0.38 0.17
128 INT172232 CALCRL Positive_regulation of Gene_expression of NRP1 1 0.02 0.07 0.17
129 INT172237 TAS2R14 Positive_regulation of Gene_expression of NRP1 1 0.01 0.07 0.17
130 INT310937 Binding of CD8A and COPD 1 0.16 1.21 0.16
131 INT117183 Binding of CXCR4 and GOLPH3 1 0.53 0.27 0.16
132 INT194700 CD28 Positive_regulation of MAPK1 1 0.10 0.55 0.16
133 INT293361 Binding of CD80 and KLRD1 1 0.00 0.38 0.16
134 INT249685 Binding of CD8A and GRDX 1 0.02 0.46 0.16
135 INT88311 ITIH4 Positive_regulation of CCR5 1 0.49 1.57 0.16
136 INT188569 Binding of CD4 and TLR4 1 0.16 0.34 0.16
137 INT117191 Binding of CXCR4 and Coro1a 1 0.39 0.28 0.16
138 INT293359 Binding of CD86 and KLRD1 1 0.00 0.38 0.16
139 INT193779 Positive_regulation of ITIH4 Positive_regulation of CXCR4 1 0.19 0.83 0.15
140 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
141 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
142 INT285421 Positive_regulation of Binding of TLR4 and LY96 1 0.17 0.18 0.13
143 INT312707 Positive_regulation of DPP4 Positive_regulation of Gene_expression of CD86 1 0.20 0.45 0.13
144 INT291349 CXCR4 Positive_regulation of EPHB2 1 0.42 1.87 0.13
145 INT194817 CD28 Positive_regulation of Il4 1 0.15 0.41 0.13
146 INT194717 CD28 Positive_regulation of IL13 1 0.03 0.41 0.13
147 INT181841 Binding of CD8A and PHB2 1 0.01 0.75 0.13
148 INT298471 CD40LG Positive_regulation of CD80 1 0.04 0.33 0.12
149 INT10731 NEUROD1 Regulation of CD4 1 0.42 1.3 0.12
150 INT181844 Binding of CD8A and HLA-B 1 0.14 1.82 0.12
151 INT10730 CD9 Regulation of CD4 1 0.42 1.3 0.12
152 INT298473 IL4 Positive_regulation of CD80 1 0.06 0.33 0.12
153 INT251295 Binding of CD4 and Regulation of ITIH4 1 0.11 0.24 0.11
154 INT241748 CCR5 Regulation of CD4 1 0.21 0.39 0.11
155 INT189144 MTNR1B Positive_regulation of Gene_expression of CD4 1 0.01 0.35 0.11
156 INT294441 KLK4 Negative_regulation of CXCR4 1 0.01 0 0.1
157 INT236317 IGKV2D-38 Positive_regulation of CD86 1 0.02 0.13 0.1
158 INT181845 Binding of CD8A and IFN1@ 2 0.13 0.65 0.09
159 INT333095 Localization of IL2 Negative_regulation of Negative_regulation of CD8A 1 0.10 0.8 0.09
160 INT333099 Localization of IL2 Negative_regulation of Negative_regulation of CD4 1 0.14 0.8 0.09
161 INT163664 Binding of CD8A and KRT20 1 0.27 0.5 0.09
162 INT292632 CD4 Positive_regulation of Gene_expression of IL9 1 0.24 0 0.09
163 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09
164 INT333094 HIVEP1 Regulation of CD4 1 0.00 0.22 0.09
165 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09
166 INT182644 Binding of CXCR4 and Cxcr4 1 0.10 0.66 0.09
167 INT333121 Pol Positive_regulation of CD8A 1 0.00 0.08 0.09
168 INT194674 CD28 Negative_regulation of Gene_expression of IL13 1 0.02 0.06 0.08
169 INT333089 CD4 Positive_regulation of ERVW-1 1 0.05 0.07 0.08
170 INT270201 Binding of CD28 and Cd86 1 0.10 0.58 0.08
171 INT333097 ERVW-1 Positive_regulation of CD8A 1 0.02 0.08 0.08
172 INT116439 CD8B Negative_regulation of Gene_expression of CCL2 1 0.02 0 0.08
173 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
174 INT342288 Binding of CD4 and HFE 1 0.01 1.26 0.08
175 INT15953 Binding of CD4 and IgG2a 1 0.54 0.38 0.08
176 INT183768 Csf2 Regulation of CD4 1 0.37 0.52 0.08
177 INT270202 Binding of CD28 and Cd80 1 0.09 0.58 0.08
178 INT210288 Binding of CD8A and ELAVL4 1 0.27 1.21 0.07
179 INT352358 CD86 Positive_regulation of GOPC 1 0.30 0.13 0.07
180 INT333096 Binding of CD4 and IFN1@ 1 0.12 0.17 0.07
181 INT333092 Binding of CD4 and IL2 1 0.01 0.17 0.07
182 INT333098 Binding of CD8A and IL2 1 0.01 0.17 0.07
183 INT335712 Binding of FASLG and CD8A 1 0.18 0.9 0.06
184 INT222479 Binding of Ramp1 and Rxfp2 1 0.01 0 0.06
185 INT335713 Binding of FAS and CD8A 1 0.32 0.9 0.06
186 INT335715 Binding of FASLG and CD4 1 0.22 0.9 0.06
187 INT194831 CD28 Positive_regulation of Gene_expression of Il4 1 0.15 0 0.06
188 INT335714 Binding of FAS and CD4 1 0.38 0.9 0.06
189 INT209610 Binding of Cd22 and Cd34 1 0.01 1.05 0.06
190 INT333091 Localization of IFN1@ Negative_regulation of Negative_regulation of CD4 1 0.14 0.4 0.05
191 INT222559 Binding of Ramp3 and Ramp1 1 0.02 0 0.05
192 INT222485 Binding of Iapp and Ramp1 1 0.09 0 0.05
193 INT333090 Localization of IFN1@ Negative_regulation of Negative_regulation of CD8A 1 0.10 0.4 0.05
194 INT233303 Binding of CD4 and SRY 1 0.07 0.34 0.05
195 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04
196 INT241751 Negative_regulation of Binding of CD4 and ITIH4 3 0.18 1.07 0.04
197 INT329102 Binding of CD4 and HLA-DQA2 2 0.04 0.92 0.04
198 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04
199 INT241752 ITIH4 Negative_regulation of Binding of CXCR4 1 0.08 0.71 0.04
200 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for coreceptor activity. They are ordered first by their pain relevance and then by number of times they were reported in coreceptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
2 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
3 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
4 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39
5 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
6 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44
7 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15
8 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
9 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61
10 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15
11 INT132178 Binding of CD80 41 0.47 15.55 12.98
12 INT36287 Binding of CD4 96 0.47 58.93 11.88
13 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36
14 INT102448 Gene_expression of RAMP1 23 0.75 4.62 10.9
15 INT16404 Regulation of CD4 54 0.61 33.05 10.29
16 INT10019 Binding of CD8A 57 0.36 31.49 10.08
17 INT73504 Binding of CD28 35 0.45 15.99 10.04
18 INT19620 Binding of CD86 30 0.47 12.01 9.89
19 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59
20 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74
21 INT91758 Binding of CCR5 28 0.45 20.16 7.07
22 INT17049 Localization of CD4 57 0.75 35.33 6.89
23 INT117186 Positive_regulation of CXCR4 29 0.69 24.19 6.84
24 INT120200 Binding of RAMP1 6 0.47 0.72 6.16
25 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11
26 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96
27 INT117189 Binding of CXCR4 34 0.37 24.27 5.81
28 INT56149 Localization of CD8A 56 0.74 30.41 5.75
29 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36
30 INT16405 Regulation of CD8A 38 0.45 19.04 5.31
31 INT109248 Gene_expression of Ramp1 8 0.72 2.45 4.69
32 INT116902 Positive_regulation of CD28 17 0.47 13.56 4.27
33 INT102452 Gene_expression of RAMP2 6 0.69 7.11 3.77
34 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6
35 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51
36 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08
37 INT148934 Binding of Ramp1 4 0.36 0.94 2.89
38 INT155486 Positive_regulation of Gene_expression of CD86 16 0.69 14.6 2.86
39 INT110233 Regulation of Gene_expression of CCR5 6 0.34 7.14 2.76
40 INT106433 Regulation of CCR5 11 0.59 6.93 2.75
41 INT142502 Gene_expression of Ramp1 5 0.67 2.23 2.72
42 INT75685 Regulation of CD86 12 0.58 3.55 2.66
43 INT174527 Negative_regulation of CD28 13 0.35 5.06 2.65
44 INT19621 Positive_regulation of CD86 23 0.69 14 2.58
45 INT232510 Negative_regulation of Gene_expression of CXCR4 18 0.58 20.27 2.54
46 INT113775 Negative_regulation of Gene_expression of CCR5 6 0.43 3.97 2.28
47 INT144652 Negative_regulation of Binding of CD28 6 0.55 3.09 2.28
48 INT97134 Negative_regulation of CD80 8 0.57 5.09 2.11
49 INT148456 Gene_expression of LY96 7 0.19 4.35 2.02
50 INT58691 Positive_regulation of Gene_expression of CD8A 26 0.50 15.19 1.97
51 INT194414 Positive_regulation of Gene_expression of RAMP1 4 0.60 0.57 1.89
52 INT93912 Positive_regulation of CD80 11 0.56 7.01 1.88
53 INT36018 Negative_regulation of Gene_expression of CD8A 12 0.42 6.66 1.85
54 INT174511 Positive_regulation of Gene_expression of CD28 7 0.41 4.31 1.83
55 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
56 INT19617 Negative_regulation of CD86 12 0.42 3.68 1.77
57 INT147636 Regulation of CD80 3 0.60 1.27 1.73
58 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71
59 INT141967 Gene_expression of RAMP3 4 0.69 3.35 1.69
60 INT209896 Positive_regulation of Gene_expression of CD80 19 0.49 11.9 1.59
61 INT157769 Binding of LY96 8 0.47 2.5 1.59
62 INT209959 Negative_regulation of Binding of CD80 3 0.42 0.9 1.52
63 INT171133 Localization of CD28 8 0.71 3.42 1.48
64 INT148933 Localization of Ramp1 1 0.77 0.75 1.48
65 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39
66 INT174486 Regulation of Gene_expression of CD4 12 0.36 6.09 1.39
67 INT166595 Positive_regulation of Binding of RAMP1 2 0.45 0.18 1.36
68 INT142503 Positive_regulation of Gene_expression of Ramp1 1 0.43 0.83 1.26
69 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
70 INT185396 Gene_expression of PVRL1 17 0.34 15.18 1.18
71 INT161486 Regulation of Ramp1 2 0.61 1.64 1.16
72 INT193815 Regulation of Gene_expression of CXCR4 17 0.61 20.27 1.15
73 INT241757 Localization of CCR5 6 0.71 5.7 1.14
74 INT194413 Positive_regulation of RAMP1 1 0.36 0.07 1.08
75 INT138543 Negative_regulation of Cd28 3 0.11 2.1 1.01
76 INT58692 Regulation of Gene_expression of CD8A 11 0.42 10.16 1
77 INT223967 Regulation of Gene_expression of RAMP1 1 0.39 0.5 0.97
78 INT182211 Transcription of CXCR4 5 0.69 3.8 0.95
79 INT56151 Positive_regulation of Positive_regulation of CD8A 11 0.34 9.74 0.94
80 INT264171 Positive_regulation of Positive_regulation of CD4 5 0.49 4.74 0.94
81 INT119324 Positive_regulation of Gene_expression of Ramp1 3 0.53 0.94 0.89
82 INT209958 Negative_regulation of Binding of CD86 1 0.40 0.28 0.85
83 INT149291 Negative_regulation of NRP1 5 0.40 2.64 0.84
84 INT147634 Regulation of Cd28 2 0.44 3.23 0.82
85 INT72334 Negative_regulation of LRP5 7 0.35 1.71 0.81
86 INT189171 Positive_regulation of Localization of CD4 7 0.49 5.88 0.79
87 INT149298 Protein_catabolism of NRP1 2 0.82 1.52 0.77
88 INT119331 Gene_expression of Ramp2 2 0.60 0.19 0.75
89 INT149698 Negative_regulation of Binding of Cd28 2 0.15 1.21 0.75
90 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74
91 INT149697 Binding of Cd28 2 0.12 1.16 0.74
92 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
93 INT279357 Regulation of Binding of CD28 1 0.18 0.3 0.72
94 INT139205 Binding of NRP1 27 0.45 4.34 0.71
95 INT158295 Transcription of CD8A 11 0.53 4.02 0.7
96 INT265800 Localization of NRP1 14 0.75 3.66 0.69
97 INT19218 Negative_regulation of Positive_regulation of CD4 9 0.41 9.21 0.69
98 INT188586 Negative_regulation of Gene_expression of CD28 6 0.34 1.9 0.69
99 INT202428 Positive_regulation of Binding of CD4 4 0.37 2.11 0.68
100 INT231558 Regulation of LRP5 2 0.24 1.02 0.68
101 INT171946 Positive_regulation of Binding of CCR5 1 0.47 3.86 0.66
102 INT154772 Positive_regulation of Localization of CD8A 7 0.24 3.58 0.63
103 INT329718 Transcription of Cd28 1 0.09 1.54 0.63
104 INT117661 Gene_expression of Cd22 7 0.30 5.69 0.62
105 INT191825 Regulation of Positive_regulation of CD8A 3 0.12 2.5 0.62
106 INT155485 Regulation of Gene_expression of CD86 7 0.61 3.73 0.6
107 INT93728 Gene_expression of Cd28 8 0.35 7.11 0.59
108 INT193811 Localization of CXCR4 6 0.75 7.68 0.58
109 INT346182 Positive_regulation of Gene_expression of RAMP2 1 0.14 1.51 0.58
110 INT129164 Binding of Cd22 6 0.19 4.46 0.57
111 INT40367 Positive_regulation of Gene_expression of LRP5 1 0.09 0 0.57
112 INT202427 Negative_regulation of Localization of CD4 2 0.32 3.1 0.56
113 INT142504 Positive_regulation of Ramp1 1 0.46 0.66 0.55
114 INT147635 Regulation of Positive_regulation of CD80 1 0.44 0.38 0.53
115 INT260124 Positive_regulation of Positive_regulation of CCR5 1 0.14 0.84 0.51
116 INT147456 Negative_regulation of Positive_regulation of CD80 2 0.41 1.32 0.5
117 INT202426 Transcription of CD4 6 0.69 3.96 0.49
118 INT176891 Negative_regulation of Localization of CD8A 4 0.22 2.58 0.49
119 INT119326 Positive_regulation of Ramp2 1 0.42 0.2 0.48
120 INT119327 Positive_regulation of Ramp3 1 0.45 0.19 0.48
121 INT119329 Positive_regulation of Ramp1 1 0.43 0.2 0.48
122 INT260119 Regulation of Localization of CD4 2 0.44 1.61 0.46
123 INT185393 Regulation of PVRL1 4 0.24 1.48 0.45
124 INT149293 Negative_regulation of Protein_catabolism of NRP1 1 0.05 0.93 0.44
125 INT346192 Negative_regulation of RAMP2 1 0.12 0.92 0.42
126 INT270195 Positive_regulation of Positive_regulation of CD28 1 0.25 2.49 0.41
127 INT260118 Regulation of Regulation of CD4 1 0.44 1.66 0.4
128 INT193814 Positive_regulation of Positive_regulation of CXCR4 2 0.38 3.08 0.39
129 INT287286 Positive_regulation of Binding of CXCR4 2 0.53 0.78 0.39
130 INT174476 Regulation of CD28 3 0.34 0.67 0.37
131 INT236332 Negative_regulation of Gene_expression of CD86 9 0.42 4.4 0.35
132 INT231779 Transcription of LY96 2 0.13 1.22 0.35
133 INT221044 Positive_regulation of Negative_regulation of CCR5 1 0.19 0.62 0.35
134 INT329720 Negative_regulation of Transcription of Cd28 1 0.08 0.9 0.35
135 INT97137 Negative_regulation of Gene_expression of CD80 7 0.33 3.39 0.34
136 INT185401 Regulation of Gene_expression of PVRL1 1 0.27 4.69 0.34
137 INT209602 Positive_regulation of Gene_expression of Cd22 4 0.19 3.25 0.33
138 INT260110 Positive_regulation of Regulation of CD4 2 0.48 1.5 0.32
139 INT188577 Transcription of CD28 1 0.43 0.54 0.32
140 INT188583 Regulation of Transcription of CD28 1 0.22 0.54 0.32
141 INT143442 Positive_regulation of NRP1 11 0.57 2.62 0.3
142 INT202485 Positive_regulation of Cd22 4 0.19 2.28 0.3
143 INT282775 Regulation of Positive_regulation of CD4 2 0.37 1.28 0.3
144 INT212592 Regulation of Binding of CD4 2 0.30 1.15 0.3
145 INT253647 Phosphorylation of CD8A 3 0.25 0.7 0.29
146 INT119323 Binding of Ramp3 1 0.33 0.12 0.29
147 INT119325 Binding of Ramp2 1 0.33 0.12 0.29
148 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
149 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
150 INT219213 Regulation of Binding of CD8A 1 0.30 0 0.27
151 INT171130 Protein_catabolism of CD8A 1 0.83 0.47 0.27
152 INT171131 Protein_catabolism of CD28 1 0.73 0.47 0.27
153 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
154 INT278163 Negative_regulation of Localization of CD28 1 0.08 0.87 0.26
155 INT264305 Negative_regulation of Gene_expression of NRP1 3 0.40 1.4 0.25
156 INT334543 Negative_regulation of Positive_regulation of LRP5 1 0.23 1.81 0.25
157 INT28247 Negative_regulation of Positive_regulation of CD8A 3 0.14 2.84 0.24
158 INT222653 Gene_expression of Ramp3 1 0.17 0 0.24
159 INT245085 Positive_regulation of Negative_regulation of CXCR4 1 0.47 1.7 0.23
160 INT173655 Binding of LRP5 10 0.39 3.06 0.22
161 INT204183 Negative_regulation of Negative_regulation of CD4 3 0.30 1.79 0.22
162 INT104449 Transcription of CCR5 4 0.53 2.73 0.21
163 INT296064 Positive_regulation of Transcription of CD4 1 0.28 0.11 0.21
164 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18
165 INT222647 Positive_regulation of Gene_expression of Ramp3 1 0.15 0 0.18
166 INT107316 Negative_regulation of Positive_regulation of CCR5 2 0.41 1.96 0.17
167 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
168 INT135526 Positive_regulation of Gene_expression of Cd28 2 0.32 0.9 0.15
169 INT265419 Negative_regulation of Binding of CD8A 2 0.08 0.9 0.14
170 INT329712 Positive_regulation of Cd28 2 0.10 1 0.13
171 INT265792 Regulation of Localization of NRP1 1 0.22 0.21 0.13
172 INT265797 Regulation of Protein_catabolism of NRP1 1 0.51 0.21 0.13
173 INT20433 Regulation of Phosphorylation of CD4 1 0.06 0 0.13
174 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
175 INT20434 Phosphorylation of CD4 2 0.61 0 0.12
176 INT143446 Positive_regulation of Gene_expression of NRP1 1 0.45 1.02 0.12
177 INT241759 Negative_regulation of Binding of CCR5 2 0.41 0.94 0.11
178 INT203282 Negative_regulation of Binding of CD4 2 0.30 0.63 0.11
179 INT231778 Localization of LY96 3 0.13 0.59 0.1
180 INT181847 Negative_regulation of Positive_regulation of CD86 1 0.41 0.98 0.1
181 INT185394 Binding of PVRL1 5 0.14 2.94 0.09
182 INT222603 Negative_regulation of Gene_expression of Ramp2 1 0.09 0 0.09
183 INT185395 Regulation of Regulation of PVRL1 1 0.17 0.53 0.08
184 INT352366 Localization of CD86 1 0.74 0.29 0.07
185 INT352365 Positive_regulation of Localization of CD86 1 0.50 0.29 0.07
186 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06
187 INT352367 Positive_regulation of Regulation of CD86 1 0.50 0.06 0.06
188 INT206890 Negative_regulation of Gene_expression of Ramp1 1 0.18 0.83 0.05
189 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
190 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
191 INT263800 Positive_regulation of Gene_expression of PVRL1 1 0.22 1.14 0.05
192 INT306015 Regulation of Gene_expression of LY96 1 0.05 0.3 0.05
193 INT222576 Regulation of Gene_expression of Ramp1 1 0.09 0 0.04
194 INT242172 Protein_catabolism of LRP5 1 0.64 0.06 0.04
195 INT290329 Positive_regulation of Positive_regulation of CD80 1 0.17 0.44 0.04
196 INT222643 Regulation of Gene_expression of Ramp3 1 0.14 0 0.04
197 INT222608 Negative_regulation of Gene_expression of Acvr2a 3 0.10 0.29 0.03
198 INT264199 Positive_regulation of Binding of CD86 2 0.25 0.82 0.03
199 INT183764 Negative_regulation of Transcription of CXCR4 1 0.41 0.91 0.03
200 INT183763 Negative_regulation of Transcription of CCR5 1 0.15 0.92 0.03
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