GO:0015057

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Name thrombin receptor activity
Categary Function
Go Slim No
Go Link GO:0015057
Unique Molecular Interactions 118
Total Molecular Interactions 190
Total Single Events 1049
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thrombin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for thrombin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
2 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
3 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
4 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
5 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
6 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
7 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
8 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
9 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
10 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
11 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
12 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
13 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
14 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88
15 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
16 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
17 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
18 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
19 INT124292 Binding of Trpv1 and F2rl1 1 0.46 1.1 0.81
20 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
21 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77
22 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76
23 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71
24 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
25 INT150338 Binding of F2 and F2R 1 0.11 0.4 0.67
26 INT252857 Binding of F2rl1 and Trpa1 1 0.22 0.84 0.63
27 INT138332 Binding of P2rx3 and F2rl1 1 0.35 0.25 0.59
28 INT112312 tryptase Positive_regulation of F2rl1 2 0.08 0.23 0.57
29 INT167907 Binding of F2r and ITS 1 0.01 0.7 0.55
30 INT338038 Gopc Regulation of Gene_expression of F2r 1 0.08 0 0.52
31 INT338045 F2r Regulation of Localization of Calca 1 0.03 0.05 0.52
32 INT213809 F2 Positive_regulation of F2rl3 2 0.12 0.61 0.5
33 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46
34 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46
35 INT353331 Elane Positive_regulation of F2r 1 0.08 0.78 0.44
36 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 0.09 1.26 0.42
37 INT338059 Nrtn Positive_regulation of Gene_expression of F2r 1 0.12 0.45 0.41
38 INT156237 Binding of F2r and Tnfsf14 1 0.02 1.14 0.4
39 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 0.09 1.15 0.4
40 INT353332 Binding of F2r and Pawr 1 0.18 0.67 0.39
41 INT150333 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0.67 0.38
42 INT156235 Tnfsf14 Positive_regulation of F2r 1 0.03 1.03 0.35
43 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
44 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
45 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31
46 INT353335 F2r Regulation of Positive_regulation of Mif 1 0.27 0.11 0.31
47 INT191799 PROC Negative_regulation of Binding of F2r 1 0.00 0.92 0.3
48 INT353336 F2r Regulation of Localization of Mif 1 0.23 0.24 0.28
49 INT224462 Positive_regulation of F2RL1 Positive_regulation of MMP1 1 0.10 0.47 0.28
50 INT292570 Binding of F2RL1 and HTR1A 1 0.07 0.8 0.28
51 INT292568 Binding of F2RL1 and MRGPRX1 1 0.07 0.81 0.28
52 INT292571 Positive_regulation of F2RL1 Positive_regulation of Localization of IL6 1 0.07 0.8 0.27
53 INT353330 F2r Positive_regulation of Positive_regulation of Mif 1 0.46 0 0.26
54 INT123663 F2R Positive_regulation of MAPK14 1 0.12 0.42 0.26
55 INT123662 Negative_regulation of F2R Positive_regulation of MAPK14 1 0.08 0.42 0.26
56 INT305686 Binding of Gfap and F2r 1 0.01 0 0.25
57 INT292563 F2RL1 Negative_regulation of TNF 1 0.15 0.73 0.25
58 INT191792 Binding of F2r and Serpinc1 1 0.00 3.74 0.24
59 INT341538 F2 Positive_regulation of F2RL1 1 0.02 0.68 0.24
60 INT123660 F2R Positive_regulation of PAR1 2 0.10 1.96 0.22
61 INT292556 Binding of F2RL1 and TLR4 1 0.05 0.52 0.22
62 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
63 INT338042 F2r Positive_regulation of Localization of Prkca 1 0.06 0.1 0.2
64 INT123664 F2R Positive_regulation of PAR4 1 0.03 0.51 0.19
65 INT207151 PLA2G6 Positive_regulation of Localization of F2rl1 1 0.16 0.73 0.18
66 INT341531 F2RL1 Regulation of CD55 1 0.33 0.41 0.18
67 INT207147 Pla2g1b Positive_regulation of Localization of F2rl1 1 0.03 0.73 0.18
68 INT195115 Gene_expression of Gopc Positive_regulation of Positive_regulation of F2r 1 0.17 1.67 0.18
69 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18
70 INT207144 F2r Positive_regulation of Pawr 1 0.14 0.51 0.16
71 INT207117 Binding of VEGFA and F2r 1 0.02 0.56 0.15
72 INT338040 Ctsg Positive_regulation of F2r 1 0.29 0 0.15
73 INT338052 F2r Positive_regulation of F2rl3 1 0.12 0 0.15
74 INT105253 Positive_regulation of Binding of Rnpep and F2rl1 1 0.02 0 0.15
75 INT105252 Binding of Rnpep and F2rl1 1 0.01 0 0.15
76 INT338056 Ctsg Positive_regulation of F2rl3 1 0.30 0 0.15
77 INT341529 PRSS1 Positive_regulation of Gene_expression of F2RL1 1 0.06 0 0.11
78 INT341543 PRSS1 Positive_regulation of Transcription of F2RL1 1 0.06 0 0.11
79 INT338041 F2r Positive_regulation of Pard3 1 0.15 0.05 0.11
80 INT347515 Binding of GP1BA and Vwf 1 0.01 0.19 0.11
81 INT338048 F2rl3 Positive_regulation of Pard3 1 0.11 0.05 0.11
82 INT262255 Binding of APC and F2R 1 0.05 3 0.1
83 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
84 INT37547 Binding of GP1BA and F8 1 0.03 0.15 0.07
85 INT353341 F2r Positive_regulation of Negative_regulation of Mif 1 0.49 0 0.05
86 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
87 INT175631 F2RL1 Positive_regulation of Positive_regulation of MMP1 1 0.08 0.69 0.04
88 INT105260 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0 0.03
89 INT261728 PSMB6 Negative_regulation of Transcription of F2R 1 0.01 0.17 0.03
90 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03
91 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03
92 INT261729 COL5A2 Regulation of Gene_expression of F2R 1 0.18 0 0
93 INT261732 F2 Positive_regulation of F2R 1 0.14 0 0
94 INT338047 Binding of F2r and Pard3 1 0.11 0 0
95 INT142143 F2r Regulation of Plcg1 1 0.02 0.07 0
96 INT261730 ROCK1 Positive_regulation of Positive_regulation of F2R 1 0.37 0 0
97 INT142142 F2r Positive_regulation of Phosphorylation of Plcg1 1 0.03 0.08 0
98 INT341540 Positive_regulation of F2RL1 Positive_regulation of Gene_expression of AREG 1 0.18 0.51 0
99 INT353337 F2r Positive_regulation of Gene_expression of Mif 1 0.46 0 0
100 INT261735 Positive_regulation of F2 Positive_regulation of F2R 1 0.14 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thrombin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in thrombin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
2 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
3 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
4 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
5 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
6 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
7 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
8 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
9 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
10 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
11 INT159819 Gene_expression of F2rl3 5 0.45 5.53 5.24
12 INT90848 Localization of F2rl1 23 0.80 3.15 5.2
13 INT105256 Positive_regulation of Gene_expression of F2rl1 6 0.68 10.09 4.83
14 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66
15 INT107860 Positive_regulation of Gene_expression of F2RL1 10 0.68 6.36 3.88
16 INT100729 Localization of F2RL1 7 0.75 5.29 3.37
17 INT46754 Localization of F2r 7 0.78 2.36 3.24
18 INT58433 Negative_regulation of F2r 9 0.59 2.77 3.08
19 INT224481 Regulation of F2RL1 4 0.37 5.07 2.74
20 INT161942 Regulation of Gene_expression of F2RL1 12 0.62 4.84 2.73
21 INT82653 Regulation of F2r 8 0.36 3.78 2.62
22 INT111017 Regulation of F2rl1 3 0.22 0 2.61
23 INT150339 Gene_expression of F2R 10 0.73 3.59 2.46
24 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37
25 INT138331 Binding of F2rl1 4 0.36 1.92 2.32
26 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29
27 INT224480 Binding of F2RL1 5 0.36 5.2 2.19
28 INT82652 Negative_regulation of F2r 4 0.37 3.5 2.19
29 INT111018 Binding of F2rl1 5 0.30 3.11 2.02
30 INT224496 Negative_regulation of F2RL1 3 0.48 1.85 1.97
31 INT156231 Binding of F2r 9 0.23 3.78 1.57
32 INT158311 Positive_regulation of F2rl3 7 0.51 1.77 1.44
33 INT96651 Negative_regulation of F2rl1 4 0.37 2.26 1.4
34 INT119743 Negative_regulation of Positive_regulation of F2rl1 3 0.43 1.97 1.3
35 INT327936 Regulation of Gene_expression of F2rl1 1 0.61 2.62 1.26
36 INT117498 Regulation of Positive_regulation of F2r 1 0.18 0.91 1.24
37 INT98976 Regulation of F2r 7 0.60 0.71 1.22
38 INT338033 Localization of F2r 1 0.41 0.62 1.2
39 INT224494 Regulation of Positive_regulation of F2RL1 4 0.37 1.67 1.11
40 INT159330 Positive_regulation of Localization of F2rl1 1 0.49 0.34 1.02
41 INT112311 Regulation of F2rl1 2 0.27 0.73 0.97
42 INT224489 Negative_regulation of Gene_expression of F2RL1 3 0.57 1.51 0.96
43 INT195105 Negative_regulation of Gene_expression of F2r 3 0.37 1.41 0.91
44 INT101495 Regulation of Positive_regulation of F2rl1 1 0.26 0.88 0.91
45 INT79181 Negative_regulation of GP1BA 2 0.06 2.23 0.8
46 INT195099 Positive_regulation of Gene_expression of F2r 7 0.57 5.31 0.78
47 INT353325 Positive_regulation of Localization of F2r 1 0.49 1.31 0.76
48 INT62192 Regulation of Localization of F2r 2 0.60 0.59 0.7
49 INT292595 Negative_regulation of Positive_regulation of F2RL1 3 0.40 1.29 0.63
50 INT100730 Positive_regulation of Localization of F2RL1 2 0.49 0.99 0.62
51 INT207089 Regulation of Negative_regulation of F2r 1 0.17 1.49 0.62
52 INT353321 Regulation of Positive_regulation of F2r 1 0.60 0.6 0.62
53 INT297831 Protein_catabolism of F2rl1 2 0.10 0.5 0.6
54 INT123672 Positive_regulation of F2R 9 0.47 0.77 0.58
55 INT191777 Binding of F2r 2 0.02 0.89 0.54
56 INT124290 Negative_regulation of Gene_expression of F2rl1 3 0.42 1.48 0.52
57 INT338026 Regulation of Localization of F2r 1 0.25 0.05 0.52
58 INT99615 Gene_expression of GP1BA 12 0.75 2.98 0.5
59 INT111019 Negative_regulation of Binding of F2rl1 1 0.35 0 0.48
60 INT213786 Positive_regulation of Positive_regulation of F2rl3 1 0.27 0.92 0.46
61 INT113641 Negative_regulation of Gene_expression of GP1BA 4 0.57 2.2 0.44
62 INT156226 Transcription of F2rl1 1 0.23 1.25 0.41
63 INT166066 Negative_regulation of Localization of F2rl1 1 0.43 0.47 0.4
64 INT156230 Positive_regulation of Binding of F2rl1 1 0.21 1.11 0.4
65 INT112310 Negative_regulation of Regulation of F2rl1 1 0.03 0 0.39
66 INT292591 Negative_regulation of Negative_regulation of F2RL1 1 0.35 0 0.36
67 INT144981 Binding of F2R 3 0.36 1.66 0.35
68 INT353324 Negative_regulation of Positive_regulation of F2r 1 0.41 0.24 0.35
69 INT161343 Negative_regulation of Positive_regulation of F2rl3 1 0.31 0 0.29
70 INT224491 Transcription of F2RL1 1 0.68 0.31 0.26
71 INT94657 Transcription of F2rl1 1 0.69 0.5 0.26
72 INT105257 Regulation of Localization of F2rl1 1 0.23 0 0.26
73 INT62191 Negative_regulation of Localization of F2r 1 0.35 0 0.26
74 INT195091 Negative_regulation of Positive_regulation of F2r 1 0.48 1.69 0.25
75 INT158312 Negative_regulation of F2rl3 3 0.52 1.8 0.24
76 INT305682 Positive_regulation of Positive_regulation of F2r 1 0.03 0 0.24
77 INT17010 Regulation of GP1BA 2 0.03 0.93 0.18
78 INT195112 Positive_regulation of Positive_regulation of F2r 1 0.41 0.97 0.18
79 INT207129 Localization of F2rl1 1 0.22 0.72 0.18
80 INT160255 Negative_regulation of Negative_regulation of F2rl3 1 0.38 1.8 0.18
81 INT261745 Regulation of F2R 1 0.43 0.22 0.16
82 INT261739 Regulation of Gene_expression of F2R 1 0.26 0.22 0.16
83 INT98700 Regulation of Gene_expression of F2r 1 0.45 0 0.15
84 INT292590 Positive_regulation of Negative_regulation of F2RL1 1 0.38 0 0.15
85 INT207087 Negative_regulation of Binding of F2r 1 0.27 0.06 0.14
86 INT213764 Binding of F2rl3 2 0.21 0.37 0.11
87 INT341581 Positive_regulation of Transcription of F2RL1 1 0.44 0 0.11
88 INT307530 Negative_regulation of Binding of F2R 1 0.03 0 0.09
89 INT145503 Protein_catabolism of F2r 1 0.66 0.46 0.07
90 INT195082 Regulation of Gene_expression of F2r 1 0.37 0.67 0.07
91 INT292586 Phosphorylation of F2RL1 1 0.51 0 0.07
92 INT292582 Negative_regulation of Phosphorylation of F2RL1 1 0.35 0 0.07
93 INT261737 Transcription of F2R 1 0.50 0.31 0.05
94 INT353327 Transcription of F2r 1 0.67 0.21 0.03
95 INT191771 Positive_regulation of Gene_expression of F2r 1 0.01 0.31 0.03
96 INT338031 Transcription of F2r 1 0.39 0 0
97 INT338028 Positive_regulation of Gene_expression of F2rl3 1 0.20 0 0
98 INT149028 Positive_regulation of Gene_expression of F2rl1 1 0.43 0 0
99 INT149032 Regulation of Gene_expression of F2rl1 1 0.23 0 0
100 INT306376 Positive_regulation of GP1BA 1 0.05 0 0
101 INT353323 Negative_regulation of Gene_expression of F2r 1 0.41 0 0
102 INT261741 Negative_regulation of Positive_regulation of F2R 1 0.40 0 0
103 INT261743 Positive_regulation of Positive_regulation of F2R 1 0.44 0 0
104 INT338034 Transcription of F2rl3 1 0.28 0 0
105 INT292596 Positive_regulation of Binding of F2RL1 1 0.41 0 0
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