GO:0015267

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Name channel activity
Categary Function
Go Slim No
Go Link GO:0015267
Unique Molecular Interactions 504
Total Molecular Interactions 661
Total Single Events 7659
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for channel activity. They are ordered first by their pain relevance and then by number of times they were reported for channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5
2 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
3 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
4 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
5 INT154685 Syt17 Positive_regulation of Trpa1 1 0.32 0.71 1.4
6 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
7 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3
8 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
9 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
10 INT134384 Trpa1 Negative_regulation of Gene_expression of Trpm8 1 0.47 1.21 1.02
11 INT166625 Acer3 Positive_regulation of Trpa1 1 0.01 1.91 1
12 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
13 INT307100 Trpv1 Regulation of Binding of Trpa1 1 0.31 1.81 0.97
14 INT307103 Trpa1 Regulation of Binding of Trpv1 1 0.31 1.81 0.97
15 INT149389 Olfr1241 Positive_regulation of Trpa1 1 0.02 0.31 0.94
16 INT149390 Foxm1 Positive_regulation of Trpa1 1 0.28 0.31 0.94
17 INT221916 RPS3AP18 Negative_regulation of Positive_regulation of Trpa1 1 0.00 0.75 0.93
18 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
19 INT149391 Trpa1 Positive_regulation of Positive_regulation of Olfr1241 1 0.03 0.26 0.88
20 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
21 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
22 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
23 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
24 INT150643 Binding of Bdkrb2 and Trpa1 1 0.36 0.55 0.78
25 INT166902 NPPB Positive_regulation of TRPA1 1 0.78 0.76 0.77
26 INT252858 C5 Negative_regulation of Positive_regulation of Trpa1 1 0.02 0.78 0.74
27 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
28 INT142225 Urb1 Positive_regulation of Trpa1 1 0.04 0.59 0.71
29 INT307754 Ik Negative_regulation of Trpa1 1 0.07 0.08 0.71
30 INT221938 Binding of TRPA1 and Tceb1 1 0.02 0 0.71
31 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71
32 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
33 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
34 INT199395 Mip Positive_regulation of Positive_regulation of Trpv1 1 0.01 0.86 0.69
35 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
36 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
37 INT283049 Car2 Positive_regulation of Trpa1 1 0.20 1.33 0.67
38 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
39 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
40 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
41 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
42 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64
43 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63
44 INT252857 Binding of F2rl1 and Trpa1 1 0.22 0.84 0.63
45 INT252859 Binding of Ngf and Trpa1 1 0.19 0.84 0.62
46 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
47 INT284792 Binding of Trpa1 and DRGX 1 0.02 0.66 0.6
48 INT284790 Trpa1 Positive_regulation of Regulation of Napa 1 0.19 0 0.59
49 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
50 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
51 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
52 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
53 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
54 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
55 INT138352 Foxm1 Positive_regulation of Trpa1 1 0.05 0.33 0.51
56 INT142230 Urb1 Positive_regulation of Gene_expression of Trpa1 1 0.04 0.4 0.5
57 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47
58 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 0.01 0.97 0.46
59 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
60 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
61 INT142226 Trpa1 Regulation of Trpv1 2 0.35 0.39 0.44
62 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
63 INT116609 Lnpep Negative_regulation of Bcl2 1 0.05 0.62 0.43
64 INT116606 Lnpep Regulation of Gene_expression of Bcl2 1 0.07 0.62 0.43
65 INT296231 Anxa1 Regulation of Gene_expression of Trpa1 1 0.03 0.57 0.43
66 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
67 INT116607 Lnpep Negative_regulation of Gene_expression of Bcl2 1 0.10 0.62 0.43
68 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
69 INT309143 Dlat Positive_regulation of Bcl2 1 0.06 1.04 0.42
70 INT309152 Dlat Positive_regulation of Gene_expression of Bcl2 1 0.04 1.05 0.42
71 INT235878 Creb1 Positive_regulation of Gene_expression of Bcl2 1 0.05 0.17 0.38
72 INT155062 Csf2 Positive_regulation of Transcription of Bcl2 1 0.31 2.91 0.36
73 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
74 INT167045 TRPA1 Regulation of PTGS1 1 0.19 0.1 0.35
75 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
76 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
77 INT167047 TRPA1 Regulation of CNR1 1 0.12 0.1 0.35
78 INT167046 TRPA1 Regulation of TRPV1 1 0.48 0.1 0.35
79 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
80 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34
81 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
82 INT353010 Binding of GJA8 and TNF 1 0.02 0.24 0.33
83 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
84 INT155060 Stat3 Negative_regulation of Bcl2 1 0.21 3.7 0.33
85 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
86 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
87 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
88 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
89 INT146247 Pcbd1 Positive_regulation of Trpa1 1 0.02 0 0.31
90 INT166901 NPPB Positive_regulation of Gene_expression of TRPA1 1 0.68 0.33 0.3
91 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
92 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
93 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
94 INT353009 Binding of GJA8 and VSIG1 1 0.00 0 0.29
95 INT109711 Mip Positive_regulation of Rtcd1 1 0.00 0 0.29
96 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28
97 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28
98 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
99 INT172905 Binding of Bad and Bcl2 3 0.08 6.46 0.27
100 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
101 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26
102 INT272157 Gh1 Negative_regulation of Bcl2 1 0.23 1.2 0.26
103 INT272158 Gh1 Regulation of Bcl2 1 0.15 1.2 0.26
104 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
105 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
106 INT221939 Tceb1 Negative_regulation of Positive_regulation of TRPA1 1 0.02 0 0.26
107 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
108 INT284783 Napa Positive_regulation of Positive_regulation of Trpa1 1 0.20 0 0.25
109 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24
110 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
111 INT268768 Mip Regulation of Positive_regulation of Ccr1 1 0.44 0.83 0.23
112 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
113 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23
114 INT196133 Binding of Gopc and Trpa1 1 0.12 0 0.22
115 INT217349 Mip Positive_regulation of IL8 1 0.05 1.28 0.22
116 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
117 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
118 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
119 INT284787 Napa Positive_regulation of Binding of Trpa1 1 0.22 0 0.2
120 INT284782 Napa Positive_regulation of Trpa1 1 0.30 0 0.2
121 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
122 INT242319 D12Pgn2 Positive_regulation of Trpa1 1 0.01 0.47 0.19
123 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
124 INT242632 Ret Positive_regulation of Gene_expression of Trpa1 1 0.33 0.09 0.18
125 INT155063 Csf2 Negative_regulation of Gene_expression of Bax 1 0.27 1.46 0.18
126 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
127 INT285026 Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
128 INT285022 Regulation of Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
129 INT149797 RGD1565648 Positive_regulation of Trpa1 1 0.00 0.18 0.17
130 INT149798 Atp7b Positive_regulation of Trpa1 1 0.23 0.18 0.17
131 INT155066 Csf2 Negative_regulation of Bax 1 0.12 1.89 0.17
132 INT241250 Binding of Pkd2 and Trpc1 1 0.23 0.3 0.17
133 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
134 INT155233 TXNIP Regulation of BCL2 1 0.23 0.15 0.17
135 INT285024 Bcl2 Regulation of Bak1 1 0.09 0.71 0.17
136 INT229203 Binding of Bcl2 and Cyp2c11 1 0.36 1.2 0.17
137 INT155068 Csf2 Negative_regulation of Bcl2 1 0.12 1.88 0.17
138 INT163273 H2BFM Regulation of TRPA1 1 0.23 0.42 0.17
139 INT137869 Gene_expression of Artn Positive_regulation of Gene_expression of Trpa1 1 0.52 0.16 0.17
140 INT142229 Trpa1 Regulation of Trpv4 1 0.15 0.1 0.17
141 INT155232 TXNIP Regulation of BAX 1 0.23 0.15 0.17
142 INT142223 Trpa1 Negative_regulation of Trpm8 1 0.20 0.1 0.17
143 INT347445 CD99 Positive_regulation of BCL2 1 0.17 0.95 0.16
144 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
145 INT242318 Ptgds Positive_regulation of Trpa1 1 0.29 0.06 0.16
146 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15
147 INT260059 AKTIP Positive_regulation of TRPA1 1 0.02 0 0.15
148 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
149 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14
150 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
151 INT221937 Negative_regulation of Binding of TRPA1 and Tceb1 1 0.02 0 0.14
152 INT141497 Pyroxd1 Positive_regulation of Trpa1 1 0.01 0.18 0.14
153 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
154 INT141496 Negative_regulation of Pyroxd1 Positive_regulation of Trpa1 1 0.01 0.18 0.14
155 INT296233 Binding of Anxa1 and Trpa1 1 0.03 0.78 0.14
156 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13
157 INT309139 Edc4 Positive_regulation of Bcl2 1 0.03 0.12 0.13
158 INT148594 Binding of BCL2 and CD34 1 0.39 1.17 0.13
159 INT353011 GJA8 Regulation of USE1 1 0.00 0.35 0.13
160 INT150061 Binding of TRPV1 and Trpa1 1 0.24 0.1 0.13
161 INT309142 Edc4 Regulation of Bcl2 1 0.02 0.12 0.13
162 INT246016 Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
163 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
164 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
165 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
166 INT348542 BCL2 Negative_regulation of NLRP1 1 0.07 2.02 0.13
167 INT246017 Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
168 INT172899 Binding of Bcl2 and Bcl2l1 3 0.02 5.54 0.12
169 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 0.00 0.53 0.12
170 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
171 INT296238 Trpm8 Regulation of Trpa1 1 0.30 0.21 0.12
172 INT305194 Bcl2 Positive_regulation of Epo 1 0.06 0.29 0.12
173 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
174 INT146244 Trpa1 Regulation of HalphaSS 1 0.01 0 0.11
175 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 0.01 0.72 0.11
176 INT285030 Binding of Bax and Slc25a4 1 0.03 0.84 0.11
177 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
178 INT221684 Binding of Bcl2 and FRTS 1 0.01 1.19 0.11
179 INT146242 Trpa1 Regulation of Trpv1 1 0.24 0 0.11
180 INT241248 Binding of Pkd1 and Pkd2 3 0.22 1.52 0.1
181 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1
182 INT146246 HalphaSS Positive_regulation of Trpa1 1 0.02 0 0.1
183 INT352751 Pkd2 Regulation of Localization of Vegfa 1 0.11 0.47 0.1
184 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1
185 INT151094 Binding of TRPA1 and TRPM8 1 0.41 0.2 0.1
186 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1
187 INT352750 Pkd2 Positive_regulation of Vegfa 1 0.20 0.47 0.1
188 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
189 INT239643 Binding of BCL2 and BCL2L11 3 0.16 2.26 0.09
190 INT282094 Apoa2 Negative_regulation of BCL2 1 0.06 1.15 0.09
191 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
192 INT275183 Bad Positive_regulation of Gene_expression of Bcl2 1 0.08 0.63 0.09
193 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
194 INT294637 Bcl2a1a Positive_regulation of Gene_expression of Bcl2 1 0.15 0.97 0.09
195 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
196 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
197 INT241249 Pkd2 Regulation of Trpc1 1 0.21 0.14 0.09
198 INT286565 Pkd2 Positive_regulation of Positive_regulation of Pkd1 1 0.21 0.11 0.09
199 INT204300 Bcl2 Negative_regulation of Positive_regulation of Bak1 1 0.02 1.13 0.09
200 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported for channel activity. They are ordered first by their pain relevance and then by number of times they were reported in channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65
2 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9
3 INT109431 Gene_expression of Trpa1 123 0.78 51.84 59.98
4 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
5 INT109430 Positive_regulation of Trpa1 119 0.70 44 49.14
6 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
7 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
8 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
9 INT149387 Negative_regulation of Trpa1 55 0.59 21.91 28.31
10 INT127499 Positive_regulation of TRPA1 72 0.70 21.7 26.86
11 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
12 INT127500 Gene_expression of TRPA1 79 0.78 24.58 23.3
13 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
14 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
15 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
16 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
17 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
18 INT134596 Regulation of Trpa1 32 0.62 18.78 17.02
19 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
20 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
21 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
22 INT120432 Regulation of Trpa1 22 0.61 9.65 12.36
23 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
24 INT69867 Gene_expression of Mip 36 0.75 24.54 10.38
25 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
26 INT134597 Binding of Trpa1 21 0.48 9.41 9.74
27 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
28 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
29 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
30 INT146346 Negative_regulation of Gene_expression of Trpa1 15 0.59 11.76 8.83
31 INT146241 Positive_regulation of Gene_expression of Trpa1 23 0.69 8.07 8.74
32 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
33 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
34 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
35 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
36 INT130502 Negative_regulation of Trpa1 17 0.59 5.75 8.06
37 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
38 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
39 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
40 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
41 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
42 INT134379 Binding of Trpa1 13 0.48 7.16 7.27
43 INT131745 Positive_regulation of Gene_expression of Trpa1 13 0.69 8.07 6.95
44 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
45 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
46 INT126484 Localization of Trpa1 15 0.80 4.08 6.64
47 INT131744 Transcription of Trpa1 9 0.68 7.67 6.47
48 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
49 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
50 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
51 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
52 INT169687 Regulation of Gene_expression of Trpa1 10 0.60 7.02 5.94
53 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
54 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
55 INT145929 Regulation of Bax 20 0.60 18.12 5.35
56 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
57 INT147869 Positive_regulation of Gene_expression of TRPA1 5 0.70 5.33 5.21
58 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
59 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
60 INT147870 Binding of TRPA1 11 0.48 3.12 4.77
61 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
62 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
63 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
64 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16
65 INT84686 Regulation of BAX 26 0.49 28.54 4.13
66 INT123752 Regulation of Bax 19 0.60 16.45 4
67 INT112692 Localization of Bax 31 0.80 20.97 3.98
68 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
69 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
70 INT124579 Localization of BAX 35 0.78 30.31 3.43
71 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
72 INT159899 Localization of Trpa1 9 0.75 1.9 3.4
73 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
74 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
75 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
76 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
77 INT136891 Negative_regulation of TRPA1 7 0.43 2.45 3.06
78 INT204122 Gene_expression of GJA8 13 0.47 22.98 3.04
79 INT105884 Binding of Bcl2 19 0.35 15.67 3
80 INT147542 Negative_regulation of Positive_regulation of Trpa1 6 0.59 2.63 3
81 INT168745 Negative_regulation of Regulation of Trpa1 1 0.43 3.26 2.87
82 INT142500 Transcription of Trpa1 11 0.67 5.27 2.78
83 INT151865 Regulation of TRPA1 5 0.45 2.78 2.7
84 INT86713 Positive_regulation of Mip 10 0.67 6.44 2.63
85 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
86 INT138351 Negative_regulation of Gene_expression of Trpa1 6 0.43 2.77 2.44
87 INT147543 Positive_regulation of Positive_regulation of Trpa1 7 0.69 2.24 2.38
88 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
89 INT147349 Localization of Bcl2 13 0.65 7.83 2.31
90 INT269695 Negative_regulation of Negative_regulation of Trpa1 3 0.43 1.94 2.25
91 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24
92 INT103966 Negative_regulation of Gene_expression of BAX 9 0.56 7.95 2.14
93 INT77627 Regulation of Gene_expression of BAX 14 0.44 15.09 2.12
94 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
95 INT154970 Localization of Bax 15 0.74 11.12 2.11
96 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03
97 INT98836 Transcription of Bax 6 0.69 5.04 1.96
98 INT151818 Negative_regulation of Positive_regulation of TRPA1 3 0.58 0.56 1.96
99 INT134442 Transcription of Bax 14 0.67 7.6 1.9
100 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
101 INT101108 Localization of Bcl2 16 0.72 11.68 1.86
102 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86
103 INT134443 Binding of Bax 10 0.47 5.62 1.84
104 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
105 INT304624 Positive_regulation of Regulation of Trpa1 1 0.44 2.64 1.76
106 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
107 INT134382 Positive_regulation of Transcription of Trpa1 2 0.46 2.48 1.71
108 INT210590 Positive_regulation of Gene_expression of Mip 10 0.67 8.09 1.68
109 INT147224 Negative_regulation of Positive_regulation of Trpa1 2 0.58 2.92 1.66
110 INT151096 Localization of TRPA1 8 0.80 2.06 1.65
111 INT101958 Positive_regulation of Transcription of Bcl2 4 0.50 2.22 1.65
112 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
113 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
114 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
115 INT131743 Regulation of Gene_expression of Trpa1 2 0.44 1.76 1.58
116 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
117 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
118 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
119 INT127323 Positive_regulation of Positive_regulation of Trpa1 8 0.69 0.96 1.42
120 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
121 INT269692 Regulation of Negative_regulation of Trpa1 1 0.45 0.17 1.39
122 INT69863 Binding of Mip 7 0.36 4.54 1.33
123 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
124 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
125 INT101107 Positive_regulation of Localization of Bcl2 3 0.48 3.13 1.28
126 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
127 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2
128 INT154487 Regulation of Positive_regulation of TRPA1 2 0.27 1.18 1.19
129 INT141189 Negative_regulation of Transcription of Bax 1 0.41 1.42 1.14
130 INT268763 Negative_regulation of Mip 3 0.41 2.61 1.12
131 INT172855 Binding of Bcl2 37 0.32 23.41 1.09
132 INT70021 Localization of BCL2 23 0.74 21.6 1.09
133 INT265086 Regulation of Negative_regulation of Trpa1 1 0.44 1.44 1.09
134 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
135 INT135122 Binding of GJA8 3 0.11 2.08 0.97
136 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
137 INT175507 Regulation of Gene_expression of Bax 13 0.50 10.91 0.95
138 INT98134 Binding of BAX 17 0.39 11.45 0.93
139 INT101050 Localization of Mip 4 0.78 1.9 0.93
140 INT151115 Regulation of Regulation of Bcl2 4 0.21 4.12 0.88
141 INT92117 Phosphorylation of BCL2 26 0.80 9.93 0.86
142 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
143 INT137512 Positive_regulation of Positive_regulation of BAX 5 0.49 4.91 0.85
144 INT144697 Regulation of Gene_expression of Bax 8 0.37 9.5 0.81
145 INT82896 Transcription of BAX 3 0.67 4.61 0.8
146 INT70019 Binding of BCL2 25 0.47 17.55 0.79
147 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
148 INT109404 Transcription of BCL2 6 0.69 4.49 0.77
149 INT148984 Positive_regulation of Localization of BAX 6 0.48 5.29 0.77
150 INT221914 Negative_regulation of Binding of Trpa1 1 0.18 0.65 0.77
151 INT124844 Regulation of Positive_regulation of Bcl2 3 0.43 2.55 0.75
152 INT155392 Negative_regulation of Negative_regulation of Bcl2 3 0.21 1.64 0.74
153 INT134444 Positive_regulation of Binding of Bcl2 3 0.47 2.67 0.72
154 INT148471 Negative_regulation of Transcription of Trpa1 1 0.38 0.29 0.69
155 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
156 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
157 INT204120 Positive_regulation of GJA8 2 0.30 1.51 0.63
158 INT221915 Positive_regulation of Localization of Trpa1 1 0.21 0.5 0.63
159 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
160 INT70025 Positive_regulation of Positive_regulation of BCL2 3 0.27 0.96 0.58
161 INT265087 Regulation of Binding of Trpa1 1 0.44 0.61 0.58
162 INT178128 Negative_regulation of Phosphorylation of BCL2 7 0.27 3.94 0.56
163 INT241235 Binding of Pkd2 11 0.48 2.43 0.55
164 INT155090 Regulation of Positive_regulation of BCL2 3 0.26 1.78 0.54
165 INT241243 Gene_expression of Pkd2 30 0.77 9.05 0.53
166 INT176242 Binding of Bax 10 0.42 10.18 0.52
167 INT144696 Regulation of Transcription of Bcl2 5 0.44 2.96 0.51
168 INT151819 Positive_regulation of Positive_regulation of TRPA1 3 0.50 0.15 0.51
169 INT268755 Negative_regulation of Gene_expression of Mip 1 0.41 1.73 0.51
170 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
171 INT134445 Positive_regulation of Positive_regulation of Bcl2 3 0.47 2.43 0.49
172 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
173 INT102108 Protein_catabolism of Bax 8 0.64 5.69 0.48
174 INT221676 Protein_catabolism of Bcl2 4 0.24 2.77 0.48
175 INT134446 Positive_regulation of Binding of Bax 1 0.49 0.72 0.48
176 INT229243 Negative_regulation of Phosphorylation of BAX 1 0.18 2.32 0.47
177 INT204052 Transcription of Bcl2 5 0.51 3.25 0.45
178 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
179 INT140295 Protein_catabolism of BCL2 4 0.64 5.7 0.44
180 INT220424 Positive_regulation of Negative_regulation of Bcl2 2 0.14 1.81 0.44
181 INT183187 Transcription of Mip 2 0.69 0.69 0.43
182 INT135078 Positive_regulation of Localization of Trpa1 2 0.49 0.14 0.43
183 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
184 INT152059 Regulation of Transcription of Bax 1 0.26 0.07 0.42
185 INT105888 Phosphorylation of BAX 9 0.80 4.78 0.4
186 INT135802 Positive_regulation of Negative_regulation of Bax 2 0.41 0.57 0.4
187 INT268751 Positive_regulation of Binding of Mip 1 0.49 0.91 0.4
188 INT283042 Regulation of Transcription of Trpa1 1 0.43 1.31 0.4
189 INT241236 Negative_regulation of Pkd2 11 0.43 1.82 0.39
190 INT260061 Positive_regulation of Binding of TRPA1 1 0.45 0.18 0.39
191 INT229233 Positive_regulation of Phosphorylation of BAX 1 0.21 1.94 0.38
192 INT155724 Negative_regulation of Transcription of Bcl2 6 0.53 2.35 0.37
193 INT284781 Positive_regulation of Binding of Trpa1 1 0.45 0 0.36
194 INT204069 Negative_regulation of Positive_regulation of Bax 5 0.31 3.08 0.34
195 INT169538 Negative_regulation of Localization of Bax 3 0.49 1.41 0.34
196 INT184482 Positive_regulation of Positive_regulation of Bax 5 0.41 4.7 0.33
197 INT221191 Negative_regulation of Localization of Bax 4 0.38 2.85 0.33
198 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
199 INT109530 Negative_regulation of Positive_regulation of BAX 3 0.42 3.01 0.3
200 INT82900 Positive_regulation of Transcription of BAX 2 0.49 1.86 0.29
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