GO:0015271

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Name outward rectifier potassium channel activity
Categary Function
Go Slim No
Go Link GO:0015271
Unique Molecular Interactions 50
Total Molecular Interactions 101
Total Single Events 515
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for outward rectifier potassium channel activity. They are ordered first by their pain relevance and then by number of times they were reported for outward rectifier potassium channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
2 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
3 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
4 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
5 INT200307 Rest Negative_regulation of Rorb 1 0.00 0.1 1.03
6 INT65631 Ufm1 Positive_regulation of Kcna5 1 0.02 0 0.99
7 INT200308 Binding of Rest and Rorb 1 0.00 0 0.87
8 INT154193 Binding of KCNK2 and Mtap2 1 0.22 0.48 0.74
9 INT200317 Rest Negative_regulation of Transcription of Oprm1 1 0.31 0 0.64
10 INT200321 Binding of Rest and Negative_regulation of Gene_expression of Oprm1 1 0.36 0.05 0.49
11 INT154592 Binding of Ntrk2 and Positive_regulation of Gene_expression of Kcna3 1 0.11 0.16 0.44
12 INT200327 Oprm1 Negative_regulation of Gene_expression of Rest 1 0.31 0 0.41
13 INT200314 Oprm1 Regulation of Rest 1 0.20 0.1 0.39
14 INT200353 Rest Negative_regulation of Oprm1 1 0.31 0.1 0.39
15 INT200302 Rest Regulation of Rorb 1 0.00 0.07 0.38
16 INT334632 Binding of Kcna2 and Eae1 1 0.17 0.87 0.35
17 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
18 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
19 INT200352 Binding of Rest and Rcor2 1 0.16 0.44 0.34
20 INT200351 Sp1 Positive_regulation of Gene_expression of Rest 1 0.34 0.07 0.3
21 INT154194 Binding of KCNK2 and Akap5 1 0.08 0.19 0.29
22 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24
23 INT200309 Positive_regulation of Binding of Rest and Sp3 1 0.41 0.88 0.24
24 INT97691 Binding of REST and HDAC9 1 0.26 0.09 0.23
25 INT154594 Ntf5 Positive_regulation of Gene_expression of Kcna3 1 0.05 0.07 0.23
26 INT154590 Bdnf Positive_regulation of Gene_expression of Kcna3 1 0.07 0.07 0.23
27 INT154591 Binding of Ntrk2 and Positive_regulation of Kcna3 1 0.11 0.08 0.22
28 INT97694 Ngf Negative_regulation of Gene_expression of REST 1 0.01 0.09 0.21
29 INT154593 Ntrk2 Regulation of Kcna3 1 0.06 0.06 0.19
30 INT104797 Smarce1 Positive_regulation of REST 1 0.01 0.24 0.15
31 INT200338 Rest Positive_regulation of Gene_expression of Oprm1 1 0.36 0 0.13
32 INT231223 Binding of KCNQ1 and Nav1 1 0.03 0.59 0.11
33 INT153637 Gene_expression of REST Positive_regulation of Gene_expression of Oprm1 1 0.03 0.08 0.1
34 INT153636 Binding of REST and Oprm1 1 0.02 0.09 0.09
35 INT146754 KCNQ1 Regulation of Ros1 1 0.01 0.23 0.08
36 INT196213 REST Regulation of Gene_expression of CACNA1A 1 0.46 0.08 0.08
37 INT200311 Htt Positive_regulation of Rest 1 0.05 0.75 0.03
38 INT280849 REST Negative_regulation of Gene_expression of Avp 1 0.09 0.09 0
39 INT196208 REST Regulation of CACNA1A 1 0.46 0.06 0
40 INT196216 Binding of CACNA1A and REST 1 0.28 0 0
41 INT121179 Binding of Htt and Rest 1 0.07 0.45 0
42 INT222138 Binding of Kcnb1 and Pirt 1 0.00 0.08 0
43 INT222137 Binding of Kcnb1 and Gcnt3 1 0.01 0 0
44 INT280848 Binding of REST and Rest 1 0.02 0.09 0
45 INT196215 Binding of L1RE1 and REST 1 0.33 0.47 0
46 INT196209 Binding of REST and SNAP25 1 0.25 0 0
47 INT121178 Binding of Bdnf and Rest 1 0.10 0.91 0
48 INT280837 Binding of Rest and Negative_regulation of Gene_expression of Avp 1 0.00 0.09 0
49 INT196214 Binding of FRAXD and REST 1 0.00 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for outward rectifier potassium channel activity. They are ordered first by their pain relevance and then by number of times they were reported in outward rectifier potassium channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48540 Gene_expression of Kcna5 37 0.77 14.04 16.07
2 INT65627 Negative_regulation of Kcna5 19 0.59 7.82 10.79
3 INT74075 Negative_regulation of Kcna3 20 0.59 4.68 8.64
4 INT65630 Regulation of Kcna5 11 0.62 6.61 7.22
5 INT48542 Gene_expression of Kcna3 18 0.77 6.53 7.15
6 INT110605 Gene_expression of KCNK2 24 0.78 5.71 6.85
7 INT48541 Positive_regulation of Kcna5 12 0.69 5.51 6.35
8 INT97693 Gene_expression of REST 29 0.75 5.51 5.26
9 INT200248 Gene_expression of Rest 1 0.66 1.25 3.7
10 INT110608 Negative_regulation of KCNK2 10 0.59 0.91 3.26
11 INT116917 Positive_regulation of KCNK2 9 0.68 1.02 3.24
12 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11
13 INT65628 Regulation of Gene_expression of Kcna5 4 0.61 1.66 2.98
14 INT199255 Binding of Rest 14 0.41 1.43 2.94
15 INT110609 Binding of KCNK2 3 0.48 0.25 2.88
16 INT65629 Positive_regulation of Gene_expression of Kcna5 5 0.69 2.48 2.76
17 INT116215 Transcription of Kcna5 6 0.53 3.62 2.75
18 INT123795 Positive_regulation of KCNQ1 13 0.49 3.53 2.65
19 INT116216 Negative_regulation of Gene_expression of Kcna5 4 0.43 3.11 2.64
20 INT99800 Binding of Kcna5 4 0.47 0.96 2.55
21 INT51584 Regulation of KCNQ1 10 0.44 3.21 1.84
22 INT131751 Localization of Kcna5 1 0.71 0 1.7
23 INT97985 Regulation of Kcna3 3 0.45 0.15 1.68
24 INT153635 Positive_regulation of Gene_expression of REST 10 0.54 1.38 1.6
25 INT28367 Positive_regulation of REST 10 0.54 2.07 1.52
26 INT87571 Negative_regulation of KCNQ1 6 0.41 1.69 1.51
27 INT110610 Regulation of KCNK2 4 0.60 0.81 1.42
28 INT165005 Binding of REST 26 0.43 2.81 1.39
29 INT154587 Transcription of Kcna3 3 0.38 1.28 1.11
30 INT87002 Negative_regulation of Gene_expression of Kcna3 2 0.35 1.78 1.09
31 INT131840 Transcription of KCNK2 5 0.70 0.74 0.99
32 INT190591 Positive_regulation of Rest 3 0.37 2.52 0.92
33 INT99801 Regulation of Binding of Kcna5 1 0.26 0.14 0.9
34 INT200255 Localization of Rest 1 0.68 0.14 0.86
35 INT137788 Negative_regulation of Positive_regulation of KCNQ1 1 0.21 1.02 0.83
36 INT110607 Regulation of Gene_expression of KCNK2 4 0.45 0.59 0.64
37 INT154586 Regulation of Gene_expression of Kcna3 1 0.28 0.22 0.59
38 INT218605 Negative_regulation of Kcna2 2 0.41 1.68 0.55
39 INT200273 Negative_regulation of Rest 1 0.43 0.69 0.55
40 INT153634 Regulation of REST 4 0.48 1.42 0.54
41 INT107996 Negative_regulation of Regulation of Kcna5 1 0.12 0.67 0.54
42 INT154585 Positive_regulation of Transcription of Kcna3 1 0.23 0.18 0.49
43 INT116214 Regulation of Transcription of Kcna5 1 0.27 0.52 0.44
44 INT154192 Positive_regulation of Gene_expression of KCNK2 2 0.59 0.26 0.42
45 INT74076 Positive_regulation of Kcna3 2 0.31 0.18 0.4
46 INT165006 Positive_regulation of Binding of REST 1 0.23 0.94 0.4
47 INT137786 Positive_regulation of Negative_regulation of KCNQ1 1 0.25 0.46 0.38
48 INT200269 Negative_regulation of Transcription of Rest 1 0.31 0.08 0.35
49 INT334624 Positive_regulation of Gene_expression of Kcna2 1 0.49 0.86 0.35
50 INT200245 Transcription of Rest 1 0.51 0.08 0.35
51 INT334621 Gene_expression of Kcna2 1 0.65 0.86 0.34
52 INT334623 Negative_regulation of Gene_expression of Kcna2 1 0.41 0.86 0.34
53 INT200270 Regulation of Rest 1 0.20 0.07 0.32
54 INT200256 Negative_regulation of Regulation of Rest 1 0.32 0.07 0.32
55 INT136267 Binding of KCNQ1 3 0.36 3.28 0.28
56 INT222131 Gene_expression of Kcnb1 1 0.67 0 0.28
57 INT154588 Negative_regulation of Transcription of Kcna3 1 0.19 0.09 0.25
58 INT154584 Negative_regulation of Positive_regulation of Kcna3 1 0.19 0.09 0.24
59 INT104789 Negative_regulation of REST 3 0.33 0.44 0.23
60 INT154589 Positive_regulation of Gene_expression of Kcna3 1 0.23 0.07 0.23
61 INT239610 Localization of KCNQ1 4 0.62 1.47 0.2
62 INT328848 Positive_regulation of Positive_regulation of KCNK2 1 0.46 0.27 0.18
63 INT200275 Positive_regulation of Gene_expression of Rest 1 0.59 0.92 0.17
64 INT216248 Negative_regulation of Gene_expression of KCNQ1 1 0.38 0.33 0.14
65 INT200281 Negative_regulation of Negative_regulation of Rest 1 0.31 0.44 0.11
66 INT196248 Localization of REST 1 0.66 0.15 0.08
67 INT218607 Regulation of Kcna2 1 0.38 0.29 0.08
68 INT222132 Positive_regulation of Gene_expression of Kcnb1 1 0.38 0 0.05
69 INT222136 Positive_regulation of Kcnb1 1 0.38 0 0.05
70 INT222134 Negative_regulation of Gene_expression of Kcnb1 1 0.37 0 0.04
71 INT328850 Localization of KCNK2 1 0.73 0.09 0.03
72 INT62353 Negative_regulation of Kcnb1 1 0.41 0 0
73 INT262506 Phosphorylation of Kcna5 1 0.26 0.59 0
74 INT196244 Negative_regulation of Gene_expression of REST 1 0.38 0.09 0
75 INT328843 Negative_regulation of Gene_expression of KCNK2 1 0.42 0.08 0
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