GO:0015276

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Name ligand-gated ion channel activity
Categary Function
Go Slim No
Go Link GO:0015276
Unique Molecular Interactions 17
Total Molecular Interactions 21
Total Single Events 563
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ligand-gated ion channel activity. They are ordered first by their pain relevance and then by number of times they were reported for ligand-gated ion channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149743 Ean5 Positive_regulation of Gene_expression of P2rx2 1 0.10 1.54 1.5
2 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
3 INT105809 ATP8A2 Positive_regulation of P2RX2 1 0.13 0.11 0.7
4 INT158104 Binding of Trpv1 and P2rx2 1 0.03 0.27 0.4
5 INT170773 Binding of P2RX3 and P2RX2 1 0.07 0.27 0.35
6 INT159179 Mmp3 Regulation of Chrng 1 0.01 0.32 0.29
7 INT215167 Phosphorylation of Prkaca Positive_regulation of P2rx2 1 0.06 0.13 0.18
8 INT267660 CFTR Regulation of Gene_expression of P2RX2 1 0.25 0.51 0.18
9 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17
10 INT261626 Binding of CHRNA5 and MAOA 1 0.22 1.6 0.17
11 INT336665 Binding of P2rx1 and P2rx2 1 0.07 0 0.14
12 INT215169 Ptger2 Regulation of P2rx2 1 0.19 0.31 0.11
13 INT261625 Binding of CHRNA3 and CPD 1 0.07 0.35 0.08
14 INT126110 Chrng Positive_regulation of Chrm1 1 0.00 0.1 0
15 INT126111 Chrm1 Positive_regulation of Chrng 1 0.00 0.1 0
16 INT281097 Binding of P2rx3 and P2rx2 1 0.06 0 0
17 INT296725 Binding of P2rx2 and Afm 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ligand-gated ion channel activity. They are ordered first by their pain relevance and then by number of times they were reported in ligand-gated ion channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
2 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
3 INT91285 Negative_regulation of P2rx2 29 0.57 12.74 15.48
4 INT92839 Regulation of P2rx2 36 0.45 13.19 15.38
5 INT78234 Positive_regulation of Gene_expression of P2rx2 18 0.69 12.86 12.75
6 INT105304 Negative_regulation of Gene_expression of P2rx2 11 0.28 11.07 9.53
7 INT116705 Positive_regulation of Positive_regulation of P2rx2 13 0.49 9.44 9.47
8 INT89048 Gene_expression of P2RX2 28 0.75 8.75 7.9
9 INT89046 Positive_regulation of P2RX2 15 0.67 7.25 7.52
10 INT120261 Binding of P2rx2 19 0.28 5.8 6.72
11 INT105306 Regulation of Gene_expression of P2rx2 7 0.21 6.92 5.22
12 INT148649 Transcription of P2rx2 8 0.43 8.11 4.79
13 INT112040 Localization of P2RX2 6 0.73 4.69 4.3
14 INT215163 Phosphorylation of P2rx2 19 0.60 1.43 3.62
15 INT81830 Localization of P2rx2 14 0.73 5.42 3.16
16 INT89045 Negative_regulation of P2RX2 4 0.41 2.75 2.88
17 INT130906 Regulation of P2RX2 1 0.26 2.41 2.57
18 INT25739 Negative_regulation of Chrng 8 0.50 1.34 2.11
19 INT148648 Negative_regulation of Transcription of P2rx2 3 0.29 3.54 1.94
20 INT112041 Regulation of Positive_regulation of P2RX2 3 0.44 2.37 1.75
21 INT25738 Positive_regulation of Chrng 7 0.43 0.99 1.69
22 INT216511 Negative_regulation of Gene_expression of P2RX2 1 0.03 1.74 1.54
23 INT168726 Negative_regulation of Positive_regulation of P2rx2 1 0.07 0.09 1.44
24 INT168727 Negative_regulation of Negative_regulation of P2rx2 1 0.07 0.09 1.43
25 INT142815 Regulation of Regulation of P2rx2 4 0.33 0.69 1.33
26 INT25741 Regulation of Chrng 4 0.52 0.89 1.22
27 INT18724 Binding of Chrng 4 0.47 0.37 1.18
28 INT154813 Regulation of Transcription of P2rx2 2 0.26 2.38 1.17
29 INT215499 Positive_regulation of Phosphorylation of P2rx2 3 0.37 0.57 1.07
30 INT57773 Gene_expression of Chrng 4 0.08 0.23 0.99
31 INT57842 Positive_regulation of Binding of Chrng 2 0.03 0.25 0.75
32 INT102085 Positive_regulation of Positive_regulation of P2RX2 1 0.49 0.31 0.64
33 INT215501 Positive_regulation of Binding of P2rx2 3 0.37 0.61 0.56
34 INT107819 Positive_regulation of Localization of P2rx2 1 0.24 0.66 0.55
35 INT163185 Negative_regulation of Transcription of Chrng 1 0.39 0.62 0.49
36 INT163186 Transcription of Chrng 1 0.48 0.6 0.49
37 INT105817 Positive_regulation of Gene_expression of P2RX2 1 0.44 0.19 0.45
38 INT57772 Negative_regulation of Gene_expression of Chrng 1 0.04 0 0.44
39 INT57774 Negative_regulation of Negative_regulation of Chrng 1 0.04 0 0.44
40 INT119181 Regulation of Gene_expression of P2RX2 1 0.58 0.37 0.37
41 INT257576 Binding of P2RX2 4 0.20 1.29 0.36
42 INT25740 Positive_regulation of Negative_regulation of Chrng 1 0.35 0.24 0.35
43 INT217405 Regulation of Positive_regulation of P2rx2 1 0.32 0 0.33
44 INT215492 Negative_regulation of Phosphorylation of P2rx2 1 0.31 0 0.31
45 INT18725 Negative_regulation of Binding of Chrng 1 0.13 0 0.3
46 INT160516 Positive_regulation of Transcription of P2rx2 1 0.13 0.2 0.24
47 INT261645 Positive_regulation of CHRNA5 1 0.37 0.69 0.14
48 INT261639 Positive_regulation of CHRNA3 1 0.38 0.68 0.14
49 INT261641 Localization of CHRNA5 1 0.64 0.91 0.09
50 INT261646 Localization of CHRNA3 1 0.65 0.91 0.09
51 INT289460 Transcription of P2RX2 1 0.06 0.1 0
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