GO:0015278

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Name calcium-release channel activity
Categary Function
Go Slim No
Go Link GO:0015278
Unique Molecular Interactions 25
Total Molecular Interactions 42
Total Single Events 239
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calcium-release channel activity. They are ordered first by their pain relevance and then by number of times they were reported for calcium-release channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
2 INT158545 Binding of Trpc3 and Jph2 1 0.55 0 1.24
3 INT311533 ROS1 Positive_regulation of Positive_regulation of RYR3 1 0.28 0.18 0.26
4 INT311532 ROS1 Regulation of RYR3 1 0.43 0.18 0.25
5 INT283373 Pcbd1 Regulation of RYR1 1 0.00 1.45 0.21
6 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13
7 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
8 INT351427 Binding of PIK3C3 and RYR1 1 0.00 0 0.11
9 INT225740 RYR1 Positive_regulation of Binding of Entpd1 1 0.08 0.08 0.1
10 INT192046 Negative_regulation of Binding of RYR2 and Cbx5 1 0.01 1.12 0
11 INT326979 HLN2 Negative_regulation of JPH3 1 0.02 2.05 0
12 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
13 INT266704 Binding of RYR1 and TRDN 1 0.34 0 0
14 INT192049 Negative_regulation of Binding of RYR2 and Cbx1 1 0.01 1.12 0
15 INT192045 Jup Positive_regulation of RYR2 1 0.11 0.29 0
16 INT283372 Binding of RYR1 and Pcbd1 1 0.00 0.28 0
17 INT326980 HSD11B1 Negative_regulation of JPH3 1 0.03 2.05 0
18 INT192047 Binding of RYR2 and Cbx1 1 0.01 1.12 0
19 INT192043 Binding of RYR2 and Cbx5 1 0.01 1.12 0
20 INT192048 Binding of DSP and Ryr2 1 0.24 1.1 0
21 INT271027 Binding of RYR1 and Car2 1 0.03 0.46 0
22 INT192042 Binding of Jup and Ryr2 1 0.17 1.09 0
23 INT266703 Binding of RYR1 and DIXDC1 1 0.26 0.1 0
24 INT296930 Casq1 Negative_regulation of RYR1 1 0.00 0.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for calcium-release channel activity. They are ordered first by their pain relevance and then by number of times they were reported in calcium-release channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT59555 Binding of RYR1 39 0.42 8.65 4.92
2 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26
3 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11
4 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04
5 INT11713 Localization of RYR1 22 0.76 10.42 1.64
6 INT55305 Regulation of RYR1 14 0.45 5.27 1.33
7 INT15647 Regulation of Positive_regulation of RYR1 1 0.26 0.23 0.45
8 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44
9 INT158544 Binding of Jph2 1 0.48 0 0.31
10 INT80636 Positive_regulation of Localization of RYR1 2 0.47 0.78 0.29
11 INT311550 Positive_regulation of Positive_regulation of RYR3 1 0.33 0.18 0.26
12 INT311547 Positive_regulation of RYR3 1 0.45 0.17 0.26
13 INT59650 Regulation of Binding of RYR1 1 0.04 0 0.23
14 INT120216 Regulation of RYR2 2 0.28 1.03 0.22
15 INT49908 Regulation of Gene_expression of RYR1 3 0.45 0.32 0.19
16 INT60209 Transcription of RYR1 3 0.69 3.06 0.16
17 INT158175 Positive_regulation of Gene_expression of RYR1 2 0.48 1.35 0.13
18 INT165787 Positive_regulation of RYR2 2 0.23 1.3 0.11
19 INT63111 Gene_expression of JPH3 3 0.65 3.29 0.08
20 INT149214 Regulation of Jph2 1 0.39 0 0.07
21 INT192016 Localization of RYR2 5 0.25 4.18 0.05
22 INT192012 Binding of RYR2 2 0.30 3.61 0.05
23 INT221865 Positive_regulation of Localization of RYR2 2 0.15 4.56 0.05
24 INT271024 Negative_regulation of Binding of RYR1 3 0.05 1.07 0.04
25 INT192023 Negative_regulation of RYR2 1 0.15 1.86 0.04
26 INT288855 Positive_regulation of JPH3 2 0.22 2.92 0.03
27 INT322462 Transcription of Ryr2 1 0.55 0.47 0.03
28 INT219581 Binding of Ryr2 2 0.27 4.54 0
29 INT219567 Phosphorylation of Ryr2 2 0.62 0.22 0
30 INT326992 Phosphorylation of JPH3 1 0.16 2.15 0
31 INT219566 Localization of Ryr2 1 0.45 0.49 0
32 INT211904 Negative_regulation of Localization of RYR1 1 0.37 0.64 0
33 INT326074 Positive_regulation of Gene_expression of JPH3 1 0.24 0.5 0
34 INT326990 Binding of JPH3 1 0.07 1.95 0
35 INT326995 Localization of JPH3 1 0.15 1.82 0
36 INT322461 Negative_regulation of Transcription of Ryr2 1 0.45 0 0
37 INT219582 Positive_regulation of Phosphorylation of Ryr2 1 0.30 0.22 0
38 INT192020 Regulation of Localization of RYR2 1 0.15 0.27 0
39 INT326994 Regulation of JPH3 1 0.05 2.28 0
40 INT80635 Regulation of Localization of RYR1 1 0.04 0.1 0
41 INT211903 Negative_regulation of Gene_expression of RYR1 1 0.37 0.06 0
42 INT297204 Regulation of Ryr2 1 0.08 0.3 0
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