GO:0015279

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Name store-operated calcium channel activity
Categary Function
Go Slim No
Go Link GO:0015279
Unique Molecular Interactions 49
Total Molecular Interactions 57
Total Single Events 478
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for store-operated calcium channel activity. They are ordered first by their pain relevance and then by number of times they were reported for store-operated calcium channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT251167 Clu Positive_regulation of Trpc6 1 0.12 0.2 0.6
2 INT309062 Binding of Trpc1 and Trpc6 1 0.23 0.43 0.6
3 INT261629 Binding of CPD and TRPC5 1 0.04 0.52 0.32
4 INT160439 Sub1 Regulation of Trpc6 1 0.21 0.17 0.32
5 INT309057 Binding of Trpc1 and Trpc5 1 0.27 0.21 0.32
6 INT309059 Binding of Trpc6 and Trpc5 1 0.24 0.23 0.29
7 INT309055 Binding of Trpc3 and Trpc6 1 0.15 0.23 0.28
8 INT309058 Binding of Trpc3 and Trpc1 1 0.13 0.23 0.28
9 INT309063 Binding of Trpc3 and Trpc4 1 0.11 0.23 0.28
10 INT309056 Binding of Trpc4 and Trpc6 1 0.15 0.23 0.28
11 INT161175 Binding of Trpc6 and Mapk1 1 0.32 1.49 0.23
12 INT149220 Binding of Trpc1 and Trpc3 1 0.35 0 0.18
13 INT241250 Binding of Pkd2 and Trpc1 1 0.23 0.3 0.17
14 INT209196 IL1B Positive_regulation of Gene_expression of TRPC3 1 0.68 0.23 0.15
15 INT311733 Plat Regulation of Protein_catabolism of Orai1 1 0.28 0.71 0.13
16 INT161174 Binding of Ang and Trpc6 1 0.29 0.74 0.11
17 INT161178 Binding of Nfkb1 and Trpc6 1 0.35 0.74 0.11
18 INT209195 IL1B Regulation of Gene_expression of TRPC3 1 0.26 0 0.11
19 INT149219 Binding of Ryr1 and Trpc1 1 0.35 0 0.11
20 INT152818 Faah Regulation of Trpc1 1 0.20 0.32 0.09
21 INT241249 Pkd2 Regulation of Trpc1 1 0.21 0.14 0.09
22 INT107885 Negative_regulation of TRPC6 Negative_regulation of Trpc4 1 0.01 0 0.08
23 INT237822 Binding of Stim1 and Trpc1 1 0.54 0.27 0.08
24 INT94654 Trpc2 Positive_regulation of Positive_regulation of Tyr 1 0.40 0 0.08
25 INT8928 Negative_regulation of Trpc4 Negative_regulation of Positive_regulation of Acta1 1 0.02 0.18 0.05
26 INT215810 Positive_regulation of Binding of Ca2 and Orai1 1 0.01 0.06 0.03
27 INT215811 Binding of Ca2 and Orai1 1 0.01 0.06 0.03
28 INT161177 Ang Positive_regulation of Trpc6 1 0.31 0.5 0
29 INT161176 Ang Positive_regulation of Positive_regulation of Trpc6 1 0.31 0.5 0
30 INT249178 Negative_regulation of CA2 Positive_regulation of TRPC4 1 0.16 0 0
31 INT276585 Binding of Trpc5 and Trpc6 1 0.17 0.26 0
32 INT249157 Negative_regulation of CA2 Positive_regulation of TRPC5 1 0.14 0 0
33 INT249176 Binding of ITPR3 and TRPC1 1 0.02 0 0
34 INT249197 Negative_regulation of CA2 Positive_regulation of TRPC1 1 0.16 0 0
35 INT161179 Positive_regulation of Ang Positive_regulation of Trpc6 1 0.31 0.5 0
36 INT249196 Positive_regulation of PRKCA Positive_regulation of TRPC3 1 0.08 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for store-operated calcium channel activity. They are ordered first by their pain relevance and then by number of times they were reported in store-operated calcium channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT127981 Gene_expression of Trpc1 25 0.77 10.51 11.67
2 INT36715 Gene_expression of Trpc4 50 0.68 4.18 11.13
3 INT160437 Gene_expression of Trpc6 24 0.78 9.09 4.75
4 INT132700 Positive_regulation of Trpc1 6 0.39 4.33 3.89
5 INT131978 Gene_expression of Trpc1 15 0.71 4.67 3.19
6 INT50743 Positive_regulation of Trpc2 12 0.44 1.99 1.87
7 INT6301 Positive_regulation of Trpc6 8 0.67 4.15 1.59
8 INT209307 Positive_regulation of Gene_expression of Trpc4 1 0.58 0.59 1.52
9 INT145127 Positive_regulation of Gene_expression of Trpc1 4 0.30 3.56 1.46
10 INT259086 Binding of Trpc1 3 0.22 1.27 1.37
11 INT160438 Positive_regulation of Gene_expression of Trpc6 6 0.70 3.44 1.29
12 INT152486 Positive_regulation of Gene_expression of Trpc1 2 0.41 0.89 1.29
13 INT138085 Regulation of Trpc1 2 0.32 0.53 1.28
14 INT138084 Localization of Trpc1 4 0.79 0.2 1.26
15 INT114568 Negative_regulation of Trpc1 4 0.41 0.56 1.19
16 INT145128 Gene_expression of Trpc6 12 0.75 5.59 1.17
17 INT152487 Positive_regulation of Trpc1 2 0.38 0.85 1.17
18 INT259087 Negative_regulation of Binding of Trpc1 1 0.17 1.04 1.05
19 INT107874 Positive_regulation of Trpc4 3 0.58 0.09 1.02
20 INT143779 Positive_regulation of Trpc6 3 0.70 2.22 0.9
21 INT50744 Negative_regulation of Positive_regulation of Trpc2 1 0.21 0.51 0.85
22 INT129556 Transcription of Trpc4 3 0.60 0.23 0.76
23 INT62421 Gene_expression of Trpc2 8 0.68 5.48 0.67
24 INT221935 Gene_expression of TRPC1 5 0.45 0.53 0.62
25 INT119367 Negative_regulation of Trpc6 2 0.30 0.41 0.59
26 INT79797 Positive_regulation of TRPC3 4 0.38 0.12 0.58
27 INT149350 Regulation of Gene_expression of Trpc1 1 0.19 1.13 0.57
28 INT209298 Regulation of Gene_expression of Trpc4 1 0.38 0.17 0.54
29 INT209198 Gene_expression of TRPC3 5 0.72 0.52 0.53
30 INT145129 Positive_regulation of Gene_expression of Trpc6 4 0.67 2.91 0.51
31 INT140496 Positive_regulation of TRPC1 3 0.29 0.43 0.42
32 INT209281 Binding of Trpc4 3 0.31 0.22 0.41
33 INT143780 Positive_regulation of Positive_regulation of Trpc6 2 0.47 0.72 0.41
34 INT309076 Binding of Trpc6 1 0.26 0.49 0.41
35 INT165349 Positive_regulation of Positive_regulation of Trpc1 1 0.39 0.74 0.39
36 INT8921 Negative_regulation of Trpc4 3 0.36 0.18 0.33
37 INT31964 Localization of Trpc6 4 0.65 0.63 0.3
38 INT131151 Regulation of TRPC4 1 0.26 0.42 0.29
39 INT196106 Transcription of Trpc6 1 0.43 0.25 0.29
40 INT209294 Regulation of Trpc4 1 0.23 0.12 0.29
41 INT209311 Positive_regulation of Regulation of Trpc4 1 0.39 0 0.29
42 INT209309 Regulation of Positive_regulation of Trpc4 1 0.23 0 0.29
43 INT209277 Localization of Trpc4 1 0.63 0.24 0.27
44 INT157906 Binding of TRPC1 2 0.32 0.91 0.26
45 INT209197 Positive_regulation of Gene_expression of TRPC3 1 0.64 0.29 0.26
46 INT209278 Negative_regulation of Gene_expression of Trpc4 1 0.36 0.13 0.26
47 INT164306 Regulation of Gene_expression of Trpc6 1 0.62 1.67 0.17
48 INT309759 Transcription of TRPC5 1 0.22 0 0.16
49 INT85628 Positive_regulation of Positive_regulation of Trpc2 1 0.32 0.47 0.14
50 INT161171 Regulation of Gene_expression of Trpc6 1 0.60 0.6 0.14
51 INT311710 Protein_catabolism of Orai1 1 0.48 0.63 0.13
52 INT145628 Negative_regulation of Trpc6 1 0.40 0 0.13
53 INT311723 Positive_regulation of Protein_catabolism of Orai1 1 0.27 0.69 0.13
54 INT129774 Binding of Trpc2 2 0.18 0.73 0.12
55 INT164307 Regulation of Trpc6 2 0.31 0.85 0.11
56 INT215824 Gene_expression of Orai1 3 0.35 0 0.1
57 INT309074 Negative_regulation of Gene_expression of Trpc1 1 0.25 0.16 0.09
58 INT62423 Regulation of Gene_expression of Trpc2 1 0.45 0.33 0.08
59 INT237803 Binding of Trpc1 1 0.35 0.16 0.08
60 INT149213 Regulation of Trpc1 1 0.17 0 0.07
61 INT164304 Negative_regulation of Gene_expression of Trpc6 1 0.59 0.81 0.07
62 INT8925 Positive_regulation of Negative_regulation of Trpc4 1 0.08 0.18 0.05
63 INT196111 Negative_regulation of Trpc1 1 0.33 0 0.04
64 INT159768 Localization of Trpc1 1 0.04 0.1 0.04
65 INT159767 Positive_regulation of Localization of Trpc1 1 0.03 0.1 0.04
66 INT209288 Regulation of Transcription of Trpc4 1 0.38 0 0.03
67 INT127979 Transcription of Trpc1 1 0.65 0 0.03
68 INT215827 Binding of Orai1 1 0.12 0.06 0.03
69 INT110740 Binding of Trpc6 2 0.39 1.11 0
70 INT132339 Regulation of Trpc2 1 0.22 0 0
71 INT249281 Positive_regulation of Binding of TRPC1 1 0.40 0 0
72 INT249251 Negative_regulation of Binding of TRPC1 1 0.25 0 0
73 INT249286 Regulation of TRPC3 1 0.35 0 0
74 INT215826 Positive_regulation of Gene_expression of Orai1 1 0.24 0 0
75 INT209304 Regulation of Regulation of Trpc4 1 0.20 0.06 0
76 INT161172 Positive_regulation of Positive_regulation of Trpc6 1 0.39 0.5 0
77 INT249252 Gene_expression of TRPC4 1 0.44 0 0
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