GO:0015280

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Name ligand-gated sodium channel activity
Categary Function
Go Slim No
Go Link GO:0015280
Unique Molecular Interactions 108
Total Molecular Interactions 170
Total Single Events 1258
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ligand-gated sodium channel activity. They are ordered first by their pain relevance and then by number of times they were reported for ligand-gated sodium channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT354207 Igfbp7 Positive_regulation of Accn3 1 0.52 6.55 3.24
2 INT113451 Ngf Regulation of Gene_expression of ASIC3 1 0.07 1.35 2.18
3 INT113452 Ngf Positive_regulation of Gene_expression of ASIC3 1 0.19 1.34 2.08
4 INT354210 Binding of Igfbp7 and Accn3 1 0.27 3.91 1.64
5 INT147033 Positive_regulation of Binding of Sds and Accn3 1 0.13 0.73 1.23
6 INT147032 Binding of Sds and Accn3 1 0.09 0.73 1.22
7 INT354224 Bdnf Positive_regulation of Transcription of Accn3 1 0.09 1.04 0.95
8 INT120820 Binding of ASIC3 and Dlg4 3 0.02 0.11 0.84
9 INT140004 Srxn1 Negative_regulation of Accn2 1 0.01 0.47 0.83
10 INT107246 Ngf Regulation of Transcription of ASIC1 1 0.01 0.57 0.81
11 INT120819 Binding of ASIC3 and Lin7b 1 0.01 0 0.73
12 INT120818 Lin7b Positive_regulation of ASIC3 1 0.01 0 0.71
13 INT98525 Binding of Accn2 and Accn3 1 0.01 0.38 0.68
14 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67
15 INT152282 Binding of Accn1 and Trpv1 1 0.10 0.42 0.49
16 INT354218 Igfbp7 Positive_regulation of Accn1 1 0.04 0.74 0.44
17 INT130975 Binding of ASIC3 and Slc9a3r1 1 0.06 0.26 0.43
18 INT354206 Arc Positive_regulation of Accn2 1 0.02 0.57 0.42
19 INT354208 Arc Positive_regulation of Accn3 1 0.08 0.97 0.42
20 INT354221 Igfbp7 Positive_regulation of Accn2 1 0.11 0.57 0.42
21 INT354719 Binding of ASIC1 and Pick1 1 0.40 2.34 0.4
22 INT106114 Binding of ASIC2 and Pick1 1 0.14 0.1 0.4
23 INT106116 Binding of ASIC1 and Pick1 1 0.04 0.1 0.4
24 INT106115 Pick1 Positive_regulation of Phosphorylation of ASIC2 1 0.13 0.07 0.39
25 INT106117 Pick1 Positive_regulation of ASIC2 1 0.14 0.09 0.39
26 INT120821 Dlg4 Positive_regulation of ASIC3 1 0.02 0 0.36
27 INT130974 Slc9a3r1 Positive_regulation of ASIC3 1 0.08 0.29 0.36
28 INT140802 Accn2 Regulation of Transcription of Accn1 1 0.24 0 0.36
29 INT153650 Accn4 Positive_regulation of Regulation of ASIC1 1 0.12 0.1 0.33
30 INT153651 Accn4 Regulation of ASIC1 1 0.08 0.08 0.31
31 INT101371 Inadl Positive_regulation of Gene_expression of ASIC3 1 0.02 0.46 0.27
32 INT208037 Binding of Accn1 and Accn3 1 0.15 0.3 0.25
33 INT208036 Binding of Cnga3 and Accn1 1 0.01 0.3 0.25
34 INT188842 Accn3 Positive_regulation of Calca 1 0.08 0.46 0.25
35 INT330797 Positive_regulation of Accn2 Positive_regulation of Ca2 1 0.03 0 0.23
36 INT103147 Accn3 Regulation of Scnn1a 1 0.19 0.47 0.23
37 INT354723 Binding of ASIC3 and Myo18a 1 0.00 0.25 0.23
38 INT354217 Arc Positive_regulation of Accn1 1 0.01 0.29 0.21
39 INT354710 Pick1 Regulation of ASIC1 1 0.37 1.12 0.21
40 INT354220 Igfbp7 Positive_regulation of Gene_expression of Accn3 1 0.33 0.29 0.2
41 INT354721 Pick1 Regulation of Gene_expression of ASIC1 1 0.37 1.1 0.2
42 INT354211 Igfbp7 Positive_regulation of Gene_expression of Accn1 1 0.04 0.29 0.2
43 INT354216 Binding of Accn3 and Positive_regulation of Gene_expression of Accn1 1 0.06 0.29 0.2
44 INT354225 Accn3 Positive_regulation of Gene_expression of Accn1 1 0.06 0.29 0.2
45 INT354226 Arc Positive_regulation of Gene_expression of Accn3 1 0.06 0.29 0.2
46 INT354214 Arc Positive_regulation of Gene_expression of Accn1 1 0.01 0.29 0.2
47 INT330795 Positive_regulation of Accn2 Positive_regulation of Positive_regulation of Ca2 1 0.03 0 0.18
48 INT354703 Binding of ASIC1 and Myo18a 1 0.00 1.11 0.17
49 INT330798 Fig4 Negative_regulation of Gene_expression of Accn2 1 0.03 0 0.16
50 INT194341 Binding of Trpv1 and Accn3 1 0.30 0.68 0.16
51 INT317071 KCNC4 Regulation of SCNN1G 1 0.03 0.17 0.13
52 INT122271 Binding of ASIC2 and ASIC1 1 0.26 0.14 0.13
53 INT354705 Binding of ASIC2 and Dlg4 1 0.00 0.11 0.12
54 INT354702 Binding of ASIC2 and Gopc 1 0.07 0.1 0.11
55 INT354714 Binding of ASIC3 and Gopc 1 0.08 0.1 0.11
56 INT354717 Binding of ASIC1 and Dlg4 1 0.02 0 0.11
57 INT354712 Pick1 Positive_regulation of Gene_expression of ASIC1 1 0.39 0.74 0.11
58 INT354215 Binding of Car2 and Accn3 1 0.03 0.21 0.1
59 INT354713 Pick1 Regulation of Localization of ASIC1 1 0.22 0.48 0.08
60 INT354213 Igfbp7 Regulation of Accn3 1 0.18 0.17 0.08
61 INT354209 Igfbp7 Regulation of Positive_regulation of Accn3 1 0.29 0.15 0.07
62 INT196624 TNF Negative_regulation of Transcription of SCNN1G 1 0.02 0.07 0.07
63 INT354709 Gene_expression of Pick1 Positive_regulation of ASIC1 1 0.39 0.17 0.04
64 INT354682 Binding of ASIC1 and PKN1 1 0.01 0.19 0.04
65 INT354707 Binding of Bfar and Positive_regulation of Gene_expression of ASIC1 1 0.05 0 0.04
66 INT317072 SCNN1G Regulation of NA 1 0.00 0.08 0.04
67 INT354724 Bfar Regulation of Gene_expression of ASIC1 1 0.06 0.23 0.03
68 INT196617 TNF Negative_regulation of Gene_expression of SCNN1G 1 0.02 0.08 0.03
69 INT196625 TNF Negative_regulation of Positive_regulation of SCNN1G 1 0.02 0.14 0.03
70 INT354711 Regulation of Binding of ASIC1 and Pick1 1 0.51 0.19 0.03
71 INT196607 IFNG Regulation of Gene_expression of SCNN1G 1 0.03 0.08 0.03
72 INT354716 Pick1 Regulation of Binding of ASIC1 1 0.37 0.2 0.03
73 INT354722 Pick1 Positive_regulation of Localization of ASIC1 1 0.39 0 0
74 INT317075 Binding of NA and SCNN1G 1 0.00 0 0
75 INT354706 Pick1 Positive_regulation of ASIC1 1 0.36 0 0
76 INT317074 CA2 Regulation of SCNN1G 1 0.01 0.08 0
77 INT354725 Negative_regulation of Binding of ASIC1 and Bfar 1 0.05 0 0
78 INT208051 Binding of SNRNP70 and Accn1 1 0.01 1.81 0
79 INT354708 Negative_regulation of Binding of ASIC1 and Myo18a 1 0.00 0.13 0
80 INT354699 Binding of Accn2 and Pick1 1 0.07 0.22 0
81 INT354720 Binding of ASIC1 and Bfar 1 0.05 0.61 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ligand-gated sodium channel activity. They are ordered first by their pain relevance and then by number of times they were reported in ligand-gated sodium channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98521 Gene_expression of Accn2 52 0.74 23.45 35.09
2 INT98522 Gene_expression of Accn3 68 0.78 26.95 28.6
3 INT100124 Gene_expression of Accn3 38 0.78 30.02 23.63
4 INT81087 Gene_expression of ASIC3 30 0.75 13.62 16.54
5 INT81088 Gene_expression of ASIC1 26 0.77 17.8 15.07
6 INT115071 Positive_regulation of Accn3 14 0.70 16.56 14.24
7 INT98524 Positive_regulation of Accn2 15 0.49 9.48 11.57
8 INT68290 Gene_expression of Accn1 32 0.73 7.36 11.23
9 INT109578 Positive_regulation of Accn3 16 0.70 9.09 10.05
10 INT93191 Gene_expression of Accn2 22 0.76 10.04 8.91
11 INT120651 Positive_regulation of Gene_expression of Accn2 13 0.66 9.02 8.58
12 INT126989 Transcription of Accn2 8 0.63 5.22 6.77
13 INT154773 Regulation of Accn3 7 0.62 7.09 6.63
14 INT136496 Regulation of Accn3 5 0.45 3.72 6.53
15 INT93193 Positive_regulation of Accn2 16 0.69 7.2 6.37
16 INT93195 Negative_regulation of Accn2 14 0.59 7.23 6.31
17 INT109577 Positive_regulation of Gene_expression of Accn3 9 0.67 4.77 5.76
18 INT140799 Positive_regulation of Gene_expression of Accn3 6 0.68 5.44 5.06
19 INT93192 Transcription of Accn2 5 0.52 4.63 4.79
20 INT81086 Positive_regulation of Accn1 8 0.65 7.51 4.62
21 INT100125 Negative_regulation of Accn3 11 0.59 5.85 4.32
22 INT77515 Positive_regulation of ASIC3 12 0.67 3.67 4.19
23 INT147028 Negative_regulation of Accn2 6 0.14 2.06 3.92
24 INT81089 Positive_regulation of ASIC1 14 0.65 4.42 3.82
25 INT93200 Gene_expression of ASIC2 6 0.60 3.27 3.7
26 INT72256 Binding of Accn3 6 0.47 2.01 3.2
27 INT104902 Regulation of ASIC1 6 0.51 5.17 3.13
28 INT101368 Positive_regulation of Gene_expression of ASIC3 6 0.32 2.61 3.06
29 INT93198 Transcription of ASIC1 7 0.62 1.96 3.04
30 INT165084 Transcription of Accn3 3 0.70 3.4 3.01
31 INT276842 Positive_regulation of Transcription of Accn3 2 0.49 3.32 2.93
32 INT93197 Positive_regulation of ASIC2 7 0.61 1.94 2.79
33 INT100126 Localization of Accn3 7 0.77 2.73 2.76
34 INT72253 Positive_regulation of Accn1 8 0.63 2.64 2.73
35 INT113450 Regulation of ASIC3 4 0.21 1.81 2.73
36 INT115070 Binding of Accn3 4 0.47 3.8 2.7
37 INT142310 Negative_regulation of Gene_expression of Accn2 3 0.30 2.07 2.64
38 INT295924 Regulation of Gene_expression of Accn2 5 0.14 2.82 2.62
39 INT75551 Localization of Accn1 6 0.68 1.75 2.58
40 INT120814 Negative_regulation of ASIC3 10 0.28 0.99 2.53
41 INT101369 Binding of ASIC3 3 0.32 1.11 2.5
42 INT72254 Gene_expression of Accn1 9 0.71 3.24 2.46
43 INT136190 Transcription of Accn1 5 0.61 2.75 2.24
44 INT98514 Positive_regulation of Gene_expression of ASIC1 2 0.57 3.83 2.2
45 INT98523 Localization of Accn2 4 0.22 1.07 2.16
46 INT166766 Regulation of Accn2 2 0.11 2.02 2.16
47 INT135892 Localization of Accn2 4 0.74 2.23 2.12
48 INT99951 Regulation of Accn1 5 0.26 2.65 2.1
49 INT104899 Regulation of Accn2 5 0.39 3.47 2.07
50 INT129155 Negative_regulation of Accn3 4 0.46 1.36 2.07
51 INT165083 Positive_regulation of Positive_regulation of Accn1 1 0.47 3.91 2.07
52 INT93196 Negative_regulation of ASIC1 7 0.43 2.97 2
53 INT126988 Transcription of Accn3 5 0.61 0.88 2
54 INT147030 Positive_regulation of Positive_regulation of Accn2 3 0.21 1.44 1.94
55 INT165081 Positive_regulation of Positive_regulation of Accn2 3 0.49 2.79 1.9
56 INT136192 Negative_regulation of Gene_expression of Accn2 1 0.35 2.44 1.71
57 INT107245 Binding of ASIC1 4 0.00 1.82 1.63
58 INT295922 Positive_regulation of Transcription of Accn2 1 0.14 2.19 1.45
59 INT165085 Positive_regulation of Positive_regulation of Accn3 1 0.48 2.65 1.43
60 INT159464 Negative_regulation of Accn1 4 0.37 1.07 1.41
61 INT165082 Regulation of Gene_expression of Accn2 1 0.27 1.64 1.4
62 INT220070 Negative_regulation of ASIC2 1 0.02 1.09 1.39
63 INT196687 Positive_regulation of SCNN1G 6 0.06 3.85 1.32
64 INT158848 Negative_regulation of Gene_expression of Accn3 3 0.37 0.6 1.31
65 INT72250 Binding of Accn1 3 0.44 2.87 1.27
66 INT91914 Binding of Accn1 3 0.36 0.44 1.24
67 INT131136 Binding of Accn2 3 0.36 1.44 1.23
68 INT112703 Binding of Accn2 4 0.37 0.64 1.19
69 INT141743 Positive_regulation of Positive_regulation of Accn3 2 0.39 1.11 1.19
70 INT142309 Regulation of Gene_expression of Accn3 2 0.50 1.34 1.16
71 INT276839 Regulation of Transcription of Accn3 1 0.29 1.22 1.06
72 INT120696 Gene_expression of SCNN1G 9 0.43 5.46 1.03
73 INT93194 Negative_regulation of Transcription of Accn2 2 0.35 1.69 1
74 INT136193 Positive_regulation of Gene_expression of Accn2 1 0.38 1.43 0.97
75 INT120697 Negative_regulation of SCNN1G 6 0.32 3.53 0.92
76 INT68289 Positive_regulation of Gene_expression of Accn1 2 0.45 0.34 0.83
77 INT166006 Gene_expression of Scnn1a 2 0.46 0.32 0.83
78 INT153649 Negative_regulation of Gene_expression of ASIC1 3 0.42 0.38 0.79
79 INT76766 Transcription of ASIC2 2 0.24 0.08 0.79
80 INT107244 Positive_regulation of Transcription of ASIC1 1 0.03 0.46 0.79
81 INT143673 Regulation of Gene_expression of Accn1 4 0.43 0.81 0.78
82 INT354685 Localization of ASIC1 1 0.66 1.25 0.77
83 INT242575 Positive_regulation of Transcription of Accn2 1 0.18 0.15 0.64
84 INT97026 Regulation of ASIC2 2 0.16 0.74 0.61
85 INT354687 Regulation of Gene_expression of ASIC1 1 0.51 1 0.59
86 INT97022 Positive_regulation of Positive_regulation of ASIC1 1 0.49 0.37 0.55
87 INT97023 Positive_regulation of Positive_regulation of ASIC2 1 0.29 0.37 0.54
88 INT208024 Negative_regulation of Binding of Accn1 1 0.39 1.26 0.5
89 INT78817 Binding of Scnn1a 2 0.35 0 0.48
90 INT194340 Localization of Accn3 1 0.69 0.36 0.46
91 INT166007 Negative_regulation of Gene_expression of Scnn1a 1 0.26 0.32 0.46
92 INT23645 Regulation of Scnn1a 2 0.23 1.18 0.44
93 INT194338 Positive_regulation of Transcription of Accn3 1 0.59 0.43 0.44
94 INT166767 Negative_regulation of Gene_expression of Accn1 1 0.12 0.13 0.44
95 INT130967 Regulation of Localization of ASIC3 1 0.21 0.24 0.42
96 INT130968 Localization of ASIC3 1 0.53 0.24 0.42
97 INT170830 Localization of Scnn1a 1 0.37 0.39 0.41
98 INT106112 Phosphorylation of ASIC2 1 0.32 0.07 0.38
99 INT140801 Negative_regulation of Gene_expression of Accn3 1 0.41 0.06 0.36
100 INT106113 Regulation of Positive_regulation of ASIC2 1 0.17 0.06 0.36
101 INT23646 Negative_regulation of Scnn1a 6 0.57 1.8 0.35
102 INT140798 Localization of Accn1 3 0.76 0.24 0.34
103 INT119656 Regulation of Accn1 1 0.31 0.2 0.33
104 INT140800 Negative_regulation of Gene_expression of Accn1 1 0.40 0.08 0.33
105 INT285182 Negative_regulation of Accn1 1 0.04 1.06 0.31
106 INT97025 Positive_regulation of Positive_regulation of ASIC3 1 0.09 0.18 0.27
107 INT91915 Negative_regulation of Binding of Accn1 1 0.19 0 0.25
108 INT93199 Negative_regulation of Transcription of ASIC1 1 0.00 0.72 0.24
109 INT103145 Positive_regulation of Scnn1a 1 0.21 0.47 0.24
110 INT147753 Negative_regulation of Negative_regulation of Accn2 1 0.43 0.53 0.24
111 INT147752 Regulation of Negative_regulation of Accn2 1 0.27 0.44 0.22
112 INT97024 Negative_regulation of Regulation of ASIC2 1 0.25 0.14 0.21
113 INT120694 Negative_regulation of Gene_expression of SCNN1G 3 0.32 2.08 0.19
114 INT317078 Regulation of SCNN1G 1 0.04 0.58 0.18
115 INT354688 Phosphorylation of ASIC1 1 0.67 0.23 0.16
116 INT354693 Regulation of Localization of ASIC1 1 0.51 0 0.14
117 INT196671 Positive_regulation of Positive_regulation of SCNN1G 2 0.04 1.04 0.13
118 INT196674 Transcription of SCNN1G 1 0.04 0.22 0.1
119 INT196692 Positive_regulation of Gene_expression of SCNN1G 2 0.06 0.35 0.09
120 INT120695 Regulation of Gene_expression of SCNN1G 1 0.22 0.77 0.08
121 INT354694 Negative_regulation of Localization of ASIC1 1 0.35 0.48 0.08
122 INT196680 Negative_regulation of Positive_regulation of SCNN1G 1 0.04 0.28 0.07
123 INT208021 Positive_regulation of Gene_expression of Accn1 1 0.63 0.21 0.07
124 INT354689 Positive_regulation of Phosphorylation of ASIC1 1 0.41 0 0.06
125 INT79048 Positive_regulation of Localization of Accn1 2 0.46 0.45 0.05
126 INT317082 Positive_regulation of Negative_regulation of SCNN1G 1 0.04 0 0.03
127 INT354686 Regulation of Binding of ASIC1 1 0.37 0 0
128 INT317079 Negative_regulation of Binding of SCNN1G 1 0.04 0 0
129 INT169579 Regulation of Gene_expression of Accn3 1 0.45 0 0
130 INT317080 Binding of SCNN1G 1 0.03 0 0
131 INT208022 Regulation of Gene_expression of Accn1 1 0.41 0.13 0
132 INT354684 Negative_regulation of Binding of ASIC1 1 0.35 0.13 0
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