GO:0015377

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Name cation:chloride symporter activity
Categary Function
Go Slim No
Go Link GO:0015377
Unique Molecular Interactions 29
Total Molecular Interactions 36
Total Single Events 601
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cation:chloride symporter activity. They are ordered first by their pain relevance and then by number of times they were reported for cation:chloride symporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
2 INT326194 Bdnf Regulation of Slc12a5 1 0.05 0.85 1.35
3 INT247924 Slc12a5 Regulation of Gene_expression of Slc12a2 1 0.25 1.43 1.23
4 INT247926 Slc12a5 Regulation of Cl 1 0.01 1.43 1.23
5 INT247925 Slc12a2 Regulation of Cl 1 0.01 1.44 1.23
6 INT169096 Hpcl1 Regulation of Gene_expression of Slc12a5 1 0.02 0.05 0.95
7 INT261783 Bdnf Regulation of Gene_expression of Slc12a5 1 0.09 0 0.87
8 INT215596 Bdnf Positive_regulation of Negative_regulation of Slc12a5 1 0.14 0.76 0.86
9 INT261786 Bdnf Negative_regulation of Slc12a5 1 0.14 0.05 0.85
10 INT244396 Binding of Cl and Slc12a2 1 0.03 0.88 0.76
11 INT139131 Negative_regulation of Ltp Negative_regulation of Slc12a5 1 0.17 0.15 0.7
12 INT139132 Ltp Negative_regulation of Slc12a5 1 0.17 0.15 0.69
13 INT139133 Slc12a5 Negative_regulation of Gene_expression of Ltp 1 0.20 0.11 0.59
14 INT125492 D2Mit212 Negative_regulation of Slc12a7 1 0.00 0 0.54
15 INT261782 Bdnf Positive_regulation of Gene_expression of Slc12a5 1 0.18 0 0.44
16 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41
17 INT261788 Bdnf Regulation of Slc12a5 1 0.10 0.07 0.38
18 INT32636 Slc12a3 Regulation of Localization of Nppa 1 0.00 0.41 0.23
19 INT294904 Binding of Pax3 and Slc12a3 1 0.02 1.9 0.2
20 INT261784 Positive_regulation of Bdnf Positive_regulation of Slc12a5 1 0.15 0.77 0.2
21 INT244338 Slc12a7 Positive_regulation of SERPINH1 1 0.00 0.26 0.13
22 INT261789 PDGFA Positive_regulation of Slc12a5 1 0.07 0.15 0.12
23 INT257511 Regulation of Binding of Slc12a2 and Slc4a4 1 0.02 0.16 0.06
24 INT257510 Binding of Slc12a2 and Slc4a4 1 0.01 0.16 0.06
25 INT257509 Binding of Slc12a4 and Slc4a4 1 0.00 0.08 0.03
26 INT257508 Regulation of Binding of Slc12a4 and Slc4a4 1 0.00 0.08 0.03
27 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0
28 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cation:chloride symporter activity. They are ordered first by their pain relevance and then by number of times they were reported in cation:chloride symporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103172 Gene_expression of Slc12a5 81 0.77 39.45 36.22
2 INT103169 Negative_regulation of Slc12a5 38 0.58 27.75 20.81
3 INT100115 Gene_expression of Slc12a2 34 0.76 39.15 15.69
4 INT103170 Negative_regulation of Gene_expression of Slc12a5 26 0.58 17.25 14.4
5 INT91360 Negative_regulation of Slc12a2 16 0.54 10.46 12.89
6 INT127009 Positive_regulation of Phosphorylation of Slc12a2 5 0.70 5.3 9.9
7 INT127010 Phosphorylation of Slc12a2 6 0.82 4.68 9.66
8 INT62014 Negative_regulation of Slc12a2 17 0.49 12.85 8.99
9 INT138889 Positive_regulation of Slc12a2 23 0.65 18.53 8.85
10 INT127008 Positive_regulation of Slc12a2 2 0.70 4.73 7.61
11 INT138890 Regulation of Slc12a5 12 0.45 11.61 7.46
12 INT94356 Regulation of Slc12a2 11 0.58 12.8 6.59
13 INT103171 Positive_regulation of Slc12a5 15 0.51 3.6 6.25
14 INT146488 Gene_expression of Slc12a2 16 0.73 4.63 5.11
15 INT121252 Regulation of Gene_expression of Slc12a5 10 0.61 6.47 4.87
16 INT244386 Positive_regulation of Gene_expression of Slc12a2 10 0.58 18.39 4.5
17 INT126099 Gene_expression of Slc12a5 9 0.77 5.72 4.36
18 INT139130 Positive_regulation of Gene_expression of Slc12a5 8 0.51 4.43 4.33
19 INT139129 Negative_regulation of Negative_regulation of Slc12a5 4 0.43 5.53 4.29
20 INT24377 Localization of Slc12a7 5 0.06 0 4.26
21 INT203314 Negative_regulation of Gene_expression of Slc12a5 3 0.31 4.74 4.03
22 INT118644 Regulation of Slc12a2 5 0.45 2.43 3.6
23 INT165590 Negative_regulation of Slc12a5 5 0.43 2.62 2.96
24 INT110333 Positive_regulation of Negative_regulation of Slc12a5 4 0.50 3.18 2.77
25 INT244385 Phosphorylation of Slc12a2 12 0.77 4.67 2.74
26 INT24376 Negative_regulation of Localization of Slc12a7 3 0.02 0 2.67
27 INT138891 Regulation of Gene_expression of Slc12a2 5 0.58 4.83 2.64
28 INT127007 Positive_regulation of Positive_regulation of Slc12a2 2 0.70 1.42 2.46
29 INT247918 Positive_regulation of Positive_regulation of Slc12a2 1 0.39 2.55 1.86
30 INT210693 Positive_regulation of Gene_expression of Slc12a2 5 0.46 1.3 1.77
31 INT244384 Binding of Slc12a5 2 0.46 2.47 1.71
32 INT244392 Binding of Slc12a2 3 0.35 2.05 1.68
33 INT24358 Binding of Slc12a3 3 0.36 0.35 1.67
34 INT117710 Binding of Slc12a2 4 0.19 0.13 1.48
35 INT326191 Localization of Slc12a5 1 0.14 0.85 1.32
36 INT121251 Transcription of Slc12a5 2 0.66 1.72 1.27
37 INT244393 Positive_regulation of Phosphorylation of Slc12a2 1 0.65 1.92 1.12
38 INT247922 Phosphorylation of Slc12a5 3 0.79 2.42 1.11
39 INT127004 Regulation of Phosphorylation of Slc12a2 1 0.54 0.35 1.1
40 INT149656 Negative_regulation of Gene_expression of Slc12a2 3 0.38 2.36 1.02
41 INT228404 Gene_expression of Slc12a3 6 0.35 7.18 1
42 INT160022 Transcription of Slc12a2 2 0.53 0.75 0.97
43 INT24359 Negative_regulation of Binding of Slc12a3 1 0.41 0.35 0.88
44 INT43642 Positive_regulation of Slc12a3 3 0.41 0.7 0.83
45 INT160020 Transcription of Slc12a5 2 0.53 0.75 0.83
46 INT247920 Positive_regulation of Phosphorylation of Slc12a5 2 0.51 0.9 0.63
47 INT203328 Positive_regulation of Gene_expression of Slc12a5 2 0.50 1.56 0.63
48 INT261776 Positive_regulation of Positive_regulation of Slc12a5 1 0.37 0 0.61
49 INT228394 Localization of Slc12a3 1 0.07 2.72 0.58
50 INT261771 Negative_regulation of Positive_regulation of Slc12a5 1 0.32 0 0.56
51 INT125490 Regulation of Negative_regulation of Slc12a7 1 0.00 0 0.56
52 INT247919 Regulation of Phosphorylation of Slc12a5 1 0.59 1.54 0.54
53 INT125491 Negative_regulation of Slc12a7 1 0.00 0 0.54
54 INT247921 Negative_regulation of Phosphorylation of Slc12a5 1 0.56 1.58 0.49
55 INT165591 Negative_regulation of Negative_regulation of Slc12a5 1 0.43 0.35 0.49
56 INT243938 Regulation of Phosphorylation of Slc12a5 1 0.18 1.1 0.48
57 INT243918 Phosphorylation of Slc12a5 1 0.25 1.1 0.48
58 INT243914 Positive_regulation of Slc12a5 1 0.14 0 0.47
59 INT259832 Positive_regulation of Slc12a3 3 0.23 2.07 0.46
60 INT160019 Regulation of Transcription of Slc12a2 1 0.26 0.41 0.46
61 INT328606 Regulation of Regulation of Slc12a2 1 0.10 0 0.42
62 INT38022 Gene_expression of Slc12a7 3 0.17 2.78 0.41
63 INT100114 Localization of Slc12a2 3 0.73 2.02 0.31
64 INT259848 Regulation of Slc12a3 2 0.12 2.1 0.3
65 INT244383 Transcription of Slc12a2 2 0.67 0.82 0.29
66 INT261773 Negative_regulation of Slc12a4 1 0.12 0.66 0.27
67 INT243985 Regulation of Slc12a5 1 0.13 0.55 0.24
68 INT203305 Regulation of Gene_expression of Slc12a5 1 0.32 0.8 0.22
69 INT134515 Gene_expression of Slc12a3 3 0.68 9.57 0.21
70 INT294897 Negative_regulation of Slc12a3 2 0.20 1.77 0.2
71 INT244389 Negative_regulation of Positive_regulation of Slc12a2 1 0.40 0.4 0.2
72 INT244390 Negative_regulation of Transcription of Slc12a5 1 0.54 0.4 0.2
73 INT293099 Regulation of Gene_expression of Slc12a3 1 0.14 1.53 0.14
74 INT134514 Regulation of Slc12a3 1 0.62 0 0.14
75 INT246699 Positive_regulation of Gene_expression of Slc12a7 1 0.13 2.05 0.12
76 INT246704 Positive_regulation of Slc12a7 1 0.13 2.05 0.12
77 INT134513 Negative_regulation of Slc12a3 2 0.37 0 0.09
78 INT261781 Regulation of Positive_regulation of Slc12a5 1 0.20 0.08 0.09
79 INT134516 Positive_regulation of Gene_expression of Slc12a3 2 0.50 1.23 0.07
80 INT228403 Binding of Slc12a3 2 0.16 0.52 0.07
81 INT292542 Localization of Slc12a2 1 0.66 0 0.07
82 INT293109 Positive_regulation of Transcription of Slc12a2 1 0.10 0.35 0.05
83 INT257507 Regulation of Slc12a4 1 0.04 0 0
84 INT293112 Negative_regulation of Gene_expression of Slc12a3 1 0.15 3.89 0
85 INT311636 Positive_regulation of Gene_expression of Slc12a3 1 0.23 0.62 0
86 INT257506 Gene_expression of Slc12a4 1 0.09 0 0
87 INT293100 Regulation of Positive_regulation of Slc12a2 1 0.08 0.19 0
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