GO:0015459

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Name potassium channel regulator activity
Categary Function
Go Slim No
Go Link GO:0015459
Unique Molecular Interactions 70
Total Molecular Interactions 114
Total Single Events 537
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for potassium channel regulator activity. They are ordered first by their pain relevance and then by number of times they were reported for potassium channel regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
2 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
3 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06
4 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 0.27 0.71 1.78
5 INT296283 Kcnip3 Regulation of Positive_regulation of Cysltr1 1 0.01 0.85 0.94
6 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
7 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
8 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
9 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
10 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
11 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
12 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
13 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
14 INT296289 Grin2a Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
15 INT296282 Grin2b Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
16 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
17 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
18 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
19 INT155406 Binding of Adrb2 and Ngf 1 0.05 0.39 0.53
20 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 0.10 0 0.52
21 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
22 INT35167 Adrb2 Positive_regulation of Trh 1 0.05 0 0.45
23 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
24 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
25 INT13879 Binding of PSMB9 and KCNAB2 1 0.03 0.19 0.41
26 INT296296 Binding of Grin2b and Kcnip3 1 0.24 0 0.4
27 INT296300 Binding of Grin1 and Kcnip3 1 0.18 0 0.4
28 INT296301 Binding of Grin2a and Kcnip3 1 0.27 0 0.4
29 INT179207 KCNAB2 Regulation of Gene_expression of ATP1A4 1 0.00 1.25 0.37
30 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
31 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37
32 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
33 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
34 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
35 INT263979 Binding of ADRB2 and ATF3 1 0.01 0.5 0.32
36 INT29099 Binding of ADRB2 and PPAP2A 1 0.03 0.77 0.22
37 INT139902 Kcne2 Positive_regulation of Gpr83 1 0.03 1.43 0.22
38 INT164136 Binding of DRD2 and Prl 1 0.09 0 0.22
39 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
40 INT112912 Nts Positive_regulation of Phosphorylation of Arpp19 1 0.18 0 0.21
41 INT127715 Q Negative_regulation of Kcnmb1 1 0.00 0.27 0.21
42 INT210551 Binding of KCNH2 and KCNE2 1 0.08 0 0.19
43 INT156970 Negative_regulation of Kcnip3 Positive_regulation of Transcription of Creb1 1 0.47 0.45 0.17
44 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
45 INT156971 Kcnip3 Negative_regulation of Creb1 1 0.48 0.46 0.17
46 INT296276 Binding of Preb and Kcnip3 1 0.02 0.06 0.16
47 INT296294 Binding of Kcnip3 and Dre 1 0.13 0.06 0.16
48 INT128705 Binding of Adrb2 and Ahsg 1 0.00 0.23 0.15
49 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
50 INT202255 Binding of DRD2 and TCN1 1 0.16 0 0.12
51 INT133989 Pdx1 Regulation of Kcnip3 1 0.07 0 0.04
52 INT133988 Kcnip3 Regulation of Meis1 1 0.02 0 0.04
53 INT133991 Kcnip3 Regulation of Pou2f1 1 0.03 0 0.04
54 INT133985 Kcnip3 Regulation of Pou1f1 1 0.02 0 0.04
55 INT133995 Meis1 Regulation of Kcnip3 1 0.02 0 0.04
56 INT133979 Pou1f1 Regulation of Kcnip3 1 0.02 0 0.04
57 INT134001 Kcnip3 Regulation of Pdx1 1 0.07 0 0.04
58 INT133980 Kcnip3 Regulation of Gene_expression of Npff 1 0.23 0 0.04
59 INT133984 Pou2f1 Regulation of Kcnip3 1 0.03 0 0.04
60 INT202573 Binding of DIO2 and DRD4 1 0.07 0.09 0.03
61 INT202571 Binding of DRD2 and DRD4 1 0.41 0.76 0
62 INT233526 Tlr4 Regulation of Adrb2 1 0.03 0.07 0
63 INT339701 LGALS2 Regulation of SGK2 1 0.00 0.1 0
64 INT339704 MBL2 Regulation of SGK2 1 0.06 0.1 0
65 INT317778 Binding of ADRB2 and GOPC 1 0.10 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for potassium channel regulator activity. They are ordered first by their pain relevance and then by number of times they were reported in potassium channel regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49774 Binding of DRD2 48 0.48 17.42 20.73
2 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
3 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
4 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
5 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
6 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
7 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
8 INT133971 Binding of Kcnip3 4 0.42 5.54 6.12
9 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
10 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
11 INT149217 Gene_expression of Kcnip3 2 0.63 6.31 5.26
12 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
13 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
14 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
15 INT35999 Positive_regulation of KCNAB2 6 0.65 5.12 4.31
16 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
17 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
18 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
19 INT100591 Regulation of Kcnip3 3 0.50 2.51 3.17
20 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
21 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
22 INT147412 Binding of DRD4 11 0.47 7.57 2.77
23 INT33480 Gene_expression of Adrb2 4 0.66 1.96 2.77
24 INT189863 Gene_expression of DRD4 11 0.68 7.65 2.66
25 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46
26 INT3531 Regulation of Adrb2 7 0.44 1.48 2.25
27 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
28 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
29 INT100590 Negative_regulation of Kcnip3 5 0.58 2.39 2.13
30 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
31 INT15998 Gene_expression of Kcne2 7 0.46 8.1 1.61
32 INT39969 Localization of Kcne2 4 0.61 1.11 1.56
33 INT16658 Binding of Kcne2 2 0.19 0 1.54
34 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
35 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
36 INT13880 Gene_expression of KCNAB2 3 0.27 2.95 1.38
37 INT69498 Positive_regulation of DRD4 3 0.50 0.95 1.3
38 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
39 INT77216 Localization of DRD2 3 0.75 0 1.19
40 INT41475 Positive_regulation of Localization of ADRB2 2 0.49 0.18 1.12
41 INT49796 Positive_regulation of Binding of Adrb2 1 0.00 0 1.02
42 INT52186 Positive_regulation of Positive_regulation of ADRB2 1 0.14 0 1.02
43 INT49795 Negative_regulation of Binding of Adrb2 1 0.00 0 1.02
44 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
45 INT210571 Gene_expression of KCNE2 7 0.61 2.7 0.97
46 INT138548 Negative_regulation of Gene_expression of Adrb2 1 0.41 0.85 0.96
47 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
48 INT14976 Negative_regulation of Adrb2 3 0.24 0.75 0.86
49 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86
50 INT42863 Regulation of Adrb2 1 0.11 1.02 0.85
51 INT42862 Regulation of Binding of Adrb2 1 0.15 1.03 0.85
52 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
53 INT33481 Positive_regulation of Gene_expression of Adrb2 2 0.48 0.38 0.78
54 INT296263 Localization of Kcnip3 1 0.69 0.34 0.76
55 INT31778 Negative_regulation of Adrb2 2 0.07 1.34 0.72
56 INT179216 Regulation of Gene_expression of KCNAB2 1 0.03 2.35 0.72
57 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
58 INT67452 Positive_regulation of Regulation of ADRB2 1 0.41 0.26 0.68
59 INT149215 Regulation of Gene_expression of Kcnip3 2 0.36 0.18 0.66
60 INT38479 Positive_regulation of Kcne2 4 0.40 1 0.63
61 INT296252 Negative_regulation of Localization of Kcnip3 1 0.39 0.21 0.6
62 INT296250 Phosphorylation of Kcnip3 1 0.66 0.15 0.56
63 INT179218 Regulation of KCNAB2 1 0.03 2.47 0.52
64 INT202581 Positive_regulation of Gene_expression of DRD2 2 0.49 0.81 0.47
65 INT124786 Localization of Adrb2 1 0.04 0.07 0.44
66 INT13884 Positive_regulation of Positive_regulation of Adrb2 1 0.34 0 0.42
67 INT296259 Positive_regulation of Gene_expression of Kcnip3 1 0.43 0.53 0.41
68 INT13881 Binding of KCNAB2 1 0.13 0.19 0.41
69 INT128845 Phosphorylation of ADRB2 1 0.01 0 0.39
70 INT40833 Negative_regulation of Localization of ADRB2 2 0.40 0.58 0.38
71 INT210567 Binding of KCNE2 1 0.07 0 0.38
72 INT513 Transcription of Adrb2 2 0.06 0.55 0.37
73 INT66776 Negative_regulation of Kcne2 6 0.35 2.48 0.33
74 INT69748 Regulation of Kcne2 2 0.03 1.01 0.3
75 INT317793 Regulation of Gene_expression of ADRB2 1 0.45 0.26 0.27
76 INT353393 Transcription of DRD4 1 0.63 0.57 0.27
77 INT283235 Localization of KCNAB2 1 0.02 0.94 0.26
78 INT283232 Negative_regulation of Localization of KCNAB2 1 0.01 0.95 0.26
79 INT139652 Negative_regulation of Arpp19 1 0.12 0.1 0.26
80 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23
81 INT112901 Phosphorylation of Arpp19 1 0.34 0 0.21
82 INT115874 Negative_regulation of Positive_regulation of Adrb2 1 0.20 0 0.21
83 INT133507 Regulation of Negative_regulation of Adrb2 1 0.18 0 0.17
84 INT239609 Positive_regulation of KCNE2 1 0.40 1.29 0.15
85 INT224096 Positive_regulation of Negative_regulation of DRD2 1 0.05 0.38 0.15
86 INT81943 Regulation of Regulation of Adrb2 1 0.29 0 0.12
87 INT81944 Regulation of Positive_regulation of Adrb2 1 0.18 0 0.12
88 INT328682 Positive_regulation of Gene_expression of Kcne2 1 0.07 0.82 0.1
89 INT328694 Negative_regulation of Gene_expression of Kcne2 1 0.06 2.16 0.08
90 INT271054 Regulation of DRD4 1 0.12 0.61 0.07
91 INT209147 Regulation of Transcription of ADRB2 1 0.27 0 0.07
92 INT209148 Transcription of ADRB2 1 0.53 0 0.06
93 INT328691 Transcription of Kcne2 1 0.07 0.54 0.03
94 INT202574 Negative_regulation of DRD4 1 0.42 0.29 0
95 INT339741 Binding of SGK2 1 0.16 0.1 0
96 INT339761 Regulation of SGK2 1 0.20 0.1 0
97 INT339765 Positive_regulation of SGK2 1 0.20 0.1 0
98 INT202583 Negative_regulation of Binding of DRD4 1 0.42 0.29 0
99 INT339774 Positive_regulation of Binding of SGK2 1 0.22 0.1 0
100 INT349673 Positive_regulation of Gene_expression of ADRB2 1 0.14 0 0
101 INT202576 Regulation of Gene_expression of DRD4 1 0.44 0.45 0
102 INT230388 Localization of Adrb2 1 0.51 0.71 0
103 INT328678 Regulation of Gene_expression of Kcne2 1 0.05 0.72 0
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