GO:0015949

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Name nucleobase-containing small molecule interconversion
Categary Process
Go Slim No
Go Link GO:0015949
Unique Molecular Interactions 73
Total Molecular Interactions 107
Total Single Events 725
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nucleobase-containing small molecule interconversion. They are ordered first by their pain relevance and then by number of times they were reported for nucleobase-containing small molecule interconversion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 0.54 0.5 0.85
2 INT243678 Binding of GSR and Ugcg 2 0.03 2.84 0.83
3 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
4 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
5 INT15221 RRM1 Regulation of Localization of VIP 1 0.12 0.08 0.74
6 INT15222 RRM1 Regulation of VIP 1 0.12 0.08 0.74
7 INT26230 Binding of GSR and HTR1D 1 0.12 0.15 0.69
8 INT26231 Binding of GSR and HTR1B 1 0.12 0.15 0.66
9 INT347362 RYBP Regulation of Gene_expression of GSR 1 0.01 0 0.57
10 INT347369 RYBP Positive_regulation of GSR 1 0.01 0.43 0.51
11 INT210160 Binding of TNFRSF8 and TXN 1 0.47 4.16 0.48
12 INT347367 RYBP Negative_regulation of GSR 1 0.01 0.09 0.48
13 INT347364 RYBP Regulation of GSR 1 0.01 0.06 0.48
14 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
15 INT100282 TXN Negative_regulation of Transcription of POMC 1 0.54 0.39 0.43
16 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42
17 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42
18 INT83348 GSR Negative_regulation of JUND 1 0.20 0.72 0.33
19 INT83347 GSR Negative_regulation of NFKB1 1 0.25 0.72 0.33
20 INT336936 Binding of GSR and Nr3c2 1 0.06 2.29 0.31
21 INT26235 Binding of GSR and Htr1a 1 0.12 0.09 0.31
22 INT346957 HDAC9 Positive_regulation of Gene_expression of GSR 1 0.03 1.28 0.27
23 INT179233 IRF6 Negative_regulation of Binding of GSR 1 0.03 0.83 0.25
24 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
25 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
26 INT100279 TXN Negative_regulation of Gene_expression of HSP90B2P 1 0.13 0.3 0.24
27 INT100280 TXN Positive_regulation of Gene_expression of MC1R 1 0.33 0.22 0.24
28 INT162931 TXNRD1 Negative_regulation of Phosphorylation of NQO1 1 0.13 0.5 0.23
29 INT179230 Binding of MAPK14 and GSR 1 0.03 0.5 0.23
30 INT179229 Binding of GSR and NR3C2 1 0.03 0.37 0.23
31 INT100284 TXN Positive_regulation of Gene_expression of POMC 1 0.65 0 0.19
32 INT319173 TXN Positive_regulation of Gene_expression of SOD2 1 0.23 0.1 0.18
33 INT146743 Positive_regulation of Binding of GSR and PLA2G4A 1 0.40 0.14 0.11
34 INT146742 Binding of GSR and PLA2G4A 1 0.28 0.14 0.11
35 INT302883 Binding of TXN and Alb 1 0.06 4.13 0.1
36 INT278604 GSR Regulation of Gene_expression of SULT2A1 1 0.02 0.05 0.07
37 INT107727 ASIP Negative_regulation of RRM2 1 0.29 0.43 0.07
38 INT179232 Binding of CREM and GSR 1 0.00 0 0.06
39 INT210146 Binding of EGFR and TXN 1 0.15 0.09 0.06
40 INT210155 TXN Positive_regulation of Gene_expression of TNFRSF8 1 0.49 0.22 0.05
41 INT210156 Binding of TNFSF8 and TXN 1 0.10 0.4 0.04
42 INT155231 Positive_regulation of PPARA Positive_regulation of TXN 1 0.37 0.17 0.04
43 INT210154 TXN Regulation of Gene_expression of FASLG 1 0.09 0.23 0.03
44 INT297374 Binding of TXNRD1 and Rxra 1 0.01 0.2 0.03
45 INT286268 Binding of GSR and Gpx1 2 0.02 0 0
46 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0
47 INT210159 Binding of PRDX1 and TXN 1 0.21 0 0
48 INT98354 TXNRD1 Positive_regulation of Positive_regulation of ESR1 1 0.00 0.05 0
49 INT210163 Binding of FAS and TXN 1 0.19 0 0
50 INT308132 Binding of RRM1 and F2 1 0.01 0 0
51 INT322607 Binding of RRM2 and TF 1 0.02 0.09 0
52 INT210162 TXN Negative_regulation of TNFRSF8 1 0.37 0.15 0
53 INT79644 CTNNBL1 Positive_regulation of Binding of GSR 1 0.08 0 0
54 INT79652 RIMS3 Regulation of GSR 1 0.03 0 0
55 INT177298 Binding of GSR and GMEB1 1 0.01 0 0
56 INT210153 Regulation of Binding of TNFRSF8 and TXN 1 0.44 0.49 0
57 INT210147 Binding of TXN and TNFRSF6B 1 0.01 0 0
58 INT302882 Positive_regulation of Binding of TXN and Alb 1 0.05 1.51 0
59 INT265023 Gsr Negative_regulation of Binding of GSR 1 0.04 0.13 0
60 INT210150 TXN Regulation of TNFRSF8 1 0.26 0.2 0
61 INT79645 RIMS3 Positive_regulation of Phosphorylation of GSR 1 0.04 0 0
62 INT351596 Regulation of Binding of GSR and Gpx1 1 0.02 0 0
63 INT310320 GSR Negative_regulation of COQ10A 1 0.01 0.06 0
64 INT98355 TXNRD1 Negative_regulation of Positive_regulation of ESR1 1 0.00 0.09 0
65 INT330060 GSR Positive_regulation of Gene_expression of Ros1 1 0.00 0.61 0
66 INT95055 Binding of CYP1A2 and TXNRD1 1 0.04 0 0
67 INT210152 Positive_regulation of Binding of TNFRSF8 and TXN 1 0.49 0.49 0
68 INT79650 CTNNBL1 Regulation of GSR 1 0.07 0 0
69 INT177266 GSR Positive_regulation of Gene_expression of CXADR 1 0.13 0 0
70 INT79647 RIMS3 Positive_regulation of Binding of GSR 1 0.04 0 0
71 INT274705 Binding of TXNRD1 and Dh 1 0.00 0 0
72 INT210164 Binding of TXN and TXNRD1 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for nucleobase-containing small molecule interconversion. They are ordered first by their pain relevance and then by number of times they were reported in nucleobase-containing small molecule interconversion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25
2 INT3845 Gene_expression of GSR 79 0.76 44.69 11.19
3 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37
4 INT52924 Negative_regulation of GSR 49 0.58 28.08 9.28
5 INT100772 Negative_regulation of TXNRD1 10 0.41 3.47 4.74
6 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43
7 INT33951 Regulation of TXNRD1 18 0.51 6.97 4.02
8 INT26233 Binding of GSR 45 0.46 18.22 3.74
9 INT91070 Regulation of GSR 27 0.59 16.64 3.42
10 INT83351 Positive_regulation of Gene_expression of GSR 15 0.64 12.03 2.97
11 INT77339 Positive_regulation of RRM2 5 0.41 1.36 2.88
12 INT53707 Negative_regulation of RRM1 4 0.59 0.44 2.87
13 INT57957 Localization of TXNRD1 14 0.64 4.01 2.7
14 INT145126 Positive_regulation of GLRX 5 0.12 4.55 2.53
15 INT79658 Transcription of GSR 8 0.68 3.59 2.19
16 INT69703 Gene_expression of TXN 20 0.71 3.57 2.01
17 INT110580 Regulation of Transcription of GSR 2 0.27 0.98 1.94
18 INT100286 Localization of TXN 21 0.73 5.13 1.48
19 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27
20 INT110582 Localization of GSR 10 0.79 4.03 1.19
21 INT88568 Positive_regulation of RRM1 4 0.41 1.81 1.14
22 INT281849 Binding of RRM2 5 0.17 0.43 1.07
23 INT69705 Positive_regulation of TXN 8 0.63 2.35 0.89
24 INT110859 Negative_regulation of Positive_regulation of TXNRD1 1 0.41 0.65 0.82
25 INT210193 Binding of TXN 31 0.44 6.88 0.78
26 INT115293 Regulation of Gene_expression of TXN 2 0.19 0.78 0.73
27 INT170772 Negative_regulation of Gene_expression of GSR 8 0.41 3.05 0.7
28 INT110581 Positive_regulation of Localization of GSR 1 0.68 0.33 0.7
29 INT106382 Gene_expression of NME1 13 0.66 5.18 0.56
30 INT179248 Positive_regulation of Positive_regulation of GSR 3 0.40 4.65 0.56
31 INT83349 Negative_regulation of Binding of GSR 3 0.39 1.48 0.49
32 INT77338 Negative_regulation of RRM2 2 0.38 0 0.49
33 INT107683 Positive_regulation of Negative_regulation of NME1 1 0.49 0.93 0.48
34 INT107684 Phosphorylation of NME1 1 0.61 0.92 0.48
35 INT107687 Negative_regulation of NME1 1 0.57 0.91 0.48
36 INT155236 Negative_regulation of TXN 5 0.53 0.66 0.46
37 INT351236 Negative_regulation of Negative_regulation of TXNRD1 1 0.22 0.06 0.44
38 INT210194 Positive_regulation of Gene_expression of TXN 1 0.46 1.17 0.43
39 INT100287 Regulation of TXN 2 0.41 0.62 0.42
40 INT168433 Regulation of GLRX 1 0.05 0.66 0.34
41 INT25725 Positive_regulation of NME1 1 0.01 0.25 0.34
42 INT258059 Negative_regulation of Positive_regulation of GSR 3 0.41 1.79 0.33
43 INT286267 Positive_regulation of Negative_regulation of GSR 1 0.12 0.9 0.33
44 INT83354 Positive_regulation of Binding of GSR 2 0.43 0.69 0.31
45 INT271882 Protein_catabolism of TXN 1 0.09 0.17 0.31
46 INT129470 Regulation of RRM2 4 0.22 0.36 0.27
47 INT274774 Regulation of RRM1 2 0.16 0.07 0.27
48 INT98363 Positive_regulation of Gene_expression of TXNRD1 8 0.35 0.29 0.24
49 INT308129 Positive_regulation of Positive_regulation of RRM1 2 0.04 0.82 0.24
50 INT184652 Binding of RRM1 5 0.22 0.55 0.23
51 INT210191 Positive_regulation of Positive_regulation of TXN 1 0.46 1.16 0.21
52 INT179250 Negative_regulation of Transcription of GSR 2 0.56 1.7 0.18
53 INT179247 Negative_regulation of Localization of GSR 1 0.24 0.65 0.18
54 INT184651 Gene_expression of RRM1 6 0.48 3.46 0.15
55 INT274773 Gene_expression of RRM2 1 0.08 0.21 0.15
56 INT184649 Localization of RRM1 3 0.07 1.08 0.13
57 INT197840 Binding of NME1 2 0.04 1.14 0.11
58 INT144156 Negative_regulation of Localization of TXNRD1 1 0.47 0 0.11
59 INT315821 Regulation of Transcription of RRM1 1 0.21 0.67 0.1
60 INT315817 Transcription of RRM1 2 0.42 0.67 0.09
61 INT264609 Regulation of Gene_expression of GSR 3 0.43 2.44 0.07
62 INT276800 Transcription of TXNRD1 2 0.19 0.36 0.07
63 INT184647 Regulation of Localization of RRM1 1 0.04 0.07 0.07
64 INT242044 Protein_catabolism of GSR 3 0.88 0.05 0.06
65 INT170769 Negative_regulation of Negative_regulation of GSR 2 0.41 0.95 0.06
66 INT330353 Positive_regulation of Gene_expression of RRM1 1 0.04 1.01 0.06
67 INT330365 Positive_regulation of Localization of RRM1 1 0.04 1.01 0.06
68 INT336934 Regulation of Regulation of GSR 1 0.07 0.87 0.05
69 INT128408 Positive_regulation of Positive_regulation of TXNRD1 2 0.30 0 0
70 INT336935 Positive_regulation of Protein_catabolism of GSR 1 0.13 0 0
71 INT302881 Negative_regulation of Binding of TXN 1 0.05 1.43 0
72 INT276805 Negative_regulation of Gene_expression of TXNRD1 1 0.13 0 0
73 INT200735 Regulation of NME1 1 0.60 1.03 0
74 INT106385 Regulation of Gene_expression of NME1 1 0.23 0.13 0
75 INT320323 Negative_regulation of Transcription of RRM1 1 0.25 0 0
76 INT276808 Positive_regulation of Transcription of GSR 1 0.19 0 0
77 INT210205 Localization of GLRX 1 0.18 0 0
78 INT123080 Regulation of Regulation of TXNRD1 1 0.01 0 0
79 INT98362 Positive_regulation of Binding of TXNRD1 1 0.02 0.07 0
80 INT79653 Phosphorylation of GSR 1 0.59 0 0
81 INT210197 Positive_regulation of Binding of TXN 1 0.63 0.19 0
82 INT106383 Positive_regulation of Gene_expression of NME1 1 0.59 0.13 0
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