GO:0016005

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Name phospholipase A2 activator activity
Categary Function
Go Slim No
Go Link GO:0016005
Unique Molecular Interactions 112
Total Molecular Interactions 139
Total Single Events 2453
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phospholipase A2 activator activity. They are ordered first by their pain relevance and then by number of times they were reported for phospholipase A2 activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
2 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
3 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
4 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
5 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
6 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
7 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
8 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
9 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
10 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
11 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
12 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
13 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
14 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
15 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
16 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
17 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
18 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
19 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
20 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
21 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
22 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
23 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
24 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
25 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
26 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
27 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
28 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
29 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
30 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
31 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
32 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
33 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
34 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
35 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
36 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
37 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
38 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
39 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
40 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
41 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
42 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
43 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
44 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
45 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
46 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
47 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
48 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
49 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
50 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
51 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
52 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
53 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
54 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
55 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
56 INT166162 Ccr9 Negative_regulation of Positive_regulation of Casp3 1 0.18 1.49 0.28
57 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
58 INT149713 Binding of Casp3 and Fas 1 0.40 1.09 0.25
59 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
60 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
61 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22
62 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
63 INT181675 Positive_regulation of Casp9 Positive_regulation of Casp3 1 0.06 0.51 0.2
64 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
65 INT181677 Casp9 Positive_regulation of Casp3 1 0.06 0.5 0.19
66 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
67 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18
68 INT275400 Casp3 Positive_regulation of NDRG1 1 0.00 1.36 0.18
69 INT96416 CYC1 Positive_regulation of Casp3 1 0.02 0.96 0.17
70 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15
71 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
72 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
73 INT275397 Binding of ITIH4 and Casp3 1 0.02 0.64 0.13
74 INT252631 Binding of Casp3 and Tnfrsf1a 1 0.10 0.69 0.13
75 INT275389 Binding of Casp3 and Htatsf1 1 0.00 0.64 0.13
76 INT252632 Binding of Casp3 and Tradd 1 0.11 0.68 0.12
77 INT349345 Bdnf Negative_regulation of Positive_regulation of Casp3 1 0.13 1.02 0.12
78 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
79 INT315391 IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
80 INT315390 Positive_regulation of IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
81 INT142961 Binding of Nfkb1 and Casp3 1 0.00 1.02 0.11
82 INT234062 Nes Positive_regulation of Casp3 1 0.18 0.08 0.11
83 INT285023 Casp3 Negative_regulation of Casp7 1 0.07 0.44 0.1
84 INT203849 Ass1 Positive_regulation of Casp3 1 0.00 0.71 0.07
85 INT211347 Binding of Sigmar1 and Positive_regulation of Casp3 1 0.12 0.92 0.06
86 INT242411 Mch Positive_regulation of Casp3 1 0.09 0.15 0.04
87 INT302983 Fadd Positive_regulation of Casp3 1 0.15 1.13 0.04
88 INT242413 Regulation of Mch Positive_regulation of Casp3 1 0.05 0.16 0.04
89 INT267217 Gene_expression of Hspb8 Negative_regulation of Positive_regulation of Casp3 1 0.14 2.8 0.04
90 INT322358 Binding of Parp1 and Casp3 1 0.05 1.08 0.04
91 INT172897 Negative_regulation of Lox Positive_regulation of Positive_regulation of Casp3 1 0.04 1.19 0.03
92 INT172910 Lox Positive_regulation of Positive_regulation of Casp3 1 0.03 1.19 0.03
93 INT345350 Casp3 Positive_regulation of Prkcd 1 0.05 0.79 0.03
94 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0
95 INT333772 Positive_regulation of Casp3 Positive_regulation of Gga3 1 0.05 0.5 0
96 INT247847 Narfl Positive_regulation of Positive_regulation of Casp3 1 0.02 0.79 0
97 INT333696 Tpsg1 Positive_regulation of Casp3 1 0.08 3.18 0
98 INT157755 Tmx1 Regulation of Positive_regulation of Casp3 1 0.15 0 0
99 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
100 INT333771 Casp3 Positive_regulation of Gga3 1 0.05 0.5 0
101 INT226042 Binding of Casp1 and Casp3 1 0.02 0.73 0
102 INT268633 Mpz Positive_regulation of Positive_regulation of Casp3 1 0.14 0 0
103 INT157754 Tmx1 Regulation of Gene_expression of Casp3 1 0.15 0 0
104 INT302675 Binding of OPA1 and PLAA 1 0.15 0.73 0
105 INT229809 Fos Regulation of Casp3 1 0.06 0.32 0
106 INT322365 TNF Positive_regulation of Positive_regulation of Casp3 1 0.01 1.54 0
107 INT333698 Gene_expression of Hr Negative_regulation of Casp3 1 0.14 0.73 0
108 INT201755 ROS1 Positive_regulation of Casp3 1 0.00 1.4 0
109 INT263335 Olfm4 Regulation of Regulation of Casp3 1 0.00 0.33 0
110 INT319170 Casp3 Regulation of Hdac1 1 0.01 0.27 0
111 INT277694 Cdkn1a Positive_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
112 INT242159 Wnt2 Positive_regulation of Localization of Casp3 1 0.05 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phospholipase A2 activator activity. They are ordered first by their pain relevance and then by number of times they were reported in phospholipase A2 activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
5 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
6 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
7 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
8 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
9 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
10 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
11 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
12 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
13 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
14 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
15 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
16 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
17 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
18 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
19 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
20 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
21 INT98178 Localization of Casp3 32 0.65 21.01 7.77
22 INT57232 Binding of Casp3 22 0.36 9.42 6.2
23 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
24 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
25 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
26 INT31118 Localization of Casp3 17 0.73 11.55 2.3
27 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
28 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
29 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
30 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
31 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
32 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
33 INT31117 Binding of Casp3 14 0.23 5.27 0.93
34 INT159409 Gene_expression of PLAA 2 0.54 6.14 0.89
35 INT131105 Positive_regulation of Negative_regulation of Casp3 3 0.29 3.15 0.84
36 INT181667 Regulation of Regulation of Casp3 1 0.22 1.7 0.77
37 INT129490 Negative_regulation of Protein_catabolism of Casp3 4 0.22 3.91 0.71
38 INT351454 Regulation of Transcription of Casp3 1 0.02 0.51 0.67
39 INT242061 Positive_regulation of Negative_regulation of Casp3 3 0.09 1.7 0.58
40 INT181673 Negative_regulation of Transcription of Casp3 3 0.34 0.61 0.55
41 INT129144 Regulation of Localization of Casp3 1 0.26 0.84 0.44
42 INT153436 Positive_regulation of Localization of Casp3 3 0.49 2.12 0.43
43 INT155293 Positive_regulation of Protein_catabolism of Casp3 3 0.45 1.7 0.4
44 INT165916 Negative_regulation of Localization of Casp3 2 0.41 2.41 0.34
45 INT141820 Positive_regulation of Binding of Casp3 1 0.12 0.55 0.24
46 INT195018 Regulation of Negative_regulation of Casp3 1 0.21 0.48 0.2
47 INT302703 Binding of PLAA 1 0.13 0.87 0.15
48 INT123522 Phosphorylation of Casp3 3 0.80 1.36 0.14
49 INT302683 Negative_regulation of PLAA 1 0.15 0.4 0.13
50 INT226041 Positive_regulation of Binding of Casp3 1 0.12 0.82 0.12
51 INT171688 Positive_regulation of Transcription of Casp3 3 0.28 1.16 0.08
52 INT288609 Regulation of Regulation of Casp3 1 0.05 0.69 0.07
53 INT333205 Negative_regulation of Protein_catabolism of Casp3 1 0.04 0.6 0.05
54 INT302701 Positive_regulation of PLAA 1 0.18 0 0
55 INT304140 Regulation of Negative_regulation of Casp3 1 0.05 0.67 0
56 INT237443 Positive_regulation of Phosphorylation of Casp3 1 0.39 0.09 0
57 INT159172 Negative_regulation of Negative_regulation of Casp3 1 0.09 0.07 0
58 INT302687 Regulation of PLAA 1 0.19 0.24 0
59 INT228785 Positive_regulation of Transcription of Casp3 1 0.17 0.06 0
60 INT242155 Negative_regulation of Localization of Casp3 1 0.04 0.25 0
61 INT228792 Transcription of Casp3 1 0.24 0.05 0
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