GO:0016020

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Name membrane
Categary Component
Go Slim No
Go Link GO:0016020
Unique Molecular Interactions 17857
Total Molecular Interactions 24720
Total Single Events 204076
Pain Genes Associated 2342

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for membrane. They are ordered first by their pain relevance and then by number of times they were reported for membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
3 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
4 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
5 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
6 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
7 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
8 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
9 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
10 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
11 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
12 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
13 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
14 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
15 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
16 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
17 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
18 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
19 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52
20 INT33314 Binding of Ap1m1 and Ap1m2 1 0.07 0.97 5.42
21 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
22 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
23 INT164362 Binding of NLRP1 and VTA1 1 0.15 2.37 4.67
24 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
25 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
26 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
27 INT14095 Binding of Vsig2 and Coq10a 2 0.33 1.98 4.55
28 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
29 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
30 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
31 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
32 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
33 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
34 INT122567 Mog Positive_regulation of Eae1 8 0.31 10.18 4.26
35 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
36 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
37 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
38 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
39 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
40 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
41 INT107801 Ugt1a5 Positive_regulation of Localization of Prl 3 0.76 1 3.9
42 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
43 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
44 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
45 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
46 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
47 INT180813 Ngf Positive_regulation of Sorbs1 1 0.04 2.09 3.79
48 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
49 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
50 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
51 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
52 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
53 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5
54 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
55 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
56 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4
57 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
58 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
59 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
60 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
61 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
62 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
63 INT56458 Binding of GPM6A and IGHG3 4 0.02 0 3.31
64 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
65 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
66 INT48162 RIMS3 Regulation of Localization of LTC4S 1 0.10 2.14 3.25
67 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
68 INT354207 Igfbp7 Positive_regulation of Accn3 1 0.52 6.55 3.24
69 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
70 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
71 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
72 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
73 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17
74 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
75 INT289979 Binding of Helt and Negative_regulation of Maoa 1 0.00 0.17 3.14
76 INT211694 Binding of Cntnap1 and Nav1 1 0.04 0 3.14
77 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
78 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
79 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
80 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
81 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
82 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
83 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
84 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
85 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
86 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
87 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
88 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96
89 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
90 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
91 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
92 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
93 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
94 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
95 INT130085 Crp Positive_regulation of Gene_expression of Vcam1 1 0.23 4.34 2.84
96 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
97 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
98 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
99 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
100 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
101 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
102 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
103 INT151381 St8sia1 Positive_regulation of Cck 1 0.19 0.45 2.7
104 INT87267 Binding of BMP8B and KRIT1 1 0.06 0.16 2.69
105 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
106 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
107 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
108 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
109 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
110 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
111 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
112 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
113 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
114 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
115 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
116 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
117 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
118 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
119 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
120 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
121 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
122 INT67905 Binding of Spn and Fosl1 1 0.24 2.1 2.54
123 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
124 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
125 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
126 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
127 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
128 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
129 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49
130 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
131 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48
132 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
133 INT96462 Pnoc Positive_regulation of Pag1 1 0.01 0.74 2.45
134 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
135 INT135867 Zfp821 Positive_regulation of Positive_regulation of Chrne 1 0.01 0 2.44
136 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
137 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
138 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
139 INT37873 Pag1 Regulation of Nrm 2 0.04 1.1 2.41
140 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
141 INT317526 Binding of Hint1 and Gipc1 1 0.00 0.25 2.38
142 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
143 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
144 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
145 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
146 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
147 INT158809 Pag1 Regulation of Rvm 1 0.02 1.28 2.33
148 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
149 INT249013 Gabrg1 Negative_regulation of Per2 1 0.34 0.07 2.31
150 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
151 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
152 INT128778 Binding of Mcam and Nav1 1 0.03 0.51 2.28
153 INT128777 Binding of Cntn1 and Nav1 1 0.48 0.51 2.28
154 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27
155 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
156 INT211748 Binding of Pag1 and Mors1 2 0.07 0.2 2.26
157 INT350148 Binding of IL12A and ERAL1 1 0.21 8.23 2.26
158 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26
159 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
160 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
161 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
162 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
163 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
164 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
165 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
166 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
167 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
168 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
169 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18
170 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
171 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
172 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
173 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14
174 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
175 INT142527 Binding of Slc1a2 and Slc1a3 2 0.31 0.12 2.13
176 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
177 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13
178 INT140019 Avp Positive_regulation of Localization of Kitl 1 0.00 1 2.13
179 INT18593 Binding of Sst and Fdft1 2 0.11 0.08 2.12
180 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
181 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
182 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
183 INT83425 Binding of CD40LG and IGHG3 11 0.21 4.56 2.09
184 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
185 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
186 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
187 INT107268 Binding of ITGAL and NCR3 1 0.01 2.76 2.07
188 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
189 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06
190 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
191 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
192 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
193 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
194 INT167530 Phax Regulation of Gene_expression of Trpv1 1 0.16 0.86 2.05
195 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
196 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
197 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01
198 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
199 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
200 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2

Single Events

The table below shows the top 100 pain related interactions that have been reported for membrane. They are ordered first by their pain relevance and then by number of times they were reported in membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59
2 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
3 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42
4 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42
5 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
6 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
7 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
8 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
9 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59
10 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87
11 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
12 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
13 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
14 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74
15 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
16 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
17 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55
18 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16
19 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
20 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4
21 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
22 INT1878 Binding of HLA-B 440 0.48 321.16 127.36
23 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34
24 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
25 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75
26 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
27 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
28 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
29 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
30 INT114 Binding of Oprl1 139 0.48 23 103.35
31 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03
32 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76
33 INT65500 Gene_expression of App 605 0.78 429.94 98.31
34 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
35 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
36 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66
37 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02
38 INT38731 Localization of Trpv1 138 0.81 52.73 90.49
39 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
40 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
41 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
42 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
43 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
44 INT4830 Binding of Trpv1 158 0.48 45.11 84.2
45 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02
46 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
47 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
48 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
49 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
50 INT920 Localization of PLOD1 223 0.81 42.25 78.7
51 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65
52 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37
53 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7
54 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
55 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23
56 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
57 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68
58 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4
59 INT4153 Binding of Insrr 109 0.40 17.99 72.15
60 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9
61 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
62 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
63 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
64 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15
65 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
66 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
67 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17
68 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
69 INT6926 Regulation of Pag1 72 0.39 55.79 65.09
70 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
71 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
72 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23
73 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
74 INT96622 Localization of Trpv1 110 0.81 59.82 63.25
75 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1
76 INT46 Localization of Ren 233 0.81 46.15 62.44
77 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
78 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
79 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
80 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52
81 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
82 INT109431 Gene_expression of Trpa1 123 0.78 51.84 59.98
83 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
84 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
85 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
86 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67
87 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
88 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
89 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
90 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
91 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
92 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31
93 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
94 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7
95 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
96 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
97 INT7800 Localization of Pag1 51 0.56 33.06 53.74
98 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67
99 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
100 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
101 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71
102 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
103 INT61873 Gene_expression of Arc 128 0.78 128.25 52.24
104 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92
105 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
106 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
107 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
108 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
109 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
110 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24
111 INT109430 Positive_regulation of Trpa1 119 0.70 44 49.14
112 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
113 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
114 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
115 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
116 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
117 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89
118 INT654 Localization of REN 250 0.81 75.12 47.86
119 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85
120 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
121 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
122 INT1715 Positive_regulation of Nrm 51 0.70 24 47.53
123 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
124 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
125 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
126 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01
127 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85
128 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
129 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
130 INT98498 Binding of Trpv1 75 0.48 33.67 44.4
131 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23
132 INT127013 Negative_regulation of Slc1a3 37 0.54 14.16 43.97
133 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
134 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01
135 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
136 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
137 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
138 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4
139 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
140 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03
141 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
142 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84
143 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
144 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
145 INT97596 Localization of S100a8 94 0.78 90.69 40.41
146 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
147 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
148 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21
149 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
150 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03
151 INT173693 Localization of Gopc 249 0.65 70.49 38.81
152 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66
153 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
154 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
155 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
156 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
157 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
158 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
159 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02
160 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
161 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38
162 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
163 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
164 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
165 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01
166 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88
167 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78
168 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
169 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
170 INT103172 Gene_expression of Slc12a5 81 0.77 39.45 36.22
171 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
172 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
173 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85
174 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
175 INT13501 Binding of Drd2 65 0.48 23.76 35.6
176 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
177 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97
178 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77
179 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76
180 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
181 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
182 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52
183 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
184 INT96624 Positive_regulation of Positive_regulation of Trpv1 62 0.70 20.5 34.28
185 INT223416 Gene_expression of Trhde 2 0.48 64.16 34.21
186 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15
187 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05
188 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
189 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
190 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72
191 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
192 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
193 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
194 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52
195 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
196 INT1116 Regulation of Ren 103 0.62 27.66 33.26
197 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19
198 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
199 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05
200 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
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