GO:0016021

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Name integral to membrane
Categary Component
Go Slim No
Go Link GO:0016021
Unique Molecular Interactions 15963
Total Molecular Interactions 22309
Total Single Events 192390
Pain Genes Associated 2194

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for integral to membrane. They are ordered first by their pain relevance and then by number of times they were reported for integral to membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
2 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
3 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
4 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
5 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
6 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
7 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
8 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
9 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
10 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
11 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
12 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
13 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
14 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
15 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
16 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
17 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
18 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
19 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
20 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
21 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52
22 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
23 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
24 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
25 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
26 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
27 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
28 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58
29 INT14095 Binding of Vsig2 and Coq10a 2 0.33 1.98 4.55
30 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
31 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
32 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
33 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
34 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
35 INT122567 Mog Positive_regulation of Eae1 8 0.31 10.18 4.26
36 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
37 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
38 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
39 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
40 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
41 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
42 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
43 INT107801 Ugt1a5 Positive_regulation of Localization of Prl 3 0.76 1 3.9
44 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
45 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
46 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
47 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
48 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
49 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
50 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
51 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
52 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
53 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
54 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64
55 INT64883 Ptger2 Positive_regulation of Ina 1 0.03 1.26 3.64
56 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
57 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
58 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
59 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5
60 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
61 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
62 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4
63 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
64 INT212658 KCNA1 Positive_regulation of Cort 1 0.00 2.58 3.36
65 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
66 INT56458 Binding of GPM6A and IGHG3 4 0.02 0 3.31
67 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
68 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
69 INT48162 RIMS3 Regulation of Localization of LTC4S 1 0.10 2.14 3.25
70 INT354207 Igfbp7 Positive_regulation of Accn3 1 0.52 6.55 3.24
71 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
72 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
73 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
74 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
75 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17
76 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
77 INT289979 Binding of Helt and Negative_regulation of Maoa 1 0.00 0.17 3.14
78 INT211694 Binding of Cntnap1 and Nav1 1 0.04 0 3.14
79 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
80 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
81 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
82 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1
83 INT101408 Binding of Grin1 and Olr1469 1 0.03 0.86 3.1
84 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
85 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
86 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
87 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
88 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
89 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
90 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
91 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
92 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
93 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
94 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96
95 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
96 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
97 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
98 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
99 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
100 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
101 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
102 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85
103 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
104 INT130085 Crp Positive_regulation of Gene_expression of Vcam1 1 0.23 4.34 2.84
105 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
106 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
107 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
108 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
109 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
110 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76
111 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
112 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
113 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
114 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
115 INT69057 H2-M3 Regulation of Klkb1 1 0.00 0.42 2.71
116 INT151381 St8sia1 Positive_regulation of Cck 1 0.19 0.45 2.7
117 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
118 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
119 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
120 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
121 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
122 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
123 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64
124 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
125 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
126 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
127 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
128 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
129 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
130 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
131 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
132 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
133 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
134 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
135 INT67905 Binding of Spn and Fosl1 1 0.24 2.1 2.54
136 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
137 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
138 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
139 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
140 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
141 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
142 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
143 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
144 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
145 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
146 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
147 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49
148 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
149 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48
150 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
151 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
152 INT96462 Pnoc Positive_regulation of Pag1 1 0.01 0.74 2.45
153 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
154 INT135867 Zfp821 Positive_regulation of Positive_regulation of Chrne 1 0.01 0 2.44
155 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
156 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
157 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
158 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
159 INT37873 Pag1 Regulation of Nrm 2 0.04 1.1 2.41
160 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
161 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
162 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
163 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
164 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
165 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
166 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
167 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
168 INT158809 Pag1 Regulation of Rvm 1 0.02 1.28 2.33
169 INT108987 Ngf Regulation of Gene_expression of Sit1 1 0.00 1.46 2.32
170 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
171 INT249013 Gabrg1 Negative_regulation of Per2 1 0.34 0.07 2.31
172 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
173 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
174 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
175 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
176 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
177 INT128778 Binding of Mcam and Nav1 1 0.03 0.51 2.28
178 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27
179 INT211748 Binding of Pag1 and Mors1 2 0.07 0.2 2.26
180 INT321477 Binding of Ubqln1 and Flvcr2 1 0.00 0.81 2.26
181 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26
182 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
183 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24
184 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
185 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
186 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
187 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
188 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
189 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
190 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
191 INT146930 CAP1 Regulation of ABCB1 1 0.29 0.3 2.19
192 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
193 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
194 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
195 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18
196 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
197 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
198 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
199 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
200 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15

Single Events

The table below shows the top 100 pain related interactions that have been reported for integral to membrane. They are ordered first by their pain relevance and then by number of times they were reported in integral to membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59
2 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
3 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42
4 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42
5 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81
6 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
7 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
8 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
9 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
10 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
11 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05
12 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59
13 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
14 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87
15 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
16 INT1212 Binding of Oprl1 312 0.48 28.6 225.15
17 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
18 INT767 Localization of Gnrhr 565 0.80 106.68 214.57
19 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
20 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
21 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74
22 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
23 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
24 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
25 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
26 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93
27 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
28 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
29 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61
30 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
31 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99
32 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24
33 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16
34 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
35 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4
36 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74
37 INT1878 Binding of HLA-B 440 0.48 321.16 127.36
38 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
39 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34
40 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
41 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
42 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
43 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75
44 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38
45 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
46 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
47 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
48 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83
49 INT114 Binding of Oprl1 139 0.48 23 103.35
50 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03
51 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
52 INT74826 Gene_expression of Slc1a2 131 0.78 61.83 100.84
53 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76
54 INT65500 Gene_expression of App 605 0.78 429.94 98.31
55 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
56 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
57 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79
58 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66
59 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49
60 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02
61 INT38731 Localization of Trpv1 138 0.81 52.73 90.49
62 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
63 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7
64 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
65 INT10166 Localization of Tnf 237 0.81 153.95 88.64
66 INT73340 Negative_regulation of Faah 134 0.59 38.67 85.03
67 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
68 INT4830 Binding of Trpv1 158 0.48 45.11 84.2
69 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71
70 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56
71 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
72 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
73 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
74 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64
75 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65
76 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98
77 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46
78 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37
79 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
80 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13
81 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88
82 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7
83 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
84 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23
85 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
86 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
87 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68
88 INT4153 Binding of Insrr 109 0.40 17.99 72.15
89 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9
90 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06
91 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
92 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
93 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
94 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15
95 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
96 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
97 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17
98 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
99 INT6926 Regulation of Pag1 72 0.39 55.79 65.09
100 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
101 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
102 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23
103 INT96622 Localization of Trpv1 110 0.81 59.82 63.25
104 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1
105 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
106 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42
107 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
108 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52
109 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98
110 INT109431 Gene_expression of Trpa1 123 0.78 51.84 59.98
111 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26
112 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
113 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
114 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23
115 INT7340 Regulation of Grin1 87 0.62 30.37 57.93
116 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
117 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
118 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59
119 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35
120 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
121 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82
122 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66
123 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
124 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31
125 INT49436 Binding of TRPV1 145 0.48 38.35 55.08
126 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
127 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
128 INT7800 Localization of Pag1 51 0.56 33.06 53.74
129 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
130 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21
131 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
132 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
133 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71
134 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
135 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92
136 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
137 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
138 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
139 INT74827 Positive_regulation of Gene_expression of Slc1a2 52 0.70 26.54 50.63
140 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14
141 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24
142 INT109430 Positive_regulation of Trpa1 119 0.70 44 49.14
143 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
144 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
145 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
146 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
147 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89
148 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85
149 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
150 INT1715 Positive_regulation of Nrm 51 0.70 24 47.53
151 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
152 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31
153 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
154 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
155 INT9383 Localization of TRPV1 98 0.81 33.23 46.24
156 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01
157 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85
158 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
159 INT98498 Binding of Trpv1 75 0.48 33.67 44.4
160 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23
161 INT127013 Negative_regulation of Slc1a3 37 0.54 14.16 43.97
162 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
163 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01
164 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
165 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
166 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
167 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
168 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84
169 INT81251 Gene_expression of Trpv2 78 0.78 28.27 41.76
170 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
171 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56
172 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
173 INT49643 Gene_expression of Bdkrb1 39 0.78 46.49 40.21
174 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
175 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
176 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21
177 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
178 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03
179 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66
180 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
181 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
182 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
183 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
184 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
185 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25
186 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
187 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02
188 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
189 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
190 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
191 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01
192 INT11246 Binding of Grin1 65 0.48 14.53 36.93
193 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88
194 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78
195 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76
196 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
197 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
198 INT103172 Gene_expression of Slc12a5 81 0.77 39.45 36.22
199 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
200 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
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