GO:0016079

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Name synaptic vesicle exocytosis
Categary Process
Go Slim No
Go Link GO:0016079
Unique Molecular Interactions 102
Total Molecular Interactions 118
Total Single Events 1238
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for synaptic vesicle exocytosis. They are ordered first by their pain relevance and then by number of times they were reported for synaptic vesicle exocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
2 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
3 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
4 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
5 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
6 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
7 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
8 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
9 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
10 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
11 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
12 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
13 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
14 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
15 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
16 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
17 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
18 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
19 INT255292 Regulation of Binding of Napb and Vamp2 1 0.07 0 0.3
20 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
21 INT255286 Binding of Napb and Vamp2 1 0.09 0 0.29
22 INT255284 Binding of Vamp2 and Vti1b 1 0.16 0 0.29
23 INT194977 Binding of Alox5 and Syt1 1 0.04 0.65 0.27
24 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
25 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
26 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
27 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
28 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
29 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
30 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
31 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
32 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
33 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15
34 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
35 INT214953 Syt1 Regulation of Rims1 1 0.25 0 0.12
36 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
37 INT214952 Vamp2 Regulation of Rims1 1 0.17 0 0.12
38 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
39 INT214955 Binding of Syt1 and Vamp2 1 0.22 0 0.1
40 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1
41 INT214957 Vamp2 Regulation of Neu3 1 0.00 0 0.1
42 INT214951 Binding of Syt1 and Vamp1 1 0.22 0 0.1
43 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1
44 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
45 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
46 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
47 INT249413 Binding of Vamp2 and Napa 1 0.15 0.05 0.09
48 INT221954 Binding of CDK5 and CDK5R2 1 0.02 0.36 0.09
49 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
50 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
51 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
52 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
53 INT263761 Grin1 Regulation of Localization of Vamp2 1 0.27 0.17 0.07
54 INT263777 Grin2a Regulation of Localization of Vamp2 1 0.26 0.17 0.07
55 INT263734 Dlg4 Regulation of Localization of Vamp2 1 0.15 0.17 0.07
56 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
57 INT303055 Akt1 Negative_regulation of Syt1 1 0.21 0 0.07
58 INT263739 Grin2b Regulation of Localization of Vamp2 1 0.24 0.17 0.07
59 INT263735 Localization of Neto1 Regulation of Localization of Vamp2 1 0.35 0.18 0.05
60 INT238619 Binding of Apba1 and Regulation of Localization of Grin2d 1 0.01 0 0.05
61 INT303086 Binding of Mafk and Syt1 1 0.23 0.18 0.05
62 INT303057 Binding of Syn1 and Syt1 1 0.07 0.19 0.05
63 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
64 INT303059 Binding of Syt1 and Sdcbp 1 0.04 0.19 0.05
65 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
66 INT249421 Binding of Stx1a and Vamp2 1 0.10 0 0.04
67 INT249404 Binding of Snap25 and Vamp2 1 0.16 0 0.04
68 INT303054 Rorb Positive_regulation of Gene_expression of Syt1 1 0.01 0 0.03
69 INT219352 CDK5 Negative_regulation of PAK1 1 0.22 0.72 0.03
70 INT215243 Binding of Rab3a and Noc2l 1 0.00 0.26 0
71 INT217031 Binding of P2rx7 and Positive_regulation of Casp1 1 0.02 0 0
72 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
73 INT215241 Binding of Rab3a and Rph3a 1 0.00 0.26 0
74 INT249410 Vamp2 Regulation of Binding of Stx1a 1 0.06 0 0
75 INT216942 Positive_regulation of P2rx7 Positive_regulation of Casp1 1 0.14 0 0
76 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
77 INT303160 Binding of Trim3 and Trim9 1 0.21 0 0
78 INT249407 Mbp Positive_regulation of Localization of Vamp2 1 0.13 0.11 0
79 INT215238 Binding of Rab3a and Sytl4 1 0.01 0.26 0
80 INT249422 Binding of Mbp and Vamp2 1 0.12 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for synaptic vesicle exocytosis. They are ordered first by their pain relevance and then by number of times they were reported in synaptic vesicle exocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
3 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
4 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
5 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
6 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
7 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
8 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
9 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
10 INT141751 Localization of Syt1 21 0.78 11.19 5.98
11 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
12 INT141750 Positive_regulation of Localization of Syt1 10 0.67 5.53 5.28
13 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
14 INT106274 Positive_regulation of Syt1 16 0.67 9.76 4.1
15 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
16 INT22578 Gene_expression of Syt1 43 0.77 11.02 3.66
17 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
18 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
19 INT151268 Phosphorylation of Syt1 4 0.61 1.65 2.95
20 INT141752 Negative_regulation of Localization of Syt1 5 0.42 4.96 2.68
21 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
22 INT346375 Protein_catabolism of Vamp2 1 0.33 1.56 2.46
23 INT249378 Negative_regulation of Vamp2 3 0.20 0.27 2.4
24 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
25 INT151272 Positive_regulation of Phosphorylation of Syt1 2 0.45 0.32 1.93
26 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
27 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
28 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
29 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
30 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
31 INT106273 Positive_regulation of Positive_regulation of Syt1 2 0.29 1.22 1.42
32 INT171147 Binding of Syt1 7 0.35 6.11 1.36
33 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
34 INT249383 Binding of Vamp2 5 0.23 0.33 1.03
35 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
36 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
37 INT234081 Gene_expression of Vamp2 9 0.51 0.71 0.94
38 INT249377 Localization of Vamp2 4 0.51 0.4 0.93
39 INT127452 Positive_regulation of CDK5 5 0.32 1.88 0.87
40 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
41 INT219358 Gene_expression of CDK5 9 0.58 5.65 0.81
42 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
43 INT150608 Regulation of Apba1 1 0.00 1.27 0.69
44 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
45 INT22577 Positive_regulation of Gene_expression of Syt1 6 0.50 1.49 0.65
46 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
47 INT327659 Regulation of Syt1 1 0.20 0 0.56
48 INT346370 Regulation of Localization of Vamp2 1 0.15 0.08 0.53
49 INT346393 Regulation of Protein_catabolism of Vamp2 1 0.09 0.08 0.53
50 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
51 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
52 INT336690 Negative_regulation of Gene_expression of Vamp2 2 0.16 0.28 0.46
53 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
54 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
55 INT146045 Regulation of Gene_expression of Syt1 4 0.21 0.84 0.4
56 INT234828 Gene_expression of RAB3A 2 0.30 2.05 0.37
57 INT221973 Negative_regulation of CDK5 4 0.57 2.26 0.36
58 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
59 INT106271 Negative_regulation of Positive_regulation of Syt1 1 0.25 0.34 0.3
60 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
61 INT354299 Positive_regulation of Syt1 1 0.67 0.1 0.27
62 INT160928 Negative_regulation of Syt1 4 0.57 1.9 0.25
63 INT139810 Gene_expression of Apba1 1 0.00 0.87 0.24
64 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
65 INT221896 Protein_catabolism of Syt1 2 0.22 0.36 0.2
66 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
67 INT219375 Localization of CDK5 4 0.52 2.8 0.19
68 INT221974 Phosphorylation of CDK5 1 0.56 0.99 0.19
69 INT216889 Phosphorylation of P2rx7 1 0.23 0 0.18
70 INT307467 Regulation of Binding of P2rx7 1 0.08 0 0.16
71 INT221972 Regulation of CDK5 1 0.42 1.87 0.16
72 INT270813 Positive_regulation of Localization of P2rx7 1 0.46 0.24 0.15
73 INT346395 Positive_regulation of Protein_catabolism of Vamp2 1 0.16 0.13 0.13
74 INT341559 Positive_regulation of Gene_expression of CDK5 1 0.23 0.25 0.11
75 INT351388 Positive_regulation of Binding of Syt1 1 0.11 0.33 0.1
76 INT303069 Transcription of Syt1 1 0.41 0 0.09
77 INT249379 Positive_regulation of Vamp2 3 0.33 0 0.08
78 INT307481 Phosphorylation of P2rx7 1 0.15 0.35 0.08
79 INT307480 Positive_regulation of Phosphorylation of P2rx7 1 0.09 0.35 0.08
80 INT190861 Binding of Syt1 1 0.03 0.55 0.08
81 INT238599 Binding of Apba1 1 0.08 0 0.07
82 INT341567 Negative_regulation of Gene_expression of CDK5 1 0.27 0.24 0.07
83 INT219355 Binding of CDK5 3 0.35 2.02 0.06
84 INT234092 Regulation of Vamp2 2 0.20 0.17 0.05
85 INT351387 Regulation of Syt1 1 0.11 0.32 0.05
86 INT336691 Regulation of Gene_expression of Vamp2 1 0.19 0.43 0.03
87 INT171149 Negative_regulation of Gene_expression of Syt1 2 0.45 0.22 0
88 INT215230 Gene_expression of Rab3a 1 0.02 0.39 0
89 INT215227 Positive_regulation of Gene_expression of Rab3a 1 0.02 0.39 0
90 INT303192 Gene_expression of Trim9 1 0.32 0.28 0
91 INT249397 Negative_regulation of Binding of Vamp2 1 0.28 0 0
92 INT215232 Binding of Rab3a 1 0.01 0.25 0
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